Hemostasis in the Lab, Approaching to the Correct Diagnosis in the Coagulopathies

Lopez S N; Cortina DLR E; Gonzalez P M; Nunez T M

doi:doi:10.11648/j.ajp.20200602.16

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Hemostasis in the Lab, Approaching to the Correct Diagnosis in the Coagulopathies

Lopez S N, Cortina DLR E, Gonzalez P M, Nunez T M

Received: 2 October 2019 Accepted: 24 February 2020 Published: 6 March 2020

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Abstract

Coagulation is the result of a coordinated interaction of blood proteins, circulating cells, endothelium cells and extracellular matrix proteins in the vessel wall. This process works in conjunction with other mechanisms that have to keep the blood in an effective flow, without hemorrity when damage occurs or without a thrombus when clotting begins. Most of the time, there is not so much information that a clotting test gives us, however, in the face of a real clinical scenario that concurrent with a personal haemorrhage, this is essential to take action. In addition, there is a thrombophilic scenario that has to be investigated. In all of them, it is important to note that doctors have to take into account that the pre-analytical phase plays a fundamental role, so it is very important to look around any situation that may impact the patient's results. There is a wide range of laboratory tests to evaluate different mechanisms of hemostasis, according to the history and characteristic of the clinical patient. With this in mind, there is a right time to ask for the right test, to get a better result for diagnosis and treatment. Analytical quality is the set of actions that are carried out in the laboratory with the aim of obtaining an accurate result, reflecting the real situation of the patient. Grossly, platelets, clotting factors and the fibrinolytic system could be studied, not all patients need all tests, they could be solved with a simple test, but may require a deep focus; that is why the patient with a history of mucocutaneous bleeding has to be studied for thrombocytopaties or VWD; a patient with muscle or joint bleeding has to be a factor deficiency test. We propose an initial approach to detecting the pathological situations essential to make decisions. Each person has different symptoms and different approaches, which is why identification and the right tests give us the greatest opportunity to get the right diagnosis.

DOI	10.11648/j.ajp.20200602.16
Published in	American Journal of Pediatrics (Volume 6, Issue 2, June 2020)
Page(s)	98-104
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Blood Coagulation, Hemostasis, Blood Test, Clinical Laboratory, Coagulopathty

References

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[17]	Kitchen S, Geisen U, Kappelmayer J, Quehenberger P, et al. 2018. Evaluating the analytical performance of four new coagulation assays for the measurement of fibrinogen, D-dimer and thrombin time. Int J Lab Hematol; 40: 637–644.
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APA Style

Lopez S N, Cortina DLR E, Gonzalez P M, Nunez T M. (2020). Hemostasis in the Lab, Approaching to the Correct Diagnosis in the Coagulopathies. American Journal of Pediatrics, 6(2), 98-104. https://doi.org/10.11648/j.ajp.20200602.16

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ACS Style

Lopez S N; Cortina DLR E; Gonzalez P M; Nunez T M. Hemostasis in the Lab, Approaching to the Correct Diagnosis in the Coagulopathies. Am. J. Pediatr. 2020, 6(2), 98-104. doi: 10.11648/j.ajp.20200602.16

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AMA Style

Lopez S N, Cortina DLR E, Gonzalez P M, Nunez T M. Hemostasis in the Lab, Approaching to the Correct Diagnosis in the Coagulopathies. Am J Pediatr. 2020;6(2):98-104. doi: 10.11648/j.ajp.20200602.16

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@article{10.11648/j.ajp.20200602.16,
  author = {Lopez S N and Cortina DLR E and Gonzalez P M and Nunez T M},
  title = {Hemostasis in the Lab, Approaching to the Correct Diagnosis in the Coagulopathies},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {2},
  pages = {98-104},
  doi = {10.11648/j.ajp.20200602.16},
  url = {https://doi.org/10.11648/j.ajp.20200602.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200602.16},
  abstract = {Coagulation is the result of a coordinated interaction of blood proteins, circulating cells, endothelium cells and extracellular matrix proteins in the vessel wall. This process works in conjunction with other mechanisms that have to keep the blood in an effective flow, without hemorrity when damage occurs or without a thrombus when clotting begins. Most of the time, there is not so much information that a clotting test gives us, however, in the face of a real clinical scenario that concurrent with a personal haemorrhage, this is essential to take action. In addition, there is a thrombophilic scenario that has to be investigated. In all of them, it is important to note that doctors have to take into account that the pre-analytical phase plays a fundamental role, so it is very important to look around any situation that may impact the patient's results. There is a wide range of laboratory tests to evaluate different mechanisms of hemostasis, according to the history and characteristic of the clinical patient. With this in mind, there is a right time to ask for the right test, to get a better result for diagnosis and treatment. Analytical quality is the set of actions that are carried out in the laboratory with the aim of obtaining an accurate result, reflecting the real situation of the patient. Grossly, platelets, clotting factors and the fibrinolytic system could be studied, not all patients need all tests, they could be solved with a simple test, but may require a deep focus; that is why the patient with a history of mucocutaneous bleeding has to be studied for thrombocytopaties or VWD; a patient with muscle or joint bleeding has to be a factor deficiency test. We propose an initial approach to detecting the pathological situations essential to make decisions. Each person has different symptoms and different approaches, which is why identification and the right tests give us the greatest opportunity to get the right diagnosis.},
 year = {2020}
}

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TY  - JOUR
T1  - Hemostasis in the Lab, Approaching to the Correct Diagnosis in the Coagulopathies
AU  - Lopez S N
AU  - Cortina DLR E
AU  - Gonzalez P M
AU  - Nunez T M
Y1  - 2020/03/06
PY  - 2020
N1  - https://doi.org/10.11648/j.ajp.20200602.16
DO  - 10.11648/j.ajp.20200602.16
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
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PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20200602.16
AB  - Coagulation is the result of a coordinated interaction of blood proteins, circulating cells, endothelium cells and extracellular matrix proteins in the vessel wall. This process works in conjunction with other mechanisms that have to keep the blood in an effective flow, without hemorrity when damage occurs or without a thrombus when clotting begins. Most of the time, there is not so much information that a clotting test gives us, however, in the face of a real clinical scenario that concurrent with a personal haemorrhage, this is essential to take action. In addition, there is a thrombophilic scenario that has to be investigated. In all of them, it is important to note that doctors have to take into account that the pre-analytical phase plays a fundamental role, so it is very important to look around any situation that may impact the patient's results. There is a wide range of laboratory tests to evaluate different mechanisms of hemostasis, according to the history and characteristic of the clinical patient. With this in mind, there is a right time to ask for the right test, to get a better result for diagnosis and treatment. Analytical quality is the set of actions that are carried out in the laboratory with the aim of obtaining an accurate result, reflecting the real situation of the patient. Grossly, platelets, clotting factors and the fibrinolytic system could be studied, not all patients need all tests, they could be solved with a simple test, but may require a deep focus; that is why the patient with a history of mucocutaneous bleeding has to be studied for thrombocytopaties or VWD; a patient with muscle or joint bleeding has to be a factor deficiency test. We propose an initial approach to detecting the pathological situations essential to make decisions. Each person has different symptoms and different approaches, which is why identification and the right tests give us the greatest opportunity to get the right diagnosis.
VL  - 6
IS  - 2
ER  -

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Author Information

Lopez S N

Pediatric Hematologists, Hematology Department, National Institute of Pediatrics, Mexico City, Mexico
Cortina DLR E

Laboratory of Thrombosis, Fibrinolysis and Platelet Function, National Institute of Cardiology, Ignacio Chavez, Mexico City, Mexico
Gonzalez P M

Pediatric Hematologists, Hematology Department, National Institute of Pediatrics, Mexico City, Mexico
Nunez T M

Pediatric Hematologists, Hematology Department, National Institute of Pediatrics, Mexico City, Mexico

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APA Style

Lopez S N, Cortina DLR E, Gonzalez P M, Nunez T M. (2020). Hemostasis in the Lab, Approaching to the Correct Diagnosis in the Coagulopathies. American Journal of Pediatrics, 6(2), 98-104. https://doi.org/10.11648/j.ajp.20200602.16

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ACS Style

Lopez S N; Cortina DLR E; Gonzalez P M; Nunez T M. Hemostasis in the Lab, Approaching to the Correct Diagnosis in the Coagulopathies. Am. J. Pediatr. 2020, 6(2), 98-104. doi: 10.11648/j.ajp.20200602.16

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AMA Style

Lopez S N, Cortina DLR E, Gonzalez P M, Nunez T M. Hemostasis in the Lab, Approaching to the Correct Diagnosis in the Coagulopathies. Am J Pediatr. 2020;6(2):98-104. doi: 10.11648/j.ajp.20200602.16

Copy | Download

@article{10.11648/j.ajp.20200602.16,
  author = {Lopez S N and Cortina DLR E and Gonzalez P M and Nunez T M},
  title = {Hemostasis in the Lab, Approaching to the Correct Diagnosis in the Coagulopathies},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {2},
  pages = {98-104},
  doi = {10.11648/j.ajp.20200602.16},
  url = {https://doi.org/10.11648/j.ajp.20200602.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200602.16},
  abstract = {Coagulation is the result of a coordinated interaction of blood proteins, circulating cells, endothelium cells and extracellular matrix proteins in the vessel wall. This process works in conjunction with other mechanisms that have to keep the blood in an effective flow, without hemorrity when damage occurs or without a thrombus when clotting begins. Most of the time, there is not so much information that a clotting test gives us, however, in the face of a real clinical scenario that concurrent with a personal haemorrhage, this is essential to take action. In addition, there is a thrombophilic scenario that has to be investigated. In all of them, it is important to note that doctors have to take into account that the pre-analytical phase plays a fundamental role, so it is very important to look around any situation that may impact the patient's results. There is a wide range of laboratory tests to evaluate different mechanisms of hemostasis, according to the history and characteristic of the clinical patient. With this in mind, there is a right time to ask for the right test, to get a better result for diagnosis and treatment. Analytical quality is the set of actions that are carried out in the laboratory with the aim of obtaining an accurate result, reflecting the real situation of the patient. Grossly, platelets, clotting factors and the fibrinolytic system could be studied, not all patients need all tests, they could be solved with a simple test, but may require a deep focus; that is why the patient with a history of mucocutaneous bleeding has to be studied for thrombocytopaties or VWD; a patient with muscle or joint bleeding has to be a factor deficiency test. We propose an initial approach to detecting the pathological situations essential to make decisions. Each person has different symptoms and different approaches, which is why identification and the right tests give us the greatest opportunity to get the right diagnosis.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Hemostasis in the Lab, Approaching to the Correct Diagnosis in the Coagulopathies
AU  - Lopez S N
AU  - Cortina DLR E
AU  - Gonzalez P M
AU  - Nunez T M
Y1  - 2020/03/06
PY  - 2020
N1  - https://doi.org/10.11648/j.ajp.20200602.16
DO  - 10.11648/j.ajp.20200602.16
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 98
EP  - 104
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20200602.16
AB  - Coagulation is the result of a coordinated interaction of blood proteins, circulating cells, endothelium cells and extracellular matrix proteins in the vessel wall. This process works in conjunction with other mechanisms that have to keep the blood in an effective flow, without hemorrity when damage occurs or without a thrombus when clotting begins. Most of the time, there is not so much information that a clotting test gives us, however, in the face of a real clinical scenario that concurrent with a personal haemorrhage, this is essential to take action. In addition, there is a thrombophilic scenario that has to be investigated. In all of them, it is important to note that doctors have to take into account that the pre-analytical phase plays a fundamental role, so it is very important to look around any situation that may impact the patient's results. There is a wide range of laboratory tests to evaluate different mechanisms of hemostasis, according to the history and characteristic of the clinical patient. With this in mind, there is a right time to ask for the right test, to get a better result for diagnosis and treatment. Analytical quality is the set of actions that are carried out in the laboratory with the aim of obtaining an accurate result, reflecting the real situation of the patient. Grossly, platelets, clotting factors and the fibrinolytic system could be studied, not all patients need all tests, they could be solved with a simple test, but may require a deep focus; that is why the patient with a history of mucocutaneous bleeding has to be studied for thrombocytopaties or VWD; a patient with muscle or joint bleeding has to be a factor deficiency test. We propose an initial approach to detecting the pathological situations essential to make decisions. Each person has different symptoms and different approaches, which is why identification and the right tests give us the greatest opportunity to get the right diagnosis.
VL  - 6
IS  - 2
ER  -

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