Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants

Yuko Sakurai; Motoichiro Sakurai

doi:doi:10.11648/j.ajp.20200603.37

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Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants

Yuko Sakurai, Motoichiro Sakurai

Published in American Journal of Pediatrics (Volume 6, Issue 3)

Received: 27 July 2020 Accepted: 10 August 2020 Published: 18 August 2020

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Abstract

IL-6 is thought to be involved in the prognosis of extremely low birth weight infants, in whom it leads to newborn organopathy. IL-6 also influences various processes in vivo, including thrombocytopoiesis. In the present study, we investigated whether the influence of IL-6 in the fetal period could be evaluated using the actual number of infant platelets, which is an index of thrombocytopoiesis. We retrospectively examined the perinatal information of extremely low birth weight infants, IL-6, the number of platelets (Plt), and the number of immature platelets fraction (IPF). The study population included 81 infants. The mean gestational age of the infants was 26.1±2.5 weeks and the mean birth weight was 729±161 g. The immature platelet count (Plt×IPF) was positively correlated with the IgM level (R=0.45, p<0.01) and the membrane rupture time (R=0.095, p<0.01). In addition, the Plt×IPF in the group in which the cord blood IL-6 level was ≥11 pg/mL was significantly higher than that in the group in which the cord blood IL-6 was <11 pg/mL (p<0.01). The Plt×IPF value at birth was associated with the IL-6 level in extremely low birth weight infants, which suggests the possibility that it may be used to evaluate fetal inflammation.

Published in	American Journal of Pediatrics (Volume 6, Issue 3)
DOI	10.11648/j.ajp.20200603.37
Page(s)	334-340
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Extra-low Birth Weight Infants, Platelet Count, Immature Platelet Fraction, Chorioamnionitis, Fetal Inflammatory Response Syndrome (FIRS)

References

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APA Style

Yuko Sakurai, Motoichiro Sakurai. (2020). Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants. American Journal of Pediatrics, 6(3), 334-340. https://doi.org/10.11648/j.ajp.20200603.37

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ACS Style

Yuko Sakurai; Motoichiro Sakurai. Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants. Am. J. Pediatr. 2020, 6(3), 334-340. doi: 10.11648/j.ajp.20200603.37

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AMA Style

Yuko Sakurai, Motoichiro Sakurai. Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants. Am J Pediatr. 2020;6(3):334-340. doi: 10.11648/j.ajp.20200603.37

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@article{10.11648/j.ajp.20200603.37,
  author = {Yuko Sakurai and Motoichiro Sakurai},
  title = {Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {3},
  pages = {334-340},
  doi = {10.11648/j.ajp.20200603.37},
  url = {https://doi.org/10.11648/j.ajp.20200603.37},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200603.37},
  abstract = {IL-6 is thought to be involved in the prognosis of extremely low birth weight infants, in whom it leads to newborn organopathy. IL-6 also influences various processes in vivo, including thrombocytopoiesis. In the present study, we investigated whether the influence of IL-6 in the fetal period could be evaluated using the actual number of infant platelets, which is an index of thrombocytopoiesis. We retrospectively examined the perinatal information of extremely low birth weight infants, IL-6, the number of platelets (Plt), and the number of immature platelets fraction (IPF). The study population included 81 infants. The mean gestational age of the infants was 26.1±2.5 weeks and the mean birth weight was 729±161 g. The immature platelet count (Plt×IPF) was positively correlated with the IgM level (R=0.45, p<0.01) and the membrane rupture time (R=0.095, p<0.01). In addition, the Plt×IPF in the group in which the cord blood IL-6 level was ≥11 pg/mL was significantly higher than that in the group in which the cord blood IL-6 was <11 pg/mL (p<0.01). The Plt×IPF value at birth was associated with the IL-6 level in extremely low birth weight infants, which suggests the possibility that it may be used to evaluate fetal inflammation.},
 year = {2020}
}

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TY - JOUR
T1 - Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants
AU - Yuko Sakurai
AU - Motoichiro Sakurai
Y1 - 2020/08/18
PY - 2020
N1 - https://doi.org/10.11648/j.ajp.20200603.37
DO - 10.11648/j.ajp.20200603.37
T2 - American Journal of Pediatrics
JF - American Journal of Pediatrics
JO - American Journal of Pediatrics
SP - 334
EP - 340
PB - Science Publishing Group
SN - 2472-0909
UR - https://doi.org/10.11648/j.ajp.20200603.37
AB - IL-6 is thought to be involved in the prognosis of extremely low birth weight infants, in whom it leads to newborn organopathy. IL-6 also influences various processes in vivo, including thrombocytopoiesis. In the present study, we investigated whether the influence of IL-6 in the fetal period could be evaluated using the actual number of infant platelets, which is an index of thrombocytopoiesis. We retrospectively examined the perinatal information of extremely low birth weight infants, IL-6, the number of platelets (Plt), and the number of immature platelets fraction (IPF). The study population included 81 infants. The mean gestational age of the infants was 26.1±2.5 weeks and the mean birth weight was 729±161 g. The immature platelet count (Plt×IPF) was positively correlated with the IgM level (R=0.45, p<0.01) and the membrane rupture time (R=0.095, p<0.01). In addition, the Plt×IPF in the group in which the cord blood IL-6 level was ≥11 pg/mL was significantly higher than that in the group in which the cord blood IL-6 was <11 pg/mL (p<0.01). The Plt×IPF value at birth was associated with the IL-6 level in extremely low birth weight infants, which suggests the possibility that it may be used to evaluate fetal inflammation.
VL - 6
IS - 3
ER -

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Author Information

Yuko Sakurai

Division of Neonatology, Showa University Koto Toyosu Hospital, Tokyo, Japan; Division of Neonatology, Japanese Red Cross Medical Center, Tokyo, Japan
Motoichiro Sakurai

Division of Neonatology, Showa University Koto Toyosu Hospital, Tokyo, Japan

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Plain Text BibTeX RIS

APA Style

Yuko Sakurai, Motoichiro Sakurai. (2020). Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants. American Journal of Pediatrics, 6(3), 334-340. https://doi.org/10.11648/j.ajp.20200603.37

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ACS Style

Yuko Sakurai; Motoichiro Sakurai. Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants. Am. J. Pediatr. 2020, 6(3), 334-340. doi: 10.11648/j.ajp.20200603.37

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AMA Style

Yuko Sakurai, Motoichiro Sakurai. Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants. Am J Pediatr. 2020;6(3):334-340. doi: 10.11648/j.ajp.20200603.37

Copy | Download

@article{10.11648/j.ajp.20200603.37,
  author = {Yuko Sakurai and Motoichiro Sakurai},
  title = {Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {3},
  pages = {334-340},
  doi = {10.11648/j.ajp.20200603.37},
  url = {https://doi.org/10.11648/j.ajp.20200603.37},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200603.37},
  abstract = {IL-6 is thought to be involved in the prognosis of extremely low birth weight infants, in whom it leads to newborn organopathy. IL-6 also influences various processes in vivo, including thrombocytopoiesis. In the present study, we investigated whether the influence of IL-6 in the fetal period could be evaluated using the actual number of infant platelets, which is an index of thrombocytopoiesis. We retrospectively examined the perinatal information of extremely low birth weight infants, IL-6, the number of platelets (Plt), and the number of immature platelets fraction (IPF). The study population included 81 infants. The mean gestational age of the infants was 26.1±2.5 weeks and the mean birth weight was 729±161 g. The immature platelet count (Plt×IPF) was positively correlated with the IgM level (R=0.45, p<0.01) and the membrane rupture time (R=0.095, p<0.01). In addition, the Plt×IPF in the group in which the cord blood IL-6 level was ≥11 pg/mL was significantly higher than that in the group in which the cord blood IL-6 was <11 pg/mL (p<0.01). The Plt×IPF value at birth was associated with the IL-6 level in extremely low birth weight infants, which suggests the possibility that it may be used to evaluate fetal inflammation.},
 year = {2020}
}

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