The regional cerebral blood flow (rCBF) and the cerebral vasoreactivity of the patients with depressive disorder were observed by SPECT and acetazolamide stress SPECT test respectively. Eighteen unmedicated depressed patients and nineteen healthy control subjects were included. Baseline SPECT was performed in both patients and control subjects. Acetazolamide stress SPECT test was performed two days later in patients two hours after taking 2g acetazolamide orally. It was found that there was significant difference between the untreated depressed patients and the controls, because there was relatively reduced perfusion in frontal lobe, temporal lobe, left parietal lobe and right basal ganglia in depressed patients. After acetazolamide stress SPECT test, the perfusion of decreased regions in baseline step was increased. No potential ischemic lesion was found. The perfusion of some specific regions of the depressed patients decreased. Acetazolamide stress SPECT test could not reveal silent brain ischemia in the depressed patients. The perfusion of decreased regions in the baseline imaging was increased in acetazolamide stress SPECT test.
| Published in | Advances in Applied Physiology (Volume 1, Issue 3) |
| DOI | 10.11648/j.aap.20160103.11 |
| Page(s) | 38-42 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Depression, Regional Cerebral Blood Flow, SPECT, Acetazolamide
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APA Style
Yi Xu, Jian Gong, Hao Xu. (2016). Acetazolamide Stress SPECT Test on Cerebral Blood Flow in Patients with Depressive Disorder. Advances in Applied Physiology, 1(3), 38-42. https://doi.org/10.11648/j.aap.20160103.11
ACS Style
Yi Xu; Jian Gong; Hao Xu. Acetazolamide Stress SPECT Test on Cerebral Blood Flow in Patients with Depressive Disorder. Adv. Appl. Physiol. 2016, 1(3), 38-42. doi: 10.11648/j.aap.20160103.11
AMA Style
Yi Xu, Jian Gong, Hao Xu. Acetazolamide Stress SPECT Test on Cerebral Blood Flow in Patients with Depressive Disorder. Adv Appl Physiol. 2016;1(3):38-42. doi: 10.11648/j.aap.20160103.11
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Download@article{10.11648/j.aap.20160103.11,
author = {Yi Xu and Jian Gong and Hao Xu},
title = {Acetazolamide Stress SPECT Test on Cerebral Blood Flow in Patients with Depressive Disorder},
journal = {Advances in Applied Physiology},
volume = {1},
number = {3},
pages = {38-42},
doi = {10.11648/j.aap.20160103.11},
url = {https://doi.org/10.11648/j.aap.20160103.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aap.20160103.11},
abstract = {The regional cerebral blood flow (rCBF) and the cerebral vasoreactivity of the patients with depressive disorder were observed by SPECT and acetazolamide stress SPECT test respectively. Eighteen unmedicated depressed patients and nineteen healthy control subjects were included. Baseline SPECT was performed in both patients and control subjects. Acetazolamide stress SPECT test was performed two days later in patients two hours after taking 2g acetazolamide orally. It was found that there was significant difference between the untreated depressed patients and the controls, because there was relatively reduced perfusion in frontal lobe, temporal lobe, left parietal lobe and right basal ganglia in depressed patients. After acetazolamide stress SPECT test, the perfusion of decreased regions in baseline step was increased. No potential ischemic lesion was found. The perfusion of some specific regions of the depressed patients decreased. Acetazolamide stress SPECT test could not reveal silent brain ischemia in the depressed patients. The perfusion of decreased regions in the baseline imaging was increased in acetazolamide stress SPECT test.},
year = {2016}
}
TY - JOUR T1 - Acetazolamide Stress SPECT Test on Cerebral Blood Flow in Patients with Depressive Disorder AU - Yi Xu AU - Jian Gong AU - Hao Xu Y1 - 2016/10/28 PY - 2016 N1 - https://doi.org/10.11648/j.aap.20160103.11 DO - 10.11648/j.aap.20160103.11 T2 - Advances in Applied Physiology JF - Advances in Applied Physiology JO - Advances in Applied Physiology SP - 38 EP - 42 PB - Science Publishing Group SN - 2471-9714 UR - https://doi.org/10.11648/j.aap.20160103.11 AB - The regional cerebral blood flow (rCBF) and the cerebral vasoreactivity of the patients with depressive disorder were observed by SPECT and acetazolamide stress SPECT test respectively. Eighteen unmedicated depressed patients and nineteen healthy control subjects were included. Baseline SPECT was performed in both patients and control subjects. Acetazolamide stress SPECT test was performed two days later in patients two hours after taking 2g acetazolamide orally. It was found that there was significant difference between the untreated depressed patients and the controls, because there was relatively reduced perfusion in frontal lobe, temporal lobe, left parietal lobe and right basal ganglia in depressed patients. After acetazolamide stress SPECT test, the perfusion of decreased regions in baseline step was increased. No potential ischemic lesion was found. The perfusion of some specific regions of the depressed patients decreased. Acetazolamide stress SPECT test could not reveal silent brain ischemia in the depressed patients. The perfusion of decreased regions in the baseline imaging was increased in acetazolamide stress SPECT test. VL - 1 IS - 3 ER -
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