Advances in Applied Physiology

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Mn2+ - Negatively Charged Pegylated Dendrimer G2-Tryptophan: Novel Nano Magnetic Resonance Imaging Agent

Received: 24 December 2016    Accepted: 22 March 2017    Published: 14 July 2017
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Abstract

Due to the new proclamation of the harmful symptoms of Gd (III) based MRI differentiate operators in the patients with harmed renal capacities, there is a solid consideration on emerging substitute differentiate specialists for MRI. A polymer with core of PEG and citrus extract as a shell was created for double modular imaging. After amalgamation of the polymer, ALGD-Trp Conjugate and after that Mn2+ stacked on the dendrimer. Differentiate upgraded MRI of the focused on double imaging operator was assessed by AFM magnifying lens. Growth is one of driving reason for death in everywhere throughout the world. Early determination of tumor known as a decent solution. Achieving a capable and non-obtrusive contrast agent with high specificity, sensitivity and capacity to target cancer cells are essential. Among of different malignancies distinguishing strategies, Magnetic Resonance Imaging is an important technique, however its burdens including low resolution, In this study, Tryptophan was appended on the Anionic direct globular dendrimer with polyethylene glycol center and citrus extract bunches around it. Tryptophan was utilized to enhance intra-cell take-up and gathering in human bosom malignancy cells lastly differentiate operator (Mn2+) stacked in orchestrated dendrimers. The contrast agent was characterized with different techniques such as FT-IR, FTIR, Zeta sizer, UV-spectroscopy. ICP-AES was used to assess the intra-cell take-up of Mn2+ iones. Cytotoxicity studies and evaluation of cell passing mechanism were performed in bosom tumor MCF-7 cell line. Then, impact of various grouping of new difference specialist on T1 and T2 assessed in-vitro utilizing MR imaging. In light of the outcomes exhibited that Mn2+ - Anionic straight globular dendrimer G2-Tryptophancontrastagentdid not demonstrate any significant toxicity (cancer and ordinary cells), The outcomes demonstrated the new focused on nano differentiate specialist fitting accumulation in the tumor cells and solid T1intense flag on compared to Magnevist as a standard CA. This novel complexity specialist can be presented as a decent CA applicant in early identification of tumor.

DOI 10.11648/j.aap.20170201.11
Published in Advances in Applied Physiology (Volume 2, Issue 1, October 2017)
Page(s) 1-9
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Synthesis, Biological Activity, Mn2+ Dendrimer G2-Tryptophan, MRI

References
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Author Information
  • Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

  • Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

  • Pharma Chemie Company, Tehran, Iran

  • Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

  • Department of Medical Nanotechnology, Faculty of Advanced Sciences &Technology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran

  • Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

  • Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

  • Medical Nanotechnologies in Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

  • Department of Radio Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

  • Department of Radio Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

  • Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

  • Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

  • Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

  • Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

  • Depertment of Periodontology and Oral and Dental Disease Research Center, Zahedan University of Medical Science, Zahedan, Iran

  • Department of Radio Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

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    Asma Keshavarz, Soodeh Hajbabaei, Jafar Sojoodi, Mostafa Saffari, Mohammad Amin Aghaii Afshar, et al. (2017). Mn2+ - Negatively Charged Pegylated Dendrimer G2-Tryptophan: Novel Nano Magnetic Resonance Imaging Agent. Advances in Applied Physiology, 2(1), 1-9. https://doi.org/10.11648/j.aap.20170201.11

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    Asma Keshavarz; Soodeh Hajbabaei; Jafar Sojoodi; Mostafa Saffari; Mohammad Amin Aghaii Afshar, et al. Mn2+ - Negatively Charged Pegylated Dendrimer G2-Tryptophan: Novel Nano Magnetic Resonance Imaging Agent. Adv. Appl. Physiol. 2017, 2(1), 1-9. doi: 10.11648/j.aap.20170201.11

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    AMA Style

    Asma Keshavarz, Soodeh Hajbabaei, Jafar Sojoodi, Mostafa Saffari, Mohammad Amin Aghaii Afshar, et al. Mn2+ - Negatively Charged Pegylated Dendrimer G2-Tryptophan: Novel Nano Magnetic Resonance Imaging Agent. Adv Appl Physiol. 2017;2(1):1-9. doi: 10.11648/j.aap.20170201.11

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  • @article{10.11648/j.aap.20170201.11,
      author = {Asma Keshavarz and Soodeh Hajbabaei and Jafar Sojoodi and Mostafa Saffari and Mohammad Amin Aghaii Afshar and Fatemeh Monnavari and Esmaeil Mohammadi Pargoo and Rahimeh Rasouli and Hadi Hejazinia and Artin Assadi and Leila Badrzadeh and Shirin Abbasnezhad and Seyed Ataollah Sadat Shandiz and Mohammad Saffari and Masood Bamedi and Mehdi Shafiee Ardestani},
      title = {Mn2+ - Negatively Charged Pegylated Dendrimer G2-Tryptophan: Novel Nano Magnetic Resonance Imaging Agent},
      journal = {Advances in Applied Physiology},
      volume = {2},
      number = {1},
      pages = {1-9},
      doi = {10.11648/j.aap.20170201.11},
      url = {https://doi.org/10.11648/j.aap.20170201.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.aap.20170201.11},
      abstract = {Due to the new proclamation of the harmful symptoms of Gd (III) based MRI differentiate operators in the patients with harmed renal capacities, there is a solid consideration on emerging substitute differentiate specialists for MRI. A polymer with core of PEG and citrus extract as a shell was created for double modular imaging. After amalgamation of the polymer, ALGD-Trp Conjugate and after that Mn2+ stacked on the dendrimer. Differentiate upgraded MRI of the focused on double imaging operator was assessed by AFM magnifying lens. Growth is one of driving reason for death in everywhere throughout the world. Early determination of tumor known as a decent solution. Achieving a capable and non-obtrusive contrast agent with high specificity, sensitivity and capacity to target cancer cells are essential. Among of different malignancies distinguishing strategies, Magnetic Resonance Imaging is an important technique, however its burdens including low resolution, In this study, Tryptophan was appended on the Anionic direct globular dendrimer with polyethylene glycol center and citrus extract bunches around it. Tryptophan was utilized to enhance intra-cell take-up and gathering in human bosom malignancy cells lastly differentiate operator (Mn2+) stacked in orchestrated dendrimers. The contrast agent was characterized with different techniques such as FT-IR, FTIR, Zeta sizer, UV-spectroscopy. ICP-AES was used to assess the intra-cell take-up of Mn2+ iones. Cytotoxicity studies and evaluation of cell passing mechanism were performed in bosom tumor MCF-7 cell line. Then, impact of various grouping of new difference specialist on T1 and T2 assessed in-vitro utilizing MR imaging. In light of the outcomes exhibited that Mn2+ - Anionic straight globular dendrimer G2-Tryptophancontrastagentdid not demonstrate any significant toxicity (cancer and ordinary cells), The outcomes demonstrated the new focused on nano differentiate specialist fitting accumulation in the tumor cells and solid T1intense flag on compared to Magnevist as a standard CA. This novel complexity specialist can be presented as a decent CA applicant in early identification of tumor.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Mn2+ - Negatively Charged Pegylated Dendrimer G2-Tryptophan: Novel Nano Magnetic Resonance Imaging Agent
    AU  - Asma Keshavarz
    AU  - Soodeh Hajbabaei
    AU  - Jafar Sojoodi
    AU  - Mostafa Saffari
    AU  - Mohammad Amin Aghaii Afshar
    AU  - Fatemeh Monnavari
    AU  - Esmaeil Mohammadi Pargoo
    AU  - Rahimeh Rasouli
    AU  - Hadi Hejazinia
    AU  - Artin Assadi
    AU  - Leila Badrzadeh
    AU  - Shirin Abbasnezhad
    AU  - Seyed Ataollah Sadat Shandiz
    AU  - Mohammad Saffari
    AU  - Masood Bamedi
    AU  - Mehdi Shafiee Ardestani
    Y1  - 2017/07/14
    PY  - 2017
    N1  - https://doi.org/10.11648/j.aap.20170201.11
    DO  - 10.11648/j.aap.20170201.11
    T2  - Advances in Applied Physiology
    JF  - Advances in Applied Physiology
    JO  - Advances in Applied Physiology
    SP  - 1
    EP  - 9
    PB  - Science Publishing Group
    SN  - 2471-9714
    UR  - https://doi.org/10.11648/j.aap.20170201.11
    AB  - Due to the new proclamation of the harmful symptoms of Gd (III) based MRI differentiate operators in the patients with harmed renal capacities, there is a solid consideration on emerging substitute differentiate specialists for MRI. A polymer with core of PEG and citrus extract as a shell was created for double modular imaging. After amalgamation of the polymer, ALGD-Trp Conjugate and after that Mn2+ stacked on the dendrimer. Differentiate upgraded MRI of the focused on double imaging operator was assessed by AFM magnifying lens. Growth is one of driving reason for death in everywhere throughout the world. Early determination of tumor known as a decent solution. Achieving a capable and non-obtrusive contrast agent with high specificity, sensitivity and capacity to target cancer cells are essential. Among of different malignancies distinguishing strategies, Magnetic Resonance Imaging is an important technique, however its burdens including low resolution, In this study, Tryptophan was appended on the Anionic direct globular dendrimer with polyethylene glycol center and citrus extract bunches around it. Tryptophan was utilized to enhance intra-cell take-up and gathering in human bosom malignancy cells lastly differentiate operator (Mn2+) stacked in orchestrated dendrimers. The contrast agent was characterized with different techniques such as FT-IR, FTIR, Zeta sizer, UV-spectroscopy. ICP-AES was used to assess the intra-cell take-up of Mn2+ iones. Cytotoxicity studies and evaluation of cell passing mechanism were performed in bosom tumor MCF-7 cell line. Then, impact of various grouping of new difference specialist on T1 and T2 assessed in-vitro utilizing MR imaging. In light of the outcomes exhibited that Mn2+ - Anionic straight globular dendrimer G2-Tryptophancontrastagentdid not demonstrate any significant toxicity (cancer and ordinary cells), The outcomes demonstrated the new focused on nano differentiate specialist fitting accumulation in the tumor cells and solid T1intense flag on compared to Magnevist as a standard CA. This novel complexity specialist can be presented as a decent CA applicant in early identification of tumor.
    VL  - 2
    IS  - 1
    ER  - 

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