Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives

Ekwere Ifeoma Toyin; Naiho Alexander Obidike; Ojieh Emeka Anthony; Odigie Mike Osagie; Ohwin Peggy Ejiro

doi:doi:10.11648/j.aap.20190401.12

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Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives

Ekwere Ifeoma Toyin, Naiho Alexander Obidike, Ojieh Emeka Anthony, Odigie Mike Osagie, Ohwin Peggy Ejiro

Published in Advances in Applied Physiology (Volume 4, Issue 1)

Received: 20 May 2019 Accepted: 24 June 2019 Published: 13 July 2019

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Abstract

Overtime, Diastolic dysfunction (DD), which is seen in damping blood, and pressure build up within the ventricles has been associated with different disease states including chronic hypertension, coronary heart disease, aging, aortic stenosis, hypertrophic and restrictive cardiomyopathies. Diagnosis is by echocardiography (ECG) and often cumbersome. Howbeit, in acute stages of hypertension, prolongation of ventricular activation time in an ECG session has been described as potential marker for diagnosing DD. Current study was therefore undertaken to investigate ventricular activation time in essentially hypertensive Nigerians. One hundred and sixty two (162) hypertensives were recruited for the study. Their compliance to antihypertensive medication, blood pressure control, and electrocardiographic changes were determined and measured. Venous blood sample was then drawn and placed in special tubes to determine the serum magnesium concentrations, using a standard Colorimetric assay machine, Using the statistical measure of association (correlation), correlation between serum magnesium and ECG parameters was calculated using the Pearson’s correlation coefficient. One way analysis of variance (ANOVA) was also explored in obtaining differences in mean between variables. From our observations, only a weak correlation was found between serum magnesium levels and ECG findings across the study population. This proved statistically insignificant at p < 0.05. Other factors such as antihypertensive medications, duration of blood pressure and the control of blood pressure did not show any significant relationship.

Published in	Advances in Applied Physiology (Volume 4, Issue 1)
DOI	10.11648/j.aap.20190401.12
Page(s)	5-10
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diastolic Dysfunction, Magnesium, Hypertension

References

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[4]	Sontia B, Touyz RM (2007). Role of magnesium in hypertension. Achieves of Biochemistry and Biophysics; 458 (1): 33-39.
[5]	Cunha A. R, Umbelino B, Correia ML, Neves MF (2012). Magnesium and Vascular Changes in Hypertension. International Journal of Hypertension; 1-7.
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[7]	Nagueh SF, Smiseth OA, Appleton CP, Byrd BF, Dokainish H, Edvardsen T (2016). Recommendations for the evaluation of left ventricular diastolic function by echocardiography: An update from the American society of echocardiography and the European association of cardiovascular imaging. European Heart Journal - Cardiovascular Imaging; 17 (12): 1321–1360.
[8]	Singh AS, Masuku MB (2014). Sampling Techniques and Determination of Sample Size in Applied Statistics Research: An Overview. International Journal of Economics, Commerce and Management; 2 (11): 1-22.
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[10]	Boles U, Almuntaser I, Brown A, Murphy RR, Mahmud A, Feely J (2010). Ventricular activation time as a marker for diastolic dysfunction in early hypertension. Am J. Hypertens; 23 (7): 781-5.
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[15]	Lameris AL, Monnens LA, Bindels RJ, Hoenderop JG (2012). Drug-induced alterations in Mg2+ homoeostasis. Clin Sci (Lond); 123 (1): 1-14.
[16]	Meijs MF, Bots ML, Vonken E. (2007). “Rationale and design of the SMART Heart study: A prediction model for lelf ventricular hypertrophy in hypertension”. Neth J. 15 (9): 295-8.
[17]	Oladapo O. O, Salako L, Sadiq L, Shoyinka K, Adedapo K, Falase AO. Target-organ damage and cardiovascular complications in hypertensive Nigerian Yoruba adults: a cross-sectional study. Cardiovasc J Afr. 2012 Aug; 23 (7): 379-84.
[18]	Adamu GU, Katibi AI, Opadijo GO, Omotoso AB, Araoye AM. Prevalence of left ventricular diastolic dysfunction in newly diagnosed Nigerians with systemic hypertension: a pulsed wave Doppler echocardiographic study. Afr Health Sci. 2010 Jun; 10 (2): 177-82.
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APA Style

Ekwere Ifeoma Toyin, Naiho Alexander Obidike, Ojieh Emeka Anthony, Odigie Mike Osagie, Ohwin Peggy Ejiro. (2019). Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives. Advances in Applied Physiology, 4(1), 5-10. https://doi.org/10.11648/j.aap.20190401.12

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ACS Style

Ekwere Ifeoma Toyin; Naiho Alexander Obidike; Ojieh Emeka Anthony; Odigie Mike Osagie; Ohwin Peggy Ejiro. Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives. Adv. Appl. Physiol. 2019, 4(1), 5-10. doi: 10.11648/j.aap.20190401.12

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AMA Style

Ekwere Ifeoma Toyin, Naiho Alexander Obidike, Ojieh Emeka Anthony, Odigie Mike Osagie, Ohwin Peggy Ejiro. Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives. Adv Appl Physiol. 2019;4(1):5-10. doi: 10.11648/j.aap.20190401.12

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@article{10.11648/j.aap.20190401.12,
  author = {Ekwere Ifeoma Toyin and Naiho Alexander Obidike and Ojieh Emeka Anthony and Odigie Mike Osagie and Ohwin Peggy Ejiro},
  title = {Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives},
  journal = {Advances in Applied Physiology},
  volume = {4},
  number = {1},
  pages = {5-10},
  doi = {10.11648/j.aap.20190401.12},
  url = {https://doi.org/10.11648/j.aap.20190401.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aap.20190401.12},
  abstract = {Overtime, Diastolic dysfunction (DD), which is seen in damping blood, and pressure build up within the ventricles has been associated with different disease states including chronic hypertension, coronary heart disease, aging, aortic stenosis, hypertrophic and restrictive cardiomyopathies. Diagnosis is by echocardiography (ECG) and often cumbersome. Howbeit, in acute stages of hypertension, prolongation of ventricular activation time in an ECG session has been described as potential marker for diagnosing DD. Current study was therefore undertaken to investigate ventricular activation time in essentially hypertensive Nigerians. One hundred and sixty two (162) hypertensives were recruited for the study. Their compliance to antihypertensive medication, blood pressure control, and electrocardiographic changes were determined and measured. Venous blood sample was then drawn and placed in special tubes to determine the serum magnesium concentrations, using a standard Colorimetric assay machine, Using the statistical measure of association (correlation), correlation between serum magnesium and ECG parameters was calculated using the Pearson’s correlation coefficient. One way analysis of variance (ANOVA) was also explored in obtaining differences in mean between variables. From our observations, only a weak correlation was found between serum magnesium levels and ECG findings across the study population. This proved statistically insignificant at p < 0.05. Other factors such as antihypertensive medications, duration of blood pressure and the control of blood pressure did not show any significant relationship.},
 year = {2019}
}

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TY  - JOUR
T1  - Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives
AU  - Ekwere Ifeoma Toyin
AU  - Naiho Alexander Obidike
AU  - Ojieh Emeka Anthony
AU  - Odigie Mike Osagie
AU  - Ohwin Peggy Ejiro
Y1  - 2019/07/13
PY  - 2019
N1  - https://doi.org/10.11648/j.aap.20190401.12
DO  - 10.11648/j.aap.20190401.12
T2  - Advances in Applied Physiology
JF  - Advances in Applied Physiology
JO  - Advances in Applied Physiology
SP  - 5
EP  - 10
PB  - Science Publishing Group
SN  - 2471-9714
UR  - https://doi.org/10.11648/j.aap.20190401.12
AB  - Overtime, Diastolic dysfunction (DD), which is seen in damping blood, and pressure build up within the ventricles has been associated with different disease states including chronic hypertension, coronary heart disease, aging, aortic stenosis, hypertrophic and restrictive cardiomyopathies. Diagnosis is by echocardiography (ECG) and often cumbersome. Howbeit, in acute stages of hypertension, prolongation of ventricular activation time in an ECG session has been described as potential marker for diagnosing DD. Current study was therefore undertaken to investigate ventricular activation time in essentially hypertensive Nigerians. One hundred and sixty two (162) hypertensives were recruited for the study. Their compliance to antihypertensive medication, blood pressure control, and electrocardiographic changes were determined and measured. Venous blood sample was then drawn and placed in special tubes to determine the serum magnesium concentrations, using a standard Colorimetric assay machine, Using the statistical measure of association (correlation), correlation between serum magnesium and ECG parameters was calculated using the Pearson’s correlation coefficient. One way analysis of variance (ANOVA) was also explored in obtaining differences in mean between variables. From our observations, only a weak correlation was found between serum magnesium levels and ECG findings across the study population. This proved statistically insignificant at p < 0.05. Other factors such as antihypertensive medications, duration of blood pressure and the control of blood pressure did not show any significant relationship.
VL  - 4
IS  - 1
ER  -

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Author Information

Ekwere Ifeoma Toyin

College of Health Sciences, Delta State University, Abraka, Nigeria
Naiho Alexander Obidike

College of Health Sciences, Delta State University, Abraka, Nigeria
Ojieh Emeka Anthony

College of Health Sciences, Delta State University, Abraka, Nigeria
Odigie Mike Osagie

College of Health Sciences, Delta State University, Abraka, Nigeria
Ohwin Peggy Ejiro

College of Health Sciences, Delta State University, Abraka, Nigeria

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APA Style

Ekwere Ifeoma Toyin, Naiho Alexander Obidike, Ojieh Emeka Anthony, Odigie Mike Osagie, Ohwin Peggy Ejiro. (2019). Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives. Advances in Applied Physiology, 4(1), 5-10. https://doi.org/10.11648/j.aap.20190401.12

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ACS Style

Ekwere Ifeoma Toyin; Naiho Alexander Obidike; Ojieh Emeka Anthony; Odigie Mike Osagie; Ohwin Peggy Ejiro. Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives. Adv. Appl. Physiol. 2019, 4(1), 5-10. doi: 10.11648/j.aap.20190401.12

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AMA Style

Ekwere Ifeoma Toyin, Naiho Alexander Obidike, Ojieh Emeka Anthony, Odigie Mike Osagie, Ohwin Peggy Ejiro. Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives. Adv Appl Physiol. 2019;4(1):5-10. doi: 10.11648/j.aap.20190401.12

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@article{10.11648/j.aap.20190401.12,
  author = {Ekwere Ifeoma Toyin and Naiho Alexander Obidike and Ojieh Emeka Anthony and Odigie Mike Osagie and Ohwin Peggy Ejiro},
  title = {Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives},
  journal = {Advances in Applied Physiology},
  volume = {4},
  number = {1},
  pages = {5-10},
  doi = {10.11648/j.aap.20190401.12},
  url = {https://doi.org/10.11648/j.aap.20190401.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aap.20190401.12},
  abstract = {Overtime, Diastolic dysfunction (DD), which is seen in damping blood, and pressure build up within the ventricles has been associated with different disease states including chronic hypertension, coronary heart disease, aging, aortic stenosis, hypertrophic and restrictive cardiomyopathies. Diagnosis is by echocardiography (ECG) and often cumbersome. Howbeit, in acute stages of hypertension, prolongation of ventricular activation time in an ECG session has been described as potential marker for diagnosing DD. Current study was therefore undertaken to investigate ventricular activation time in essentially hypertensive Nigerians. One hundred and sixty two (162) hypertensives were recruited for the study. Their compliance to antihypertensive medication, blood pressure control, and electrocardiographic changes were determined and measured. Venous blood sample was then drawn and placed in special tubes to determine the serum magnesium concentrations, using a standard Colorimetric assay machine, Using the statistical measure of association (correlation), correlation between serum magnesium and ECG parameters was calculated using the Pearson’s correlation coefficient. One way analysis of variance (ANOVA) was also explored in obtaining differences in mean between variables. From our observations, only a weak correlation was found between serum magnesium levels and ECG findings across the study population. This proved statistically insignificant at p < 0.05. Other factors such as antihypertensive medications, duration of blood pressure and the control of blood pressure did not show any significant relationship.},
 year = {2019}
}

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TY  - JOUR
T1  - Diastolic Dysfunction and Its Implications to Serum Magnesium Changes in Hypertensives
AU  - Ekwere Ifeoma Toyin
AU  - Naiho Alexander Obidike
AU  - Ojieh Emeka Anthony
AU  - Odigie Mike Osagie
AU  - Ohwin Peggy Ejiro
Y1  - 2019/07/13
PY  - 2019
N1  - https://doi.org/10.11648/j.aap.20190401.12
DO  - 10.11648/j.aap.20190401.12
T2  - Advances in Applied Physiology
JF  - Advances in Applied Physiology
JO  - Advances in Applied Physiology
SP  - 5
EP  - 10
PB  - Science Publishing Group
SN  - 2471-9714
UR  - https://doi.org/10.11648/j.aap.20190401.12
AB  - Overtime, Diastolic dysfunction (DD), which is seen in damping blood, and pressure build up within the ventricles has been associated with different disease states including chronic hypertension, coronary heart disease, aging, aortic stenosis, hypertrophic and restrictive cardiomyopathies. Diagnosis is by echocardiography (ECG) and often cumbersome. Howbeit, in acute stages of hypertension, prolongation of ventricular activation time in an ECG session has been described as potential marker for diagnosing DD. Current study was therefore undertaken to investigate ventricular activation time in essentially hypertensive Nigerians. One hundred and sixty two (162) hypertensives were recruited for the study. Their compliance to antihypertensive medication, blood pressure control, and electrocardiographic changes were determined and measured. Venous blood sample was then drawn and placed in special tubes to determine the serum magnesium concentrations, using a standard Colorimetric assay machine, Using the statistical measure of association (correlation), correlation between serum magnesium and ECG parameters was calculated using the Pearson’s correlation coefficient. One way analysis of variance (ANOVA) was also explored in obtaining differences in mean between variables. From our observations, only a weak correlation was found between serum magnesium levels and ECG findings across the study population. This proved statistically insignificant at p < 0.05. Other factors such as antihypertensive medications, duration of blood pressure and the control of blood pressure did not show any significant relationship.
VL  - 4
IS  - 1
ER  -

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