Brain Metastases in a Patient with Ovarian Cancer
International Journal of Neurologic Physical Therapy
Volume 3, Issue 6, December 2017, Pages: 54-58
Received: Aug. 22, 2017; Accepted: Sep. 4, 2017; Published: Dec. 18, 2017
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Kantenga Dieu Merci Kabulo, Department of Neurosurgery, University of Zimbabwe, Harare, Zimbabwe
Patrice Nday Ntenga, Neurological Clinic of the National Teaching Hospital-FANN, Dakar, Senegal
Nathaniel Hurunangoni Zimani, Department of Neurosurgery, University of Zimbabwe, Harare, Zimbabwe
Kazadi Kaluile Ntenga Kalangu, Department of Neurosurgery, University of Zimbabwe, Harare, Zimbabwe
Rudo Makunike Mutasa, Department of Pathology, University of Zimbabwe, Harare, Zimbabwe
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Brain metastases are associated with a poor prognosis. Depending on the patient’s age, functional status, extent of systemic disease, and number of metastases. We report a case of 22-year-old female who presented with 2 months history of headache and vomiting and 1 day history of not communicating, neck stiffness, and generalized body weakness. Patient has been unwell for 2 months after she had collapsed at school 2 months prior complaining of severe headache, she allegedly stroked one month prior with left sided weakness. No history of trauma and seizures but had history of falling and remaining unconscious for unspecified period of time. No history of chronic illness and no family history of malignancies. Brain CT scan and MRI documented multiple lobulated irregularly enhancing brain parenchymal mass lesions of variable sizes, patient was taken to theatre and burr hole for brain tumor biopsy was done and specimen taken for histology which confirmed metastatic carcinoma and the tumor immunoreacted negatively to TTF1 and positively to CK7. Treatment of brain metastasis has evolved over the years from WBRT only for most patients to multimodal therapy including surgical resection, if feasible, followed by Whole brain Radiotherapy (WBRT) and/or chemotherapy.
Brain Metastases, Ovarian Cancer, Wholebrain Radiotherapy
To cite this article
Kantenga Dieu Merci Kabulo, Patrice Nday Ntenga, Nathaniel Hurunangoni Zimani, Kazadi Kaluile Ntenga Kalangu, Rudo Makunike Mutasa, Brain Metastases in a Patient with Ovarian Cancer, International Journal of Neurologic Physical Therapy. Vol. 3, No. 6, 2017, pp. 54-58. doi: 10.11648/j.ijnpt.20170306.12
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
R. R. Langley and I. J. Fidler, “The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs,” International Journal of Cancer, vol. 128, no. 11, pp. 2527–2535, 2011.
A. Tosoni, M. Ermani, and A. A. Brandes, “The pathogenesis and treatment of brain metastases: a comprehensive review,” Critical Reviews in Oncology/Hematology, vol. 52, no. 3, pp. 199–215, 2004.
L. J. Schouten, J. Rutten, H. A. M. Huveneers, and A. Twijnstra, “Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma,” Cancer, vol. 94, no. 10, pp. 2698–2705, 2002.
Bruzzone M, Campora E, Chiara S, et al Cerebral metastases secondary to ovarian cancer: still an unusual event. GynecolOncol. 1993; 49: 37-40.
Pectasides D, Aravantinos G, Fountzilas G, et al. Brain metastases from epithelial ovarian cancer. The Hellenic Cooperative Oncology Group (HeCOG) experience and review of the literature. Anticancer Res. 2005; 25: 3553-3558.
Cohen ZR, Suki D, Weinberg JS, et al. Brain metastases in patients with ovarian carcinoma: prognostic factors and outcome. J Neurooncol. 2004; 66: 313-325.
Geisler JP, Geisler HE. Brain metastases in epithelial ovarian carcinoma. GynecolOncol. 1995; 57: 246-249.
Kazuhiko OGAWA, Yoshihiko YOSHII et al. Treatment and Prognosis of Brain Metastases From Gynecological Cancers Neurol Med Chir (Tokyo) 48, 57-63, 2008).
Neville F. Hacker, and ArchanaRao Surgical management of lung, liver and brain metastases from gynecological cancers: a literature review Hacker and Rao Gynecologic Oncology Research and Practice (2016) 3: 7 DOI 10.1186/s40661-016-0028-3
Piura E, Piura B. Brain metastases from ovarian carcinoma. ISRN Oncol. 2011; 2011: 527453.
Pakneshan S, Safarpour D, Tavassoli F, Jabbari B. Brain metastasis from ovarian cancer: a systematic review. J Neurooncol. 2014; 119: 1–6.
Piura E, Piura B. Brain metastases from cervical carcinoma: overview of pertinent literature. Eur J GynaecolOncol. 2012; 33: 567–73.
Piura E, Piura B. Brain metastases from endometrial carcinoma. ISRN Oncol. 2012; 2012: 581749.
Killackey MA, Davis AR. Papillary serous carcinoma of the peritoneal surface: matched-case comparison with papillary serous ovarian carcinoma. GynecolOncol 1993; 51: 171-4.
Cormio G, Lissoni A, Losa G, Zanetta G, Pellegrino A, Mangioni C. Brain metastases from endometrial carcinoma. GynecolOncol 1996; 61: 40-3. 11.
Orru S, Lay G, Dessi M, Murtas R, Deidda MA, Amichetti M. Brain metastases from endometrial carcinoma: report of three cases and review of the literature. Tumori 2007; 93: 112-7.
DimitriosPectasides, Melina Pectasides, Theofanis Economopoulos, Brain Metastases from Epithelial Ovarian Cancer: A Review of the Literature, The Oncologist 2006; 11: 252–260.
Mark S. Green berg, Han dbook of Neurosurgery, Thieme New York • Stuttgart • Delhi • Rio de Janeiro. 8th edition.
Edward Monaco, III, MD Douglas Kondziolka, MD Sanjay Mongia, MD Management of Brain Metastases From Ovarian and Endometrial Carcinoma With Stereotactic Radiosurgery ª2008 American Cancer Society DOI 10.1002/cncr.23868
Wen PY, Black PM, Loeffler JS: Treatment of metastatic cancer: metastatic brain tumor, in Devita VT Jr, Hellman S, Rosenberg SA (eds ): Cancer: Principles and Practice of Oncology, ed 6. Philadelphia, Lippincott-Raven, 2001, pp 2655–2670.
Borgelt B, Gelber R, Kramer S, Brady LW, Chang CH, Davis LW, Perez CA, Hendrickson FR: The palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 6: 1–9, 1980.
Plaxe SC, Dottino PR, Lipsztein R, Dalton J, Cohen CJ. Clinical features and treatment outcome of patients with epithelial carcinoma of the ovary metastatic to the central nervous system. Obstet Gynecol. 1990; 75: 278–81.
LeRoux PD, Berger MS, Elliott JP, Tamimi HK. Cerebral metastases from ovarian carcinoma. Cancer. 1991; 67: 2194–9.
Kawamura D, Tanaka T, Fuga M, Yanagisawa T, Tochigi S, Irie K, Hasegawa Y, Abe T. Slow progression of calcified cerebellar metastasis from ovarian cancer: a case report and review of the literature. Neurol Med Chir. 2013; 53: 722–6.
Kim TJ, Song S, Kim CK, Kim WY, Choi CH, Lee JH, Lee JW, Bae DS, Kim BG. Prognostic factors associated with brain metastases from epithelial ovarian carcinoma. Int J Gynecol Cancer. 2007; 17: 1252–7.
Schultheiss TE, Kun LE, Ang KK, Stephens LC. Radiation response of the central nervous system. Int J RadiatOncolBiol Phys. 1995; 31: 1093–112.
Esra ÇABUK CÖMERT, Tevfi k Berk BİLDACI et al. Outcomes in 12 gynecologic cancer patients with brain metastasis: a single center’s experience, Turk J Med Sci 2012; 42 (3): 385-394 © TÜBİTAK.
Barker GH, Orledge J, Wiltshaw E. Involvement of the central nervous system in patients with ovarian carcinoma. Br J ObstetGynaecol 1981; 88: 690-4.
Lassman AB, DeAngelis LM. Brain metastases. NeurolClin 2003; 21: 1-23.
Lesser GJ. Chemotherapy of cerebral metastases from solid tumors. NeurosurgClin N Am 1996; 7: 527-36.
Ettie Piura and Benjamin Piura, Brain Metastases from Ovarian Carcinoma International Scholarly Research Network ISRN Oncology Volume 2011, Article ID 527453, 13 pages doi: 10.5402/2011/527453
Larson DM, Copeland LJ, Mose RP, Malone JM Jr, Gershenson DM, Wharton JT. Central nervous system metastases in epithelial ovarian carcinoma. ObstetGynecol 1986; 68: 746-50.
Andrew D. Norden, Patrick Y. Wen and SantoshKesari, Brain metastases, 2005 Lippincott Williams & Wilkins 1350-7540.
Black PM, Johnson MD. Surgical resection for patients with solid brain metastases: current status. J Neurooncol 2004; 69: 119–124. This is a detailed review of the evidence regarding surgical management of brain metastases.
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