American Journal of Pharmacology and Phytotherapy

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Onion, Orange and Prickly Pear Peel Extracts Mixed with Beef Meatballs Ameliorate the Effect of Alloxan Induced Diabetic Rats

Received: 17 October 2016    Accepted: 14 November 2016    Published: 12 December 2016
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Abstract

The present study was carried out to investigate the effectiveness of three plant parts methanol extracts (orange peel extract, OPE, red onion skin powder, ROSE, and prickly pear extract, PPE) mixed with beef meatballs in modulating hyperglycemia using alloxan induced diabetic rats model. Treatment of animals with alloxan caused a significant increase (p≤0.05) in serum glucose concentration (49.47%) compared to normal control group. Compared to the diabetic control, hypoglycemic capability of beef meatballs supplemented with 0.1% plant parts methanolic extracts was demonstrated by significant (p≤0.05) decreasing of glucose concentration in serum. The rate of decreasing was recorded 29.91, 39.99, 31.15 and 41.75% for meatballs supplemented with OPE, ROSE, PPPE and their mixture, respectively. The same behavior was recorded for liver tissue malonaldialdehyde (MDA) level, the biomarker of oxidative stress in liver. Activities of AST, ALT and ALP were increased significantly (P<0.05) in alloxan-induced diabetic rats in comparison with normal control group. Treatment with meatballs mixed with selected methanolic extracts to diabetic rats significantly (P < 0.05) decreased the elevated AST, ALT and ALP almost near to normal levels. In conclusion, OPE, ROSE and PPPE have ameliorated the effect of alloxan induced diabetes in rats. So, we advise to use these plant parts extracts in human nutrition as natural food additives for their anti-hyperglycemic effects.

DOI 10.11648/j.ajpp.20160101.14
Published in American Journal of Pharmacology and Phytotherapy (Volume 1, Issue 1, December 2016)
Page(s) 15-24
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

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Copyright © The Author(s), 2024. Published by Science Publishing Group

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Keywords

Plant Parts, Liver Functions, Aminotransferases, Glucose, Malonaldialdehyde, Glutathione

References
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Author Information
  • Nutrition and Food Science Department, Faculty of Home Economics, Minoufiya University, Shebin El-Kom, Egypt

  • Division of Home Economics, Faculty of Specific Education, Port Said University, Port Saied, Egypt

  • Division of Home Economics, Faculty of Specific Education, Port Said University, Port Saied, Egypt

  • Division of Home Economics, Faculty of Specific Education, Port Said University, Port Saied, Egypt

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    Yousif Elhassaneen, Samia Goarge, Ryeaan Sayed, Mayada Younis. (2016). Onion, Orange and Prickly Pear Peel Extracts Mixed with Beef Meatballs Ameliorate the Effect of Alloxan Induced Diabetic Rats. American Journal of Pharmacology and Phytotherapy, 1(1), 15-24. https://doi.org/10.11648/j.ajpp.20160101.14

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    Yousif Elhassaneen; Samia Goarge; Ryeaan Sayed; Mayada Younis. Onion, Orange and Prickly Pear Peel Extracts Mixed with Beef Meatballs Ameliorate the Effect of Alloxan Induced Diabetic Rats. Am. J. Pharmacol. Phytother. 2016, 1(1), 15-24. doi: 10.11648/j.ajpp.20160101.14

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    AMA Style

    Yousif Elhassaneen, Samia Goarge, Ryeaan Sayed, Mayada Younis. Onion, Orange and Prickly Pear Peel Extracts Mixed with Beef Meatballs Ameliorate the Effect of Alloxan Induced Diabetic Rats. Am J Pharmacol Phytother. 2016;1(1):15-24. doi: 10.11648/j.ajpp.20160101.14

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  • @article{10.11648/j.ajpp.20160101.14,
      author = {Yousif Elhassaneen and Samia Goarge and Ryeaan Sayed and Mayada Younis},
      title = {Onion, Orange and Prickly Pear Peel Extracts Mixed with Beef Meatballs Ameliorate the Effect of Alloxan Induced Diabetic Rats},
      journal = {American Journal of Pharmacology and Phytotherapy},
      volume = {1},
      number = {1},
      pages = {15-24},
      doi = {10.11648/j.ajpp.20160101.14},
      url = {https://doi.org/10.11648/j.ajpp.20160101.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajpp.20160101.14},
      abstract = {The present study was carried out to investigate the effectiveness of three plant parts methanol extracts (orange peel extract, OPE, red onion skin powder, ROSE, and prickly pear extract, PPE) mixed with beef meatballs in modulating hyperglycemia using alloxan induced diabetic rats model. Treatment of animals with alloxan caused a significant increase (p≤0.05) in serum glucose concentration (49.47%) compared to normal control group. Compared to the diabetic control, hypoglycemic capability of beef meatballs supplemented with 0.1% plant parts methanolic extracts was demonstrated by significant (p≤0.05) decreasing of glucose concentration in serum. The rate of decreasing was recorded 29.91, 39.99, 31.15 and 41.75% for meatballs supplemented with OPE, ROSE, PPPE and their mixture, respectively. The same behavior was recorded for liver tissue malonaldialdehyde (MDA) level, the biomarker of oxidative stress in liver. Activities of AST, ALT and ALP were increased significantly (P<0.05) in alloxan-induced diabetic rats in comparison with normal control group. Treatment with meatballs mixed with selected methanolic extracts to diabetic rats significantly (P < 0.05) decreased the elevated AST, ALT and ALP almost near to normal levels. In conclusion, OPE, ROSE and PPPE have ameliorated the effect of alloxan induced diabetes in rats. So, we advise to use these plant parts extracts in human nutrition as natural food additives for their anti-hyperglycemic effects.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Onion, Orange and Prickly Pear Peel Extracts Mixed with Beef Meatballs Ameliorate the Effect of Alloxan Induced Diabetic Rats
    AU  - Yousif Elhassaneen
    AU  - Samia Goarge
    AU  - Ryeaan Sayed
    AU  - Mayada Younis
    Y1  - 2016/12/12
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    N1  - https://doi.org/10.11648/j.ajpp.20160101.14
    DO  - 10.11648/j.ajpp.20160101.14
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    JF  - American Journal of Pharmacology and Phytotherapy
    JO  - American Journal of Pharmacology and Phytotherapy
    SP  - 15
    EP  - 24
    PB  - Science Publishing Group
    UR  - https://doi.org/10.11648/j.ajpp.20160101.14
    AB  - The present study was carried out to investigate the effectiveness of three plant parts methanol extracts (orange peel extract, OPE, red onion skin powder, ROSE, and prickly pear extract, PPE) mixed with beef meatballs in modulating hyperglycemia using alloxan induced diabetic rats model. Treatment of animals with alloxan caused a significant increase (p≤0.05) in serum glucose concentration (49.47%) compared to normal control group. Compared to the diabetic control, hypoglycemic capability of beef meatballs supplemented with 0.1% plant parts methanolic extracts was demonstrated by significant (p≤0.05) decreasing of glucose concentration in serum. The rate of decreasing was recorded 29.91, 39.99, 31.15 and 41.75% for meatballs supplemented with OPE, ROSE, PPPE and their mixture, respectively. The same behavior was recorded for liver tissue malonaldialdehyde (MDA) level, the biomarker of oxidative stress in liver. Activities of AST, ALT and ALP were increased significantly (P<0.05) in alloxan-induced diabetic rats in comparison with normal control group. Treatment with meatballs mixed with selected methanolic extracts to diabetic rats significantly (P < 0.05) decreased the elevated AST, ALT and ALP almost near to normal levels. In conclusion, OPE, ROSE and PPPE have ameliorated the effect of alloxan induced diabetes in rats. So, we advise to use these plant parts extracts in human nutrition as natural food additives for their anti-hyperglycemic effects.
    VL  - 1
    IS  - 1
    ER  - 

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