Onion, Orange and Prickly Pear Peel Extracts Mixed with Beef Meatballs Ameliorate the Effect of Alloxan Induced Diabetic Rats
American Journal of Pharmacology and Phytotherapy
Volume 1, Issue 1, December 2016, Pages: 15-24
Received: Oct. 17, 2016; Accepted: Nov. 14, 2016; Published: Dec. 12, 2016
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Yousif Elhassaneen, Nutrition and Food Science Department, Faculty of Home Economics, Minoufiya University, Shebin El-Kom, Egypt
Samia Goarge, Division of Home Economics, Faculty of Specific Education, Port Said University, Port Saied, Egypt
Ryeaan Sayed, Division of Home Economics, Faculty of Specific Education, Port Said University, Port Saied, Egypt
Mayada Younis, Division of Home Economics, Faculty of Specific Education, Port Said University, Port Saied, Egypt
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The present study was carried out to investigate the effectiveness of three plant parts methanol extracts (orange peel extract, OPE, red onion skin powder, ROSE, and prickly pear extract, PPE) mixed with beef meatballs in modulating hyperglycemia using alloxan induced diabetic rats model. Treatment of animals with alloxan caused a significant increase (p≤0.05) in serum glucose concentration (49.47%) compared to normal control group. Compared to the diabetic control, hypoglycemic capability of beef meatballs supplemented with 0.1% plant parts methanolic extracts was demonstrated by significant (p≤0.05) decreasing of glucose concentration in serum. The rate of decreasing was recorded 29.91, 39.99, 31.15 and 41.75% for meatballs supplemented with OPE, ROSE, PPPE and their mixture, respectively. The same behavior was recorded for liver tissue malonaldialdehyde (MDA) level, the biomarker of oxidative stress in liver. Activities of AST, ALT and ALP were increased significantly (P<0.05) in alloxan-induced diabetic rats in comparison with normal control group. Treatment with meatballs mixed with selected methanolic extracts to diabetic rats significantly (P < 0.05) decreased the elevated AST, ALT and ALP almost near to normal levels. In conclusion, OPE, ROSE and PPPE have ameliorated the effect of alloxan induced diabetes in rats. So, we advise to use these plant parts extracts in human nutrition as natural food additives for their anti-hyperglycemic effects.
Plant Parts, Liver Functions, Aminotransferases, Glucose, Malonaldialdehyde, Glutathione
To cite this article
Yousif Elhassaneen, Samia Goarge, Ryeaan Sayed, Mayada Younis, Onion, Orange and Prickly Pear Peel Extracts Mixed with Beef Meatballs Ameliorate the Effect of Alloxan Induced Diabetic Rats, American Journal of Pharmacology and Phytotherapy. Vol. 1, No. 1, 2016, pp. 15-24. doi: 10.11648/j.ajpp.20160101.14
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