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The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers

Received: 11 October 2016    Accepted: 09 February 2017    Published: 01 March 2017
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Abstract

On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.

DOI 10.11648/j.pst.20170101.14
Published in Pharmaceutical Science and Technology (Volume 1, Issue 1, June 2017)
Page(s) 10-12
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Free Amino Acids, Regulatory Effects, Oncology

References
[1] Nefyodov L. Taurine (biochemistry, pharmacology, medical application) Grodno RIPH. - 1999.- 145 p.
[2] Amino Acids And Their Derivatives (chemistry, biochemistry, pharmacology, medicine) /ed. L.Nefyodov // Proc of Internat. Symp; Grodno. – 1996. - 125 p.
[3] Nefyodov, L. I., Karavay, P. A., Karavay, N. L. Regulatory action of free amino acids and development on the basis of highly of substances infusion solutions with pathogenetic deterministic composition. Laboratory diagnosis Eastern Europe. – 2014.- V.3.- p. 111-115.
[4] Holden, J. T. Amino Acid Pools. Elsevier, Amsterdam – 1962. - 815 p.
[5] Lubec, C. Amino Acids (Chemistry, Biology, Medicine) Escom New York – 1990.- 1196 p.
[6] Nefyodov, L. I. The results of biochemical research and development of nitrogen-containing compounds of natural origin: methodology of exploitation of biological properties as universal natural regulators of metabolism and drugs. – 2010.- http://www.nil.grsu.by/index.php?page=index.
[7] Nefyodov LI. et al. Amino acids and their derivatives in tumour tissue from patients with breast cancer treated with Ukrain. Part VI. Drugs Exp Clin Res. -1996. V.22, №3-5.-p. 155-157.
[8] Nefyodov LI. et al. Amino acids and their derivatives in blood plasma of patients with breast cancer treated with Ukrain. Part V. Drugs Exp Clin Res. -1996. –V.22, V.3-5.-p. 159-61.
[9] Biological activity and transport of drugs / ed. L. Nefyodov // Proc of Internat. Symp.; Grodno. – 1999. – 189 p.
[10] VI Ordinary General Assembly Society of Biochemistry of Belarus / ed. L. Nefyodov // Proc of Internat. Symp;. Grodno. – 2000. – 225 p.
[11] Amino acids and their derivatives in biology and medicine / ed. L. Nefyodov // Proc of Internat. Symp;. – Grodno. – 2001. – 124 p.
[12] Nefyodov, L. I. Target - oriented regulation of metabolic equilibrium by amino acids and strategy of their application as drugs with directional effects /L.I. Nefyodov // XXXVII Zjazd Polskiego towarzystwa biochemicznego, Torun.- 10-14 IX.- 2001.- p.327
[13] Ihata, Y., Miyagi, E., Numazaki, R. Amino acid profile index for early detection of endometrial cancer: verification as a novel diagnostic marker. – 2013.- Int. J. Clin. Oncol. V.19, №3.- p.364-372.
[14] Fafournoux, P., Bruhat, A., Jousse, C. Amino acid regulation of gene expression. – 2000.- BioChem. J. - V. 351.- №1.- p.1–12.
[15] Meijer, A. Amino acids as regulators and components of nonproteinogenic pathways. – 2003.- J. Nutr. V6.- №1.- p.2057S-2062S.
[16] Bruhat, A., Cherasse, Y., Chaveroux, C., et al. Amino acids as reg- ulators of gene expression in mammals: molecular mechanisms. - 2009.- Biofactors.- V35.- №3.- p.249-257.
[17] Ananieva E. Targeting amino acid metabolism in cancer growth and anti-tumor immune response. - 2015.- World J Biol Chem. – V.6.-V4.- 281–289. doi: 10.4331/wjbc.v6.i4.281.
[18] Hong Ma. Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy. – 2014.- World J Gastroenterol. – V.20.- №26.- p.8653–8659. doi: 10.3748/wjg.v20.i26.8653
[19] Karavay P. A. Amino acids in Metabolomics: Perspective for the Use of Regulatory effects of Fee Amino Acids in the Creation on their Basis of Infusion Solutions/ Karavay P, Nefyodov L. I., Karavay N.L.//International Journal of Hematology & Therapy, 2016, V 2, № 2, p.1-2. doi: 10.15436/2381-1404.16.10. ISSN: 2381-1404. http://www.ommegaonline.org /article-deta¬ils/850
[20] Karavay A. Metabolic Comfort in Oncology and Free Amino Acids: Perspectives for the Use of Their Regulatory Actions in Physiological Concentrations/ Karavay A., Karavay P., Koliada T., Nefyodov L.//Academic Web Journal of Medical Science Volume 1 issue 1 pp 001-004 November, 2016 ISSN: 2545-4986 http://academicwebpublishers.org/journals/AWJMS/Karavay%20et%20al.html).
Author Information
  • Department of Biochemistry, Yanka Kupala State University of Grodno, Grodno, Belarus

  • Department of Hyperbaric Oxygenation, Grodno State Medical Hospital, Grodno, Belarus

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  • APA Style

    L. Nefyodov, N. Karavay. (2017). The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers. Pharmaceutical Science and Technology, 1(1), 10-12. https://doi.org/10.11648/j.pst.20170101.14

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    ACS Style

    L. Nefyodov; N. Karavay. The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers. Pharm. Sci. Technol. 2017, 1(1), 10-12. doi: 10.11648/j.pst.20170101.14

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    AMA Style

    L. Nefyodov, N. Karavay. The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers. Pharm Sci Technol. 2017;1(1):10-12. doi: 10.11648/j.pst.20170101.14

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  • @article{10.11648/j.pst.20170101.14,
      author = {L. Nefyodov and N. Karavay},
      title = {The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers},
      journal = {Pharmaceutical Science and Technology},
      volume = {1},
      number = {1},
      pages = {10-12},
      doi = {10.11648/j.pst.20170101.14},
      url = {https://doi.org/10.11648/j.pst.20170101.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.pst.20170101.14},
      abstract = {On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.},
     year = {2017}
    }
    

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    AB  - On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.
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