Ophthalmic formulations are not completely available for eliciting therapeutic action because of various reasons such as rapid tear drainage, blinking of eye, lower residence time and lower cul de sac volume. Ophthalmic formulation gets easily drained off due to eye blinking due to low viscosity. Posaconazole is known to have antifungal efficacy as oral route, however ophthalmic efficacy is not studied. The objective of present work was to develop long retentive posaconazole ophthalmic suspension based on polymer platform system of carbopol 974 P and xanthan gum. This synergistic polymer platform was pre-identified by means of experimental design study. Polymer based formulation helps to retain the drug at the site of action for longer duration and does not get washed away due to eye blinking phenomenon. Sterilization is key parameters for ophthalmic formulation. Different methods of sterilization were studied for posaconazole drug as well as polymer mixture and finished product. The developed formulations were characterized for homogeneity, pH, particle size, viscosity, osmolality, rheology study, mucoadhesive strength, contact angle, assay of posaconazole and benzalkonium chloride, degradation product, polymorphic form evaluation, eye irritation test and pharmacodynamic efficacy study. A stable long retentive posaconazole ophthalmic formulation was developed based on principles of quality by design. The developed formulation can be easily manufactured at bigger scale without need of any sophisticated equipment.
| DOI | 10.11648/j.pst.20200401.11 |
| Published in | Pharmaceutical Science and Technology (Volume 4, Issue 1, June 2020) |
| Page(s) | 1-10 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Ocular Long Retentive, Posaconazole, Ophthalmic Suspension
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APA Style
Jadhav Simta, Inamdar Kavita, Bhitre Milind. (2020). Novel Long Retentive Posaconazole Ophthalmic Suspension. Pharmaceutical Science and Technology, 4(1), 1-10. https://doi.org/10.11648/j.pst.20200401.11
ACS Style
Jadhav Simta; Inamdar Kavita; Bhitre Milind. Novel Long Retentive Posaconazole Ophthalmic Suspension. Pharm. Sci. Technol. 2020, 4(1), 1-10. doi: 10.11648/j.pst.20200401.11
AMA Style
Jadhav Simta, Inamdar Kavita, Bhitre Milind. Novel Long Retentive Posaconazole Ophthalmic Suspension. Pharm Sci Technol. 2020;4(1):1-10. doi: 10.11648/j.pst.20200401.11
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Download@article{10.11648/j.pst.20200401.11,
author = {Jadhav Simta and Inamdar Kavita and Bhitre Milind},
title = {Novel Long Retentive Posaconazole Ophthalmic Suspension},
journal = {Pharmaceutical Science and Technology},
volume = {4},
number = {1},
pages = {1-10},
doi = {10.11648/j.pst.20200401.11},
url = {https://doi.org/10.11648/j.pst.20200401.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20200401.11},
abstract = {Ophthalmic formulations are not completely available for eliciting therapeutic action because of various reasons such as rapid tear drainage, blinking of eye, lower residence time and lower cul de sac volume. Ophthalmic formulation gets easily drained off due to eye blinking due to low viscosity. Posaconazole is known to have antifungal efficacy as oral route, however ophthalmic efficacy is not studied. The objective of present work was to develop long retentive posaconazole ophthalmic suspension based on polymer platform system of carbopol 974 P and xanthan gum. This synergistic polymer platform was pre-identified by means of experimental design study. Polymer based formulation helps to retain the drug at the site of action for longer duration and does not get washed away due to eye blinking phenomenon. Sterilization is key parameters for ophthalmic formulation. Different methods of sterilization were studied for posaconazole drug as well as polymer mixture and finished product. The developed formulations were characterized for homogeneity, pH, particle size, viscosity, osmolality, rheology study, mucoadhesive strength, contact angle, assay of posaconazole and benzalkonium chloride, degradation product, polymorphic form evaluation, eye irritation test and pharmacodynamic efficacy study. A stable long retentive posaconazole ophthalmic formulation was developed based on principles of quality by design. The developed formulation can be easily manufactured at bigger scale without need of any sophisticated equipment.},
year = {2020}
}
TY - JOUR T1 - Novel Long Retentive Posaconazole Ophthalmic Suspension AU - Jadhav Simta AU - Inamdar Kavita AU - Bhitre Milind Y1 - 2020/02/14 PY - 2020 N1 - https://doi.org/10.11648/j.pst.20200401.11 DO - 10.11648/j.pst.20200401.11 T2 - Pharmaceutical Science and Technology JF - Pharmaceutical Science and Technology JO - Pharmaceutical Science and Technology SP - 1 EP - 10 PB - Science Publishing Group SN - 2640-4540 UR - https://doi.org/10.11648/j.pst.20200401.11 AB - Ophthalmic formulations are not completely available for eliciting therapeutic action because of various reasons such as rapid tear drainage, blinking of eye, lower residence time and lower cul de sac volume. Ophthalmic formulation gets easily drained off due to eye blinking due to low viscosity. Posaconazole is known to have antifungal efficacy as oral route, however ophthalmic efficacy is not studied. The objective of present work was to develop long retentive posaconazole ophthalmic suspension based on polymer platform system of carbopol 974 P and xanthan gum. This synergistic polymer platform was pre-identified by means of experimental design study. Polymer based formulation helps to retain the drug at the site of action for longer duration and does not get washed away due to eye blinking phenomenon. Sterilization is key parameters for ophthalmic formulation. Different methods of sterilization were studied for posaconazole drug as well as polymer mixture and finished product. The developed formulations were characterized for homogeneity, pH, particle size, viscosity, osmolality, rheology study, mucoadhesive strength, contact angle, assay of posaconazole and benzalkonium chloride, degradation product, polymorphic form evaluation, eye irritation test and pharmacodynamic efficacy study. A stable long retentive posaconazole ophthalmic formulation was developed based on principles of quality by design. The developed formulation can be easily manufactured at bigger scale without need of any sophisticated equipment. VL - 4 IS - 1 ER -
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