Diabetes mellitus is one of the most costly and burdensome chronic disease of our time. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to resistance to the action of insulin, insufficient insulin secretion, or both. Diabetes mellitus causes nephropathy and fatty change in the liver and vascular changes. Rosiglitazone and repaglinide are new anti-diabetic agents. Rosiglitazone is a thiazolidinedione's agent acting as insulin-sensitizer. Repaglinide a non-sulphonyl urea insulin secretagogue, is a prandial glucose regulator. The present study is aimed to assess the potential protective role of Rosiglitazone and Repaglinide on Liver and Kidney tissues of diabetic guinea pig (Caviaporcellus). The used Guinea pigs were divided into five groups. Diabetes mellitus is induced in 4 groups of them by oral administration of fructose 50% concentration. One of the diabetic groups was served as diabetic non treated and the other 3 groups were treated by Rosiglitazone, Repaglinide and a combination of both drugs, respectively. Blood samples were collected for the biochemical studies. The animals were sacrificed and the liver and kidney were excised to be used for the histopathological studies. The present study showed that, the combination of rosiglitazone & repaglinide may have a synergistic protective effect against diabetes mellitus - induced renal and liver tissues damage. This study proved that the combination of rosiglitazone &repaglinide in treatment of diabetes mellitus is better than rosiglitazone or repaglinidealone in protection of the Liver and Kidney tissues of diabetic Guinea pigs, Caviaporcellus.
| Published in | International Journal of Ecotoxicology and Ecobiology (Volume 1, Issue 2) |
| DOI | 10.11648/j.ijee.20160102.13 |
| Page(s) | 39-48 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Rosiglitazone, Repaglinide, Liver, Kidney, Guinea Pig, (Caviaporcellus)
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APA Style
Ali Abd Alsalaam, Fathy M. Elshaer, Hamdi Abdou Mansour. (2016). The Possible Protective Role of Both, Rosiglitazone and Repaglinide on Liver and Kidney of Diabetic Guinea Pig (Caviaporcellus). International Journal of Ecotoxicology and Ecobiology, 1(2), 39-48. https://doi.org/10.11648/j.ijee.20160102.13
ACS Style
Ali Abd Alsalaam; Fathy M. Elshaer; Hamdi Abdou Mansour. The Possible Protective Role of Both, Rosiglitazone and Repaglinide on Liver and Kidney of Diabetic Guinea Pig (Caviaporcellus). Int. J. Ecotoxicol. Ecobiol. 2016, 1(2), 39-48. doi: 10.11648/j.ijee.20160102.13
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Download@article{10.11648/j.ijee.20160102.13,
author = {Ali Abd Alsalaam and Fathy M. Elshaer and Hamdi Abdou Mansour},
title = {The Possible Protective Role of Both, Rosiglitazone and Repaglinide on Liver and Kidney of Diabetic Guinea Pig (Caviaporcellus)},
journal = {International Journal of Ecotoxicology and Ecobiology},
volume = {1},
number = {2},
pages = {39-48},
doi = {10.11648/j.ijee.20160102.13},
url = {https://doi.org/10.11648/j.ijee.20160102.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijee.20160102.13},
abstract = {Diabetes mellitus is one of the most costly and burdensome chronic disease of our time. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to resistance to the action of insulin, insufficient insulin secretion, or both. Diabetes mellitus causes nephropathy and fatty change in the liver and vascular changes. Rosiglitazone and repaglinide are new anti-diabetic agents. Rosiglitazone is a thiazolidinedione's agent acting as insulin-sensitizer. Repaglinide a non-sulphonyl urea insulin secretagogue, is a prandial glucose regulator. The present study is aimed to assess the potential protective role of Rosiglitazone and Repaglinide on Liver and Kidney tissues of diabetic guinea pig (Caviaporcellus). The used Guinea pigs were divided into five groups. Diabetes mellitus is induced in 4 groups of them by oral administration of fructose 50% concentration. One of the diabetic groups was served as diabetic non treated and the other 3 groups were treated by Rosiglitazone, Repaglinide and a combination of both drugs, respectively. Blood samples were collected for the biochemical studies. The animals were sacrificed and the liver and kidney were excised to be used for the histopathological studies. The present study showed that, the combination of rosiglitazone & repaglinide may have a synergistic protective effect against diabetes mellitus - induced renal and liver tissues damage. This study proved that the combination of rosiglitazone &repaglinide in treatment of diabetes mellitus is better than rosiglitazone or repaglinidealone in protection of the Liver and Kidney tissues of diabetic Guinea pigs, Caviaporcellus.},
year = {2016}
}
TY - JOUR T1 - The Possible Protective Role of Both, Rosiglitazone and Repaglinide on Liver and Kidney of Diabetic Guinea Pig (Caviaporcellus) AU - Ali Abd Alsalaam AU - Fathy M. Elshaer AU - Hamdi Abdou Mansour Y1 - 2016/07/28 PY - 2016 N1 - https://doi.org/10.11648/j.ijee.20160102.13 DO - 10.11648/j.ijee.20160102.13 T2 - International Journal of Ecotoxicology and Ecobiology JF - International Journal of Ecotoxicology and Ecobiology JO - International Journal of Ecotoxicology and Ecobiology SP - 39 EP - 48 PB - Science Publishing Group SN - 2575-1735 UR - https://doi.org/10.11648/j.ijee.20160102.13 AB - Diabetes mellitus is one of the most costly and burdensome chronic disease of our time. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to resistance to the action of insulin, insufficient insulin secretion, or both. Diabetes mellitus causes nephropathy and fatty change in the liver and vascular changes. Rosiglitazone and repaglinide are new anti-diabetic agents. Rosiglitazone is a thiazolidinedione's agent acting as insulin-sensitizer. Repaglinide a non-sulphonyl urea insulin secretagogue, is a prandial glucose regulator. The present study is aimed to assess the potential protective role of Rosiglitazone and Repaglinide on Liver and Kidney tissues of diabetic guinea pig (Caviaporcellus). The used Guinea pigs were divided into five groups. Diabetes mellitus is induced in 4 groups of them by oral administration of fructose 50% concentration. One of the diabetic groups was served as diabetic non treated and the other 3 groups were treated by Rosiglitazone, Repaglinide and a combination of both drugs, respectively. Blood samples were collected for the biochemical studies. The animals were sacrificed and the liver and kidney were excised to be used for the histopathological studies. The present study showed that, the combination of rosiglitazone & repaglinide may have a synergistic protective effect against diabetes mellitus - induced renal and liver tissues damage. This study proved that the combination of rosiglitazone &repaglinide in treatment of diabetes mellitus is better than rosiglitazone or repaglinidealone in protection of the Liver and Kidney tissues of diabetic Guinea pigs, Caviaporcellus. VL - 1 IS - 2 ER -
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