Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats

Christopher Ekpenyong

doi:doi:10.11648/j.ijee.20170202.13

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Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats

Christopher Ekpenyong

Published in International Journal of Ecotoxicology and Ecobiology (Volume 2, Issue 2)

Received: 5 May 2017 Accepted: 3 June 2017 Published: 21 July 2017

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Abstract

The therapeutic use of medicinal plants and plant products to mitigate solvent/xenobiotic-induced haematological disorders has not been adequately explored. The aim of this study was to evaluate the effect of Cymbopogon citratus (C. citratus) leaf decoctions on gasoline vapour (GV)-induced haematological disorders and oxidative stress in rats. Seventy-two female rats weighing 180-200g were randomly selected and divided into six groups (n = 12 per group). Animals in group 1 served as unexposed controls, while animals in group 2 were exposed to gasoline vapour (GV) alone for 35 days. Animals in groups 3, 4, and 5 were exposed to GV and co-administered C. citratus leaf extract (500 mg/kg, 1000 mg/kg, and 1500 mg/kg, respectively), and animals in group 6 were exposed to GV and co-administered vitamin C (200 mg/kg) for the same time period. Exposure of animals to GV alone significantly (p < 0.05) decreased packed cell volume (PCV), haemoglobin concentration (HB), total red blood cells (RBC), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC). Total white blood cells (WBC), WBC lineages and malondialdehyde (MDA) levels significantly increased (p < 0.05) compared to the corresponding values in the control group. Supplementation with C. citratus leaf decoction and vitamin C reversed these GV-induced changes in haematological indices and MDA levels. Therefore, C. citratus leaf decoctions and vitamin C supplementation provided an ameliorative effect on GV-induced haematotoxicity and oxidative stress in a rat model of gasoline exposure.

Published in	International Journal of Ecotoxicology and Ecobiology (Volume 2, Issue 2)
DOI	10.11648/j.ijee.20170202.13
Page(s)	74-79
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Lemongrass, Gasoline Fumes, Haematotoxicity, Amelioration, Rat

References

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APA Style

Christopher Ekpenyong. (2017). Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats. International Journal of Ecotoxicology and Ecobiology, 2(2), 74-79. https://doi.org/10.11648/j.ijee.20170202.13

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ACS Style

Christopher Ekpenyong. Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats. Int. J. Ecotoxicol. Ecobiol. 2017, 2(2), 74-79. doi: 10.11648/j.ijee.20170202.13

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AMA Style

Christopher Ekpenyong. Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats. Int J Ecotoxicol Ecobiol. 2017;2(2):74-79. doi: 10.11648/j.ijee.20170202.13

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@article{10.11648/j.ijee.20170202.13,
  author = {Christopher Ekpenyong},
  title = {Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats},
  journal = {International Journal of Ecotoxicology and Ecobiology},
  volume = {2},
  number = {2},
  pages = {74-79},
  doi = {10.11648/j.ijee.20170202.13},
  url = {https://doi.org/10.11648/j.ijee.20170202.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijee.20170202.13},
  abstract = {The therapeutic use of medicinal plants and plant products to mitigate solvent/xenobiotic-induced haematological disorders has not been adequately explored. The aim of this study was to evaluate the effect of Cymbopogon citratus (C. citratus) leaf decoctions on gasoline vapour (GV)-induced haematological disorders and oxidative stress in rats. Seventy-two female rats weighing 180-200g were randomly selected and divided into six groups (n = 12 per group). Animals in group 1 served as unexposed controls, while animals in group 2 were exposed to gasoline vapour (GV) alone for 35 days. Animals in groups 3, 4, and 5 were exposed to GV and co-administered C. citratus leaf extract (500 mg/kg, 1000 mg/kg, and 1500 mg/kg, respectively), and animals in group 6 were exposed to GV and co-administered vitamin C (200 mg/kg) for the same time period. Exposure of animals to GV alone significantly (p < 0.05) decreased packed cell volume (PCV), haemoglobin concentration (HB), total red blood cells (RBC), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC). Total white blood cells (WBC), WBC lineages and malondialdehyde (MDA) levels significantly increased (p < 0.05) compared to the corresponding values in the control group. Supplementation with C. citratus leaf decoction and vitamin C reversed these GV-induced changes in haematological indices and MDA levels. Therefore, C. citratus leaf decoctions and vitamin C supplementation provided an ameliorative effect on GV-induced haematotoxicity and oxidative stress in a rat model of gasoline exposure.},
 year = {2017}
}

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TY  - JOUR
T1  - Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats
AU  - Christopher Ekpenyong
Y1  - 2017/07/21
PY  - 2017
N1  - https://doi.org/10.11648/j.ijee.20170202.13
DO  - 10.11648/j.ijee.20170202.13
T2  - International Journal of Ecotoxicology and Ecobiology
JF  - International Journal of Ecotoxicology and Ecobiology
JO  - International Journal of Ecotoxicology and Ecobiology
SP  - 74
EP  - 79
PB  - Science Publishing Group
SN  - 2575-1735
UR  - https://doi.org/10.11648/j.ijee.20170202.13
AB  - The therapeutic use of medicinal plants and plant products to mitigate solvent/xenobiotic-induced haematological disorders has not been adequately explored. The aim of this study was to evaluate the effect of Cymbopogon citratus (C. citratus) leaf decoctions on gasoline vapour (GV)-induced haematological disorders and oxidative stress in rats. Seventy-two female rats weighing 180-200g were randomly selected and divided into six groups (n = 12 per group). Animals in group 1 served as unexposed controls, while animals in group 2 were exposed to gasoline vapour (GV) alone for 35 days. Animals in groups 3, 4, and 5 were exposed to GV and co-administered C. citratus leaf extract (500 mg/kg, 1000 mg/kg, and 1500 mg/kg, respectively), and animals in group 6 were exposed to GV and co-administered vitamin C (200 mg/kg) for the same time period. Exposure of animals to GV alone significantly (p < 0.05) decreased packed cell volume (PCV), haemoglobin concentration (HB), total red blood cells (RBC), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC). Total white blood cells (WBC), WBC lineages and malondialdehyde (MDA) levels significantly increased (p < 0.05) compared to the corresponding values in the control group. Supplementation with C. citratus leaf decoction and vitamin C reversed these GV-induced changes in haematological indices and MDA levels. Therefore, C. citratus leaf decoctions and vitamin C supplementation provided an ameliorative effect on GV-induced haematotoxicity and oxidative stress in a rat model of gasoline exposure.
VL  - 2
IS  - 2
ER  -

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Christopher Ekpenyong

Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria

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Christopher Ekpenyong. (2017). Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats. International Journal of Ecotoxicology and Ecobiology, 2(2), 74-79. https://doi.org/10.11648/j.ijee.20170202.13

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ACS Style

Christopher Ekpenyong. Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats. Int. J. Ecotoxicol. Ecobiol. 2017, 2(2), 74-79. doi: 10.11648/j.ijee.20170202.13

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AMA Style

Christopher Ekpenyong. Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats. Int J Ecotoxicol Ecobiol. 2017;2(2):74-79. doi: 10.11648/j.ijee.20170202.13

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@article{10.11648/j.ijee.20170202.13,
  author = {Christopher Ekpenyong},
  title = {Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats},
  journal = {International Journal of Ecotoxicology and Ecobiology},
  volume = {2},
  number = {2},
  pages = {74-79},
  doi = {10.11648/j.ijee.20170202.13},
  url = {https://doi.org/10.11648/j.ijee.20170202.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijee.20170202.13},
  abstract = {The therapeutic use of medicinal plants and plant products to mitigate solvent/xenobiotic-induced haematological disorders has not been adequately explored. The aim of this study was to evaluate the effect of Cymbopogon citratus (C. citratus) leaf decoctions on gasoline vapour (GV)-induced haematological disorders and oxidative stress in rats. Seventy-two female rats weighing 180-200g were randomly selected and divided into six groups (n = 12 per group). Animals in group 1 served as unexposed controls, while animals in group 2 were exposed to gasoline vapour (GV) alone for 35 days. Animals in groups 3, 4, and 5 were exposed to GV and co-administered C. citratus leaf extract (500 mg/kg, 1000 mg/kg, and 1500 mg/kg, respectively), and animals in group 6 were exposed to GV and co-administered vitamin C (200 mg/kg) for the same time period. Exposure of animals to GV alone significantly (p < 0.05) decreased packed cell volume (PCV), haemoglobin concentration (HB), total red blood cells (RBC), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC). Total white blood cells (WBC), WBC lineages and malondialdehyde (MDA) levels significantly increased (p < 0.05) compared to the corresponding values in the control group. Supplementation with C. citratus leaf decoction and vitamin C reversed these GV-induced changes in haematological indices and MDA levels. Therefore, C. citratus leaf decoctions and vitamin C supplementation provided an ameliorative effect on GV-induced haematotoxicity and oxidative stress in a rat model of gasoline exposure.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats
AU  - Christopher Ekpenyong
Y1  - 2017/07/21
PY  - 2017
N1  - https://doi.org/10.11648/j.ijee.20170202.13
DO  - 10.11648/j.ijee.20170202.13
T2  - International Journal of Ecotoxicology and Ecobiology
JF  - International Journal of Ecotoxicology and Ecobiology
JO  - International Journal of Ecotoxicology and Ecobiology
SP  - 74
EP  - 79
PB  - Science Publishing Group
SN  - 2575-1735
UR  - https://doi.org/10.11648/j.ijee.20170202.13
AB  - The therapeutic use of medicinal plants and plant products to mitigate solvent/xenobiotic-induced haematological disorders has not been adequately explored. The aim of this study was to evaluate the effect of Cymbopogon citratus (C. citratus) leaf decoctions on gasoline vapour (GV)-induced haematological disorders and oxidative stress in rats. Seventy-two female rats weighing 180-200g were randomly selected and divided into six groups (n = 12 per group). Animals in group 1 served as unexposed controls, while animals in group 2 were exposed to gasoline vapour (GV) alone for 35 days. Animals in groups 3, 4, and 5 were exposed to GV and co-administered C. citratus leaf extract (500 mg/kg, 1000 mg/kg, and 1500 mg/kg, respectively), and animals in group 6 were exposed to GV and co-administered vitamin C (200 mg/kg) for the same time period. Exposure of animals to GV alone significantly (p < 0.05) decreased packed cell volume (PCV), haemoglobin concentration (HB), total red blood cells (RBC), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC). Total white blood cells (WBC), WBC lineages and malondialdehyde (MDA) levels significantly increased (p < 0.05) compared to the corresponding values in the control group. Supplementation with C. citratus leaf decoction and vitamin C reversed these GV-induced changes in haematological indices and MDA levels. Therefore, C. citratus leaf decoctions and vitamin C supplementation provided an ameliorative effect on GV-induced haematotoxicity and oxidative stress in a rat model of gasoline exposure.
VL  - 2
IS  - 2
ER  -

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