Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832)

Topchiyeva Shafiga; Babaev Elmar

doi:doi:10.11648/j.ijee.20170203.11

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Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832)

Topchiyeva Shafiga, Babaev Elmar

Published in International Journal of Ecotoxicology and Ecobiology (Volume 2, Issue 3)

Received: 15 May 2017 Accepted: 20 June 2017 Published: 21 July 2017

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Abstract

The paper presents data on the study of the thermoprotective properties of the venom of the Transcaucasian Vipeta (Macrovipera lebetina obtuse) on 120 white mongrel mice subjected to thermal exposure (30 - 50°C) for 30 minutes with the injection of zootoxin in doses (2 mg / kg and 4 mg / kg). It was found that the lifespan of mice was increased with respect to a series of experiments in which the injection of venoms under the conditions of normothermia was used for 28 - 30 minutes and 15 - 20 minutes to 120.0 ± 8.5 and 160.0 ± 19.7 minutes, respectively. It was found that in the posthyperthermic period after a 30-minute thermal exposure (30 - 50°C) in the control group of animal experiments, a 100% mortality was observed during 24 hours, and with the preliminary injection of a venom in the range of doses 2 - 4 mg / kg Survival in 30% - 50% of experimental animals was noted. Thus, the thermoprotective property of the venom of the Transcaucasian vipera has been proved.

Published in	International Journal of Ecotoxicology and Ecobiology (Volume 2, Issue 3)
DOI	10.11648/j.ijee.20170203.11
Page(s)	98-101
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Venom, Macrovipera Lebetina Obtusa, Thermoprotective Property, Mices, Zootoxins

References

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[2]	Tuniyev, S. B., Orlov, N. L.,Tuniyev, B. S., Kidov F. F. On the taxonomical status of steppe viper from foothills of the south macroslope of the East Caucasus. Russ. J. Herpetol. 2013, 20, 129–146.
[3]	Abiyev H., Topchiyeva Sh. The study of the physical properties of Мacrovipera lebetina obtusа venom. Journal of Basic and Applied Scientific Research. 2013, 3 (11), 373-377.
[4]	Abiyev H. A., Babayev E. T., Topchiyeva Sh. A. The impact of environmental pollutants on viper venom Macrovipera lebetina obtusa. Journal of Entomology and Zoology Studies. 2016,4 (3), 378-381.
[5]	Ghazaryan N. A., Ghulikyan L., Kishmiryan A., Andreeva T. V., Utkin, Y. N., Tsetlin, V. I., Lomonte B., Ayvazyan N. M. Phospholipases A 2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms. Biochim. Biophys. Acta. 2015, 1848, 463–468.
[6]	Vulfius, C. A., Kasheverov, I. E., Starkov, V. G., Osipov, A. V., Andreeva, T. V., Filkin, S. Y., Gorbacheva, E. V., Astashev, M. E., Tsetlin, V. I., Utkin, Y. N. Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A 2. PLoS ONE. 2014, 9.
[7]	Sergey I. Kovalchuk, Rustam H. Ziganshin, Vladislav G. Starkov, Victor I. Tsetlin and Yuri N. Utkin. Quantitative Proteomic Analysis of Venoms from Russian Vipers of Pelias Group: Phospholipases A 2 are the Main Venom Components. Toxins. 2016, 8,105.
[8]	Artishevsky A. A. Morphofunctional changes in the thyroid gland and adrenal glands in rat embryos under the influence of hyperthermia / A. A. Artishevsky, B. C. Gaiduk. 8 Congress of the Byelorussian, fiziol. Society for them. I. P. Pavlova. Tez. Doc. Minsk, 1994, 8-9.
[9]	Khomutov A. E., Yagin V. V. Bulletin of the University of Nizhny Novgorod. Series Biology. N. Novgorod, 2005. , 2 (10), 152-156.
[10]	Khomutov AE, Pursanov K. A., Danilova O. O. Actual problems of herpetology and toxicology. Issue. 9. Togliatti, 2006, 182-188.
[11]	Khomutov AE, Pursanov K. A., Danilova O. O. Bulletin of the Nizhny Novgorod State University. N.I. Lobachevsky. Morphological changes in rat lungs under the action of heparin and zootoxins under hyperthermia. 2007, b,112-115.
[12]	Khomutov AE, Lushnikova O. V. Posthyperthermal changes in rectal temperature and survival of rats against the background of the action of zootoxins. Bulletin of the Nizhny Novgorod State University. N. I. Lobachevsky, 2009, 5, 109-112.
[13]	http://www.labome.ru/method/Protein-Quantitation.html
[14]	www.unn.ru/pages/disser/699.pdf
[15]	www.nizhgma.ru/_resources/directory/371/common/luchnikova.

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Topchiyeva Shafiga, Babaev Elmar. (2017). Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832). International Journal of Ecotoxicology and Ecobiology, 2(3), 98-101. https://doi.org/10.11648/j.ijee.20170203.11

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Topchiyeva Shafiga; Babaev Elmar. Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832). Int. J. Ecotoxicol. Ecobiol. 2017, 2(3), 98-101. doi: 10.11648/j.ijee.20170203.11

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AMA Style

Topchiyeva Shafiga, Babaev Elmar. Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832). Int J Ecotoxicol Ecobiol. 2017;2(3):98-101. doi: 10.11648/j.ijee.20170203.11

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@article{10.11648/j.ijee.20170203.11,
  author = {Topchiyeva Shafiga and Babaev Elmar},
  title = {Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832)},
  journal = {International Journal of Ecotoxicology and Ecobiology},
  volume = {2},
  number = {3},
  pages = {98-101},
  doi = {10.11648/j.ijee.20170203.11},
  url = {https://doi.org/10.11648/j.ijee.20170203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijee.20170203.11},
  abstract = {The paper presents data on the study of the thermoprotective properties of the venom of the Transcaucasian Vipeta (Macrovipera lebetina obtuse) on 120 white mongrel mice subjected to thermal exposure (30 - 50°C) for 30 minutes with the injection of zootoxin in doses (2 mg / kg and 4 mg / kg). It was found that the lifespan of mice was increased with respect to a series of experiments in which the injection of venoms under the conditions of normothermia was used for 28 - 30 minutes and 15 - 20 minutes to 120.0 ± 8.5 and 160.0 ± 19.7 minutes, respectively. It was found that in the posthyperthermic period after a 30-minute thermal exposure (30 - 50°C) in the control group of animal experiments, a 100% mortality was observed during 24 hours, and with the preliminary injection of a venom in the range of doses 2 - 4 mg / kg Survival in 30% - 50% of experimental animals was noted. Thus, the thermoprotective property of the venom of the Transcaucasian vipera has been proved.},
 year = {2017}
}

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TY  - JOUR
T1  - Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832)
AU  - Topchiyeva Shafiga
AU  - Babaev Elmar
Y1  - 2017/07/21
PY  - 2017
N1  - https://doi.org/10.11648/j.ijee.20170203.11
DO  - 10.11648/j.ijee.20170203.11
T2  - International Journal of Ecotoxicology and Ecobiology
JF  - International Journal of Ecotoxicology and Ecobiology
JO  - International Journal of Ecotoxicology and Ecobiology
SP  - 98
EP  - 101
PB  - Science Publishing Group
SN  - 2575-1735
UR  - https://doi.org/10.11648/j.ijee.20170203.11
AB  - The paper presents data on the study of the thermoprotective properties of the venom of the Transcaucasian Vipeta (Macrovipera lebetina obtuse) on 120 white mongrel mice subjected to thermal exposure (30 - 50°C) for 30 minutes with the injection of zootoxin in doses (2 mg / kg and 4 mg / kg). It was found that the lifespan of mice was increased with respect to a series of experiments in which the injection of venoms under the conditions of normothermia was used for 28 - 30 minutes and 15 - 20 minutes to 120.0 ± 8.5 and 160.0 ± 19.7 minutes, respectively. It was found that in the posthyperthermic period after a 30-minute thermal exposure (30 - 50°C) in the control group of animal experiments, a 100% mortality was observed during 24 hours, and with the preliminary injection of a venom in the range of doses 2 - 4 mg / kg Survival in 30% - 50% of experimental animals was noted. Thus, the thermoprotective property of the venom of the Transcaucasian vipera has been proved.
VL  - 2
IS  - 3
ER  -

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Author Information

Topchiyeva Shafiga

National Academy of Sciences of Azerbaijan, Baku, Azerbaijan
Babaev Elmar

National Academy of Sciences of Azerbaijan, Baku, Azerbaijan

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Topchiyeva Shafiga, Babaev Elmar. (2017). Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832). International Journal of Ecotoxicology and Ecobiology, 2(3), 98-101. https://doi.org/10.11648/j.ijee.20170203.11

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ACS Style

Topchiyeva Shafiga; Babaev Elmar. Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832). Int. J. Ecotoxicol. Ecobiol. 2017, 2(3), 98-101. doi: 10.11648/j.ijee.20170203.11

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AMA Style

Topchiyeva Shafiga, Babaev Elmar. Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832). Int J Ecotoxicol Ecobiol. 2017;2(3):98-101. doi: 10.11648/j.ijee.20170203.11

Copy | Download

@article{10.11648/j.ijee.20170203.11,
  author = {Topchiyeva Shafiga and Babaev Elmar},
  title = {Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832)},
  journal = {International Journal of Ecotoxicology and Ecobiology},
  volume = {2},
  number = {3},
  pages = {98-101},
  doi = {10.11648/j.ijee.20170203.11},
  url = {https://doi.org/10.11648/j.ijee.20170203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijee.20170203.11},
  abstract = {The paper presents data on the study of the thermoprotective properties of the venom of the Transcaucasian Vipeta (Macrovipera lebetina obtuse) on 120 white mongrel mice subjected to thermal exposure (30 - 50°C) for 30 minutes with the injection of zootoxin in doses (2 mg / kg and 4 mg / kg). It was found that the lifespan of mice was increased with respect to a series of experiments in which the injection of venoms under the conditions of normothermia was used for 28 - 30 minutes and 15 - 20 minutes to 120.0 ± 8.5 and 160.0 ± 19.7 minutes, respectively. It was found that in the posthyperthermic period after a 30-minute thermal exposure (30 - 50°C) in the control group of animal experiments, a 100% mortality was observed during 24 hours, and with the preliminary injection of a venom in the range of doses 2 - 4 mg / kg Survival in 30% - 50% of experimental animals was noted. Thus, the thermoprotective property of the venom of the Transcaucasian vipera has been proved.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Thermoprotective Properties of the Venom of the Transcaucasian Vipera (Macrovipera Lebetina Obtusa Dyigubsky, 1832)
AU  - Topchiyeva Shafiga
AU  - Babaev Elmar
Y1  - 2017/07/21
PY  - 2017
N1  - https://doi.org/10.11648/j.ijee.20170203.11
DO  - 10.11648/j.ijee.20170203.11
T2  - International Journal of Ecotoxicology and Ecobiology
JF  - International Journal of Ecotoxicology and Ecobiology
JO  - International Journal of Ecotoxicology and Ecobiology
SP  - 98
EP  - 101
PB  - Science Publishing Group
SN  - 2575-1735
UR  - https://doi.org/10.11648/j.ijee.20170203.11
AB  - The paper presents data on the study of the thermoprotective properties of the venom of the Transcaucasian Vipeta (Macrovipera lebetina obtuse) on 120 white mongrel mice subjected to thermal exposure (30 - 50°C) for 30 minutes with the injection of zootoxin in doses (2 mg / kg and 4 mg / kg). It was found that the lifespan of mice was increased with respect to a series of experiments in which the injection of venoms under the conditions of normothermia was used for 28 - 30 minutes and 15 - 20 minutes to 120.0 ± 8.5 and 160.0 ± 19.7 minutes, respectively. It was found that in the posthyperthermic period after a 30-minute thermal exposure (30 - 50°C) in the control group of animal experiments, a 100% mortality was observed during 24 hours, and with the preliminary injection of a venom in the range of doses 2 - 4 mg / kg Survival in 30% - 50% of experimental animals was noted. Thus, the thermoprotective property of the venom of the Transcaucasian vipera has been proved.
VL  - 2
IS  - 3
ER  -

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