Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with <i>Schistosoma mansoni</i>

Fayez A. Bakry; Somaya M Ismail

doi:doi:10.11648/j.jb.20170101.12

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Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni

Fayez A. Bakry, Somaya M Ismail

Published in Journal of Biomaterials (Volume 1, Issue 1)

Received: 7 March 2017 Accepted: 29 March 2017 Published: 3 May 2017

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Abstract

This study elucidates the potential of the plant extract of Phoenix dactylifera and Zingiber officinal plantsin treating Schistosoma mansoni infected mice. The parasitological parameters, worm burden/mouse, number of ova/g tissue in the liver and intestine and the developmental stages of ova in infected treated mice were determined. In addition, glycolytic enzymes,liver function enzymes and histological changes in liver tissues of infected treated mice were studied.The present results showed a significant reduction in the number of worms in groups treated with plant extracts as well as in the number of mature and live ova in the treated group compared to the infected control group. In addition, the present results showed a significant reduction in Lactate dehydrogenase, Aspartate aminotransferase and alanine aminotransferase enzyme activity in Schistosoma mansoni infected group as compared to the normal, healthy control, while a significant increase was noticed in acid phosphatase, alkaline phosphatase level and other glycolytic enzymes as compared to the normal healthy control. Moreover, treatment of the infected mice with plant extracts recorded no significant difference in the level of liver function enzymes andall glycolytic enzymes as compared to the normal healthy control. A noticeable remark to the effect of Z. officinal and P. Dactylifera pointed out to that there is no side effects on liver function and all glycolytic enzymes and as compared to the normal, healthy control group. In conclusion, plant extracts can be applied clinically as a prophylactic treatment against schistosomiasis together with the ideal antischistosomal drug praziquantel.

Published in	Journal of Biomaterials (Volume 1, Issue 1)
DOI	10.11648/j.jb.20170101.12
Page(s)	10-18
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Phoenix dactylifera, Zingiber officinal, Schistosoma mansoni, Male Mice, Glycolytic Enzymes,Histological Changes

References

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Fayez A. Bakry, Somaya M Ismail. (2017). Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni. Journal of Biomaterials, 1(1), 10-18. https://doi.org/10.11648/j.jb.20170101.12

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Fayez A. Bakry; Somaya M Ismail. Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni. J. Biomater. 2017, 1(1), 10-18. doi: 10.11648/j.jb.20170101.12

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Fayez A. Bakry, Somaya M Ismail. Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni. J Biomater. 2017;1(1):10-18. doi: 10.11648/j.jb.20170101.12

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@article{10.11648/j.jb.20170101.12,
  author = {Fayez A. Bakry and Somaya M Ismail},
  title = {Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni},
  journal = {Journal of Biomaterials},
  volume = {1},
  number = {1},
  pages = {10-18},
  doi = {10.11648/j.jb.20170101.12},
  url = {https://doi.org/10.11648/j.jb.20170101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jb.20170101.12},
  abstract = {This study elucidates the potential of the plant extract of Phoenix dactylifera and Zingiber officinal plantsin treating Schistosoma mansoni infected mice. The parasitological parameters, worm burden/mouse, number of ova/g tissue in the liver and intestine and the developmental stages of ova in infected treated mice were determined. In addition, glycolytic enzymes,liver function enzymes and histological changes in liver tissues of infected treated mice were studied.The present results showed a significant reduction in the number of worms in groups treated with plant extracts as well as in the number of mature and live ova in the treated group compared to the infected control group. In addition, the present results showed a significant reduction in Lactate dehydrogenase, Aspartate aminotransferase and alanine aminotransferase enzyme activity in Schistosoma mansoni infected group as compared to the normal, healthy control, while a significant increase was noticed in acid phosphatase, alkaline phosphatase level and other glycolytic enzymes as compared to the normal healthy control. Moreover, treatment of the infected mice with plant extracts recorded no significant difference in the level of liver function enzymes andall glycolytic enzymes as compared to the normal healthy control. A noticeable remark to the effect of Z. officinal and P. Dactylifera pointed out to that there is no side effects on liver function and all glycolytic enzymes and as compared to the normal, healthy control group. In conclusion, plant extracts can be applied clinically as a prophylactic treatment against schistosomiasis together with the ideal antischistosomal drug praziquantel.},
 year = {2017}
}

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TY  - JOUR
T1  - Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni
AU  - Fayez A. Bakry
AU  - Somaya M Ismail
Y1  - 2017/05/03
PY  - 2017
N1  - https://doi.org/10.11648/j.jb.20170101.12
DO  - 10.11648/j.jb.20170101.12
T2  - Journal of Biomaterials
JF  - Journal of Biomaterials
JO  - Journal of Biomaterials
SP  - 10
EP  - 18
PB  - Science Publishing Group
SN  - 2640-2629
UR  - https://doi.org/10.11648/j.jb.20170101.12
AB  - This study elucidates the potential of the plant extract of Phoenix dactylifera and Zingiber officinal plantsin treating Schistosoma mansoni infected mice. The parasitological parameters, worm burden/mouse, number of ova/g tissue in the liver and intestine and the developmental stages of ova in infected treated mice were determined. In addition, glycolytic enzymes,liver function enzymes and histological changes in liver tissues of infected treated mice were studied.The present results showed a significant reduction in the number of worms in groups treated with plant extracts as well as in the number of mature and live ova in the treated group compared to the infected control group. In addition, the present results showed a significant reduction in Lactate dehydrogenase, Aspartate aminotransferase and alanine aminotransferase enzyme activity in Schistosoma mansoni infected group as compared to the normal, healthy control, while a significant increase was noticed in acid phosphatase, alkaline phosphatase level and other glycolytic enzymes as compared to the normal healthy control. Moreover, treatment of the infected mice with plant extracts recorded no significant difference in the level of liver function enzymes andall glycolytic enzymes as compared to the normal healthy control. A noticeable remark to the effect of Z. officinal and P. Dactylifera pointed out to that there is no side effects on liver function and all glycolytic enzymes and as compared to the normal, healthy control group. In conclusion, plant extracts can be applied clinically as a prophylactic treatment against schistosomiasis together with the ideal antischistosomal drug praziquantel.
VL  - 1
IS  - 1
ER  -

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Author Information

Fayez A. Bakry

Theodor Bilharz Research Institute, Giza, Egypt
Somaya M Ismail

Zoology Department- Faculty of Science, Cairo University, Giza, Egypt; Faculty of Science and Home Economics, Bisha University, Bisha, Saudi Arabia

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Fayez A. Bakry, Somaya M Ismail. (2017). Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni. Journal of Biomaterials, 1(1), 10-18. https://doi.org/10.11648/j.jb.20170101.12

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ACS Style

Fayez A. Bakry; Somaya M Ismail. Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni. J. Biomater. 2017, 1(1), 10-18. doi: 10.11648/j.jb.20170101.12

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Fayez A. Bakry, Somaya M Ismail. Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni. J Biomater. 2017;1(1):10-18. doi: 10.11648/j.jb.20170101.12

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@article{10.11648/j.jb.20170101.12,
  author = {Fayez A. Bakry and Somaya M Ismail},
  title = {Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni},
  journal = {Journal of Biomaterials},
  volume = {1},
  number = {1},
  pages = {10-18},
  doi = {10.11648/j.jb.20170101.12},
  url = {https://doi.org/10.11648/j.jb.20170101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jb.20170101.12},
  abstract = {This study elucidates the potential of the plant extract of Phoenix dactylifera and Zingiber officinal plantsin treating Schistosoma mansoni infected mice. The parasitological parameters, worm burden/mouse, number of ova/g tissue in the liver and intestine and the developmental stages of ova in infected treated mice were determined. In addition, glycolytic enzymes,liver function enzymes and histological changes in liver tissues of infected treated mice were studied.The present results showed a significant reduction in the number of worms in groups treated with plant extracts as well as in the number of mature and live ova in the treated group compared to the infected control group. In addition, the present results showed a significant reduction in Lactate dehydrogenase, Aspartate aminotransferase and alanine aminotransferase enzyme activity in Schistosoma mansoni infected group as compared to the normal, healthy control, while a significant increase was noticed in acid phosphatase, alkaline phosphatase level and other glycolytic enzymes as compared to the normal healthy control. Moreover, treatment of the infected mice with plant extracts recorded no significant difference in the level of liver function enzymes andall glycolytic enzymes as compared to the normal healthy control. A noticeable remark to the effect of Z. officinal and P. Dactylifera pointed out to that there is no side effects on liver function and all glycolytic enzymes and as compared to the normal, healthy control group. In conclusion, plant extracts can be applied clinically as a prophylactic treatment against schistosomiasis together with the ideal antischistosomal drug praziquantel.},
 year = {2017}
}

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TY  - JOUR
T1  - Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni
AU  - Fayez A. Bakry
AU  - Somaya M Ismail
Y1  - 2017/05/03
PY  - 2017
N1  - https://doi.org/10.11648/j.jb.20170101.12
DO  - 10.11648/j.jb.20170101.12
T2  - Journal of Biomaterials
JF  - Journal of Biomaterials
JO  - Journal of Biomaterials
SP  - 10
EP  - 18
PB  - Science Publishing Group
SN  - 2640-2629
UR  - https://doi.org/10.11648/j.jb.20170101.12
AB  - This study elucidates the potential of the plant extract of Phoenix dactylifera and Zingiber officinal plantsin treating Schistosoma mansoni infected mice. The parasitological parameters, worm burden/mouse, number of ova/g tissue in the liver and intestine and the developmental stages of ova in infected treated mice were determined. In addition, glycolytic enzymes,liver function enzymes and histological changes in liver tissues of infected treated mice were studied.The present results showed a significant reduction in the number of worms in groups treated with plant extracts as well as in the number of mature and live ova in the treated group compared to the infected control group. In addition, the present results showed a significant reduction in Lactate dehydrogenase, Aspartate aminotransferase and alanine aminotransferase enzyme activity in Schistosoma mansoni infected group as compared to the normal, healthy control, while a significant increase was noticed in acid phosphatase, alkaline phosphatase level and other glycolytic enzymes as compared to the normal healthy control. Moreover, treatment of the infected mice with plant extracts recorded no significant difference in the level of liver function enzymes andall glycolytic enzymes as compared to the normal healthy control. A noticeable remark to the effect of Z. officinal and P. Dactylifera pointed out to that there is no side effects on liver function and all glycolytic enzymes and as compared to the normal, healthy control group. In conclusion, plant extracts can be applied clinically as a prophylactic treatment against schistosomiasis together with the ideal antischistosomal drug praziquantel.
VL  - 1
IS  - 1
ER  -

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