Electrospun Chitosan-based Fibers for Wound Healing Applications

Sameer Sapkota; Shih-Feng Chou

doi:doi:10.11648/j.jb.20200402.13

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Electrospun Chitosan-based Fibers for Wound Healing Applications

Sameer Sapkota, Shih-Feng Chou

Published in Journal of Biomaterials (Volume 4, Issue 2)

Received: 14 November 2020 Accepted: 25 November 2020 Published: 4 December 2020

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Abstract

Chitosan, a natural-occurring biopolymer, is biocompatible to tissues with excellent antibacterial and hemostatic properties, which makes it a great candidate among wound dressing materials. In this paper, electrospun fiber-based wound dressings from blend chitosan and/or polyethylene oxide (PEO) and/or polyvinyl alcohol (PVA) fibers were reviewed. The incorporation of these water-soluble copolymers allows the entanglement of the rigid chitosan molecular chains during electrospinning leading to the production of continuous nonwoven fibers having average diameters ranging from several tenths to hundredths of nanometers. Increasing chitosan composition in the fibers improves the bulk mechanical strength of the fiber mats due to the rigid molecular structure of chitosan. The nano-sized pores within the fiber mats promote permeability of the fiber dressings, which further enhances the exchange of oxygen and nutrients with outside environment. In addition, the porous fiber mat structure facilitates the absorption of wound exudates while reducing the possibility of bacterial infections. Several studies in antibacterial and anti-inflammatory responses of chitosan-based electrospun fibers were discussed in this short review. More importantly, inclusions of small molecule drugs and/or biological agents are possible in chitosan-based electrospun fibers, which provide a multi-purpose treatment capability for wound healing applications.

Published in	Journal of Biomaterials (Volume 4, Issue 2)
DOI	10.11648/j.jb.20200402.13
Page(s)	51-57
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Electrospinning, Chitosan, Fibers, Drug Delivery, Wound Healing

References

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Sameer Sapkota, Shih-Feng Chou. (2020). Electrospun Chitosan-based Fibers for Wound Healing Applications. Journal of Biomaterials, 4(2), 51-57. https://doi.org/10.11648/j.jb.20200402.13

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ACS Style

Sameer Sapkota; Shih-Feng Chou. Electrospun Chitosan-based Fibers for Wound Healing Applications. J. Biomater. 2020, 4(2), 51-57. doi: 10.11648/j.jb.20200402.13

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AMA Style

Sameer Sapkota, Shih-Feng Chou. Electrospun Chitosan-based Fibers for Wound Healing Applications. J Biomater. 2020;4(2):51-57. doi: 10.11648/j.jb.20200402.13

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@article{10.11648/j.jb.20200402.13,
  author = {Sameer Sapkota and Shih-Feng Chou},
  title = {Electrospun Chitosan-based Fibers for Wound Healing Applications},
  journal = {Journal of Biomaterials},
  volume = {4},
  number = {2},
  pages = {51-57},
  doi = {10.11648/j.jb.20200402.13},
  url = {https://doi.org/10.11648/j.jb.20200402.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jb.20200402.13},
  abstract = {Chitosan, a natural-occurring biopolymer, is biocompatible to tissues with excellent antibacterial and hemostatic properties, which makes it a great candidate among wound dressing materials. In this paper, electrospun fiber-based wound dressings from blend chitosan and/or polyethylene oxide (PEO) and/or polyvinyl alcohol (PVA) fibers were reviewed. The incorporation of these water-soluble copolymers allows the entanglement of the rigid chitosan molecular chains during electrospinning leading to the production of continuous nonwoven fibers having average diameters ranging from several tenths to hundredths of nanometers. Increasing chitosan composition in the fibers improves the bulk mechanical strength of the fiber mats due to the rigid molecular structure of chitosan. The nano-sized pores within the fiber mats promote permeability of the fiber dressings, which further enhances the exchange of oxygen and nutrients with outside environment. In addition, the porous fiber mat structure facilitates the absorption of wound exudates while reducing the possibility of bacterial infections. Several studies in antibacterial and anti-inflammatory responses of chitosan-based electrospun fibers were discussed in this short review. More importantly, inclusions of small molecule drugs and/or biological agents are possible in chitosan-based electrospun fibers, which provide a multi-purpose treatment capability for wound healing applications.},
 year = {2020}
}

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TY  - JOUR
T1  - Electrospun Chitosan-based Fibers for Wound Healing Applications
AU  - Sameer Sapkota
AU  - Shih-Feng Chou
Y1  - 2020/12/04
PY  - 2020
N1  - https://doi.org/10.11648/j.jb.20200402.13
DO  - 10.11648/j.jb.20200402.13
T2  - Journal of Biomaterials
JF  - Journal of Biomaterials
JO  - Journal of Biomaterials
SP  - 51
EP  - 57
PB  - Science Publishing Group
SN  - 2640-2629
UR  - https://doi.org/10.11648/j.jb.20200402.13
AB  - Chitosan, a natural-occurring biopolymer, is biocompatible to tissues with excellent antibacterial and hemostatic properties, which makes it a great candidate among wound dressing materials. In this paper, electrospun fiber-based wound dressings from blend chitosan and/or polyethylene oxide (PEO) and/or polyvinyl alcohol (PVA) fibers were reviewed. The incorporation of these water-soluble copolymers allows the entanglement of the rigid chitosan molecular chains during electrospinning leading to the production of continuous nonwoven fibers having average diameters ranging from several tenths to hundredths of nanometers. Increasing chitosan composition in the fibers improves the bulk mechanical strength of the fiber mats due to the rigid molecular structure of chitosan. The nano-sized pores within the fiber mats promote permeability of the fiber dressings, which further enhances the exchange of oxygen and nutrients with outside environment. In addition, the porous fiber mat structure facilitates the absorption of wound exudates while reducing the possibility of bacterial infections. Several studies in antibacterial and anti-inflammatory responses of chitosan-based electrospun fibers were discussed in this short review. More importantly, inclusions of small molecule drugs and/or biological agents are possible in chitosan-based electrospun fibers, which provide a multi-purpose treatment capability for wound healing applications.
VL  - 4
IS  - 2
ER  -

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Author Information

Sameer Sapkota

Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, Texas, USA
Shih-Feng Chou

Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, Texas, USA

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APA Style

Sameer Sapkota, Shih-Feng Chou. (2020). Electrospun Chitosan-based Fibers for Wound Healing Applications. Journal of Biomaterials, 4(2), 51-57. https://doi.org/10.11648/j.jb.20200402.13

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ACS Style

Sameer Sapkota; Shih-Feng Chou. Electrospun Chitosan-based Fibers for Wound Healing Applications. J. Biomater. 2020, 4(2), 51-57. doi: 10.11648/j.jb.20200402.13

Copy | Download

AMA Style

Sameer Sapkota, Shih-Feng Chou. Electrospun Chitosan-based Fibers for Wound Healing Applications. J Biomater. 2020;4(2):51-57. doi: 10.11648/j.jb.20200402.13

Copy | Download

@article{10.11648/j.jb.20200402.13,
  author = {Sameer Sapkota and Shih-Feng Chou},
  title = {Electrospun Chitosan-based Fibers for Wound Healing Applications},
  journal = {Journal of Biomaterials},
  volume = {4},
  number = {2},
  pages = {51-57},
  doi = {10.11648/j.jb.20200402.13},
  url = {https://doi.org/10.11648/j.jb.20200402.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jb.20200402.13},
  abstract = {Chitosan, a natural-occurring biopolymer, is biocompatible to tissues with excellent antibacterial and hemostatic properties, which makes it a great candidate among wound dressing materials. In this paper, electrospun fiber-based wound dressings from blend chitosan and/or polyethylene oxide (PEO) and/or polyvinyl alcohol (PVA) fibers were reviewed. The incorporation of these water-soluble copolymers allows the entanglement of the rigid chitosan molecular chains during electrospinning leading to the production of continuous nonwoven fibers having average diameters ranging from several tenths to hundredths of nanometers. Increasing chitosan composition in the fibers improves the bulk mechanical strength of the fiber mats due to the rigid molecular structure of chitosan. The nano-sized pores within the fiber mats promote permeability of the fiber dressings, which further enhances the exchange of oxygen and nutrients with outside environment. In addition, the porous fiber mat structure facilitates the absorption of wound exudates while reducing the possibility of bacterial infections. Several studies in antibacterial and anti-inflammatory responses of chitosan-based electrospun fibers were discussed in this short review. More importantly, inclusions of small molecule drugs and/or biological agents are possible in chitosan-based electrospun fibers, which provide a multi-purpose treatment capability for wound healing applications.},
 year = {2020}
}

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TY  - JOUR
T1  - Electrospun Chitosan-based Fibers for Wound Healing Applications
AU  - Sameer Sapkota
AU  - Shih-Feng Chou
Y1  - 2020/12/04
PY  - 2020
N1  - https://doi.org/10.11648/j.jb.20200402.13
DO  - 10.11648/j.jb.20200402.13
T2  - Journal of Biomaterials
JF  - Journal of Biomaterials
JO  - Journal of Biomaterials
SP  - 51
EP  - 57
PB  - Science Publishing Group
SN  - 2640-2629
UR  - https://doi.org/10.11648/j.jb.20200402.13
AB  - Chitosan, a natural-occurring biopolymer, is biocompatible to tissues with excellent antibacterial and hemostatic properties, which makes it a great candidate among wound dressing materials. In this paper, electrospun fiber-based wound dressings from blend chitosan and/or polyethylene oxide (PEO) and/or polyvinyl alcohol (PVA) fibers were reviewed. The incorporation of these water-soluble copolymers allows the entanglement of the rigid chitosan molecular chains during electrospinning leading to the production of continuous nonwoven fibers having average diameters ranging from several tenths to hundredths of nanometers. Increasing chitosan composition in the fibers improves the bulk mechanical strength of the fiber mats due to the rigid molecular structure of chitosan. The nano-sized pores within the fiber mats promote permeability of the fiber dressings, which further enhances the exchange of oxygen and nutrients with outside environment. In addition, the porous fiber mat structure facilitates the absorption of wound exudates while reducing the possibility of bacterial infections. Several studies in antibacterial and anti-inflammatory responses of chitosan-based electrospun fibers were discussed in this short review. More importantly, inclusions of small molecule drugs and/or biological agents are possible in chitosan-based electrospun fibers, which provide a multi-purpose treatment capability for wound healing applications.
VL  - 4
IS  - 2
ER  -

Copy | Download