Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones
International Journal of Bioorganic Chemistry
Volume 1, Issue 1, December 2016, Pages: 21-30
Received: Dec. 9, 2016; Accepted: Jan. 4, 2017; Published: Jan. 24, 2017
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Authors
P. Christuraj, Post Graduate and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram, India
P. R. Rajakumar, Post Graduate and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram, India
C. Geetha, Post Graduate and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram, India
G. Vanangamudi, Post Graduate and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram, India
R. Arulkumran, Post Graduate and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram, India
R. Sundararajan, Post Graduate and Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram, India
G. Thirunarayanan, Chemistry Department, Annamalai University, Annamalainagar, India
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Abstract
About eleven substituted (E)-3-(5-bromothiophen-2-yl)-1-phenylprop-2-en-1-ones have been synthesized by Crossed-Aldol condensation using simple stirring of 5-bromo-2-thiophen aldehyde and various substituted acetophenones at room temperature. The obtained yields of this condensation was more than 89%. They are characterized by their analytical, UV, FT-IR and NMR spectral data. The antimicrobial activities of all synthesized chalcones have been evaluated by Bauer-Kirby disc diffusion method using gram positive and gram negative bacterial and fungal strains. From the mm of zone of inhibition values the anti-bacterial and antifungal activities of all ketones have been discussed.
Keywords
(E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-Ones, IR Spectra, NMR Spectra, Antibacterial and Antifungal Activities
To cite this article
P. Christuraj, P. R. Rajakumar, C. Geetha, G. Vanangamudi, R. Arulkumran, R. Sundararajan, G. Thirunarayanan, Synthesis, Characterization and Biological Study of Some (E)-3-(5-Bromothiophen-2-yl)-1-phenylprop-2-en-1-ones, International Journal of Bioorganic Chemistry. Vol. 1, No. 1, 2016, pp. 21-30. doi: 10.11648/j.ijbc.20160101.13
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Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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