Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum
International Journal of Photochemistry and Photobiology
Volume 1, Issue 1, June 2017, Pages: 21-26
Received: Jan. 4, 2017; Accepted: Jan. 17, 2017; Published: Mar. 2, 2017
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Md. Mamun-Or-Rashid, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh
Md. Shah Amran, mamunpdu@gmail.com
Md. Aslam Hossain, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh
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Abnormal passage of liquid or unformed stool at an increased frequency is termed as diarrhea: Infectious agents, certain medications, plant and animal toxins, gastrointestinal disorders, and substances that enhance gastrointestinal tract secretions are may be the triggers of diarrhea [1]. In recent times, medicinal plants occupy a considerable position for being the paramount sources of drug discovery irrespective of its categorized groups- herb, shrub or tree [2]. Oroxylum indicum (Linn.) Vent is widely used in Ayurvedic system of medicine [3]. The crude methanolic extract of Oroxylum indicum bark and fruits with different soluble partitionates were subjected to investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and thrombolytic, antihelmentic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment. [4] The antidiarrheal activity of methanolic bark and fruits extract and its different fractions of Oroxylum indicum (Ethyl acetate fraction, Dichloromethane fraction, Hexane fraction, Carbon tetrachloride fraction) (400mg/kg) cause reduction of diarrheal feces by 46.5%, 32.6%, 45.3%, 33.7%, 51.2%, respectively compared to standard Loperamide (82.6%). This reveals that methanol extracts of bark and fruits of Oroxylum indicum showed significant antidiarrheal activity.
Oroxylum indicum, Antidiarrheal Activity, Methanolic Extract
To cite this article
Md. Mamun-Or-Rashid, Md. Shah Amran, Md. Aslam Hossain, Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum, International Journal of Photochemistry and Photobiology. Vol. 1, No. 1, 2017, pp. 21-26. doi: 10.11648/j.ijpp.20170101.14
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Palombo EA (2006). Phytochemicals from traditional medicinal plants used in the treatment of diarrhoea: modes of action and effects on intestinal function. Phytother. Res. 20(Suppl 9): 717–724. http://dx.doi.org/10.1002/ptr.1907.
Saxe TG. Toxicity of medicinal herbal preparations. Am Fam Physician, 1987; 35: 135–42.
Radhika L. G., Meena C. V., Peter S., Rajesh K. S., Rosamma M. P. Phytochemical and antimicrobial study of Oroxylumindicum. Ancient Science of Life. 2011; 30: 114–120.
Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, Rudan I, Campbell H, Cibulskis R, Li M, Mathers C, Black RE; Child Health Epidemiology Reference Group of WHO and UNICEF. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012; 379 (9832): 2151-61.
Hutton G, Haller L, Bartram J. Global cost-benefit analysis of water supply and sanitation interventions. J Water Health. 2007; 5 (4): 481-502.
Shoba FG, Thomas M. Study of antidiarrheal activity of four medicinal plants in castor oil-induced diarrhea. J Ethnopharmacol, 2001; 76: 73-76.
Maikere-Faniyo R, Van Puyvelde L, Mutwewingabo A, Habiyaremye FX. Study of Rwandese medicinal plants used in the treatment of diarrhea. J Ethonopharmacol, 1989; 26: 101-109.
Syder JD, Merson MH. The magnitude of the global problems of acute diarrheal disease: A review of active surveillance data. Bull WHO, 1982; 60: 605-613.
Lutterodt GD. Inhibition of gastrointestinal release of acetylcholine by quercetin as a possible mode of action of Psidiumguajava leaf extracts in the treatment of acute diarrhea disease. J Ethnopharmacol, 1989; 25: 235-247.
Park K. Park’s Text book of Preventive and Social Medicine. Jabalpur, India, M/S Banarsidas Bharat Publishers, Jabalpur, 2000, pp. 172-175.
Chirac P., Torreele E. Global framework on essential health R & D. Lancet. 2006; 367: 1560–1561.
Ghani, M. 1998. Medicinal Plants of Bangladesh: Chemical Constituents and Uses of 460 Species. Asiatic Society of Bangladesh, Dhaka, Bangladesh. Pp. 329, second edition, Dhaka.
Olmstead, R. G., Zjhra, M. L., Lohmann, L. G., Grose, S. O. & Eckert, A. J. 2009. A molecular phylogeny and classification of Bignoniaceae. "American Journal of Botany", 96 (9): 1731-1743.
Das A. K. Mandal S. C, Banerjee S. K, Sinha S. studies of anti-diarrheal activity of Punicagranatum seed extracts, J Ethnopharmacol., 1999; 68: 205-208.
Kupchan SM, Tsou G, Sigel CW. Datiscacin, a novel cytotoxic cucurbitacin 20-acetate from Datiscaglomerata. J Org Chem. 1973; 38 (7): 1420–1. doi: 10.1021/jo00947a041.
Ammon PJ, Thomas, Philips S (1974). Effects of oleic and recinoleic acids net jejunal water and electrolyte movement. J. Clin. Invest. 53: 374-379.
Galvez J, Zarzuelo A, Crespo ME, Lorente MD, Ocete MA, Jimenez J (1993). Antidiarrhoeic activity of Euphorbia hirta extract and isolation of an active flavonoid constituent. PlantaMedica 59:333-336.
Meite, S., N’guessan, J. D., Bahi, C., Yapi, H. F., Djaman, A. J. and Guina, F. G. 2009. Anti-diarrheal activity of the ethyl acetate extract of Morindamorindoides in rats. Trop. J. Pharm. Res. 8, 201-207.
Mukherjee, A., C. Cao, J. Lutkenhaus 1998. Inhibition of FtsZ polymerization by SulA, an inhibitor of septation in Escherichia coli. Proc. Natl. Acad. Sci. USA 95: 2885-2890.
J Intercult Ethnopharmacol. 2016 Jun-Aug; 5 (3): 290–307. Published online 2016 May 4. doi: 10.5455/jice.20160426094553; PMCID: PMC4927135; Therapeutic significance and pharmacological activities of antidiarrheal medicinal plants mention in Ayurveda: A review Ashish Mishra, Ankit Seth, and Santosh Kumar Maurya.
Advances in Pharmacological Sciences; Volume 2015 (2015), Article ID 257057, 6 pages http://dx.doi.org/10.1155/2015/257057; Evaluation of Antidiarrheal Activity of Methanolic Extract of Maranta arundinacea Linn. Leaves Md. Khalilur Rahman, Md. Ashraf Uddin Chowdhury, Mohammed Taufiqual Islam, Md. Anisuzzaman Chowdhury, Muhammad Erfan Uddin, and Chandra Datta Sumi.
MC Complementary and Alternative Medicine; The official journal of the International Society for Complementary Medicine Research (ISCMR)201414:460; DOI: 10.1186/1472-6882-14-460; © Tadesse et al.; licensee BioMed Central Ltd. 2014; Experimental assessment of antidiarrheal and antisecretory activity of 80% methanolic leaf extract of Zehneria scabra in mice Wondmagegn Tamiru Tadess, Abebe Ejigu Hailu, Abyot Endale Gurmu and Abraham Fikru Mechesso.
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