Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum
International Journal of Photochemistry and Photobiology
Volume 1, Issue 1, June 2017, Pages: 21-26
Received: Jan. 4, 2017;
Accepted: Jan. 17, 2017;
Published: Mar. 2, 2017
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Md. Mamun-Or-Rashid, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh
Md. Shah Amran, email@example.com
Md. Aslam Hossain, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh
Abnormal passage of liquid or unformed stool at an increased frequency is termed as diarrhea: Infectious agents, certain medications, plant and animal toxins, gastrointestinal disorders, and substances that enhance gastrointestinal tract secretions are may be the triggers of diarrhea . In recent times, medicinal plants occupy a considerable position for being the paramount sources of drug discovery irrespective of its categorized groups- herb, shrub or tree . Oroxylum indicum (Linn.) Vent is widely used in Ayurvedic system of medicine . The crude methanolic extract of Oroxylum indicum bark and fruits with different soluble partitionates were subjected to investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and thrombolytic, antihelmentic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment.  The antidiarrheal activity of methanolic bark and fruits extract and its different fractions of Oroxylum indicum (Ethyl acetate fraction, Dichloromethane fraction, Hexane fraction, Carbon tetrachloride fraction) (400mg/kg) cause reduction of diarrheal feces by 46.5%, 32.6%, 45.3%, 33.7%, 51.2%, respectively compared to standard Loperamide (82.6%). This reveals that methanol extracts of bark and fruits of Oroxylum indicum showed significant antidiarrheal activity.
Md. Shah Amran,
Md. Aslam Hossain,
Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum, International Journal of Photochemistry and Photobiology.
Vol. 1, No. 1,
2017, pp. 21-26.
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