Pharmacological Properties of Calophyllum inophyllum – Updated Review
International Journal of Photochemistry and Photobiology
Volume 2, Issue 1, June 2018, Pages: 28-32
Received: Jul. 30, 2018; Accepted: Aug. 13, 2018; Published: Sep. 12, 2018
Views 560      Downloads 51
Author
Win Min Oo, Department of Biochemistry, University of Medicine, Magway, Myanmar
Article Tools
Follow on us
Abstract
Natural products have been used as medicine since ancient times. With the advancement of research methods nowadays, the pharmacological properties of herbal plants have become an important role in the development and designation of drugs for different diseases. Calophyllum inophyllum is a large tree which grows well in different parts of the world. Various parts of Calophyllum inophyllum have been investigated for the pharmacological actions and some of the active constituents have been identified and isolated successfully. Furthermore, certain molecular mechanisms underlying the pharmacological effects have been revealed by different research groups across the world in recent years. This paper aims to review the different pharmacological actions of Calophyllum inophyllum together with recently discovered active constituents and mechanistic details. The published information on the pharmacological properties of Calophyllum inophyllum was gathered by using different database platforms including Google Scholar, PubMed, ScienceDirect, Scopus and SciFinder. The results show different pharmacological actions including anti-inflammatory, anticancer, antioxidant, wound healing, osteogenic, antimicrobial, lipid-lowering and antidiabetic effects of different parts of Calophyllum inophyllum. This review will provide the researchers with the background of the therapeutic potential of Calophyllum inophyllum and the extent of discovery that will lead to develop therapeutic agents for different pathological states in future.
Keywords
Calophyllum inophyllum, Clusiaceae, Pharmacology, Pharmacological Properties
To cite this article
Win Min Oo, Pharmacological Properties of Calophyllum inophyllum – Updated Review, International Journal of Photochemistry and Photobiology. Vol. 2, No. 1, 2018, pp. 28-32. doi: 10.11648/j.ijpp.20180201.16
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Ha MH, Nguyen VT, Nguyen KQC, Cheah ELC, Heng PWS. Antimicrobial activity of Calophyllum inophyllum crude extracts obtained by pressurized liquid extraction. Asian Journal of Traditional Medicines. 2009; 4(4): 141-6.
[2]
Liu WH, Liu YW, Chen ZF, Chiou WF, Tsai YC, Chen CC. Calophyllolide content in Calophyllum inophyllum at different stages of maturity and its osteogenic activity. Molecules. 2015 July; 20(7): 12314-27.
[3]
Perumal SS, Ekambaram SP, Dhanam T. In vivo antiarthritic activity of the ethanol extracts of stem bark and seeds of Calophyllum inophyllum in Freund’s complete adjuvant induced arthritis. Pharm. Biol. 2017 Dec; 55(1): 1330-1336.
[4]
Tsai SC, Liang YH, Chiang JH, Liu FC, Lin WH, Chang SJ, Lin WY, Wu CH, Weng JR. Anti-inflammatory effects of Calophyllum inophyllum L. in RAW264.7 cells. Oncol Rep. 2012 Sep; 28(3): 1096-102.
[5]
Zakaria MB, Vijayasekaran, Llham Z, Muhamad NA. Anti-inflammatory activity of Calophyllum inophyllum fruits extracts. Procedia Chemistry. 2014 Dec; 13: 218-220.
[6]
Ee GC, Mah SH, Rahmani M, Taufiq-Yap YH, Teh SS, Lim YM. A new furanoxanthone from the stem bark of Calophyllum inophyllum. J Asian Nat Prod Res. 2011 Oct; 13(10): 956-60.
[7]
Nguyen VL, Truong CT, Nguyen BCQ, Vo TV, Dao TT, Nguyen VD, Trinh DT, Huynh HK, Bui CB. Anti-inflammatory and wound healing activities of calophyllide isolated from Calophyllum inophyllum Linn. PLoS One. 2017 Oct; 12(10): e0185674.
[8]
Aminudin NI, Ahmad F, Taher M, Zulkifli RM. ɑ-glucosidase and 15-lipoxygenase inhibitory activities of phytochemicals from Calophyllum inophyllum. Nat Prod Commun, 2015 Sep; 10(9): 1585-7.
[9]
Said T, Dutot M, Labbe A, Warnet JM, Rat P. Ocular burn: rinsing and healing with ionic marine solutions and vegetable oils. Ophthalmologica. 2009; 223(1): 52-9.
[10]
Leguillier T, Lecso-Bornet M, Lemus C, Rousseau-Ralliard D, Lebouvier N, Hnawia E, Nour M, Aalbersberg W, Ghazi K, Raharivelomanana P, Rat P. The wound healing and antibacterial activity of five ethnomedical Calophyllum inophyllum oil: an alternative therapeutic strategy to treat infected wound. PLoS One. 2015 Sep; 10(9): e0138602.
[11]
Ansel JL, Lupo E, Mijouin L, Guillot S, Butaud JF, Ho R, Lecellier G, Raharivelomanana P, Pichon C. Biological activity of Polynesian Calophyllum inophyllum oil extract on human skin cells. Planta Med. 2016 Jul; 82(11-12): 961-6.
[12]
Bhat SG, Kane JG, Sreenivasan A. The in Bitro evaluation of the antibacterial activity of undil oil (Calophyllum inophyllum linn.). Journal of the American Pharmaceutical Associaiton. 1954 Sep; 43(9):
[13]
Potti GR, Kurup PA. Anti-bacterial principle of the root bark of Calophyllum inophyllum: isolation and antibacterial activity. Indian Journal of Experimental Biology. 1970; 8(1): 39-40.
[14]
Yimdjo MC, Azebaze AG, Nkengfack AE, Meyer AM, Bodo B, Fomum ZT. Antimicrobial and cytotoxic agents from Calophyllum inophyllum. Phytochemistry. 2004 Oct; 65(20): 2789-95.
[15]
Mishra US, Murthy N, Choudhury PK, Panigrahi G, Mohapatra S, Pradha D. Antibacterial and analgesic effects of the stem barks of Calophyllum inophyllum. International journal of ChemTech Research. 2010 Apri-June; 2(2): 973-979.
[16]
Ali M, Mahmud S, Perveen S, Rizwani GH, Ahmad VU. Screening for the antimicrobial properties of the leaves of Calophyllum inophyllum Linn. (Guttiferae). Jour. Chem. Soc. Pak. 1999; 21(2): 195-198.
[17]
Xiao Q, Zeng YB, Mei WL, Zhao YX, Deng YY, Dai HF. Cytotoxic prenylated xanthones from Calophyllum inophyllum. J Asian Nat Prod Res. 2008 Sep-Oct; 10(9-10): 993-7.
[18]
Said T, Dutot M, Martin C, Beaudeux JL, Boucher C, Enee E, Baudouin C, Warnet JM, Rat P. Cytoprotective effect against UV-induced DNA damage and oxidative stress: role of new biological UV filter. Eur J Pharm Sci. 2007 Mar; 30(3-4): 203-10.
[19]
Itoigawa M, Ito C, Tan HT, Kuchide M, Tokuda H, Nishino H, Furukawa H. Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum. Cancer Lett. 2001 Aug; 169(1): 15-9.
[20]
Mah SH, Ee GC, The SS, Sukari MA. Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships. Nat Prod Res. 2015; 29(1): 98-101.
[21]
Dai HF, Zeng YB, Xiao Q, Han Z, Zhao YX, Mei WL. Caloxanthones O and P: two new prenylated xanthones from Calophyllum inophyllum. Molecules. 2010 Jan; 15(2): 606-12.
[22]
Li YZ, Li ZL, Yin SL, Shi G, Liu MS, Jing YK, Hua HM. Triterpenoids from Calophyllum inophyllum and their growth inhibitory effects on human leukemia HL-60 cells. Fitoterapia. 2010 Sepl 81(6): 586-9.
[23]
Shanmugapriya, Chen Y, Kanwar JR, Sasidharan S. Anticancer activity and molecular mechanism of polyphenol rich Calophyllum inophyllum fruit extract in MCF-7 breast cancer cells. Nutr Cancer. 2017 Nov-Dec; 69(8): 1308-1324.
[24]
Hsieh C, Lin YW, Chen CH, Ku W, Ma F, Yu H, Chu C. Yellow and green pigments from Calophyllum inophyllum L. seed oil induce cell death in colon and lung cancer cells. Oncol Lett. 2018 Apri; 15(4): 5915-5923.
[25]
Chan KM, Hamzah R, Rahaman AA, Jong VY, Khong HY, Rajab NF, Ee GC, Inayat-Hussain SH. The pyranoxanthone Inophyllin A induces oxidative stress mediated apoptosis in Jurkat T lymphoblastic leukemia cells. Food Chem Toxicol. 2012 Aug; 50(8): 2916-22.
[26]
Ibironke GF, Ugege OG. Neurobehavioural activities of the ethanol leaf extract of Calophyllum inophyllum in rodents.
[27]
Gopalakrishnan C, Shandaranarayanan D, Nazimudeen SK, Viswanatha S, Kameswaran L. Anti-inflammatory and C. N. S. depressant activities of xanthones from Calophyllum inophyllum and Mesua ferrea. Indian Journal of Pharmacology. 1980; 12(3): 181-191.
[28]
Prasad J, Shrivastava A, Khanna AK, Bhatia G, Awasthi SK, Narender T. Antidyslipidemic and antioxidant activity from the leaves of Calophyllum inophyllum. Phytomedicine. 2012 Nov; 15; 19(4): 1245-9.
[29]
Dutta S, Ray S. Evaluation of antioxidant potentials of leaf aqueous and methanolic extracts of 140 ± 17 and 97 ± 9 mg/g respectively in relation to total phenol and flavonoid contents. Int J Pharm Bio Sci. 2014 July; 5(3): 411-450.
[30]
Crane S, Aurore G, Joseph H, Mouloungui Z, Bourgeois P. Compostion of fatty acids triacylglycerols and unsaponifiable matter in Calophyllum calaba L. oil from Guadeloupe. Phytochemistry. 2005 Aug; 66(15): 1825-31.
[31]
Laure F, Raharivelomanana P, Butaud JF, Bianchini JP, Gaydou EM. Screening of anti-HIV-1 inophyllums by HPLC-DAD of Calophyllum inophyllum leaf extracts from French Polynesia Islands. Anal Chim Acta. 2008 Aug; 624(1): 147-53.
[32]
Pawar KD, Joshi SP, Bhide SR, Thengane SR. Pattern of anti-HIV dipyranocoumarin expression in callus cultures of Calophyllum inophyllum Linn. J Biotechnol. 2007 Jul; 130(4): 346-53.
[33]
Patil AD, Freyer AJ, Eggleston DS, Haltiwanger RC, Bean MF, Taylor PB, Caranfa MJ, Breen AL, Bartus HR, Johnson RK, et al. The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn. J Med Chem. 1993 Dec; 36(26): 4131-8.
[34]
Spino C, Dodier M, Sotheeswaran S. Anti-HIC coumarins from Calophyllum seed oil. Bioorganic & Medicinal Chemistry Letters. 1998; 8: 3475-3478.
[35]
Taylor PB, Culp JS, Debouck C, Johnson RK, Patil AD, Woolf DJ, Brooks I, Hertzberg RP. Kinetic and mutational analysis of human immunodeficiency virus type 1 reverse transcriptase inhibiton by inophyllums, a nobel class of non-nucleoside inhibitors. J Biol Chem. 1994 Mar; 269(9): 6325-31.
[36]
Prasad J, Maurya CK, Pandey Jm Jaiswal N, Madhur G, Srivastava AK, Narender T, Tamrakar AK. Diastereomeric mixture of calophyllic acid and isocalophyllic acid stimulates glucose uptake in skeletal muscle cells: involvement of PI-3-kinase- and ERK1/2 dependent pathways. Mol Cell Endocrinol. 2013 May; 370(1-2): 11-9.
[37]
Jaiswai N, Guanaganti N, Maurya CK, Narender T, Tamrakar AK. Free fatty acid induced impairment of insulin signaling is prevented by the diastereomeric mixture of calophyllic acid and isocalophyllic acid in skeletal muscle cells. Eur J Pharmacol. 2015 Jan; 746: 70-7.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186