Regression of Carotid Plaques in Individuals at Low-to-intermediate Cardiovascular Risk Treated with Citozym and Propulzym
European Journal of Preventive Medicine
Volume 2, Issue 3, May 2014, Pages: 33-37
Received: May 29, 2014;
Accepted: Jun. 17, 2014;
Published: Jul. 20, 2014
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Torricelli Piera, Surgical Department, Hospital “A. Cardarelli”, Campobasso, Italy
Ferorelli Pasquale, Department of Biology, University of Rome, Tor Vergata, Roma, Italy
De Martino Angelo, Department of Biology, University of Rome, Tor Vergata, Roma, Italy
Antonelli Francesco, Department of Biology, University of Rome, Tor Vergata, Roma, Italy
Shevchenko Anna, Department of Science, People’s Friendship University of Russia, Moscow, Russia
Beninati Simone, Department of Biology, University of Rome, Tor Vergata, Roma, Italy
A prospective trial was performed to assess coronary plaque regression following about 5 months of treatments with two dietary supplements, Citozym and Propulzym. Coronary segments that included the most diseased plaque of 20 selected patients were analyzed using carotid ultrasound (CDUS). Inclusion criteria were as follows: 20 subjects (10 of control group and 10 of test group) aged between 54 and 74 years with a clear diagnosis of carotid plaque and stenosis percentage of not less than 40% and not more than 70%. The data obtained showed a wide inter-individual variability, with a range of reduction from 4% to 27%. It is interesting to note that the plaque reduction in one patient reached a value of about 27% observable with the ultrasonic examination. Since it is clear that carotid plaque morphology/stability is one of the most important factor regarding the definition of cardiovascular risk, our preliminary results suggest the possibility of a non-invasive treatment of carotid plaque.
De Martino Angelo,
Regression of Carotid Plaques in Individuals at Low-to-intermediate Cardiovascular Risk Treated with Citozym and Propulzym, European Journal of Preventive Medicine.
Vol. 2, No. 3,
2014, pp. 33-37.
Johnston SC, Rothwell PM, Nguyen-Huynh MN, et al, Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack in Lancet, 2007;369, nº 9558, 283-292.
Lewis, H. D.; Davis, J. W.; Archibald, D. G.; Steinke, W. E.; Smitherman, T. C.; Doherty Je, J. E.; Schnaper, H. W.; Lewinter, M. M.; Linares, E.; Pouget, J. M.; Sabharwal, S. C.; Chesler, E.; Demots, H. Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina". New England Journal of Medicine 1983;309 (7),396–403.
Nygård, O; Vollset, SE; Refsum, H; Stensvold, I; Tverdal, A; Nordrehaug, JE; Ueland, M; Kvåle, G Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study.". JAMA : the journal of the American Medical Association 1995;274 (19): 1526–1533.
Shin MH, Moon YJ, Seo JE, Lee Y, Kim KH, Chung JH Reactive oxygen species produced by NADPH oxidase, xanthine oxidase, and mitochondrial electron transport system mediate heat shock-induced MMP-1 and MMP-9 expression. Free Radic Biol Med. 2008;44(4):635-645
Ciari I., Terzuoli L., Porcelli B., Coppola M G, Marinello E. Antioxidant status and purine bases in carotid artery plaque. Nucleosides Nucleotides & amp Nucleic Acids. 2008; 27(6):624-627
Meng XP, Yin CS, Cui JH, Li ZX, Wang L, Wang YW, Li YL. Inhibitory effect of N-acetylcysteine upon atherosclerotic processes in rabbit carotid. Zhonghua Yi Xue Za Zhi. 2009; 89 (26):1850-3
Svensson L, Norén K, Wiklund O, Lindmark H, Ohlsson B, Hultén LM Inhibitory effects of N-acetylcysteine on scavenger receptor class A expression in human macrophages. J Intern Med. 2002; 251(5):437-446
Dodd S. Dean O. Copolov DL. Malhi GS. Berk M. N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility in Expert Opinion on Biological Therapy, vol. 8, nº 12, 2008, pp. 1955–1962
Yanni AE, Yatzidis HA, Kavantzas NG, Agapitos EV, Perrea DN, Karayannacos PE. Dietary L-aspartate and L-glutamate inhibit fatty streak initiation in cholesterol-fed rabbit. Nutr Metab Cardiovasc Dis. 2003;13(2):80-86
Schlieper G, Westenfeld R, Brandenburg V, Ketteler M. Inhibitors of calcification in blood and urine. Semin Dial. 2007;20(2):113-121
Kaĭdin DA. The effect of citric acid on experimental hypercholesteremia in atherosclerosis in rabbits. Biull Eksp Biol Med. 1968;65(3):36-39
Kaĭdin DA, Grebennik LI. The effect of citric acid and alkali and alkaline earth metal carbonates on the development of experimental hypercholesteremia and atherosclerosis in rabbits. Kardiologiia. 1967;7(4):123-127.
Libby P. Inflammation in atherosclerosis Nature, 2002; 420,868–874
Ross R. Atherosclerosis — an inflammatory disease N Engl J Med, 1999;40,115–126
Wiseman H, Halliwel B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer Biochem J, 1996;313(1) 17–29
Cooke MS, Olinski R, Evans MD. Does measurement of oxidative damage to DNA have clinical significance? Clin Chim Acta, 2006; 365,30–49
Dizdaroglu M, Olinski R, Doroshow JH, Akman SA Modification of DNA bases in chromatin of intact target human cells by activated human polymorphonuclear leukocytes Cancer Res, 1993;53,1269–1272
De Flora S, Izzotti A, Walsh D, Degan P, Petrilli GL, Lewtas J Molecular epidemiology of atherosclerosis FASEB J, 1997;11,1021–1031
Collins AR, Gedik CM, Olmedilla B, Southon S, Bellizzi M Oxidative DNA damage measured in human lymphocytes: large differences between sexes and between countries, and correlations with heart disease mortality rates FASEB J, 1998;12,1397–1400
Martinet W, Knaapen MW, De Meyer GR, Herman AG, Kockx MM Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques Circulation, 2002;106,927–932
Izzotti A, Piana A, Minniti G, Vercelli M, Perrone L, De Flora S Survival of atherosclerotic patients as related to oxidative stress and gene polymorphisms Mutat Res, 2007;621,119–128
Mercer JR, Cheng KK, Figg N, Gorenne I, Mahmoudi M, J. Griffin J et al.DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome Circ Res, 2010;107,1021–1031
Honda O, Sugiyama S, Kugiyama K, Fukushima H, S. Nakamura S, S Koide et al.Echolucent carotid plaques predict future coronary events in patients with coronary artery disease J Am Coll Cardiol, 2004;43,1177–1184
Johnsen SH, Mathiesen EB, Joakimsen O, Stensland E, Wilsgaard T, Lochen ML et al.Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: a 6-year follow-up study of 6226 persons: the Tromso Study Stroke, 2007;38,2873–2880
Hellings WE, Peeters W, Moll FL, Piers SR, Van Setten J, Van der Spek PJ et al. Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study Circulation, 2010;121,1941–1950
Bitto A, De Caridi G, Polito F, Calo M, Irrera N, Altavilla D et al. Evidence for markers of hypoxia and apoptosis in explanted human carotid atherosclerotic plaques J Vasc Surg, 2010;52,1015–1021