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Effect of Aerobic Exercise on Serum Adiponectin and Serum Malondialdehyde (MDA) In Type 1 Diabetic Patients

Received: 4 August 2017    Accepted: 21 August 2017    Published: 18 September 2017
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Abstract

Type 1 diabetes is fatal unless treated with insulin. Exercise interventions have been shown to be as efficient as the pharmaceutical agents to improve glycaemic control. The aim of the current study was to determine the effect of aerobic exercise on possible mechanisms controlling insulin resistance. Forty diabetic type 1 patients of both sexes (20 females and 20 males) were participated in the study. They were randomly divided into two equal groups. Study group comprised of 20 patients participated in a supervised moderate-intensity aerobic exercise program performed on bicycle ergometer for 50 minutes, 3 times per week, for 8 weeks, in addition to their medical treatment while the control group received only their medical treatment. The result showed that a significant decrease in insulin resistance in the Study group as compared to the control group. The mean values of adiponectin were significantly increased from 5.85±0.65 to 6.6±0.56 in the study group. The mean values of Malondialdehyde (MDA) and fasting glucose were significantly decreased from 7.2±0.98, 146.88±11.42 to 6.45±0.95, 133.87±11.99 respectively in the study group. It can be concluded that aerobic exercise has a positive effect on decreasing insulin resistance and hence decrease the incidence of diabetic complications.

Published in European Journal of Preventive Medicine (Volume 5, Issue 5)
DOI 10.11648/j.ejpm.20170505.14
Page(s) 71-76
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Type 1 Diabetes, Insulin, Aerobic Exercise, Insulin Resistance

References
[1] Shoback, 2011. Greenspan's basic & clinical endocrinology (9th ed.). New York: McGraw-Hill Medical. pp. Chapter 17. ISBN 0-07-162243-8.
[2] Silpa Nadella, Justin A. Indyk, and Manmohan K. Kamboj. Management of diabetes mellitus in children and adolescents: engaging in physical activityTransl Pediatr. 2017 Jul; 6(3): 215–224. doi: 10.21037/tp.2017.05.01.
[3] Allison RL. 2017. Back to Basics: The Effect of Healthy Diet and Exercise on Chronic Disease Management. S D Med. 2017 Spec; No: 10-18
[4] Ziemke F and Mantzoros C. S., 2010. Adiponectin in insulin resistance: lessons from translational research. Am J Clin Nutr., 91(1): 258S–261S.
[5] Daniela P., Zdenka F., Kamila S., Stěpánka V., Jindřiška L., Ondřej P., Jaromír B., Tomáš N., Marek K. and Petr K., 2011. Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are NotSignificantly Affected by Systemic Diseases Industrial Health., 49, 746–754.
[6] Deshpande A. D., Harris-Hayes M. and Schootman M., 2008. Epidemiology of diabetes and diabetes-related complications. Phys Ther., 88: 1254-64.
[7] Nakhjavani M., Esteghamati A., Nowroozi S., Asgarani F., Rashidi A. and Khalilzadeh O., 2010. Type 2 diabetes mellitus duration: an independent predictor of serum malondialdehyde levels. Singapore Med J., 51(7): 582-5.
[8] Laura A. Crist, Catherine M. Champagne, Leonor Corsino, Lillian F. Lien, Guangyu Zhang and Deborah Rohm Young., 2012. Influence of Change in Aerobic Fitness and Weight on Prevalence of Metabolic Syndrome. Prev Chronic Dis., 9: E68.
[9] Sigal R. J., Kenny G. P., Boule N. G., Wells G. A., Prud’homme D. and Fortier M., 2007. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes. Annals of Internal Medicine., 147: 357–369.
[10] Gordon L. A., Morrison E. Y., McGrowder D. A., Young R., Fraser Y. T. P., Zamora E. M., Alexander-Lindo R. L. and Irving R. R., 2008. Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes. BMC Complementary and Alternative Medicine., 8: 21.
[11] Parsian H., Eizadi M., Khorshidi D. and Khanali F., 2013. The effect of long-term aerobic exercise on serum adiponectin and insulin sensitivity in type 2 diabetic patients. Journal of Jahrom University of Medical Sciences., 11 (1): 36-43.
[12] Ounis O. B., Elloumi M., Zouhal H., Makni E., Denguezli M., Amri M., Lac G. and Tabka Z., 2010. Effect of Individualized Exercise Training Combined with Diet Restriction on Inflammatory Markers and IGF-1/IGFBP-3 in Obese Children. Ann Nutr Metab., 56: 260-266.
[13] Ferreira P. A., et al., Safety of the Six-Minute Walk Test in Hospitalized Cardiac Patients. International Journal of Cardiovascular Sciences., 2011, 28(1): 70-77.
[14] Ng C. L. W., Goh S. Y., Malhotra R., Ostbye T. And Tai E. S., 2010. Minimal difference between aerobic and progressive resistance exercise on metabolic profile and fitness in older adults with diabetes mellitus: a randomized trial Journal of Physiotherapy., 56: 163-70.
[15] Richer MJ, Miiger k, Tello k, Stlle P Seeger W, Mayer E, Ghofran AH., 2016. Heart rate response during 6-minute walking testing predicts outcome in operable chronic thromboembolic pulmonary hypertension., BMC Pulm Med 2016 Jul 4: 16(1): 96.
[16] Mihriban A., HilmiIpekci s., Kebapcilar L., Dogan Dede N., Kurban s., Erbay E. and Sait Gonen M., 2014. Effect of Aerobic Exercise Training on MDA and TNF-𝛼 Levels in Patients with Type 1 Diabetes Mellitus. International Scholarly Research Notices., 2014: 1-5.
[17] Golbidi S. and Laher I., 2014. Exercise Induced Adipokine Changes and the Metabolic Syndrome Journal of Diabetes Research., 2014, 1-16.
[18] Tonoli Cajsa, Elsa Heyman, Bart Roelands, Luk Buyse, Stephen S. Cheung, Serge Berthoin and Romain Meeusen., 2012. Effects of Different Types of Acute and Chronic (Training) Exercise on Glycaemic Control in Type 1 Diabetes Mellitus A Meta-Analysis. Sports Med., 2012: 42 (12): 1059-1080.
[19] Svensson M. K., Eriksson J. W., 2011. Change in the amount of body fat and IL-6 levels is related to altered insulin sensitivity in type 1 diabetes patients with or without diabetic nephro- pathy. Horm Metab Res., 43 (3): 209-15 87.
[20] Sundell J., 2011. Resistance training is an effective tool against metabolic and frailty syndromes. Adv Prev Med., 2011, 1-7.
[21] Colberg SR, Sigar RJ, Yardley JE, et al. Physicalactivity/Exercise and Diabetes: A Position Statement of the American Diabetes Association. Diabetes Care 2016; 39: 2065-79. 10.2337/dc16-1728.
[22] Shakil-Ur-Rehman S, Karimi H, Gillani SA. Effects of supervised structured aerobic exercise training program on fasting blood glucose level, plasma insulin level, glycemic control, and insulin resistance in type 2 diabetes mellitus. Pak J Med Sci. 2017 May-Jun; 33(3): 576-580. doi: 10.12669/pjms.333.12023
[23] Michael A., Jon C., Edward P., Holly E., Jessica T., Venket R., Stephen G., George B., Maria R., Adria G., Mladen V. and Michael C., 2010. Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. Am J Physiol Endocrinol Metab., 298: 671-682.
[24] Rector S., Shana O., Ying L., Pamela S., Grace Y., Richard H., Craig S., Harold L., Kevin C. and Tom R., 2007. Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndrome. Am J Physiol Endocrinol Metab., 293: 500-506.
[25] Ibanez J., Izquierdo M., Arguelles I., Forga L., Larrion J. L., Garcia-Unciti M., Idoate F. and Gorostiaga E. M., 2005. Twice weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. Diabetes Care., 28: 662-667.
[26] Lim J. G., Kang H. J., Stewart K. J., 2004. Type 2 diabetes in Singapore: The role of exercise training for its prevention and management. Singapore Medical Journal., 45: 62–68.
[27] Eriksson M., Jhonson O., Boman K., Hallmans G., Hellsten G., Nilsson T. K. and Soderberg S., 2008. Improved fibrinolytic activity during exercise may be an effect of the adipocyte- derived hormones leptin and adiponectin. Thromb Res., 122 (5): 701-8.
[28] Saunders T. J., Palombella A., McGuire K. A., Janiszewski P. M, Despr´es J. P. and Ross R., 2012. Acute exercise increases adiponectin levels in abdominally obese men,” Nutrition and Metabolism., 2012: 1-6.
[29] Oberbach A., Tönjes A., Klöting N., Fasshauer M., Kratzsch J., Busse M., Paschke R., Stumvoll M. and Blüher M., 2006. Effect of a 4 week physical training program on plasma concentration of inflammatory markers in patients with abnormal glucose tolerance. European Journal of Endocrinology., 154 (4): 577-585.
[30] Bluher M., Bullen J. W., Lee J. H., Kralisch S., Fasshauer M., Kloting M., Nie- bauer J., Schon M. R., Williams C., M. and Mantzoros C. S., 2006. Circulating adiponec- tin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training. J Clin Endocrinol Metab; 91: 2310-2316.
[31] Lehmann R., Kaplan V. and Bingisser R., 1997. Impact of physical activity on cardiovascular risk factors in IDDM. Diabetes Care., 20 (10): 1603-11.
[32] Baldi JC, Cassuto NA, Foxx-Lupo WT, et al 2011. Glycemic status affects cardiopulmonary exercise response in ath- letes with type I diabetes. Med Sci Sports Exerc 2011 Aug; 42 (8): 1454-9 84.
[33] Ismail I, Keating SE, Baker MK, et al 2012. A systematic review and meta-analysis of the effect of aerobic vs. resistance exercise training on visceral fat. Obes Rev 2012 Jan; 13 (1): 68-91 86
[34] Bobbert T., Wegewitz U., Brechtel L. et al., 2007. Adiponectin oligomers in human serum during acute and chronic exercise: relation to lipid metabolism and insulin sensitivity,” International Journal of Sports Medicine., 28 (1): 1–8.
Cite This Article
  • APA Style

    Mai Mohamed Elbalshy, Mariam Elsayed Mohamed, Awny Fouad Rahma. (2017). Effect of Aerobic Exercise on Serum Adiponectin and Serum Malondialdehyde (MDA) In Type 1 Diabetic Patients. European Journal of Preventive Medicine, 5(5), 71-76. https://doi.org/10.11648/j.ejpm.20170505.14

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    ACS Style

    Mai Mohamed Elbalshy; Mariam Elsayed Mohamed; Awny Fouad Rahma. Effect of Aerobic Exercise on Serum Adiponectin and Serum Malondialdehyde (MDA) In Type 1 Diabetic Patients. Eur. J. Prev. Med. 2017, 5(5), 71-76. doi: 10.11648/j.ejpm.20170505.14

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    AMA Style

    Mai Mohamed Elbalshy, Mariam Elsayed Mohamed, Awny Fouad Rahma. Effect of Aerobic Exercise on Serum Adiponectin and Serum Malondialdehyde (MDA) In Type 1 Diabetic Patients. Eur J Prev Med. 2017;5(5):71-76. doi: 10.11648/j.ejpm.20170505.14

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  • @article{10.11648/j.ejpm.20170505.14,
      author = {Mai Mohamed Elbalshy and Mariam Elsayed Mohamed and Awny Fouad Rahma},
      title = {Effect of Aerobic Exercise on Serum Adiponectin and Serum Malondialdehyde (MDA) In Type 1 Diabetic Patients},
      journal = {European Journal of Preventive Medicine},
      volume = {5},
      number = {5},
      pages = {71-76},
      doi = {10.11648/j.ejpm.20170505.14},
      url = {https://doi.org/10.11648/j.ejpm.20170505.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejpm.20170505.14},
      abstract = {Type 1 diabetes is fatal unless treated with insulin. Exercise interventions have been shown to be as efficient as the pharmaceutical agents to improve glycaemic control. The aim of the current study was to determine the effect of aerobic exercise on possible mechanisms controlling insulin resistance. Forty diabetic type 1 patients of both sexes (20 females and 20 males) were participated in the study. They were randomly divided into two equal groups. Study group comprised of 20 patients participated in a supervised moderate-intensity aerobic exercise program performed on bicycle ergometer for 50 minutes, 3 times per week, for 8 weeks, in addition to their medical treatment while the control group received only their medical treatment. The result showed that a significant decrease in insulin resistance in the Study group as compared to the control group. The mean values of adiponectin were significantly increased from 5.85±0.65 to 6.6±0.56 in the study group. The mean values of Malondialdehyde (MDA) and fasting glucose were significantly decreased from 7.2±0.98, 146.88±11.42 to 6.45±0.95, 133.87±11.99 respectively in the study group. It can be concluded that aerobic exercise has a positive effect on decreasing insulin resistance and hence decrease the incidence of diabetic complications.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Effect of Aerobic Exercise on Serum Adiponectin and Serum Malondialdehyde (MDA) In Type 1 Diabetic Patients
    AU  - Mai Mohamed Elbalshy
    AU  - Mariam Elsayed Mohamed
    AU  - Awny Fouad Rahma
    Y1  - 2017/09/18
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ejpm.20170505.14
    DO  - 10.11648/j.ejpm.20170505.14
    T2  - European Journal of Preventive Medicine
    JF  - European Journal of Preventive Medicine
    JO  - European Journal of Preventive Medicine
    SP  - 71
    EP  - 76
    PB  - Science Publishing Group
    SN  - 2330-8230
    UR  - https://doi.org/10.11648/j.ejpm.20170505.14
    AB  - Type 1 diabetes is fatal unless treated with insulin. Exercise interventions have been shown to be as efficient as the pharmaceutical agents to improve glycaemic control. The aim of the current study was to determine the effect of aerobic exercise on possible mechanisms controlling insulin resistance. Forty diabetic type 1 patients of both sexes (20 females and 20 males) were participated in the study. They were randomly divided into two equal groups. Study group comprised of 20 patients participated in a supervised moderate-intensity aerobic exercise program performed on bicycle ergometer for 50 minutes, 3 times per week, for 8 weeks, in addition to their medical treatment while the control group received only their medical treatment. The result showed that a significant decrease in insulin resistance in the Study group as compared to the control group. The mean values of adiponectin were significantly increased from 5.85±0.65 to 6.6±0.56 in the study group. The mean values of Malondialdehyde (MDA) and fasting glucose were significantly decreased from 7.2±0.98, 146.88±11.42 to 6.45±0.95, 133.87±11.99 respectively in the study group. It can be concluded that aerobic exercise has a positive effect on decreasing insulin resistance and hence decrease the incidence of diabetic complications.
    VL  - 5
    IS  - 5
    ER  - 

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Author Information
  • Department of Physical Therapy for Internal Medicine, Faculty of Physical Therapy, Cairo University, Cairo, Egypt

  • Department of Physical Therapy for Internal Medicine, Faculty of Physical Therapy, Cairo University, Cairo, Egypt

  • Department of Physical Therapy for Internal Medicine, Faculty of Physical Therapy, Cairo University, Cairo, Egypt

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