Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia

Fumio Bessho; Masako Tanimura

doi:doi:10.11648/j.ejpm.20200805.11

| Peer-Reviewed

Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia

Fumio Bessho, Masako Tanimura

Published in European Journal of Preventive Medicine (Volume 8, Issue 5)

Received: 28 August 2020 Accepted: 11 September 2020 Published: 23 September 2020

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

We herein determined the effects of parental smoking on occurrence of childhood acute leukemia using the large volume of data accumulated in the Japan Children's Cancer Registry. Information on the smoking statuses of fathers was available for 4,802 acute leukemia cases diagnosed between 1985 and 2006 and that of mothers was available for 5,536 cases diagnosed between 1978 and 2006. We compared the smoking rates of parents whose children were diagnosed with leukemia with a control group of parents whose children were diagnosed with benign tumors or cancer-related diseases. The smoking rate of fathers was significantly larger than the control. The odds ratios were 1.284 for 1-9 cigarettes/day (c/d) before conception (p=0.127), 1.265 for 10-19 c/d (p=0.029), and 1.345 for more than 20 c/d (p=0.000). A logistic regression analysis controlling for sex, birth weight, paternal age at birth, and maternal smoking showed that the smoking rate of fathers whose children had acute leukemia was still significantly higher (OR 1.012, p=0.004). The difference of the smoking rate between mothers whose children had acute leukemia and the control mothers was not significant (OR 1.161, p=0.447).

Published in	European Journal of Preventive Medicine (Volume 8, Issue 5)
DOI	10.11648/j.ejpm.20200805.11
Page(s)	61-65
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Childhood Acute Leukemia, Parental Smoking, Sperm, Fetus

References

[1]	Talhout R, Schulz T, Florek E, van Benthem J, Wester P, Opperhuizen A. Hazardous compounds in tobacco smoke. Int J Environ Res Public Health 2011; 8: 613-628.
[2]	Wild CP, Kleinjans J. Children and increased susceptibility to environmental carcinogens: evidence or empathy? Cancer Epidemiol, Biomarkers Prev. 2003; 12: 1389-1394.
[3]	Pichini S, Basagaña XB, Pacifici R et al. Cord serum cotinine as a biomarker of fetal exposure to cigarette smoke at the end of pregnancy. Environ Health Perspect. 2000; 108: 1079-1083.
[4]	Thomas JL, Guo H, Carmella SG et al. Metabolites of a tobacco-specific lung carcinogen in children exposed to secondhand or thirdhand tobacco smoke in their homes. Cancer Epidemiol, Biomarkers Prev 2011; 20: 1213-1221.
[5]	de Assis KR, Ladeira MS, Bueno RC, Dos Santos BF, Dalben I, Salvadori DM. Genotoxicity of cigarette smoking in maternal and newborn lymphocytes. Mutat Res 2009; 679: 72-78.
[6]	Grufferman S, Wang HH, DeLong ER, Kimm SY, Delzell ES, Falletta JM. Environmental factors in the etiology of rhabdomyosarcoma in childhood. J Nat Cancer Inst 1982; 68: 107-113.
[7]	Stjernfeldt M, Berglund K, Lindsten J, Ludvigsson J. Maternal smoking during pregnancy and risk of childhood cancer. Lancet 1986; 1: 1350-1352.
[8]	John EM, Savitz DA, Sandler DP. Prenatal exposure to parents' smoking and childhood cancer. Am J Epidemiol 1991; 133: 123-132.
[9]	Schwartzbaum JA. Influence of the mother's prenatal drug consumption on risk of neuroblastoma in the child. Am J Epidemiol 1992; 135: 1358-1367.
[10]	Pershagen G, Ericson A, Otterblad-Olausson P. Maternal smoking in pregnancy: does it increase the risk of childhood cancer? Int J Epidemiol 1992; 21: 1-5.
[11]	Sorahan T, Lancashire R, Prior P, Peck I, Stewart A. Childhood cancer and parental use of alcohol and tobacco. Ann Epidemiol 1995; 5: 354-359.
[12]	Ji BT, Shu XO, Linet MS et al. Paternal cigarette smoking and the risk of childhood cancer among offspring of nonsmoking mothers. J Nat Cancer Inst 1997; 89: 238-244.
[13]	Tanimura M, Matsui I, Abe J et al. Increased risk of hepatoblastoma among immature children with a lower birth weight. Cancer Res 1998; 58: 3032-3035.
[14]	Bessho F: Acute non-lymphocytic leukemia is not a major type of childhood eukemia in Japan. Eur J Cancer Clin Oncol 1989; 25: 729-732.
[15]	Ministry of Health, Labour and Welfare: National Health and Nutrition Survey in Japan 2013 home page. http://www.mhlw.go.jp/bunya/kenkou/eiyou/h25-houkoku.html. July 7, 2015 Accessed July 7, 2015.
[16]	Sorahan T, Lancashire RJ, Hulten MA, Peck I, Stewart AM. Childhood cancer and parental use of tobacco: deaths from 1953 to 1955. Br J Cancer 1997; 75: 134-138.
[17]	Chang JS, Selvin S, Metayer C, Crouse V, Golembesky A, Buffler PA. Parental smoking and the risk of childhood leukemia. Am J Epidemiol 2006; 163: 1091-1100.
[18]	Rudant J, Menegaux F, Leverger G et al. Childhood hematopoietic malignancies and parental use of tobacco and alcohol: the ESCALE study (SFCE). Cancer Causes Control 2008; 19: 1277-1290.
[19]	Plichart M, Menegaux F, Lacour B et al. Parental smoking, maternal alcohol, coffee and tea consumption during pregnancy and childhood malignant central nervous system tumours: the ESCALE study (SFCE). Eur J Cancer Prev 2008; 17: 376-383.
[20]	Lee KM, Ward MH, Han S et al. Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk. Leuk Res 2009; 33: 250-258.
[21]	Metayer C, Zhang L, Wiemels JL et al. Tobacco smoke exposure and the risk of childhood acute lymphoblastic and myeloid leukemias by cytogenetic subtype. Cancer Epidemiol Biomarkers Prev 2013; 22: 1600-1611.
[22]	Pershagen G. Childhood cancer and malignancies other than lung cancer related to passive smoking. Mutat Res 1989; 222: 129-135.
[23]	Tredaniel J, Boffetta P, Little J, Saracci R, Hirsch A. Exposure to passive smoking during pregnancy and childhood, and cancer risk: the epidemiological evidence. Paediatr Perinat Epidemiol 1994; 8: 233-255.
[24]	Boffetta P, Tredaniel J, Greco A. Risk of childhood cancer and adult lung cancer after childhood exposure to passive smoke: A meta-analysis. Environ Health Perspect 2000; 108: 73-82.
[25]	Sasco AJ, Vainio H. From in utero and childhood exposure to parental smoking to childhood cancer: a possible link and the need for action. Hum Exp Toxicol 1999; 18: 192-201.
[26]	Barnes DE, Bero LA. Why review articles on the health effects of passive smoking reach different conclusions. JAMA 1998; 279: 1566-1570.
[27]	Grufferman S, Delzell ES, Maile MC, Michalopoulos G. Parents' cigarette smoking and childhood cancer. Med Hypotheses 1983; 12: 17-20.
[28]	Everson RB. Individuals transplacentally exposed to maternal smoking may be at increased cancer risk in adult life. Lancet 1980; 2: 123-127.
[29]	Maurizi-Enrici R. Anselmo AP, Osti MF et al. Analysis of the risk of solid tumor following Hodgkin's disease. Haematologica 1997; 82: 57-63.
[30]	Pang D, McNally R, Birch JM. Parental smoking and childhood cancer: results from the United Kingdom Childhood Cancer Study. Br J Cancer 2003; 88: 373-381.
[31]	Elshal MF, El-Sayed IH, Elsaied MA, El-Masry SA, Kumosani TA. Sperm head defects and disturbances in spermatozoal chromatin and DNA integrities in idiopathic infertile subjects: association with cigarette smoking. Clin Biochem 2009; 42: 589-594.
[32]	Yauk CL, Berndt ML, Williams A, Rowan-Carroll A, Douglas GR, Stämpfli MR. Mainstream tobacco smoke causes paternal germ-line DNA mutation. Cancer Res 2007; 67: 5103-5106.
[33]	Pereira CS, Juchniuk de Vozzi MS, Dos Santos SA et al. Smoking-induced chromosomal segregation anomalies identified by FISH analysis of sperm. Mol Cytogenet 2014; 7: 58.
[34]	Gerber A, Hofen-Hohloch AV, Schulze J, Groneberg DA. Tobacco smoke particles and indoor air quality (ToPIQ-II) – a modified study protocol and first results. J Occup Med and Toxol 10: 5 DOI 10.1186/ s12995-015-0047-8.
[35]	Braun M, Fromm EL, Gerber A, Klingelhöfer D, Müller R, Groneberg DA. Particulate matter emissions of four types of one cigarette brand with and without additives: a laser spectrometric particulate matter analysis of secondhand smoke. BMJ Open 2019; 9: e024400. doi: 10.1136/bmjopen- 2018-024400.
[36]	Lao XQ, Zhang Z, Lau AKH et al. Exposure to ambient fine particulate matter and semen quality in Taiwan. Occup Environ Med 2018; 75: 148-154.
[37]	Liu J, Ren L, Wei J et al. Fine particle matter disrupts the blood-testis barrier by activating TGF-beta3/p38 MAPK pathway and decreasing testosterone secretion in rat. Environ Toxicol 2 018; 33: 711-719.

Cite This Article

Plain Text BibTeX RIS

APA Style

Fumio Bessho, Masako Tanimura. (2020). Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia. European Journal of Preventive Medicine, 8(5), 61-65. https://doi.org/10.11648/j.ejpm.20200805.11

Copy | Download

ACS Style

Fumio Bessho; Masako Tanimura. Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia. Eur. J. Prev. Med. 2020, 8(5), 61-65. doi: 10.11648/j.ejpm.20200805.11

Copy | Download

AMA Style

Fumio Bessho, Masako Tanimura. Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia. Eur J Prev Med. 2020;8(5):61-65. doi: 10.11648/j.ejpm.20200805.11

Copy | Download

@article{10.11648/j.ejpm.20200805.11,
  author = {Fumio Bessho and Masako Tanimura},
  title = {Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia},
  journal = {European Journal of Preventive Medicine},
  volume = {8},
  number = {5},
  pages = {61-65},
  doi = {10.11648/j.ejpm.20200805.11},
  url = {https://doi.org/10.11648/j.ejpm.20200805.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejpm.20200805.11},
  abstract = {We herein determined the effects of parental smoking on occurrence of childhood acute leukemia using the large volume of data accumulated in the Japan Children's Cancer Registry. Information on the smoking statuses of fathers was available for 4,802 acute leukemia cases diagnosed between 1985 and 2006 and that of mothers was available for 5,536 cases diagnosed between 1978 and 2006. We compared the smoking rates of parents whose children were diagnosed with leukemia with a control group of parents whose children were diagnosed with benign tumors or cancer-related diseases. The smoking rate of fathers was significantly larger than the control. The odds ratios were 1.284 for 1-9 cigarettes/day (c/d) before conception (p=0.127), 1.265 for 10-19 c/d (p=0.029), and 1.345 for more than 20 c/d (p=0.000). A logistic regression analysis controlling for sex, birth weight, paternal age at birth, and maternal smoking showed that the smoking rate of fathers whose children had acute leukemia was still significantly higher (OR 1.012, p=0.004). The difference of the smoking rate between mothers whose children had acute leukemia and the control mothers was not significant (OR 1.161, p=0.447).},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia
AU  - Fumio Bessho
AU  - Masako Tanimura
Y1  - 2020/09/23
PY  - 2020
N1  - https://doi.org/10.11648/j.ejpm.20200805.11
DO  - 10.11648/j.ejpm.20200805.11
T2  - European Journal of Preventive Medicine
JF  - European Journal of Preventive Medicine
JO  - European Journal of Preventive Medicine
SP  - 61
EP  - 65
PB  - Science Publishing Group
SN  - 2330-8230
UR  - https://doi.org/10.11648/j.ejpm.20200805.11
AB  - We herein determined the effects of parental smoking on occurrence of childhood acute leukemia using the large volume of data accumulated in the Japan Children's Cancer Registry. Information on the smoking statuses of fathers was available for 4,802 acute leukemia cases diagnosed between 1985 and 2006 and that of mothers was available for 5,536 cases diagnosed between 1978 and 2006. We compared the smoking rates of parents whose children were diagnosed with leukemia with a control group of parents whose children were diagnosed with benign tumors or cancer-related diseases. The smoking rate of fathers was significantly larger than the control. The odds ratios were 1.284 for 1-9 cigarettes/day (c/d) before conception (p=0.127), 1.265 for 10-19 c/d (p=0.029), and 1.345 for more than 20 c/d (p=0.000). A logistic regression analysis controlling for sex, birth weight, paternal age at birth, and maternal smoking showed that the smoking rate of fathers whose children had acute leukemia was still significantly higher (OR 1.012, p=0.004). The difference of the smoking rate between mothers whose children had acute leukemia and the control mothers was not significant (OR 1.161, p=0.447).
VL  - 8
IS  - 5
ER  -

Copy | Download

Author Information

Fumio Bessho

Department of Education of General Medicine, Faculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan
Masako Tanimura

Department of Pediatrics, Kyorin University School of Medicine, Tokyo, Japan

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Fumio Bessho, Masako Tanimura. (2020). Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia. European Journal of Preventive Medicine, 8(5), 61-65. https://doi.org/10.11648/j.ejpm.20200805.11

Copy | Download

ACS Style

Fumio Bessho; Masako Tanimura. Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia. Eur. J. Prev. Med. 2020, 8(5), 61-65. doi: 10.11648/j.ejpm.20200805.11

Copy | Download

AMA Style

Fumio Bessho, Masako Tanimura. Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia. Eur J Prev Med. 2020;8(5):61-65. doi: 10.11648/j.ejpm.20200805.11

Copy | Download

@article{10.11648/j.ejpm.20200805.11,
  author = {Fumio Bessho and Masako Tanimura},
  title = {Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia},
  journal = {European Journal of Preventive Medicine},
  volume = {8},
  number = {5},
  pages = {61-65},
  doi = {10.11648/j.ejpm.20200805.11},
  url = {https://doi.org/10.11648/j.ejpm.20200805.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejpm.20200805.11},
  abstract = {We herein determined the effects of parental smoking on occurrence of childhood acute leukemia using the large volume of data accumulated in the Japan Children's Cancer Registry. Information on the smoking statuses of fathers was available for 4,802 acute leukemia cases diagnosed between 1985 and 2006 and that of mothers was available for 5,536 cases diagnosed between 1978 and 2006. We compared the smoking rates of parents whose children were diagnosed with leukemia with a control group of parents whose children were diagnosed with benign tumors or cancer-related diseases. The smoking rate of fathers was significantly larger than the control. The odds ratios were 1.284 for 1-9 cigarettes/day (c/d) before conception (p=0.127), 1.265 for 10-19 c/d (p=0.029), and 1.345 for more than 20 c/d (p=0.000). A logistic regression analysis controlling for sex, birth weight, paternal age at birth, and maternal smoking showed that the smoking rate of fathers whose children had acute leukemia was still significantly higher (OR 1.012, p=0.004). The difference of the smoking rate between mothers whose children had acute leukemia and the control mothers was not significant (OR 1.161, p=0.447).},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Effects of Parental Smoking on Occurrence of Childhood Acute Leukemia
AU  - Fumio Bessho
AU  - Masako Tanimura
Y1  - 2020/09/23
PY  - 2020
N1  - https://doi.org/10.11648/j.ejpm.20200805.11
DO  - 10.11648/j.ejpm.20200805.11
T2  - European Journal of Preventive Medicine
JF  - European Journal of Preventive Medicine
JO  - European Journal of Preventive Medicine
SP  - 61
EP  - 65
PB  - Science Publishing Group
SN  - 2330-8230
UR  - https://doi.org/10.11648/j.ejpm.20200805.11
AB  - We herein determined the effects of parental smoking on occurrence of childhood acute leukemia using the large volume of data accumulated in the Japan Children's Cancer Registry. Information on the smoking statuses of fathers was available for 4,802 acute leukemia cases diagnosed between 1985 and 2006 and that of mothers was available for 5,536 cases diagnosed between 1978 and 2006. We compared the smoking rates of parents whose children were diagnosed with leukemia with a control group of parents whose children were diagnosed with benign tumors or cancer-related diseases. The smoking rate of fathers was significantly larger than the control. The odds ratios were 1.284 for 1-9 cigarettes/day (c/d) before conception (p=0.127), 1.265 for 10-19 c/d (p=0.029), and 1.345 for more than 20 c/d (p=0.000). A logistic regression analysis controlling for sex, birth weight, paternal age at birth, and maternal smoking showed that the smoking rate of fathers whose children had acute leukemia was still significantly higher (OR 1.012, p=0.004). The difference of the smoking rate between mothers whose children had acute leukemia and the control mothers was not significant (OR 1.161, p=0.447).
VL  - 8
IS  - 5
ER  -

Copy | Download