American Journal of Psychiatry and Neuroscience

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A Biermer’s Disease Revealed by a Myogeneous Syndrome About a Rare Case in Young African Black Subject and Literature Review

Received: 12 March 2017    Accepted: 24 March 2017    Published: 10 April 2017
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Abstract

Biermer’s disease is an autoimmune disorder characterized by vitamin B12 deficiency. Neurological symptoms of B12 vitamin deficiency are polymorph. We report a case of a young black girl of 28 years old, senegalese student, consulted for walking ataxia and myalgia. The neurological examination found a myogenic syndrome of the four limbs. The electroneuromyogram showed diffuse myogenic involvement. The biological assessment found a macrocytic anemia at 112 fL with a vitamin B12 level collapsed at 74 pmol/L. The anti-parietal cell and anti-intrinsic factor were positive. Under supplementation with vitamin B12 the evolution is favorable after 8 months of treatment. Thus neurological deficiencies due to vitamin B12 deficiency are polymorphic. The dosage of vitamin B12 must be done before any neuropsychiatric symptoms that does not prove its worth.

DOI 10.11648/j.ajpn.20170502.12
Published in American Journal of Psychiatry and Neuroscience (Volume 5, Issue 2, March 2017)
Page(s) 19-21
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Biermer’s Disease, Myogeneous Syndrome, Young

References
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[2] Andres E, Affenberger S, Vinzio S, Noel E, Kaltenbach G, Schlienger JL. Carences en vitamine B12: étiologies, manifestations cliniques et traitement. Rev Med Interne 2005; 26: 938-46.
[3] Healton EB, Savage DG, Brust JC, Garret TJ, Lindenbaum J. Neurologic aspects of cobalamin deficiency. Medicine 1991; 70: 229-45.
[4] Savage DJ, Lindenbaum J. Neurological complications of aquired cobalamin deficiency: clinical aspects. Baillieres Clin Haematol 1995; 8: 657-78.
[5] Lindenbaum J, Healton EB, Savage DG, Brust JC, Garrett TG, Podell ER, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988; 318: 1720-8.
[6] Andrès E, Renaux V, Campos F, Opréa C, Sonntag-Fohrer C, Warter JM, et al. Troubles neurologiques isolés révélant une maladie de Biermer chez le sujet jeune. Rev Med Interne 2001; 22: 389-93.
[7] Andrès E, Perrin AE, Demangeat C, Kurtz JE, Vinzio S, Grunenberger F, et al. The syndrome of food-cobalamin malabsorption revisited in a department of internal medicine. A monocentric cohort study of 80 patients. Eur J Intern Med 2003; 14: 221-6.
[8] Andrès E, Goichot B, Schlienger JL. Food- cobalamin malabsorption: a usual cause of vitamin B12 deficiency. Arch Intern Med 2000; 161: 2060-1.
[9] Fine EJ, Soria E, Paroski MW, Petryk D, Thomasula L. The neurophysiological profile of vitamin B12 deficiency. Musle Nerve 1990; 13: 158-64.
[10] Björn Regland, Sara Forsmark, Lena Halaouate et al. Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia. PLoS One 2015; 10 (4): e0124648. doi: 10.1371/journal.pone.0124648.
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[13] Locatelli ER, Laureno R, Ballard P, Mark AS. MRI in vitamin B12 deficiency myelopathy. Can J Neurol Sci 1999; 26: 60-3.
[14] Scott JM, Weir DG. The methyl folate trap. Lancet 1981; 2: 337-40.
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Author Information
  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

  • Neurology Department, University Gaston BERGER, St-Louis, Senegal

  • Neurology Department, University of Thies, Thies, Senegal

  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

  • Neurology Department, University Cheikh Anta DIOP, Dakar, Senegal

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    Fall Maouly, Gaye Ndiaga Matar, Cissé Ousmane, Diop Alassane Mamadou, Diop Marième Soda, et al. (2017). A Biermer’s Disease Revealed by a Myogeneous Syndrome About a Rare Case in Young African Black Subject and Literature Review. American Journal of Psychiatry and Neuroscience, 5(2), 19-21. https://doi.org/10.11648/j.ajpn.20170502.12

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    ACS Style

    Fall Maouly; Gaye Ndiaga Matar; Cissé Ousmane; Diop Alassane Mamadou; Diop Marième Soda, et al. A Biermer’s Disease Revealed by a Myogeneous Syndrome About a Rare Case in Young African Black Subject and Literature Review. Am. J. Psychiatry Neurosci. 2017, 5(2), 19-21. doi: 10.11648/j.ajpn.20170502.12

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    AMA Style

    Fall Maouly, Gaye Ndiaga Matar, Cissé Ousmane, Diop Alassane Mamadou, Diop Marième Soda, et al. A Biermer’s Disease Revealed by a Myogeneous Syndrome About a Rare Case in Young African Black Subject and Literature Review. Am J Psychiatry Neurosci. 2017;5(2):19-21. doi: 10.11648/j.ajpn.20170502.12

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  • @article{10.11648/j.ajpn.20170502.12,
      author = {Fall Maouly and Gaye Ndiaga Matar and Cissé Ousmane and Diop Alassane Mamadou and Diop Marième Soda and Ba El Hadji Makhtar and Diagne Ngor Side and Soumaila Boubacar and Bass Anna Modji and Sow Adjaratou Djeynabou and Seck Lala Bouna and Touré Kamadore and Ndiaye Moustapha and Diop Amadou Gallo and Ndiaye Mouhamadou Mansour},
      title = {A Biermer’s Disease Revealed by a Myogeneous Syndrome About a Rare Case in Young African Black Subject and Literature Review},
      journal = {American Journal of Psychiatry and Neuroscience},
      volume = {5},
      number = {2},
      pages = {19-21},
      doi = {10.11648/j.ajpn.20170502.12},
      url = {https://doi.org/10.11648/j.ajpn.20170502.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajpn.20170502.12},
      abstract = {Biermer’s disease is an autoimmune disorder characterized by vitamin B12 deficiency. Neurological symptoms of B12 vitamin deficiency are polymorph. We report a case of a young black girl of 28 years old, senegalese student, consulted for walking ataxia and myalgia. The neurological examination found a myogenic syndrome of the four limbs. The electroneuromyogram showed diffuse myogenic involvement. The biological assessment found a macrocytic anemia at 112 fL with a vitamin B12 level collapsed at 74 pmol/L. The anti-parietal cell and anti-intrinsic factor were positive. Under supplementation with vitamin B12 the evolution is favorable after 8 months of treatment. Thus neurological deficiencies due to vitamin B12 deficiency are polymorphic. The dosage of vitamin B12 must be done before any neuropsychiatric symptoms that does not prove its worth.},
     year = {2017}
    }
    

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    T1  - A Biermer’s Disease Revealed by a Myogeneous Syndrome About a Rare Case in Young African Black Subject and Literature Review
    AU  - Fall Maouly
    AU  - Gaye Ndiaga Matar
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    AU  - Diop Alassane Mamadou
    AU  - Diop Marième Soda
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    AU  - Diagne Ngor Side
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    AU  - Bass Anna Modji
    AU  - Sow Adjaratou Djeynabou
    AU  - Seck Lala Bouna
    AU  - Touré Kamadore
    AU  - Ndiaye Moustapha
    AU  - Diop Amadou Gallo
    AU  - Ndiaye Mouhamadou Mansour
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    AB  - Biermer’s disease is an autoimmune disorder characterized by vitamin B12 deficiency. Neurological symptoms of B12 vitamin deficiency are polymorph. We report a case of a young black girl of 28 years old, senegalese student, consulted for walking ataxia and myalgia. The neurological examination found a myogenic syndrome of the four limbs. The electroneuromyogram showed diffuse myogenic involvement. The biological assessment found a macrocytic anemia at 112 fL with a vitamin B12 level collapsed at 74 pmol/L. The anti-parietal cell and anti-intrinsic factor were positive. Under supplementation with vitamin B12 the evolution is favorable after 8 months of treatment. Thus neurological deficiencies due to vitamin B12 deficiency are polymorphic. The dosage of vitamin B12 must be done before any neuropsychiatric symptoms that does not prove its worth.
    VL  - 5
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