Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients
American Journal of Psychiatry and Neuroscience
Volume 5, Issue 4, July 2017, Pages: 45-52
Received: Jun. 26, 2017; Accepted: Jul. 19, 2017; Published: Aug. 26, 2017
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Authors
Ryan Scott Anderton, School of Health Sciences and Institute for Health Research, University of Notre Dame Australia, Fremantle, Australia; Perron Institute for Neurological and Translational Science, Perth, Australia
Michelle Byrnes, Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia
Alexa Jefferson, Perron Institute for Neurological and Translational Science, Perth, Australia
Sue Walters, Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia
Soumya Ghosh, Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia
Rick Stell, Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia
Frank Louis Mastaglia, Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia
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Abstract
Impulse control disorders (ICDs) occur in a subset of Parkinson’s disease (PD) patients on dopaminergic medications however there are currently no reliable markers to identify patients at risk. Sleep disturbances are more common in patients with an ICD. Serum ferritin levels have been associated with PD disease stage and progression, but have not previously been associated with impulsivity levels. The objective of this study was to determine if serum ferritin levels and sleep disturbance are associated with high traits of impulsivity and ICD in a cohort of PD patients attending a movement disorders clinic. This study assessed impulsiveness in 87 PD patients using the Barratt Impulsiveness Scale. Severity of sleep disturbance was determined using the sleep-related items of the MDS-UPDRS. Serum ferritin, iron and transferrin levels were measured in patients, as well as 36 age-matched healthy controls. Serum ferritin levels were significantly elevated in male PD patients in the high impulsivity group compared to patients in the low (p=.022) and normal range groups (p=.024) and showed a linear increase across the three groups. Sleep disturbance also demonstrated a linear trend, which was most severe in the high impulsivity group (p=.030). A subgroup of 11 male PD patients who fulfilled the DSM-5 criteria for an ICD had significantly higher ferritin levels and more severe sleep disturbance when compared with the remaining male PD cohort. Serum ferritin levels and sleep disturbance severity are highlighted as potential markers for abnormal impulsivity and ICD in PD patients.
Keywords
Impulsivity, BIS-11, Ferritin, Sleep Disturbance, PD
To cite this article
Ryan Scott Anderton, Michelle Byrnes, Alexa Jefferson, Sue Walters, Soumya Ghosh, Rick Stell, Frank Louis Mastaglia, Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients, American Journal of Psychiatry and Neuroscience. Vol. 5, No. 4, 2017, pp. 45-52. doi: 10.11648/j.ajpn.20170504.12
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Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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