Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients
American Journal of Psychiatry and Neuroscience
Volume 5, Issue 4, July 2017, Pages: 45-52
Received: Jun. 26, 2017;
Accepted: Jul. 19, 2017;
Published: Aug. 26, 2017
Views 1862 Downloads 74
Ryan Scott Anderton, School of Health Sciences and Institute for Health Research, University of Notre Dame Australia, Fremantle, Australia; Perron Institute for Neurological and Translational Science, Perth, Australia
Michelle Byrnes, Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia
Alexa Jefferson, Perron Institute for Neurological and Translational Science, Perth, Australia
Sue Walters, Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia
Soumya Ghosh, Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia
Rick Stell, Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia
Frank Louis Mastaglia, Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia
Impulse control disorders (ICDs) occur in a subset of Parkinson’s disease (PD) patients on dopaminergic medications however there are currently no reliable markers to identify patients at risk. Sleep disturbances are more common in patients with an ICD. Serum ferritin levels have been associated with PD disease stage and progression, but have not previously been associated with impulsivity levels. The objective of this study was to determine if serum ferritin levels and sleep disturbance are associated with high traits of impulsivity and ICD in a cohort of PD patients attending a movement disorders clinic. This study assessed impulsiveness in 87 PD patients using the Barratt Impulsiveness Scale. Severity of sleep disturbance was determined using the sleep-related items of the MDS-UPDRS. Serum ferritin, iron and transferrin levels were measured in patients, as well as 36 age-matched healthy controls. Serum ferritin levels were significantly elevated in male PD patients in the high impulsivity group compared to patients in the low (p=.022) and normal range groups (p=.024) and showed a linear increase across the three groups. Sleep disturbance also demonstrated a linear trend, which was most severe in the high impulsivity group (p=.030). A subgroup of 11 male PD patients who fulfilled the DSM-5 criteria for an ICD had significantly higher ferritin levels and more severe sleep disturbance when compared with the remaining male PD cohort. Serum ferritin levels and sleep disturbance severity are highlighted as potential markers for abnormal impulsivity and ICD in PD patients.
Ryan Scott Anderton,
Frank Louis Mastaglia,
Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients, American Journal of Psychiatry and Neuroscience.
Vol. 5, No. 4,
2017, pp. 45-52.
Djamshidian, A., W. Poewe, and B. Högl, Impact of Impulse Control Disorders on Sleep-Wake Regulation in Parkinson's Disease. Parkinson's Disease, 2015. 2015: p. 970862.
Garcia-Ruiz, P. J., et al., Impulse control disorder in patients with Parkinson's disease under dopamine agonist therapy: a multicentre study. Journal of Neurology, Neurosurgery & Psychiatry, 2014. 85(8): p. 840-844.
Abosch, A., et al., Impulsive Behavior and Associated Clinical Variables in Parkinson's Disease. Psychosomatics, 2011. 52(1): p. 41-47.
Smulders, K., et al., Trait Impulsivity Is Associated with the Risk of Falls in Parkinson’s Disease. PLoS ONE, 2014. 9(3): p. e91190.
Killgore, W. D. S., et al., Sleep deprivation reduces perceived emotional intelligence and constructive thinking skills. Sleep Medicine, 2008. 9(5): p. 517-526.
Kumar, S., M. Bhatia, and M. Behari, Sleep disorders in Parkinson's disease. Movement Disorders, 2002. 17(4): p. 775-781.
Happe, S., et al., Sleep disorders and depression in patients with Parkinson's disease. Acta Neurologica Scandinavica, 2001. 104(5): p. 275-280.
Chaudhuri, K. R. and K. Logishetty, Dopamine receptor agonists and sleep disturbances in Parkinson's disease. Parkinsonism & Related Disorders, 2009. 15: p. S101-S104.
Scullin, M. K., et al., Sleep and Impulsivity in Parkinson’s Disease. Parkinsonism & related disorders, 2013. 19(11): p. 10.1016/j.parkreldis.2013.06.018.
Paavonen, E. J., et al., Short Sleep Duration and Behavioral Symptoms of Attention-Deficit/Hyperactivity Disorder in Healthy 7- to 8-Year-Old Children. Pediatrics, 2009. 123(5): p. e857.
Pourcher, E., S. Rémillard, and H. Cohen, Compulsive habits in restless legs syndrome patients under dopaminergic treatment. Journal of the Neurological Sciences, 2010. 290(1): p. 52-56.
Schulte, E. C., et al., Iron in Restless Legs Syndrome. Movement Disorders Clinical Practice, 2014. 1(3): p. 161-172.
Cortese, S., et al., Sleep disturbances and serum ferritin levels in children with attention-deficit/hyperactivity disorder. European Child & Adolescent Psychiatry, 2009. 18(7): p. 393-399.
Oner, P., et al., Ferritin and Hyperactivity Ratings in Attention Deficit Hyperactivity Disorder. Pediatrics international: official journal of the Japan Pediatric Society, 2012. 54(5): p. 688-692.
Mochizuki, H. and T. Yasuda, Iron accumulation in Parkinson’s disease. Journal of Neural Transmission, 2012. 119(12): p. 1511-1514.
Friedman, A., et al., Ferritin as an important player in neurodegeneration. Parkinsonism & Related Disorders, 2011. 17(6): p. 423-430.
Bartzokis, G., et al., Brain Ferritin Iron as a Risk Factor for Age at Onset in Neurodegenerative Diseases. Annals of the New York Academy of Sciences, 2004. 1012(1): p. 224-236.
Farhoudi, M., et al., Serum iron and ferritin level in idiopathic Parkinson. Pak J Biol Sci, 2012. 15(22): p. 1094-7.
Medeiros, M. S., et al., Iron and Oxidative Stress in Parkinson’s Disease: An Observational Study of Injury Biomarkers. PLoS ONE, 2016. 11(1): p. e0146129.
Ikeda, K., et al., Serological Profiles of Urate, Paraoxonase-1, Ferritin and Lipid in Parkinson’s Disease: Changes Linked to Disease Progression. Neurodegenerative Diseases, 2011. 8(4): p. 252-258.
Hughes, A. J., et al., Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry, 1992. 55(3): p. 181-4.
Tomlinson, C. L., et al., Systematic review of levodopa dose equivalency reporting in Parkinson's disease. Movement Disorders, 2010. 25(15): p. 2649-2653.
Goetz, C. G., et al., Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan. Movement Disorders, 2007. 22(1): p. 41-47.
Patton, J. H., M. S. Stanford, and E. S. Barratt, Factor structure of the Barratt impulsiveness scale. J Clin Psychol, 1995. 51(6): p. 768-74.
Association, A. P., Diagnostic and statistical manual of mental disorders: DSM-5, ed. A. American Psychiatric and D. S. M. T. F. American Psychiatric Association. 2013, Arlington, VA: American Psychiatric Association.
Horvath, K., et al., Is the MDS-UPDRS a Good Screening Tool for Detecting Sleep Problems and Daytime Sleepiness in Parkinson's Disease? Parkinson's Disease, 2014. 2014: p. 8.
Evans, T., et al., Extended “Timed Up and Go” assessment as a clinical indicator of cognitive state in Parkinson's disease. Journal of the Neurological Sciences, 2017. 375: p. 86-91.
Sixel-Doring, F., et al., Associated factors for REM sleep behavior disorder in Parkinson disease. Neurology, 2011. 77(11): p. 1048-1054.
Bellosta Diago, E., et al., Relación entre el trastorno de conducta del sueño REM y el trastorno de control de impulsos en pacientes con enfermedad de Parkinson. Neurología, 2016.
Bayard, S., et al., Impulse control disorder and rapid eye movement sleep behavior disorder in Parkinson's disease. Parkinsonism & Related Disorders, 2014. 20(12): p. 1411-1414.
Jehn, M., J. M. Clark, and E. Guallar, Serum Ferritin and Risk of the Metabolic Syndrome in U.S. Adults. Diabetes Care, 2004. 27: p. 2422-2428.
Zacharski, L. R., et al., Association of age, sex, and race with body iron stores in adults: Analysis of NHANES III data. American Heart Journal, 2000. 140(1): p. 98-104.
Dekker, L. H., et al., Sex Differences in the Association Between Serum Ferritin and Fasting Glucose in Type 2 Diabetes Among South Asian Surinamese, African Surinamese, and Ethnic Dutch. Diabetes Care, 2013. 36(4): p. 965.
Youssef, J., et al., Relationship of Serum Ferritin Levels to Sleep Fragmentation and Periodic Limb Movements of Sleep on Polysomnography in Autism Spectrum Disorders. Pediatric Neurology, 2013. 49(4): p. 274-278.
Daubian-Nosé, P., M. K. Frank, and A. M. Esteves, Sleep disorders: A review of the interface between restless legs syndrome and iron metabolism. Sleep Science, 2014. 7(4): p. 234-237.
Moirand, R., et al., A new syndrome of liver iron overload with normal transferrin saturation. The Lancet, 1997. 349(9045): p. 95-97.