American Journal of Psychiatry and Neuroscience

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In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan

Received: 20 October 2019    Accepted: 06 November 2019    Published: 12 November 2019
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Abstract

Application of easy Z score imaging system (eZIS) on brain perfusion SPECT images for quantitative evaluation of rCBF has attempted to explore the differential diagnosis of dementia with various degenerative diseases and to evaluate discrimination of early Alzheimer’s disease (AD) from other types of dementia. This retrospective study was done with various degenerative diseases that underwent brain perfusion SPECT using 99mTc ethyl cysteinate dimer were included. Brain perfusion SPECT was performed in 58 patients (M/F = 48/10) with mean age of 61.2±10.4 years (41-90). Decreased rCBF was observed in the area suspected early AD in 20 cases (34%) and in the frontal gyrus and insula in 10 cases (17%). And decreased rCBF was observed in occipital lobe and, precuneus, gyrus and posterior cingulate cortex in 8 cases (14%). Discrete areas of decreased rCBF were seen in 14 cases (24%) and the rest of 6 cases (11%) showed normal rCBF. Clinically suspected AD patients were divided into two groups on basis of MMSE score (group A, mild stage of AD, MMSE =20-26 and group B, moderate to severe stage of AD, MMSE=10-19). Mean MMSE and mean Z scores were 22.9±1.11 and 1.01±0.35 in group A (n = 12) while 17.56±0.96 and 2.62±0.59 in group B (n= 8). There was negative correlation between MMSE and eZIS score; r = - 0.69 in group A (p = 0.002); r = - 0.58 in group B (p = 0.019) and r = - 0.93 overall (p = 0.000). Quantification of rCBF with eZIS score was well associated with clinical MMSE scoring in this study group with clinical likelihood of having AD. In rest of the cases, SPECT findings and surface view analysis by eZIS, the affected area of decreased rCBF were consistent with clinically suspected different types of degenerative disease manifesting dementia.

DOI 10.11648/j.ajpn.20190704.14
Published in American Journal of Psychiatry and Neuroscience (Volume 7, Issue 4, December 2019)
Page(s) 100-107
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

eZIS, Alzheimer's Disease, Brain Perfusion, SPECT

References
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[3] Minoshima S, Berger KL, Lee KS, et al: Anautomated method for rotational correction and centering of three-dimensional functional brain images. J Nucl Med 1992; 33: 1579–1585.
[4] Minoshima S, Koeppe RA, Mintun MA, etal: Automated detection of the intercommissural line for stereotactic localization of functional brain images. J Nucl Med 1993; 34: 322–329.
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[6] Matsuda H, Mizumura S, Soma T, et al: Conversionof brain SPECT images between different collimators and reconstruction processes for analysis using statistical parametric mapping. Nucl Med Commun 2004; 25: 67–74.
[7] Kanetaka H, Matsuda H, Asada T, et al: Effects of partial volume correction on discrimination between very early Alzheimer’s dementia and controls using brain perfusion SPECT. Eur J Nucl Med Mol Imaging 2004; 31: 975–980.
[8] Matsuda H, Mizumura S, Nagao T, et al: Automated discrimination between very early Alzheimer’s disease and controls using an easy Z-score imaging system for multicenter brain perfusion SPECT. AJNR Am J Neuroradiol 2007; 28: 731–736.
[9] Matsuda H: Role of neuroimaging in Alzheimer’s disease, with emphasis on brain perfusion SPECT. J Nucl Med 2007; 48: 1289–1300.
[10] Waragai M, Yamada T, Matsuda H: Evaluation of brain perfusion SPECT using an easy Z-score imaging system (eZIS) as an adjunct to early diagnosis of neurodegenerative diseases. J Neurol Sci 2007; 260: 57–64.
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Author Information
  • National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BSMMU Campus Dhaka, Bangladesh

  • Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan

  • Institute of Nuclear Medicine and Allied Sciences, Mitford, SSMC Campus, Dhaka, Bangladesh

  • National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BSMMU Campus Dhaka, Bangladesh

  • Neurology, BSM Medical University, Dhaka, Bangladesh

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    Nasreen Sultana, Hiroshi Matsuda, Azmal Kabir Sarker, Jasmine Ara Haque, Rafiqul Islam. (2019). In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan. American Journal of Psychiatry and Neuroscience, 7(4), 100-107. https://doi.org/10.11648/j.ajpn.20190704.14

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    ACS Style

    Nasreen Sultana; Hiroshi Matsuda; Azmal Kabir Sarker; Jasmine Ara Haque; Rafiqul Islam. In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan. Am. J. Psychiatry Neurosci. 2019, 7(4), 100-107. doi: 10.11648/j.ajpn.20190704.14

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    AMA Style

    Nasreen Sultana, Hiroshi Matsuda, Azmal Kabir Sarker, Jasmine Ara Haque, Rafiqul Islam. In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan. Am J Psychiatry Neurosci. 2019;7(4):100-107. doi: 10.11648/j.ajpn.20190704.14

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  • @article{10.11648/j.ajpn.20190704.14,
      author = {Nasreen Sultana and Hiroshi Matsuda and Azmal Kabir Sarker and Jasmine Ara Haque and Rafiqul Islam},
      title = {In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan},
      journal = {American Journal of Psychiatry and Neuroscience},
      volume = {7},
      number = {4},
      pages = {100-107},
      doi = {10.11648/j.ajpn.20190704.14},
      url = {https://doi.org/10.11648/j.ajpn.20190704.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajpn.20190704.14},
      abstract = {Application of easy Z score imaging system (eZIS) on brain perfusion SPECT images for quantitative evaluation of rCBF has attempted to explore the differential diagnosis of dementia with various degenerative diseases and to evaluate discrimination of early Alzheimer’s disease (AD) from other types of dementia. This retrospective study was done with various degenerative diseases that underwent brain perfusion SPECT using 99mTc ethyl cysteinate dimer were included. Brain perfusion SPECT was performed in 58 patients (M/F = 48/10) with mean age of 61.2±10.4 years (41-90). Decreased rCBF was observed in the area suspected early AD in 20 cases (34%) and in the frontal gyrus and insula in 10 cases (17%). And decreased rCBF was observed in occipital lobe and, precuneus, gyrus and posterior cingulate cortex in 8 cases (14%). Discrete areas of decreased rCBF were seen in 14 cases (24%) and the rest of 6 cases (11%) showed normal rCBF. Clinically suspected AD patients were divided into two groups on basis of MMSE score (group A, mild stage of AD, MMSE =20-26 and group B, moderate to severe stage of AD, MMSE=10-19). Mean MMSE and mean Z scores were 22.9±1.11 and 1.01±0.35 in group A (n = 12) while 17.56±0.96 and 2.62±0.59 in group B (n= 8). There was negative correlation between MMSE and eZIS score; r = - 0.69 in group A (p = 0.002); r = - 0.58 in group B (p = 0.019) and r = - 0.93 overall (p = 0.000). Quantification of rCBF with eZIS score was well associated with clinical MMSE scoring in this study group with clinical likelihood of having AD. In rest of the cases, SPECT findings and surface view analysis by eZIS, the affected area of decreased rCBF were consistent with clinically suspected different types of degenerative disease manifesting dementia.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan
    AU  - Nasreen Sultana
    AU  - Hiroshi Matsuda
    AU  - Azmal Kabir Sarker
    AU  - Jasmine Ara Haque
    AU  - Rafiqul Islam
    Y1  - 2019/11/12
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajpn.20190704.14
    DO  - 10.11648/j.ajpn.20190704.14
    T2  - American Journal of Psychiatry and Neuroscience
    JF  - American Journal of Psychiatry and Neuroscience
    JO  - American Journal of Psychiatry and Neuroscience
    SP  - 100
    EP  - 107
    PB  - Science Publishing Group
    SN  - 2330-426X
    UR  - https://doi.org/10.11648/j.ajpn.20190704.14
    AB  - Application of easy Z score imaging system (eZIS) on brain perfusion SPECT images for quantitative evaluation of rCBF has attempted to explore the differential diagnosis of dementia with various degenerative diseases and to evaluate discrimination of early Alzheimer’s disease (AD) from other types of dementia. This retrospective study was done with various degenerative diseases that underwent brain perfusion SPECT using 99mTc ethyl cysteinate dimer were included. Brain perfusion SPECT was performed in 58 patients (M/F = 48/10) with mean age of 61.2±10.4 years (41-90). Decreased rCBF was observed in the area suspected early AD in 20 cases (34%) and in the frontal gyrus and insula in 10 cases (17%). And decreased rCBF was observed in occipital lobe and, precuneus, gyrus and posterior cingulate cortex in 8 cases (14%). Discrete areas of decreased rCBF were seen in 14 cases (24%) and the rest of 6 cases (11%) showed normal rCBF. Clinically suspected AD patients were divided into two groups on basis of MMSE score (group A, mild stage of AD, MMSE =20-26 and group B, moderate to severe stage of AD, MMSE=10-19). Mean MMSE and mean Z scores were 22.9±1.11 and 1.01±0.35 in group A (n = 12) while 17.56±0.96 and 2.62±0.59 in group B (n= 8). There was negative correlation between MMSE and eZIS score; r = - 0.69 in group A (p = 0.002); r = - 0.58 in group B (p = 0.019) and r = - 0.93 overall (p = 0.000). Quantification of rCBF with eZIS score was well associated with clinical MMSE scoring in this study group with clinical likelihood of having AD. In rest of the cases, SPECT findings and surface view analysis by eZIS, the affected area of decreased rCBF were consistent with clinically suspected different types of degenerative disease manifesting dementia.
    VL  - 7
    IS  - 4
    ER  - 

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