Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients

Ryan Scott Anderton; Michelle Byrnes; Alexa Jefferson; Sue Walters; Soumya Ghosh; Rick Stell; Frank Louis Mastaglia

doi:doi:10.11648/j.ajpn.20170504.12

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Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients

Ryan Scott Anderton, Michelle Byrnes, Alexa Jefferson, Sue Walters, Soumya Ghosh, Rick Stell, Frank Louis Mastaglia

Published in American Journal of Psychiatry and Neuroscience (Volume 5, Issue 4)

Received: 26 June 2017 Accepted: 19 July 2017 Published: 26 August 2017

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Abstract

Impulse control disorders (ICDs) occur in a subset of Parkinson’s disease (PD) patients on dopaminergic medications however there are currently no reliable markers to identify patients at risk. Sleep disturbances are more common in patients with an ICD. Serum ferritin levels have been associated with PD disease stage and progression, but have not previously been associated with impulsivity levels. The objective of this study was to determine if serum ferritin levels and sleep disturbance are associated with high traits of impulsivity and ICD in a cohort of PD patients attending a movement disorders clinic. This study assessed impulsiveness in 87 PD patients using the Barratt Impulsiveness Scale. Severity of sleep disturbance was determined using the sleep-related items of the MDS-UPDRS. Serum ferritin, iron and transferrin levels were measured in patients, as well as 36 age-matched healthy controls. Serum ferritin levels were significantly elevated in male PD patients in the high impulsivity group compared to patients in the low (p=.022) and normal range groups (p=.024) and showed a linear increase across the three groups. Sleep disturbance also demonstrated a linear trend, which was most severe in the high impulsivity group (p=.030). A subgroup of 11 male PD patients who fulfilled the DSM-5 criteria for an ICD had significantly higher ferritin levels and more severe sleep disturbance when compared with the remaining male PD cohort. Serum ferritin levels and sleep disturbance severity are highlighted as potential markers for abnormal impulsivity and ICD in PD patients.

Published in	American Journal of Psychiatry and Neuroscience (Volume 5, Issue 4)
DOI	10.11648/j.ajpn.20170504.12
Page(s)	45-52
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Impulsivity, BIS-11, Ferritin, Sleep Disturbance, PD

References

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APA Style

Ryan Scott Anderton, Michelle Byrnes, Alexa Jefferson, Sue Walters, Soumya Ghosh, et al. (2017). Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients. American Journal of Psychiatry and Neuroscience, 5(4), 45-52. https://doi.org/10.11648/j.ajpn.20170504.12

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ACS Style

Ryan Scott Anderton; Michelle Byrnes; Alexa Jefferson; Sue Walters; Soumya Ghosh, et al. Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients. Am. J. Psychiatry Neurosci. 2017, 5(4), 45-52. doi: 10.11648/j.ajpn.20170504.12

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AMA Style

Ryan Scott Anderton, Michelle Byrnes, Alexa Jefferson, Sue Walters, Soumya Ghosh, et al. Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients. Am J Psychiatry Neurosci. 2017;5(4):45-52. doi: 10.11648/j.ajpn.20170504.12

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@article{10.11648/j.ajpn.20170504.12,
  author = {Ryan Scott Anderton and Michelle Byrnes and Alexa Jefferson and Sue Walters and Soumya Ghosh and Rick Stell and Frank Louis Mastaglia},
  title = {Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {5},
  number = {4},
  pages = {45-52},
  doi = {10.11648/j.ajpn.20170504.12},
  url = {https://doi.org/10.11648/j.ajpn.20170504.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20170504.12},
  abstract = {Impulse control disorders (ICDs) occur in a subset of Parkinson’s disease (PD) patients on dopaminergic medications however there are currently no reliable markers to identify patients at risk. Sleep disturbances are more common in patients with an ICD. Serum ferritin levels have been associated with PD disease stage and progression, but have not previously been associated with impulsivity levels. The objective of this study was to determine if serum ferritin levels and sleep disturbance are associated with high traits of impulsivity and ICD in a cohort of PD patients attending a movement disorders clinic. This study assessed impulsiveness in 87 PD patients using the Barratt Impulsiveness Scale. Severity of sleep disturbance was determined using the sleep-related items of the MDS-UPDRS. Serum ferritin, iron and transferrin levels were measured in patients, as well as 36 age-matched healthy controls. Serum ferritin levels were significantly elevated in male PD patients in the high impulsivity group compared to patients in the low (p=.022) and normal range groups (p=.024) and showed a linear increase across the three groups. Sleep disturbance also demonstrated a linear trend, which was most severe in the high impulsivity group (p=.030). A subgroup of 11 male PD patients who fulfilled the DSM-5 criteria for an ICD had significantly higher ferritin levels and more severe sleep disturbance when compared with the remaining male PD cohort. Serum ferritin levels and sleep disturbance severity are highlighted as potential markers for abnormal impulsivity and ICD in PD patients.},
 year = {2017}
}

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TY  - JOUR
T1  - Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients
AU  - Ryan Scott Anderton
AU  - Michelle Byrnes
AU  - Alexa Jefferson
AU  - Sue Walters
AU  - Soumya Ghosh
AU  - Rick Stell
AU  - Frank Louis Mastaglia
Y1  - 2017/08/26
PY  - 2017
N1  - https://doi.org/10.11648/j.ajpn.20170504.12
DO  - 10.11648/j.ajpn.20170504.12
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 45
EP  - 52
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20170504.12
AB  - Impulse control disorders (ICDs) occur in a subset of Parkinson’s disease (PD) patients on dopaminergic medications however there are currently no reliable markers to identify patients at risk. Sleep disturbances are more common in patients with an ICD. Serum ferritin levels have been associated with PD disease stage and progression, but have not previously been associated with impulsivity levels. The objective of this study was to determine if serum ferritin levels and sleep disturbance are associated with high traits of impulsivity and ICD in a cohort of PD patients attending a movement disorders clinic. This study assessed impulsiveness in 87 PD patients using the Barratt Impulsiveness Scale. Severity of sleep disturbance was determined using the sleep-related items of the MDS-UPDRS. Serum ferritin, iron and transferrin levels were measured in patients, as well as 36 age-matched healthy controls. Serum ferritin levels were significantly elevated in male PD patients in the high impulsivity group compared to patients in the low (p=.022) and normal range groups (p=.024) and showed a linear increase across the three groups. Sleep disturbance also demonstrated a linear trend, which was most severe in the high impulsivity group (p=.030). A subgroup of 11 male PD patients who fulfilled the DSM-5 criteria for an ICD had significantly higher ferritin levels and more severe sleep disturbance when compared with the remaining male PD cohort. Serum ferritin levels and sleep disturbance severity are highlighted as potential markers for abnormal impulsivity and ICD in PD patients.
VL  - 5
IS  - 4
ER  -

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Author Information

Ryan Scott Anderton

School of Health Sciences and Institute for Health Research, University of Notre Dame Australia, Fremantle, Australia; Perron Institute for Neurological and Translational Science, Perth, Australia
Michelle Byrnes

Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia
Alexa Jefferson

Perron Institute for Neurological and Translational Science, Perth, Australia
Sue Walters

Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia
Soumya Ghosh

Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia
Rick Stell

Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia
Frank Louis Mastaglia

Perron Institute for Neurological and Translational Science, Perth, Australia; Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Australia; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia

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APA Style

Ryan Scott Anderton, Michelle Byrnes, Alexa Jefferson, Sue Walters, Soumya Ghosh, et al. (2017). Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients. American Journal of Psychiatry and Neuroscience, 5(4), 45-52. https://doi.org/10.11648/j.ajpn.20170504.12

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ACS Style

Ryan Scott Anderton; Michelle Byrnes; Alexa Jefferson; Sue Walters; Soumya Ghosh, et al. Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients. Am. J. Psychiatry Neurosci. 2017, 5(4), 45-52. doi: 10.11648/j.ajpn.20170504.12

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AMA Style

Ryan Scott Anderton, Michelle Byrnes, Alexa Jefferson, Sue Walters, Soumya Ghosh, et al. Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients. Am J Psychiatry Neurosci. 2017;5(4):45-52. doi: 10.11648/j.ajpn.20170504.12

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@article{10.11648/j.ajpn.20170504.12,
  author = {Ryan Scott Anderton and Michelle Byrnes and Alexa Jefferson and Sue Walters and Soumya Ghosh and Rick Stell and Frank Louis Mastaglia},
  title = {Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {5},
  number = {4},
  pages = {45-52},
  doi = {10.11648/j.ajpn.20170504.12},
  url = {https://doi.org/10.11648/j.ajpn.20170504.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20170504.12},
  abstract = {Impulse control disorders (ICDs) occur in a subset of Parkinson’s disease (PD) patients on dopaminergic medications however there are currently no reliable markers to identify patients at risk. Sleep disturbances are more common in patients with an ICD. Serum ferritin levels have been associated with PD disease stage and progression, but have not previously been associated with impulsivity levels. The objective of this study was to determine if serum ferritin levels and sleep disturbance are associated with high traits of impulsivity and ICD in a cohort of PD patients attending a movement disorders clinic. This study assessed impulsiveness in 87 PD patients using the Barratt Impulsiveness Scale. Severity of sleep disturbance was determined using the sleep-related items of the MDS-UPDRS. Serum ferritin, iron and transferrin levels were measured in patients, as well as 36 age-matched healthy controls. Serum ferritin levels were significantly elevated in male PD patients in the high impulsivity group compared to patients in the low (p=.022) and normal range groups (p=.024) and showed a linear increase across the three groups. Sleep disturbance also demonstrated a linear trend, which was most severe in the high impulsivity group (p=.030). A subgroup of 11 male PD patients who fulfilled the DSM-5 criteria for an ICD had significantly higher ferritin levels and more severe sleep disturbance when compared with the remaining male PD cohort. Serum ferritin levels and sleep disturbance severity are highlighted as potential markers for abnormal impulsivity and ICD in PD patients.},
 year = {2017}
}

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TY  - JOUR
T1  - Sleep Disturbance and Serum Ferritin Levels Associate with High Impulsivity and Impulse Control Disorders in Male Parkinson’s Disease Patients
AU  - Ryan Scott Anderton
AU  - Michelle Byrnes
AU  - Alexa Jefferson
AU  - Sue Walters
AU  - Soumya Ghosh
AU  - Rick Stell
AU  - Frank Louis Mastaglia
Y1  - 2017/08/26
PY  - 2017
N1  - https://doi.org/10.11648/j.ajpn.20170504.12
DO  - 10.11648/j.ajpn.20170504.12
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 45
EP  - 52
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20170504.12
AB  - Impulse control disorders (ICDs) occur in a subset of Parkinson’s disease (PD) patients on dopaminergic medications however there are currently no reliable markers to identify patients at risk. Sleep disturbances are more common in patients with an ICD. Serum ferritin levels have been associated with PD disease stage and progression, but have not previously been associated with impulsivity levels. The objective of this study was to determine if serum ferritin levels and sleep disturbance are associated with high traits of impulsivity and ICD in a cohort of PD patients attending a movement disorders clinic. This study assessed impulsiveness in 87 PD patients using the Barratt Impulsiveness Scale. Severity of sleep disturbance was determined using the sleep-related items of the MDS-UPDRS. Serum ferritin, iron and transferrin levels were measured in patients, as well as 36 age-matched healthy controls. Serum ferritin levels were significantly elevated in male PD patients in the high impulsivity group compared to patients in the low (p=.022) and normal range groups (p=.024) and showed a linear increase across the three groups. Sleep disturbance also demonstrated a linear trend, which was most severe in the high impulsivity group (p=.030). A subgroup of 11 male PD patients who fulfilled the DSM-5 criteria for an ICD had significantly higher ferritin levels and more severe sleep disturbance when compared with the remaining male PD cohort. Serum ferritin levels and sleep disturbance severity are highlighted as potential markers for abnormal impulsivity and ICD in PD patients.
VL  - 5
IS  - 4
ER  -

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