Journal of Cancer Treatment and Research

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Vertebral Giant Cell Tumor: Diagnosis Difficulties and Therapeutics’ Challenges

Received: 09 April 2014    Accepted: 09 June 2014    Published: 20 June 2014
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Abstract

Giant cell tumor remains one of the most controversial and discussed bone tumors. Its diagnosis may be very difficult especially in vertebral localization as it requires a careful study of the pathology tissue. The authors report a series of four patients, treated in the MT Kassab orthopaedic Institute for vertebral giant cell tumor (GCT), with different clinical presentation and therapeutic strategies. By presenting those cases we point to surgical and medical treatments’ difficulties and the challenge of avoiding local recurrence and distant metastasis of this tumor.

DOI 10.11648/j.jctr.20140202.12
Published in Journal of Cancer Treatment and Research (Volume 2, Issue 2, March 2014)
Page(s) 16-20
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Giant Cell Tumor, Spine Surgery, Metastasis, MRI, Bisphosphonates

References
[1] Liu HS, Wang JW. Treatment of giant cell tumor of bone: A comparison of local curettage and wide resection. Chang Keng I Hsueh 1998; 21:37– 43.
[2] Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F (eds) - WHO Classification of tumours of soft tissue and bone. IARC: Lyon 2013.
[3] Su YP, Chen WM, Chen TH. Giant cell tumors of bone: an analysis of 87 cases. Int Orthop 2004;28:239-43.
[4] Oda Y, Miura H, Tsuneyoshi M, et al. Giant cell tumor of bone: Oncological and functional results of long-term follow-up. Jpn J Clin Oncol 1998; 28:323–328.
[5] Sanjay BK, Sim FH, Unni KK, McLeod RA, Klassen RA. Giant-cell tumours of the spine. J Bone Joint Surg Br. 1993; 75:148–154. [PubMed]
[6] S.Jacopin and al. Fatal lung metastasis secondary to index finger giant cell tumor in an 8-year-old child. Orthopaedic and Traumatology: Surgery and Research (2010) 96, 310-313.
[7] Cheng JC, Johnston JO (1997) Giant cell tumor of bone. Prognosis and treatment of pulmonary metastases. Clin Orthop Relat Res 338:205–214
[8] Jacopin and al. Fatal lung metastasis secondary to index finger giant cell tumor in 8-year-old child. Orthopaedics and traumatology: surgery and research (2010) 96, 310-313
[9] Lung Fung Tse and al. Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: A case-control study. Bone 42 (2008) 68-73
[10] Khan DC, Malhotra S, Stevens RE, et al. Radiotherapy for the treatment of giant cell tumor of the spine: a report of six cases and review of the literature. Cancer Invest 1999;17:110 –113.
[11] Masui F, Ushigome S, Fujii K. Giant cell tumor of bone: A clinicopathologic study of prognostic factors. Pathol Int 1998; 48:723–729.
Author Information
  • Orthopaedic Institute of MT Kassab, Tunisia

  • Orthopaedic Institute of MT Kassab, Tunisia

  • Orthopaedic Institute of MT Kassab, Tunisia

  • Orthopaedic Institute of MT Kassab, Tunisia

  • Orthopaedic Institute of MT Kassab, Tunisia

  • Orthopaedic Institute of MT Kassab, Tunisia

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  • APA Style

    Kherfani Abdelhakim, Amri Khalil, Hachem Mahjoub, Abid Leila, Bouaziz Mouna, et al. (2014). Vertebral Giant Cell Tumor: Diagnosis Difficulties and Therapeutics’ Challenges. Journal of Cancer Treatment and Research, 2(2), 16-20. https://doi.org/10.11648/j.jctr.20140202.12

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    ACS Style

    Kherfani Abdelhakim; Amri Khalil; Hachem Mahjoub; Abid Leila; Bouaziz Mouna, et al. Vertebral Giant Cell Tumor: Diagnosis Difficulties and Therapeutics’ Challenges. J. Cancer Treat. Res. 2014, 2(2), 16-20. doi: 10.11648/j.jctr.20140202.12

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    AMA Style

    Kherfani Abdelhakim, Amri Khalil, Hachem Mahjoub, Abid Leila, Bouaziz Mouna, et al. Vertebral Giant Cell Tumor: Diagnosis Difficulties and Therapeutics’ Challenges. J Cancer Treat Res. 2014;2(2):16-20. doi: 10.11648/j.jctr.20140202.12

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  • @article{10.11648/j.jctr.20140202.12,
      author = {Kherfani Abdelhakim and Amri Khalil and Hachem Mahjoub and Abid Leila and Bouaziz Mouna and Mestiri Mondher},
      title = {Vertebral Giant Cell Tumor: Diagnosis Difficulties and Therapeutics’ Challenges},
      journal = {Journal of Cancer Treatment and Research},
      volume = {2},
      number = {2},
      pages = {16-20},
      doi = {10.11648/j.jctr.20140202.12},
      url = {https://doi.org/10.11648/j.jctr.20140202.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jctr.20140202.12},
      abstract = {Giant cell tumor remains one of the most controversial and discussed bone tumors. Its diagnosis may be very difficult especially in vertebral localization as it requires a careful study of the pathology tissue. The authors report a series of four patients, treated in the MT Kassab orthopaedic Institute for vertebral giant cell tumor (GCT), with different clinical presentation and therapeutic strategies. By presenting those cases we point to surgical and medical treatments’ difficulties and the challenge of avoiding local recurrence and distant metastasis of this tumor.},
     year = {2014}
    }
    

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    AU  - Kherfani Abdelhakim
    AU  - Amri Khalil
    AU  - Hachem Mahjoub
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    JF  - Journal of Cancer Treatment and Research
    JO  - Journal of Cancer Treatment and Research
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    UR  - https://doi.org/10.11648/j.jctr.20140202.12
    AB  - Giant cell tumor remains one of the most controversial and discussed bone tumors. Its diagnosis may be very difficult especially in vertebral localization as it requires a careful study of the pathology tissue. The authors report a series of four patients, treated in the MT Kassab orthopaedic Institute for vertebral giant cell tumor (GCT), with different clinical presentation and therapeutic strategies. By presenting those cases we point to surgical and medical treatments’ difficulties and the challenge of avoiding local recurrence and distant metastasis of this tumor.
    VL  - 2
    IS  - 2
    ER  - 

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