A new series of Co(II) and Mn(II) complexes with the Flavone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cisplatin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytotoxic activity was tested by inhibition rate as parameter. The results showed significant differences (p<0.05) for each three treatments when the inhibition rates were increased. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands.
| Published in | Journal of Cancer Treatment and Research (Volume 5, Issue 2) |
| DOI | 10.11648/j.jctr.20170502.14 |
| Page(s) | 19-23 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Flavone, Complexes, Antimicrobial Activity, Cytotoxicity Cisplatin
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APA Style
Omar H. Al-Obaidi. (2017). Study of the Cytotoxicity Effect of New Co(II) and Mn(II) Complexes of Flavon on Cancer (Cell Line RD) and Antimicrobial Activity. Journal of Cancer Treatment and Research, 5(2), 19-23. https://doi.org/10.11648/j.jctr.20170502.14
ACS Style
Omar H. Al-Obaidi. Study of the Cytotoxicity Effect of New Co(II) and Mn(II) Complexes of Flavon on Cancer (Cell Line RD) and Antimicrobial Activity. J. Cancer Treat. Res. 2017, 5(2), 19-23. doi: 10.11648/j.jctr.20170502.14
AMA Style
Omar H. Al-Obaidi. Study of the Cytotoxicity Effect of New Co(II) and Mn(II) Complexes of Flavon on Cancer (Cell Line RD) and Antimicrobial Activity. J Cancer Treat Res. 2017;5(2):19-23. doi: 10.11648/j.jctr.20170502.14
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Download@article{10.11648/j.jctr.20170502.14,
author = {Omar H. Al-Obaidi},
title = {Study of the Cytotoxicity Effect of New Co(II) and Mn(II) Complexes of Flavon on Cancer (Cell Line RD) and Antimicrobial Activity},
journal = {Journal of Cancer Treatment and Research},
volume = {5},
number = {2},
pages = {19-23},
doi = {10.11648/j.jctr.20170502.14},
url = {https://doi.org/10.11648/j.jctr.20170502.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20170502.14},
abstract = {A new series of Co(II) and Mn(II) complexes with the Flavone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cisplatin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytotoxic activity was tested by inhibition rate as parameter. The results showed significant differences (p<0.05) for each three treatments when the inhibition rates were increased. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands.},
year = {2017}
}
TY - JOUR T1 - Study of the Cytotoxicity Effect of New Co(II) and Mn(II) Complexes of Flavon on Cancer (Cell Line RD) and Antimicrobial Activity AU - Omar H. Al-Obaidi Y1 - 2017/03/22 PY - 2017 N1 - https://doi.org/10.11648/j.jctr.20170502.14 DO - 10.11648/j.jctr.20170502.14 T2 - Journal of Cancer Treatment and Research JF - Journal of Cancer Treatment and Research JO - Journal of Cancer Treatment and Research SP - 19 EP - 23 PB - Science Publishing Group SN - 2376-7790 UR - https://doi.org/10.11648/j.jctr.20170502.14 AB - A new series of Co(II) and Mn(II) complexes with the Flavone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cisplatin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytotoxic activity was tested by inhibition rate as parameter. The results showed significant differences (p<0.05) for each three treatments when the inhibition rates were increased. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands. VL - 5 IS - 2 ER -
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