Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer <i>(</i>Cell Line <i>RD)</i> and Antimicribial Activity

Omar H. Al-Obaidi

doi:doi:10.11648/j.jctr.20170503.12

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Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer (Cell Line RD) and Antimicribial Activity

Omar H. Al-Obaidi

Published in Journal of Cancer Treatment and Research (Volume 5, Issue 3)

Received: 17 September 2016 Accepted: 17 March 2017 Published: 27 March 2017

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Abstract

"The new complexes of Cr(III), Mn (II), Fe(III) and Cu(II) complexes with the chalcone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cis-platin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytotoxic activity was tested by inhibition rate as parameter. The results showed significant differences (p<0.05) for each three treatments when the inhibition rates were increased. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands. The synthesized complexes have been screened for in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus, and new prepared complexes were compared with anticancer drug cis-platin."

Published in	Journal of Cancer Treatment and Research (Volume 5, Issue 3)
DOI	10.11648/j.jctr.20170503.12
Page(s)	39-42
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Chalcone, Complexes, Antimicrobial Activity, Cytotoxicity Cisplatin

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APA Style

Omar H. Al-Obaidi. (2017). Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer (Cell Line RD) and Antimicribial Activity. Journal of Cancer Treatment and Research, 5(3), 39-42. https://doi.org/10.11648/j.jctr.20170503.12

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ACS Style

Omar H. Al-Obaidi. Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer (Cell Line RD) and Antimicribial Activity. J. Cancer Treat. Res. 2017, 5(3), 39-42. doi: 10.11648/j.jctr.20170503.12

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AMA Style

Omar H. Al-Obaidi. Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer (Cell Line RD) and Antimicribial Activity. J Cancer Treat Res. 2017;5(3):39-42. doi: 10.11648/j.jctr.20170503.12

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@article{10.11648/j.jctr.20170503.12,
  author = {Omar H. Al-Obaidi},
  title = {Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer (Cell Line RD) and Antimicribial Activity},
  journal = {Journal of Cancer Treatment and Research},
  volume = {5},
  number = {3},
  pages = {39-42},
  doi = {10.11648/j.jctr.20170503.12},
  url = {https://doi.org/10.11648/j.jctr.20170503.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20170503.12},
  abstract = {"The new complexes of Cr(III), Mn (II), Fe(III) and Cu(II) complexes with the chalcone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cis-platin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytotoxic activity was tested by inhibition rate as parameter. The results showed significant differences (p<0.05) for each three treatments when the inhibition rates were increased. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands. The synthesized complexes have been screened for in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus, and new prepared complexes were compared with anticancer drug cis-platin."},
 year = {2017}
}

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TY  - JOUR
T1  - Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer (Cell Line RD) and Antimicribial Activity
AU  - Omar H. Al-Obaidi
Y1  - 2017/03/27
PY  - 2017
N1  - https://doi.org/10.11648/j.jctr.20170503.12
DO  - 10.11648/j.jctr.20170503.12
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 39
EP  - 42
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20170503.12
AB  - "The new complexes of Cr(III), Mn (II), Fe(III) and Cu(II) complexes with the chalcone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cis-platin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytotoxic activity was tested by inhibition rate as parameter. The results showed significant differences (p<0.05) for each three treatments when the inhibition rates were increased. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands. The synthesized complexes have been screened for in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus, and new prepared complexes were compared with anticancer drug cis-platin."
VL  - 5
IS  - 3
ER  -

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Author Information

Omar H. Al-Obaidi

Chemistry Department, Education College for Girls, Al-Anbar University, Ramadi, Iraq

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APA Style

Omar H. Al-Obaidi. (2017). Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer (Cell Line RD) and Antimicribial Activity. Journal of Cancer Treatment and Research, 5(3), 39-42. https://doi.org/10.11648/j.jctr.20170503.12

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ACS Style

Omar H. Al-Obaidi. Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer (Cell Line RD) and Antimicribial Activity. J. Cancer Treat. Res. 2017, 5(3), 39-42. doi: 10.11648/j.jctr.20170503.12

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AMA Style

Omar H. Al-Obaidi. Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer (Cell Line RD) and Antimicribial Activity. J Cancer Treat Res. 2017;5(3):39-42. doi: 10.11648/j.jctr.20170503.12

Copy | Download

@article{10.11648/j.jctr.20170503.12,
  author = {Omar H. Al-Obaidi},
  title = {Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer (Cell Line RD) and Antimicribial Activity},
  journal = {Journal of Cancer Treatment and Research},
  volume = {5},
  number = {3},
  pages = {39-42},
  doi = {10.11648/j.jctr.20170503.12},
  url = {https://doi.org/10.11648/j.jctr.20170503.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20170503.12},
  abstract = {"The new complexes of Cr(III), Mn (II), Fe(III) and Cu(II) complexes with the chalcone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cis-platin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytotoxic activity was tested by inhibition rate as parameter. The results showed significant differences (p<0.05) for each three treatments when the inhibition rates were increased. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands. The synthesized complexes have been screened for in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus, and new prepared complexes were compared with anticancer drug cis-platin."},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer (Cell Line RD) and Antimicribial Activity
AU  - Omar H. Al-Obaidi
Y1  - 2017/03/27
PY  - 2017
N1  - https://doi.org/10.11648/j.jctr.20170503.12
DO  - 10.11648/j.jctr.20170503.12
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 39
EP  - 42
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20170503.12
AB  - "The new complexes of Cr(III), Mn (II), Fe(III) and Cu(II) complexes with the chalcone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cis-platin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytotoxic activity was tested by inhibition rate as parameter. The results showed significant differences (p<0.05) for each three treatments when the inhibition rates were increased. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands. The synthesized complexes have been screened for in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus, and new prepared complexes were compared with anticancer drug cis-platin."
VL  - 5
IS  - 3
ER  -

Copy | Download