Journal of Cancer Treatment and Research

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Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis

Received: 24 March 2017    Accepted: 18 April 2017    Published: 20 June 2017
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Abstract

Mitochondria are dynamic intracellular organelles involved in many vital cellular functions. It is important to maintain good mitochondrial biogenesis and health. Mitochondrial dysfunction is known to be associated with many neurodegenerative diseases, such as, Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis. In the 1930’s Warburg described a link between mitochondrial function and tumorigenesis. Modern Medicine has fallen prey to the overusage and misuse of antibiotics. This minireview postulates that this misuse may attack the mitochondrion and alter host-antibiotic interactions that might cause serious pathophysiologic conditions. One such condition may be cancer which was proposed by Warburg and supported by our work on normal mitochondria organelle transplantation in cancer. Some groups of antibiotics attack targets that are shared by prokaryotes and mitochondria. This leads to mitochondrial dysfunction possibly promoting tumorigenesis and neurodegenerative conditions.

DOI 10.11648/j.jctr.20170504.11
Published in Journal of Cancer Treatment and Research (Volume 5, Issue 4, July 2017)
Page(s) 62-65
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Antibiotics, Mitochondria, Warburg Effect, Tumorigenesis

References
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Author Information
  • The Sallie Astor Burdine Breast Foundation Baton Rouge, LA, USA; Elliott-Baucom Breast Cancer Center, Baton Rouge, LA, USA

  • The Sallie Astor Burdine Breast Foundation Baton Rouge, LA, USA

  • Elliott-Baucom Breast Cancer Center, Baton Rouge, LA, USA

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  • APA Style

    Robert L. Elliott, Xian P. Jiang, Catherine C. Baucom. (2017). Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis. Journal of Cancer Treatment and Research, 5(4), 62-65. https://doi.org/10.11648/j.jctr.20170504.11

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    ACS Style

    Robert L. Elliott; Xian P. Jiang; Catherine C. Baucom. Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis. J. Cancer Treat. Res. 2017, 5(4), 62-65. doi: 10.11648/j.jctr.20170504.11

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    AMA Style

    Robert L. Elliott, Xian P. Jiang, Catherine C. Baucom. Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis. J Cancer Treat Res. 2017;5(4):62-65. doi: 10.11648/j.jctr.20170504.11

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  • @article{10.11648/j.jctr.20170504.11,
      author = {Robert L. Elliott and Xian P. Jiang and Catherine C. Baucom},
      title = {Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis},
      journal = {Journal of Cancer Treatment and Research},
      volume = {5},
      number = {4},
      pages = {62-65},
      doi = {10.11648/j.jctr.20170504.11},
      url = {https://doi.org/10.11648/j.jctr.20170504.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jctr.20170504.11},
      abstract = {Mitochondria are dynamic intracellular organelles involved in many vital cellular functions. It is important to maintain good mitochondrial biogenesis and health. Mitochondrial dysfunction is known to be associated with many neurodegenerative diseases, such as, Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis. In the 1930’s Warburg described a link between mitochondrial function and tumorigenesis. Modern Medicine has fallen prey to the overusage and misuse of antibiotics. This minireview postulates that this misuse may attack the mitochondrion and alter host-antibiotic interactions that might cause serious pathophysiologic conditions. One such condition may be cancer which was proposed by Warburg and supported by our work on normal mitochondria organelle transplantation in cancer. Some groups of antibiotics attack targets that are shared by prokaryotes and mitochondria. This leads to mitochondrial dysfunction possibly promoting tumorigenesis and neurodegenerative conditions.},
     year = {2017}
    }
    

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    T1  - Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis
    AU  - Robert L. Elliott
    AU  - Xian P. Jiang
    AU  - Catherine C. Baucom
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    T2  - Journal of Cancer Treatment and Research
    JF  - Journal of Cancer Treatment and Research
    JO  - Journal of Cancer Treatment and Research
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    EP  - 65
    PB  - Science Publishing Group
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    UR  - https://doi.org/10.11648/j.jctr.20170504.11
    AB  - Mitochondria are dynamic intracellular organelles involved in many vital cellular functions. It is important to maintain good mitochondrial biogenesis and health. Mitochondrial dysfunction is known to be associated with many neurodegenerative diseases, such as, Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis. In the 1930’s Warburg described a link between mitochondrial function and tumorigenesis. Modern Medicine has fallen prey to the overusage and misuse of antibiotics. This minireview postulates that this misuse may attack the mitochondrion and alter host-antibiotic interactions that might cause serious pathophysiologic conditions. One such condition may be cancer which was proposed by Warburg and supported by our work on normal mitochondria organelle transplantation in cancer. Some groups of antibiotics attack targets that are shared by prokaryotes and mitochondria. This leads to mitochondrial dysfunction possibly promoting tumorigenesis and neurodegenerative conditions.
    VL  - 5
    IS  - 4
    ER  - 

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