Journal of Cancer Treatment and Research

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Concordance Between Frozen Section and Permanent Section in Assessment of Resection Margins in Breast Conserving Surgery Among Patients with Breast Cancer

Received: 03 October 2017    Accepted: 01 November 2017    Published: 22 December 2017
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Abstract

Introduction: Breast cancer is considered as one of the most common malignancies among Iranian women and the most common cancer among women worldwide, with an incidence of over one million new cases per year worldwide, and is still the leading cause of morbidity in women with 411,000 cases per annum. The purpose of current study is to evaluate the compliance between samples of Frozen Section and Permanent section with respect to examination of the breast mass margin in breast conserving surgery. Methods and materials: Current study was retrospective cross-sectional study in which, 143 patients with BC were included via convenient sampling method. Our study’s sample was obtained from patients who referred to Shohada Tajrish Hospital (Tehran, Iran) between 2009-2011 and went through breast mass surgery; subsequently, their tissue samples were assessed and reported via frozen section and permanent section methods. Obtained data was assessed via SPSS-24 software. Results: Results of Chi-square test reported the chi-square is equal to 126.392 and the degree of freedom (dof)=2, which indicates that the data is three-layered; significance=0.000 confirmed rejection of the null hypothesis and the non-uniformity of the data. Hence, It can be inferred that data are valid and testable. In the t-test, the number of data is 143 and its mean is 1.028, which is the same as the descriptive statistics. However, it differs from the mean of the society, which should be considered our Inferential-test results. Our zero assumption seeks out the same results of both methods. The results of the research are not rejected by the significance of 0.481 above 0.05, and the results can be stated to be the same on average. Conclusion: According to the obtained data, compliance of the Frozen section and the Permanent section in the examination of marginal breast masses in Shohada Tajrish Hospital; two sampling modalities show higher than 77.6% similarity. Furthermore, Frozen section modality tend to be quicker procedure and the results can be delivered to surgeon and in result he may make more accurate therapeutic decisions and this may reduce number of anesthesia and surgical procedures on a patients. Hence, due to high concordance rate between results of Frozen section and permanent section plus competitive advantage of time saving in frozen section approach, this approach may be considered as gold standard approach regarding evaluation of tumoral and non-tumoral masses in the examination of the breast mass margin in breast conserving surgery.

DOI 10.11648/j.jctr.20170506.12
Published in Journal of Cancer Treatment and Research (Volume 5, Issue 6, November 2017)
Page(s) 90-94
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Breast-Conserving Surgery, Frozen Section, Permanent Section

References
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Author Information
  • Cancer Research Center, Shohada Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

  • Cancer Research Center, Shohada Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

  • Cancer Research Center, Shohada Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

  • Cancer Research Center, Shohada Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

  • Cancer Research Center, Shohada Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

  • Cancer Research Center, Shohada Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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    Mahsa Ahadi, Elena Jamali, Behrang Kazeminezhad, Tahmine Mollasharifi, Sara Kasraee, et al. (2017). Concordance Between Frozen Section and Permanent Section in Assessment of Resection Margins in Breast Conserving Surgery Among Patients with Breast Cancer. Journal of Cancer Treatment and Research, 5(6), 90-94. https://doi.org/10.11648/j.jctr.20170506.12

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    ACS Style

    Mahsa Ahadi; Elena Jamali; Behrang Kazeminezhad; Tahmine Mollasharifi; Sara Kasraee, et al. Concordance Between Frozen Section and Permanent Section in Assessment of Resection Margins in Breast Conserving Surgery Among Patients with Breast Cancer. J. Cancer Treat. Res. 2017, 5(6), 90-94. doi: 10.11648/j.jctr.20170506.12

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    AMA Style

    Mahsa Ahadi, Elena Jamali, Behrang Kazeminezhad, Tahmine Mollasharifi, Sara Kasraee, et al. Concordance Between Frozen Section and Permanent Section in Assessment of Resection Margins in Breast Conserving Surgery Among Patients with Breast Cancer. J Cancer Treat Res. 2017;5(6):90-94. doi: 10.11648/j.jctr.20170506.12

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  • @article{10.11648/j.jctr.20170506.12,
      author = {Mahsa Ahadi and Elena Jamali and Behrang Kazeminezhad and Tahmine Mollasharifi and Sara Kasraee and Afshin Moradi},
      title = {Concordance Between Frozen Section and Permanent Section in Assessment of Resection Margins in Breast Conserving Surgery Among Patients with Breast Cancer},
      journal = {Journal of Cancer Treatment and Research},
      volume = {5},
      number = {6},
      pages = {90-94},
      doi = {10.11648/j.jctr.20170506.12},
      url = {https://doi.org/10.11648/j.jctr.20170506.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jctr.20170506.12},
      abstract = {Introduction: Breast cancer is considered as one of the most common malignancies among Iranian women and the most common cancer among women worldwide, with an incidence of over one million new cases per year worldwide, and is still the leading cause of morbidity in women with 411,000 cases per annum. The purpose of current study is to evaluate the compliance between samples of Frozen Section and Permanent section with respect to examination of the breast mass margin in breast conserving surgery. Methods and materials: Current study was retrospective cross-sectional study in which, 143 patients with BC were included via convenient sampling method. Our study’s sample was obtained from patients who referred to Shohada Tajrish Hospital (Tehran, Iran) between 2009-2011 and went through breast mass surgery; subsequently, their tissue samples were assessed and reported via frozen section and permanent section methods. Obtained data was assessed via SPSS-24 software. Results: Results of Chi-square test reported the chi-square is equal to 126.392 and the degree of freedom (dof)=2, which indicates that the data is three-layered; significance=0.000 confirmed rejection of the null hypothesis and the non-uniformity of the data. Hence, It can be inferred that data are valid and testable. In the t-test, the number of data is 143 and its mean is 1.028, which is the same as the descriptive statistics. However, it differs from the mean of the society, which should be considered our Inferential-test results. Our zero assumption seeks out the same results of both methods. The results of the research are not rejected by the significance of 0.481 above 0.05, and the results can be stated to be the same on average. Conclusion: According to the obtained data, compliance of the Frozen section and the Permanent section in the examination of marginal breast masses in Shohada Tajrish Hospital; two sampling modalities show higher than 77.6% similarity. Furthermore, Frozen section modality tend to be quicker procedure and the results can be delivered to surgeon and in result he may make more accurate therapeutic decisions and this may reduce number of anesthesia and surgical procedures on a patients. Hence, due to high concordance rate between results of Frozen section and permanent section plus competitive advantage of time saving in frozen section approach, this approach may be considered as gold standard approach regarding evaluation of tumoral and non-tumoral masses in the examination of the breast mass margin in breast conserving surgery.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Concordance Between Frozen Section and Permanent Section in Assessment of Resection Margins in Breast Conserving Surgery Among Patients with Breast Cancer
    AU  - Mahsa Ahadi
    AU  - Elena Jamali
    AU  - Behrang Kazeminezhad
    AU  - Tahmine Mollasharifi
    AU  - Sara Kasraee
    AU  - Afshin Moradi
    Y1  - 2017/12/22
    PY  - 2017
    N1  - https://doi.org/10.11648/j.jctr.20170506.12
    DO  - 10.11648/j.jctr.20170506.12
    T2  - Journal of Cancer Treatment and Research
    JF  - Journal of Cancer Treatment and Research
    JO  - Journal of Cancer Treatment and Research
    SP  - 90
    EP  - 94
    PB  - Science Publishing Group
    SN  - 2376-7790
    UR  - https://doi.org/10.11648/j.jctr.20170506.12
    AB  - Introduction: Breast cancer is considered as one of the most common malignancies among Iranian women and the most common cancer among women worldwide, with an incidence of over one million new cases per year worldwide, and is still the leading cause of morbidity in women with 411,000 cases per annum. The purpose of current study is to evaluate the compliance between samples of Frozen Section and Permanent section with respect to examination of the breast mass margin in breast conserving surgery. Methods and materials: Current study was retrospective cross-sectional study in which, 143 patients with BC were included via convenient sampling method. Our study’s sample was obtained from patients who referred to Shohada Tajrish Hospital (Tehran, Iran) between 2009-2011 and went through breast mass surgery; subsequently, their tissue samples were assessed and reported via frozen section and permanent section methods. Obtained data was assessed via SPSS-24 software. Results: Results of Chi-square test reported the chi-square is equal to 126.392 and the degree of freedom (dof)=2, which indicates that the data is three-layered; significance=0.000 confirmed rejection of the null hypothesis and the non-uniformity of the data. Hence, It can be inferred that data are valid and testable. In the t-test, the number of data is 143 and its mean is 1.028, which is the same as the descriptive statistics. However, it differs from the mean of the society, which should be considered our Inferential-test results. Our zero assumption seeks out the same results of both methods. The results of the research are not rejected by the significance of 0.481 above 0.05, and the results can be stated to be the same on average. Conclusion: According to the obtained data, compliance of the Frozen section and the Permanent section in the examination of marginal breast masses in Shohada Tajrish Hospital; two sampling modalities show higher than 77.6% similarity. Furthermore, Frozen section modality tend to be quicker procedure and the results can be delivered to surgeon and in result he may make more accurate therapeutic decisions and this may reduce number of anesthesia and surgical procedures on a patients. Hence, due to high concordance rate between results of Frozen section and permanent section plus competitive advantage of time saving in frozen section approach, this approach may be considered as gold standard approach regarding evaluation of tumoral and non-tumoral masses in the examination of the breast mass margin in breast conserving surgery.
    VL  - 5
    IS  - 6
    ER  - 

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