Journal of Cancer Treatment and Research

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MicroRNA95 May Be Involved in Oligometastatic Prostate Cancer

Received: 17 June 2019    Accepted: 19 July 2019    Published: 06 August 2019
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Abstract

The oligometastatic status in the prostate is a new entity of metastatic patients in which their treatment allows to improve survival over standard treatments. There are several theories about their biological origin, one of them being alterations in the expression of miRNas This. was a retrospective multicentre study undertaken in patients with oligometastatic prostate cancer who were diagnosed and treated at one of 7 different Spanish healthcare centres. METHODS: The study included 22 patients; healthy and primary tumour biopsy tissue was analysed in 7+2 of them in order to determine if they had a characteristic microRNA expression profile. We quantified the expression of the following miRNAs: mir‑200a, mir‑200b, mir‑200c, mir‑210, mir‑95, mir‑96, mir‑654‑3p, mir‑543‑3p, mir‑21, mir‑16‑5p, mir‑191‑5p, and mir‑93‑5p, with the latter three being endogenous‑expression controls. RESULTS: Our results show that miRNA95, and to a lesser extent, miRNA654‑3p, were significantly underexpressed (or their expression was suppressed) in tumour tissue samples compared to normal perilesional tissue in all our patients; miRNA95 was underexpressed in 67% of the patients in our sample However, we detected no relationship between miRNA95 expression and the Gleason scores obtained for our patients. CONCLUSIONS: The simple size in our series are limited, but they do allow us to infer that there could be a specific miRNA expression signature in oligometastatic patients with prostate cancer, which may be of great interest in the development of future clinical trials and subsequent studies.

DOI 10.11648/j.jctr.20190702.12
Published in Journal of Cancer Treatment and Research (Volume 7, Issue 2, June 2019)
Page(s) 33-40
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Microrna, Paraffin Blocks, Prostate Cancer, MetÁstasis Biology, Oligometastasis

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Author Information
  • Radiation Oncology Department, Provincial Hospital Consortium of Castellón, Castellón, Spain

  • Molecular Biology Department, Provincial Hospital Consortium of Castellón, Castellón, Spain

  • Radiation Oncology, International Hospital Ruber, Madrid, Spain

  • Radiation Oncology, Hospital Ramony Cajal, Madrid, Spain

  • Radiation Oncology, Hospital Virgen de la Arrixaca, Murcia, Spain

  • Radiation Oncology, Hospital Virgen de la Arrixaca, Murcia, Spain

  • Radiation Oncology, lmar Hospital, Barcelona, Spain

  • Pathology Department, Private Laboratory Dra Ramos, Valencia, Spain

  • Radiation Oncology Department, University Hospital la Fe, Valencia, Spain

  • Molecular Biology Department, Provincial Hospital Consortium of Castellón, Castellón, Spain

  • Molecular Biology Department, Provincial Hospital Consortium of Castellón, Castellón, Spain

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    Carlos Ferrer Albiach, Enrique Ochoa Aranda, Alfonso Gomez Iturriaga-Piña, Amalia Sotoca Ruiz, Fernando López Campos, et al. (2019). MicroRNA95 May Be Involved in Oligometastatic Prostate Cancer. Journal of Cancer Treatment and Research, 7(2), 33-40. https://doi.org/10.11648/j.jctr.20190702.12

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    ACS Style

    Carlos Ferrer Albiach; Enrique Ochoa Aranda; Alfonso Gomez Iturriaga-Piña; Amalia Sotoca Ruiz; Fernando López Campos, et al. MicroRNA95 May Be Involved in Oligometastatic Prostate Cancer. J. Cancer Treat. Res. 2019, 7(2), 33-40. doi: 10.11648/j.jctr.20190702.12

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    AMA Style

    Carlos Ferrer Albiach, Enrique Ochoa Aranda, Alfonso Gomez Iturriaga-Piña, Amalia Sotoca Ruiz, Fernando López Campos, et al. MicroRNA95 May Be Involved in Oligometastatic Prostate Cancer. J Cancer Treat Res. 2019;7(2):33-40. doi: 10.11648/j.jctr.20190702.12

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  • @article{10.11648/j.jctr.20190702.12,
      author = {Carlos Ferrer Albiach and Enrique Ochoa Aranda and Alfonso Gomez Iturriaga-Piña and Amalia Sotoca Ruiz and Fernando López Campos and Mariano Porras Martinez and Raquel García Gómez and Manel Algara Lopez and Virginia Ramos Fernandez and Antonio Conde Moreno and Susana Ors and Esther Flores and Francisco Garcia Piñón},
      title = {MicroRNA95 May Be Involved in Oligometastatic Prostate Cancer},
      journal = {Journal of Cancer Treatment and Research},
      volume = {7},
      number = {2},
      pages = {33-40},
      doi = {10.11648/j.jctr.20190702.12},
      url = {https://doi.org/10.11648/j.jctr.20190702.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jctr.20190702.12},
      abstract = {The oligometastatic status in the prostate is a new entity of metastatic patients in which their treatment allows to improve survival over standard treatments. There are several theories about their biological origin, one of them being alterations in the expression of miRNas This. was a retrospective multicentre study undertaken in patients with oligometastatic prostate cancer who were diagnosed and treated at one of 7 different Spanish healthcare centres. METHODS: The study included 22 patients; healthy and primary tumour biopsy tissue was analysed in 7+2 of them in order to determine if they had a characteristic microRNA expression profile. We quantified the expression of the following miRNAs: mir‑200a, mir‑200b, mir‑200c, mir‑210, mir‑95, mir‑96, mir‑654‑3p, mir‑543‑3p, mir‑21, mir‑16‑5p, mir‑191‑5p, and mir‑93‑5p, with the latter three being endogenous‑expression controls. RESULTS: Our results show that miRNA95, and to a lesser extent, miRNA654‑3p, were significantly underexpressed (or their expression was suppressed) in tumour tissue samples compared to normal perilesional tissue in all our patients; miRNA95 was underexpressed in 67% of the patients in our sample However, we detected no relationship between miRNA95 expression and the Gleason scores obtained for our patients. CONCLUSIONS: The simple size in our series are limited, but they do allow us to infer that there could be a specific miRNA expression signature in oligometastatic patients with prostate cancer, which may be of great interest in the development of future clinical trials and subsequent studies.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - MicroRNA95 May Be Involved in Oligometastatic Prostate Cancer
    AU  - Carlos Ferrer Albiach
    AU  - Enrique Ochoa Aranda
    AU  - Alfonso Gomez Iturriaga-Piña
    AU  - Amalia Sotoca Ruiz
    AU  - Fernando López Campos
    AU  - Mariano Porras Martinez
    AU  - Raquel García Gómez
    AU  - Manel Algara Lopez
    AU  - Virginia Ramos Fernandez
    AU  - Antonio Conde Moreno
    AU  - Susana Ors
    AU  - Esther Flores
    AU  - Francisco Garcia Piñón
    Y1  - 2019/08/06
    PY  - 2019
    N1  - https://doi.org/10.11648/j.jctr.20190702.12
    DO  - 10.11648/j.jctr.20190702.12
    T2  - Journal of Cancer Treatment and Research
    JF  - Journal of Cancer Treatment and Research
    JO  - Journal of Cancer Treatment and Research
    SP  - 33
    EP  - 40
    PB  - Science Publishing Group
    SN  - 2376-7790
    UR  - https://doi.org/10.11648/j.jctr.20190702.12
    AB  - The oligometastatic status in the prostate is a new entity of metastatic patients in which their treatment allows to improve survival over standard treatments. There are several theories about their biological origin, one of them being alterations in the expression of miRNas This. was a retrospective multicentre study undertaken in patients with oligometastatic prostate cancer who were diagnosed and treated at one of 7 different Spanish healthcare centres. METHODS: The study included 22 patients; healthy and primary tumour biopsy tissue was analysed in 7+2 of them in order to determine if they had a characteristic microRNA expression profile. We quantified the expression of the following miRNAs: mir‑200a, mir‑200b, mir‑200c, mir‑210, mir‑95, mir‑96, mir‑654‑3p, mir‑543‑3p, mir‑21, mir‑16‑5p, mir‑191‑5p, and mir‑93‑5p, with the latter three being endogenous‑expression controls. RESULTS: Our results show that miRNA95, and to a lesser extent, miRNA654‑3p, were significantly underexpressed (or their expression was suppressed) in tumour tissue samples compared to normal perilesional tissue in all our patients; miRNA95 was underexpressed in 67% of the patients in our sample However, we detected no relationship between miRNA95 expression and the Gleason scores obtained for our patients. CONCLUSIONS: The simple size in our series are limited, but they do allow us to infer that there could be a specific miRNA expression signature in oligometastatic patients with prostate cancer, which may be of great interest in the development of future clinical trials and subsequent studies.
    VL  - 7
    IS  - 2
    ER  - 

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