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Pattern of Distant Metastases and Promising Prognostic Factors in Bladder Cancer: A Population-Based Study
Journal of Cancer Treatment and Research
Volume 8, Issue 1, March 2020, Pages: 1-9
Received: Dec. 19, 2019; Accepted: Dec. 30, 2019; Published: Jan. 8, 2020
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Yanbo Xu, Department of Surgical Oncology, the Second Affiliated Hospital of Zhejiang University, Hangzhou, China
Hong Liu, Department of Medical Oncology, the Second Affiliated Hospital of Zhejiang University, Hangzhou, China
Yue Liu, Department of Surgical Oncology, the Second Affiliated Hospital of Zhejiang University, Hangzhou, China
Qihua Cao, Department of Surgical Oncology, the Second Affiliated Hospital of Zhejiang University, Hangzhou, China
Dong Xu, Department of Surgical Oncology and Cancer Institute, the Second Affiliated Hospital of Zhejiang University, Hangzhou, China
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The aims of this study were to evaluate the incidence and survival rates of distant metastases in newly diagnosed bladder cancer patients, and to investigate the risk and prognostic factors as well. The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for the incidence and survival rates of patients diagnosed with bladder cancer between 2010–2015. Multivariate logistic regression analyses identified risk factors for distant metastases. The survival rates were calculated by Kaplan Meier analysis. Cox regression and Fine and Grey’s model analyses were used to estimate prognostic factors associated with metastatic bladder cancers. Totally, there were 65541 patients with bladder cancer obtained from the SEER database, and 2812 were diagnosed with distant metastases on initial diagnosis (4.3%). Metastatic distribution information was concluded liver, lung, bone, brain and others. Of these, 1029 patients were bone metastases, 988 patients were lung metastases, 687 patients were liver metastases and 97 patients were brain metastases. As a result, younger age, unmarried social status, Black race, non-transitional cell carcinoma subtypes, poor differentiated grade, increased tumor stage and lymph node stage, absence of surgery to primary sites or unknown were all significantly associated with early distant metastases by logistic regression. Multivariate Cox regression analysis showed that older age, female, unmarried social status, non-TCC subtypes, increased number of metastatic sites and absence of surgery to primary sites were significantly associated with reduced overall survival. These findings in metastatic bladder cancer may help to arrange thorough evaluation and then make individualized treatment plan.
Bladder Cancer, Metastasis, Incidence, Prognosis
To cite this article
Yanbo Xu, Hong Liu, Yue Liu, Qihua Cao, Dong Xu, Pattern of Distant Metastases and Promising Prognostic Factors in Bladder Cancer: A Population-Based Study, Journal of Cancer Treatment and Research. Vol. 8, No. 1, 2020, pp. 1-9. doi: 10.11648/j.jctr.20200801.11
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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