Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats

Badkook Maha

doi:doi:10.11648/j.ajbls.20130101.11

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Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats

Badkook Maha

Published in American Journal of Biomedical and Life Sciences (Volume 1, Issue 1)

Received: 26 April 2013 Accepted: Published: 30 May 2013

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Abstract

Purpose: To investigate the effect of turmeric supplement (T), fermented milk with Probiotic strain Bifidobacterium lactis DN-173 010 (P), a combination of (T+P) on glycemia, lipidemia, and oxidative status in streptozotocin–induced diabetic rats.Materials and methods: Thirty male albino diabetic rats were fed a normal diet and divided to groups (n=6/group) according to the following treatments for 45 days: Turmeric (T) (225mg/kg/d), fermented milk Probiotics (P) (0.5ml/kg/d), Turmeric-Probiotics combination (T+ P) (225mg/kg/d + 0.5ml/kg/d), Oral hypoglycemic agent (OHA) (0.5 ml of glibenclamide; 450 µg/kg/day), and non-treated (DM). Blood glucose and glycayted hemoglobin were determined after diabetes induction and at the end of experiment. Serum insulin, total cholesterol (TC), LDL-C, HDL-C, TG, malondialdehyde (MDA), and total antioxidant capacity (TOAC) biomarker of oxidative stress were determined at the end of experiment. Results: All treatments resulted in a decrease in glucose and HbA1C compared to pretreatment. No difference in insulin concentration was observed. Serum TC was reduced by (T), while LDL-C decreased with (T) and (T+P) treatments. HDL-C was elevated with all treatments compared to control and (OHA) groups. MDA decreased with all treatments. TOAC was elevated with (T) and (T+P) but not with (P) treatment. Conclusion: Administration of Turmeric, Probiotics, and T+P combination were capable in attenuating hyperglycemia, dyslipidemia and oxidative stress initiated by STZ. However, (T) and (T+P) exerted a more potent hypolipidemic, and antioxidative effect compared to (P) alone.

Published in	American Journal of Biomedical and Life Sciences (Volume 1, Issue 1)
DOI	10.11648/j.ajbls.20130101.11
Page(s)	1-7
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diabetes, Oxidative Stress, Probiotics, Curcumin, Supplement

References

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Badkook Maha. (2013). Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats. American Journal of Biomedical and Life Sciences, 1(1), 1-7. https://doi.org/10.11648/j.ajbls.20130101.11

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ACS Style

Badkook Maha. Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats. Am. J. Biomed. Life Sci. 2013, 1(1), 1-7. doi: 10.11648/j.ajbls.20130101.11

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AMA Style

Badkook Maha. Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats. Am J Biomed Life Sci. 2013;1(1):1-7. doi: 10.11648/j.ajbls.20130101.11

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@article{10.11648/j.ajbls.20130101.11,
  author = {Badkook Maha},
  title = {Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {1},
  number = {1},
  pages = {1-7},
  doi = {10.11648/j.ajbls.20130101.11},
  url = {https://doi.org/10.11648/j.ajbls.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20130101.11},
  abstract = {Purpose: To investigate the effect of turmeric supplement (T), fermented milk with Probiotic strain Bifidobacterium lactis DN-173 010 (P), a combination of (T+P) on glycemia, lipidemia, and oxidative status in streptozotocin–induced diabetic rats.Materials and methods: Thirty male albino diabetic rats were fed a normal diet and divided to groups (n=6/group) according to the following treatments for 45 days: Turmeric (T) (225mg/kg/d), fermented milk Probiotics (P) (0.5ml/kg/d), Turmeric-Probiotics combination (T+ P) (225mg/kg/d + 0.5ml/kg/d), Oral hypoglycemic agent (OHA) (0.5 ml of glibenclamide; 450 µg/kg/day), and non-treated (DM). Blood glucose and glycayted hemoglobin were determined after diabetes induction and at the end of experiment. Serum insulin, total cholesterol (TC), LDL-C, HDL-C, TG, malondialdehyde (MDA), and total antioxidant capacity (TOAC) biomarker of oxidative stress were determined at the end of experiment. Results: All treatments resulted in a decrease in glucose and HbA1C compared to pretreatment. No difference in insulin concentration was observed. Serum TC was reduced by (T), while LDL-C decreased with (T) and (T+P) treatments. HDL-C was elevated with all treatments compared to control and (OHA) groups. MDA decreased with all treatments. TOAC was elevated with (T) and (T+P) but not with (P) treatment. Conclusion: Administration of Turmeric, Probiotics, and T+P combination were capable in attenuating hyperglycemia, dyslipidemia and oxidative stress initiated by STZ. However, (T) and (T+P) exerted a more potent hypolipidemic, and antioxidative effect compared to (P) alone.},
 year = {2013}
}

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TY  - JOUR
T1  - Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats
AU  - Badkook Maha
Y1  - 2013/05/30
PY  - 2013
N1  - https://doi.org/10.11648/j.ajbls.20130101.11
DO  - 10.11648/j.ajbls.20130101.11
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 1
EP  - 7
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20130101.11
AB  - Purpose: To investigate the effect of turmeric supplement (T), fermented milk with Probiotic strain Bifidobacterium lactis DN-173 010 (P), a combination of (T+P) on glycemia, lipidemia, and oxidative status in streptozotocin–induced diabetic rats.Materials and methods: Thirty male albino diabetic rats were fed a normal diet and divided to groups (n=6/group) according to the following treatments for 45 days: Turmeric (T) (225mg/kg/d), fermented milk Probiotics (P) (0.5ml/kg/d), Turmeric-Probiotics combination (T+ P) (225mg/kg/d + 0.5ml/kg/d), Oral hypoglycemic agent (OHA) (0.5 ml of glibenclamide; 450 µg/kg/day), and non-treated (DM). Blood glucose and glycayted hemoglobin were determined after diabetes induction and at the end of experiment. Serum insulin, total cholesterol (TC), LDL-C, HDL-C, TG, malondialdehyde (MDA), and total antioxidant capacity (TOAC) biomarker of oxidative stress were determined at the end of experiment. Results: All treatments resulted in a decrease in glucose and HbA1C compared to pretreatment. No difference in insulin concentration was observed. Serum TC was reduced by (T), while LDL-C decreased with (T) and (T+P) treatments. HDL-C was elevated with all treatments compared to control and (OHA) groups. MDA decreased with all treatments. TOAC was elevated with (T) and (T+P) but not with (P) treatment. Conclusion: Administration of Turmeric, Probiotics, and T+P combination were capable in attenuating hyperglycemia, dyslipidemia and oxidative stress initiated by STZ. However, (T) and (T+P) exerted a more potent hypolipidemic, and antioxidative effect compared to (P) alone.
VL  - 1
IS  - 1
ER  -

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Author Information

Badkook Maha

Department of Food and Nutrition, King AbdulAziz University, Jeddah, Saudi Arabia

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Badkook Maha. (2013). Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats. American Journal of Biomedical and Life Sciences, 1(1), 1-7. https://doi.org/10.11648/j.ajbls.20130101.11

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ACS Style

Badkook Maha. Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats. Am. J. Biomed. Life Sci. 2013, 1(1), 1-7. doi: 10.11648/j.ajbls.20130101.11

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AMA Style

Badkook Maha. Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats. Am J Biomed Life Sci. 2013;1(1):1-7. doi: 10.11648/j.ajbls.20130101.11

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@article{10.11648/j.ajbls.20130101.11,
  author = {Badkook Maha},
  title = {Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {1},
  number = {1},
  pages = {1-7},
  doi = {10.11648/j.ajbls.20130101.11},
  url = {https://doi.org/10.11648/j.ajbls.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20130101.11},
  abstract = {Purpose: To investigate the effect of turmeric supplement (T), fermented milk with Probiotic strain Bifidobacterium lactis DN-173 010 (P), a combination of (T+P) on glycemia, lipidemia, and oxidative status in streptozotocin–induced diabetic rats.Materials and methods: Thirty male albino diabetic rats were fed a normal diet and divided to groups (n=6/group) according to the following treatments for 45 days: Turmeric (T) (225mg/kg/d), fermented milk Probiotics (P) (0.5ml/kg/d), Turmeric-Probiotics combination (T+ P) (225mg/kg/d + 0.5ml/kg/d), Oral hypoglycemic agent (OHA) (0.5 ml of glibenclamide; 450 µg/kg/day), and non-treated (DM). Blood glucose and glycayted hemoglobin were determined after diabetes induction and at the end of experiment. Serum insulin, total cholesterol (TC), LDL-C, HDL-C, TG, malondialdehyde (MDA), and total antioxidant capacity (TOAC) biomarker of oxidative stress were determined at the end of experiment. Results: All treatments resulted in a decrease in glucose and HbA1C compared to pretreatment. No difference in insulin concentration was observed. Serum TC was reduced by (T), while LDL-C decreased with (T) and (T+P) treatments. HDL-C was elevated with all treatments compared to control and (OHA) groups. MDA decreased with all treatments. TOAC was elevated with (T) and (T+P) but not with (P) treatment. Conclusion: Administration of Turmeric, Probiotics, and T+P combination were capable in attenuating hyperglycemia, dyslipidemia and oxidative stress initiated by STZ. However, (T) and (T+P) exerted a more potent hypolipidemic, and antioxidative effect compared to (P) alone.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats
AU  - Badkook Maha
Y1  - 2013/05/30
PY  - 2013
N1  - https://doi.org/10.11648/j.ajbls.20130101.11
DO  - 10.11648/j.ajbls.20130101.11
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 1
EP  - 7
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20130101.11
AB  - Purpose: To investigate the effect of turmeric supplement (T), fermented milk with Probiotic strain Bifidobacterium lactis DN-173 010 (P), a combination of (T+P) on glycemia, lipidemia, and oxidative status in streptozotocin–induced diabetic rats.Materials and methods: Thirty male albino diabetic rats were fed a normal diet and divided to groups (n=6/group) according to the following treatments for 45 days: Turmeric (T) (225mg/kg/d), fermented milk Probiotics (P) (0.5ml/kg/d), Turmeric-Probiotics combination (T+ P) (225mg/kg/d + 0.5ml/kg/d), Oral hypoglycemic agent (OHA) (0.5 ml of glibenclamide; 450 µg/kg/day), and non-treated (DM). Blood glucose and glycayted hemoglobin were determined after diabetes induction and at the end of experiment. Serum insulin, total cholesterol (TC), LDL-C, HDL-C, TG, malondialdehyde (MDA), and total antioxidant capacity (TOAC) biomarker of oxidative stress were determined at the end of experiment. Results: All treatments resulted in a decrease in glucose and HbA1C compared to pretreatment. No difference in insulin concentration was observed. Serum TC was reduced by (T), while LDL-C decreased with (T) and (T+P) treatments. HDL-C was elevated with all treatments compared to control and (OHA) groups. MDA decreased with all treatments. TOAC was elevated with (T) and (T+P) but not with (P) treatment. Conclusion: Administration of Turmeric, Probiotics, and T+P combination were capable in attenuating hyperglycemia, dyslipidemia and oxidative stress initiated by STZ. However, (T) and (T+P) exerted a more potent hypolipidemic, and antioxidative effect compared to (P) alone.
VL  - 1
IS  - 1
ER  -

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