Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats
Purpose: To investigate the effect of turmeric supplement (T), fermented milk with Probiotic strain Bifidobacterium lactis DN-173 010 (P), a combination of (T+P) on glycemia, lipidemia, and oxidative status in streptozotocin–induced diabetic rats.Materials and methods: Thirty male albino diabetic rats were fed a normal diet and divided to groups (n=6/group) according to the following treatments for 45 days: Turmeric (T) (225mg/kg/d), fermented milk Probiotics (P) (0.5ml/kg/d), Turmeric-Probiotics combination (T+ P) (225mg/kg/d + 0.5ml/kg/d), Oral hypoglycemic agent (OHA) (0.5 ml of glibenclamide; 450 µg/kg/day), and non-treated (DM). Blood glucose and glycayted hemoglobin were determined after diabetes induction and at the end of experiment. Serum insulin, total cholesterol (TC), LDL-C, HDL-C, TG, malondialdehyde (MDA), and total antioxidant capacity (TOAC) biomarker of oxidative stress were determined at the end of experiment. Results: All treatments resulted in a decrease in glucose and HbA1C compared to pretreatment. No difference in insulin concentration was observed. Serum TC was reduced by (T), while LDL-C decreased with (T) and (T+P) treatments. HDL-C was elevated with all treatments compared to control and (OHA) groups. MDA decreased with all treatments. TOAC was elevated with (T) and (T+P) but not with (P) treatment. Conclusion: Administration of Turmeric, Probiotics, and T+P combination were capable in attenuating hyperglycemia, dyslipidemia and oxidative stress initiated by STZ. However, (T) and (T+P) exerted a more potent hypolipidemic, and antioxidative effect compared to (P) alone.
Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats, American Journal of Biomedical and Life Sciences.
Vol. 1, No. 1,
2013, pp. 1-7.
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