The certain sea cucumbers are the marine animals which are important as human delicacy food source. In addition a number of unique biological and pharmacological active compounds have been ascribed to various species of sea cucumbers. In current work the collagen peptides (CPs) from the bodies of the far-eastern holothurians (sea cucumber) Apostichopus japonicus and Cucumaria japonica by treated with a complex of proteolytic enzymes from Kamchatka crab Paralithodes camtschaticus were obtained, and the antitumor, anticoagulant, anti-inflammatory, and wound healing properties these CPs were estimated. The element and amino acid analysis of CPs from trepang and cucumaria are suggested that it’s could be regarded as a typical collagen fragments containing 6% sulfated carbohydrate and/or amino acid residues. CPs inhibited growth and progression solid Erlich tumor, but not in alike degree. Our results clearly showed, that these CPs possessed the moderate anticoagulant activity, and are preferential inhibitors of the initial link of the blood coagulation system. We also determined that the CPs revealed significant wound healing effect in regarding to thermal wounds and have high anti-inflammatory activity by used carrageenane model of acute inflammatory. Apparently, that the degree of biological activity depend on characteristics of amino acid composition and concentration of CPs. Taken together, these results indicate that CPs from sea cucumbers have similar to biological activities with other collagen peptides (components of the extracellular matrix, endostatin and others) and sulfated polysaccharides. We proposed that the obtained CPs may be applied as components functional food and nontoxic remedies of supplementary therapy for prevention and treatment of various diseases.
| Published in | American Journal of Biomedical and Life Sciences (Volume 1, Issue 1) |
| DOI | 10.11648/j.ajbls.20130101.14 |
| Page(s) | 17-26 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Bioactive Peptides, Collagen Peptides, Sea Cucumber, Marine Drugs, Functional Food, Biological Activity
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APA Style
Popov A., Popov A., Artyukov A., Krivoshapko O., Kozlovskaya E. (2013). Biological activities of collagen peptides obtained by enzymic Hydrolysis from Far-Eastern holothurians. American Journal of Biomedical and Life Sciences, 1(1), 17-26. https://doi.org/10.11648/j.ajbls.20130101.14
ACS Style
Popov A.; Popov A.; Artyukov A.; Krivoshapko O.; Kozlovskaya E. Biological activities of collagen peptides obtained by enzymic Hydrolysis from Far-Eastern holothurians. Am. J. Biomed. Life Sci. 2013, 1(1), 17-26. doi: 10.11648/j.ajbls.20130101.14
AMA Style
Popov A., Popov A., Artyukov A., Krivoshapko O., Kozlovskaya E. Biological activities of collagen peptides obtained by enzymic Hydrolysis from Far-Eastern holothurians. Am J Biomed Life Sci. 2013;1(1):17-26. doi: 10.11648/j.ajbls.20130101.14
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Download@article{10.11648/j.ajbls.20130101.14,
author = {Popov A. and Popov A. and Artyukov A. and Krivoshapko O. and Kozlovskaya E.},
title = {Biological activities of collagen peptides obtained by enzymic Hydrolysis from Far-Eastern holothurians},
journal = {American Journal of Biomedical and Life Sciences},
volume = {1},
number = {1},
pages = {17-26},
doi = {10.11648/j.ajbls.20130101.14},
url = {https://doi.org/10.11648/j.ajbls.20130101.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20130101.14},
abstract = {The certain sea cucumbers are the marine animals which are important as human delicacy food source. In addition a number of unique biological and pharmacological active compounds have been ascribed to various species of sea cucumbers. In current work the collagen peptides (CPs) from the bodies of the far-eastern holothurians (sea cucumber) Apostichopus japonicus and Cucumaria japonica by treated with a complex of proteolytic enzymes from Kamchatka crab Paralithodes camtschaticus were obtained, and the antitumor, anticoagulant, anti-inflammatory, and wound healing properties these CPs were estimated. The element and amino acid analysis of CPs from trepang and cucumaria are suggested that it’s could be regarded as a typical collagen fragments containing 6% sulfated carbohydrate and/or amino acid residues. CPs inhibited growth and progression solid Erlich tumor, but not in alike degree. Our results clearly showed, that these CPs possessed the moderate anticoagulant activity, and are preferential inhibitors of the initial link of the blood coagulation system. We also determined that the CPs revealed significant wound healing effect in regarding to thermal wounds and have high anti-inflammatory activity by used carrageenane model of acute inflammatory. Apparently, that the degree of biological activity depend on characteristics of amino acid composition and concentration of CPs. Taken together, these results indicate that CPs from sea cucumbers have similar to biological activities with other collagen peptides (components of the extracellular matrix, endostatin and others) and sulfated polysaccharides. We proposed that the obtained CPs may be applied as components functional food and nontoxic remedies of supplementary therapy for prevention and treatment of various diseases.},
year = {2013}
}
TY - JOUR T1 - Biological activities of collagen peptides obtained by enzymic Hydrolysis from Far-Eastern holothurians AU - Popov A. AU - Popov A. AU - Artyukov A. AU - Krivoshapko O. AU - Kozlovskaya E. Y1 - 2013/06/30 PY - 2013 N1 - https://doi.org/10.11648/j.ajbls.20130101.14 DO - 10.11648/j.ajbls.20130101.14 T2 - American Journal of Biomedical and Life Sciences JF - American Journal of Biomedical and Life Sciences JO - American Journal of Biomedical and Life Sciences SP - 17 EP - 26 PB - Science Publishing Group SN - 2330-880X UR - https://doi.org/10.11648/j.ajbls.20130101.14 AB - The certain sea cucumbers are the marine animals which are important as human delicacy food source. In addition a number of unique biological and pharmacological active compounds have been ascribed to various species of sea cucumbers. In current work the collagen peptides (CPs) from the bodies of the far-eastern holothurians (sea cucumber) Apostichopus japonicus and Cucumaria japonica by treated with a complex of proteolytic enzymes from Kamchatka crab Paralithodes camtschaticus were obtained, and the antitumor, anticoagulant, anti-inflammatory, and wound healing properties these CPs were estimated. The element and amino acid analysis of CPs from trepang and cucumaria are suggested that it’s could be regarded as a typical collagen fragments containing 6% sulfated carbohydrate and/or amino acid residues. CPs inhibited growth and progression solid Erlich tumor, but not in alike degree. Our results clearly showed, that these CPs possessed the moderate anticoagulant activity, and are preferential inhibitors of the initial link of the blood coagulation system. We also determined that the CPs revealed significant wound healing effect in regarding to thermal wounds and have high anti-inflammatory activity by used carrageenane model of acute inflammatory. Apparently, that the degree of biological activity depend on characteristics of amino acid composition and concentration of CPs. Taken together, these results indicate that CPs from sea cucumbers have similar to biological activities with other collagen peptides (components of the extracellular matrix, endostatin and others) and sulfated polysaccharides. We proposed that the obtained CPs may be applied as components functional food and nontoxic remedies of supplementary therapy for prevention and treatment of various diseases. VL - 1 IS - 1 ER -
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