Fine Needle Aspiration Cytology and Cell-Block Study of Various Breast Lumps
American Journal of Biomedical and Life Sciences
Volume 2, Issue 1, February 2014, Pages: 8-17
Received: Nov. 30, 2013; Published: Dec. 30, 2013
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Raafat Awad Hegazy, Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abdelmonem Awad Hegazy, Anatomy Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Fathy Ahmed Fetouh, Anatomy Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Samir Ibrahim, General Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
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Aim of the study was to evaluate the importance of the combined use of fine needle aspiration cytology (FNAC) and cell-block in the diagnosis of different breast lesions. Patient and methods: This study was a prospective study of 310 cases (301 females and 9 males) with breast swelling, coming to cytopathology unit, faculty of medicine, Zagazig University. FNAC and cell-block were performed. Cytological findings of smears and cell-blocks were correlated to histopathological results. Results: Most of cases were diagnosed as benign lesions or normal findings. The majority of FNAC samples was diagnosed as fibrocystic disease (160 cases, 51.6%), followed by fibroadenoma in 54 cases (17.4%). Positive cases for malignancy, including non-Hodgkin lymphoma and false negative cases were encountered in 50 cases (16.1%). Studying the histopathological results showed that true positive cases by FNAC and cell-block were 47 in number (15.16%) and true negative ones were 247 cases (82.90%). False positive cases were 3 in number (0.96%) and false negative ones were also 3 cases (0.96%). Sensitivity was 94% and specificity was 98%. Positive predictive and negative predictive values were 94% and 98%, respectively. False positive and false negative rates were 1.15% and 6% respectively. Total accuracy was 98%. Conclusion: It is advised to perform cell-blocks for each case of breast FNAC to decrease the pitfalls and to improve the diagnosis and management of breast lumps.
Breast, Histology, Pathology, FNAC, Cell-Block
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Raafat Awad Hegazy, Abdelmonem Awad Hegazy, Fathy Ahmed Fetouh, Samir Ibrahim, Fine Needle Aspiration Cytology and Cell-Block Study of Various Breast Lumps, American Journal of Biomedical and Life Sciences. Vol. 2, No. 1, 2014, pp. 8-17. doi: 10.11648/j.ajbls.20140201.12
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