American Journal of Biomedical and Life Sciences

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Antiplasmodial Activity of Aqueous leaf Extract of Cymbopogon citratus against Plasmodium falciparum Infected Rats

Received: 09 June 2014    Accepted: 20 June 2014    Published: 10 July 2014
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Abstract

In Nigeria, malaria is a major public health problem and there are high cost of the effective antimalarial drugs, poor quality drugs and increased emergence of Plasmodial resistance. Thus, there is a need for alternative source of medicine in malaria treatment and prevention. The antimalarial potential of aqueous leaf extracts of Cymbopogon citratus was investigated in this present study. Twenty five Swiss albino rats with average weight of 30.80g were distributed into five groups (A, B, C, D and E) with five mice per group. Group B was infected with 0.2 ml O+ human parasitized blood of Plasmodium falciparum and 0.1ml Chloroquine (Bini Laboratories Pvt Ltd). Group C, D, and E were infected with 0.2 ml O+ human parasitized blood of Plasmodium falciparum treated with 40 mg/kg, 80 mg/kg and 120 mg/kg of Cymbopogon citratus extracts respectively for three days. The mice infected with 0.2 ml O+ human parasitized blood of Plasmodium falciparum were observed for 72 hours for general symptoms of malaria. The mice tail was punctured, blood was examined under light microscope (x10) resolution) and several malaria parasites were found. Significant decrease of parasitemia levels was observed in 120 mg/kg body weight treated group compared to 0.1 ml Chloroquine the positive control. The result showed that Cymbopogon citratus possessed a good antimalarial property and can be use for prophylactic and chemotherapeutic purposes.

DOI 10.11648/j.ajbls.20140203.12
Published in American Journal of Biomedical and Life Sciences (Volume 2, Issue 3, June 2014)
Page(s) 60-64
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cymbopogon citratus, Chloroquine, Blood, Plasmodium falciparum

References
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[3] Cheel J, Theoduloz C, Rodríguez J, Schmeda-Hirschmann G (2005). Free radical scavengers and antioxidants from Lemongrass (Cymbopogon citratus (DC.) Stapf.) J. Agric. Food Chem. 53: 2511-2517.
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[17] Paranagama P.A., Abeysekera K.H.T., Abeywickrama K., Nugaliyadde L. (2003) Fungicidal and anti-aflatoxigenic effects of the essential oil of Cymbopogon citratus (DC.) Stapf (lemon grass) against Aspergillus flavus Link. Isolated from stores rice. Lett Appl Microbiol 37:86-90
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Author Information
  • Department of Biochemistry, Bingham University, Karu, Nigeria

  • Department of Biochemistry, Bingham University, Karu, Nigeria; Department of Biochemistry, Federal University of Technology, Akure, Ondo State, Nigeria

  • Department of Physiology, Bingham University, Karu, Nigeria

  • Department of Biochemistry, Bingham University, Karu, Nigeria

  • Department of Physiology, Bingham University, Karu, Nigeria

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    Shekins Osheke Okere, Janet Olayemi Sangodele, Eunice Ogunwole, Moses Dele Adams, Mercy Omoye Shafe. (2014). Antiplasmodial Activity of Aqueous leaf Extract of Cymbopogon citratus against Plasmodium falciparum Infected Rats. American Journal of Biomedical and Life Sciences, 2(3), 60-64. https://doi.org/10.11648/j.ajbls.20140203.12

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    ACS Style

    Shekins Osheke Okere; Janet Olayemi Sangodele; Eunice Ogunwole; Moses Dele Adams; Mercy Omoye Shafe. Antiplasmodial Activity of Aqueous leaf Extract of Cymbopogon citratus against Plasmodium falciparum Infected Rats. Am. J. Biomed. Life Sci. 2014, 2(3), 60-64. doi: 10.11648/j.ajbls.20140203.12

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    AMA Style

    Shekins Osheke Okere, Janet Olayemi Sangodele, Eunice Ogunwole, Moses Dele Adams, Mercy Omoye Shafe. Antiplasmodial Activity of Aqueous leaf Extract of Cymbopogon citratus against Plasmodium falciparum Infected Rats. Am J Biomed Life Sci. 2014;2(3):60-64. doi: 10.11648/j.ajbls.20140203.12

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  • @article{10.11648/j.ajbls.20140203.12,
      author = {Shekins Osheke Okere and Janet Olayemi Sangodele and Eunice Ogunwole and Moses Dele Adams and Mercy Omoye Shafe},
      title = {Antiplasmodial Activity of Aqueous leaf Extract of Cymbopogon citratus against Plasmodium falciparum Infected Rats},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {2},
      number = {3},
      pages = {60-64},
      doi = {10.11648/j.ajbls.20140203.12},
      url = {https://doi.org/10.11648/j.ajbls.20140203.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajbls.20140203.12},
      abstract = {In Nigeria, malaria is a major public health problem and there are high cost of the effective antimalarial drugs, poor quality drugs and increased emergence of Plasmodial resistance. Thus, there is a need for alternative source of medicine in malaria treatment and prevention. The antimalarial potential of aqueous leaf extracts of Cymbopogon citratus was investigated in this present study. Twenty five Swiss albino rats with average weight of 30.80g were distributed into five groups (A, B, C, D and E) with five mice per group. Group B was infected with 0.2 ml O+ human parasitized blood of Plasmodium falciparum and 0.1ml Chloroquine (Bini Laboratories Pvt Ltd). Group C, D, and E were infected with 0.2 ml O+ human parasitized blood of Plasmodium falciparum treated with 40 mg/kg, 80 mg/kg and 120 mg/kg of Cymbopogon citratus extracts respectively for three days. The mice infected with 0.2 ml O+ human parasitized blood of Plasmodium falciparum were observed for 72 hours for general symptoms of malaria. The mice tail was punctured, blood was examined under light microscope (x10) resolution) and several malaria parasites were found. Significant decrease of parasitemia levels was observed in 120 mg/kg body weight treated group compared to 0.1 ml Chloroquine the positive control. The result showed that Cymbopogon citratus possessed a good antimalarial property and can be use for prophylactic and chemotherapeutic purposes.},
     year = {2014}
    }
    

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    T1  - Antiplasmodial Activity of Aqueous leaf Extract of Cymbopogon citratus against Plasmodium falciparum Infected Rats
    AU  - Shekins Osheke Okere
    AU  - Janet Olayemi Sangodele
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    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
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    PB  - Science Publishing Group
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    UR  - https://doi.org/10.11648/j.ajbls.20140203.12
    AB  - In Nigeria, malaria is a major public health problem and there are high cost of the effective antimalarial drugs, poor quality drugs and increased emergence of Plasmodial resistance. Thus, there is a need for alternative source of medicine in malaria treatment and prevention. The antimalarial potential of aqueous leaf extracts of Cymbopogon citratus was investigated in this present study. Twenty five Swiss albino rats with average weight of 30.80g were distributed into five groups (A, B, C, D and E) with five mice per group. Group B was infected with 0.2 ml O+ human parasitized blood of Plasmodium falciparum and 0.1ml Chloroquine (Bini Laboratories Pvt Ltd). Group C, D, and E were infected with 0.2 ml O+ human parasitized blood of Plasmodium falciparum treated with 40 mg/kg, 80 mg/kg and 120 mg/kg of Cymbopogon citratus extracts respectively for three days. The mice infected with 0.2 ml O+ human parasitized blood of Plasmodium falciparum were observed for 72 hours for general symptoms of malaria. The mice tail was punctured, blood was examined under light microscope (x10) resolution) and several malaria parasites were found. Significant decrease of parasitemia levels was observed in 120 mg/kg body weight treated group compared to 0.1 ml Chloroquine the positive control. The result showed that Cymbopogon citratus possessed a good antimalarial property and can be use for prophylactic and chemotherapeutic purposes.
    VL  - 2
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