Myrtus communis has been recommended for relief of insomnia in Ethiopian traditional medicine and aromatherapy. However, no pharmacological studies have yet evaluated its sedative-hypnotic like effect. The aim of this study was to determine if the essential oil of Myrtus communis has sedative-hypnotic like activity. The essential oil of Myrtus communis (500,600, 800, and 1000 mg/kg) were administered orally to Swiss albino mice of both sex, 60 minutes before pentobarbital injection (50 mg/kg). Latency to sleep and sleep duration were recorded. More over the effect of the EO on motor-coordination and muscle relaxation were evaluated using Chimney and Traction test 60 and 90 min after administration of the respective doses of the EO respectively. The essential oil prolonged pentobarbital-induced sleeping time at 600, 800 (comparable to diazepam 3mg/kg), and at 1000 mg/kg compared to vehicle-treated group. The 50% negative response was observed on the Chimney and Traction test at 800 and 1000mg/kg respectively. The essential oil of Myrtus communis possesses dose dependent sedative-hypnotic like activity and CNS depressant activity.
| Published in | American Journal of Biomedical and Life Sciences (Volume 2, Issue 4) |
| DOI | 10.11648/j.ajbls.20140204.12 |
| Page(s) | 70-77 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Myrtus Communis, Sedative, Hypnotic, Motor Coordination, Muscle Relaxation, Essential Oil (EO)
| [1] | Gary K. ( 2007). The Prevalence, Morbidities, and Treatments of Insomnia. CNS & Neurological Disorders - Drug Targets. 6: 3-16. |
| [2] | NPC, National Prescribing Centre _Data focused commentary. (2010). Insomnia: Data focused commentary. |
| [3] | Wing Y. (2001). Herbal treatment of insomnia. HKMJ, 7:392-402. |
| [4] | Tiwari S. (2008). Plants: A Rich Source of Herbal Medicine. Journal of Natural Products: 1:27-35.. |
| [5] | Travese. (2001). Ecology of Fruit-color Polymorphism in Myrtus communis and Differential Effects of Birds and Mammals on Seed Germination and Seedling Growth, in Journal of Ecology., 89: 749-760. |
| [6] | Aronne De Micco. (2004). Hypocotyl features of Myrtus communis (Myrtaceae): a many-sided strategy for possible enhancement of seedling establishment in the Mediterranean environment, in Botanical Journal of Linnean Society, 145: 195-202. |
| [7] | Eyob H. (2010).Anxiolytic effect of the extract of Myrtus communis. |
| [8] | Mesfin T., Hedberg I. (1995). Flora of Ethiopia and Eritrea. 2:71-73. |
| [9] | Appendino G. (2002). Oligomeric acylphloroglucinols from myrtle (Myrtus communis). J. Nat. Prod., 65:334-338. |
| [10] | Cakir A. (2004). Essential oil and fatty acid composition of Hippophae Rhamnoides L., and Myrtus communis L. from Turkey. Biochem. Syst. Ecol. 3:809–816. |
| [11] | Stefania Z., Sara C., Paola M., Alessandra B., Marina C., Silvia P., Bruno M., Leonardo A. (2010). Evaluation of the Antimicrobial Properties of the Essential Oil of Myrtus communis L. against Clinical Strains of Mycobacterium spp. doi: 10:1155-931530. |
| [12] | Elfellah M., Akhter M., Khan M. (1984). Anti-hyperglycemic effect of an extract of Myrtus communis in streptozotocin induced diabetes in mice. J. Ethnopharmacol., 11: 275–281. |
| [13] | Al-Hindawi M. (1989). Anti inflammatory activity of some Iraqi plants using intact rats. Journal of Ethnopharmacology, 26:163–168. |
| [14] | Jansen, PCM. (1981) Spices, Condiments and Medicinal Plant in Ethiopia, their taxonomy and Agricultural Significance. Centre for Agricultural Publishing and Documentation, Wageningen, the Netherlands. 274. |
| [15] | Chalchat J. (1998). Essential oils of Myrtle (Myrtus communis L.) of the Miterranean littoral. Journal of Essential Oil Research, 10:613–617. |
| [16] | Health world. (2010) .http:/www.desert-tropicals.com( last retrieved on January 3, 2010. |
| [17] | Shron.,http://www.ehealthyland.com/health/essential-oil/myrtle-essential-oil-health-benefits.html (last retrieved on January 29, 2010. |
| [18] | Suite101http://aromatherapy.com/article.cfm/myrtle_essential_oil (last retrieved on January 15, 2010). |
| [19] | Mansouri S., Foroumadi A., Ghaneie T., Najar A. (2001). Antibacterial activity of the crude extracts and fractionated constituents of Myrtus communis. Pharm. Biol. 39, 399–401. |
| [20] | Chryssavgi G., Vassiliki P., Athanasios M., Kibouris T., Komaitis M. (2008). Essential oil composition of Pistacia lentiscus and Myrtus communis L: Evaluation of antioxidant capacity of methanolic extracts. Food Chem. 107: 1120–1130. |
| [21] | Rainer W., Peter K. (2008). The Homeopathic Preparation Neurexan® vs. Valerian for the Treatment of Insomnia: An Observational Study. The Scientific World JOURNAL., 8: 411–420. |
| [22] | Vogel H., Wolfgang J., Scholkens A., Sandow J.,Muller G., Vogel F.(2002). Hypnotic activity. Drug Discovery and Evaluation Pharmacological Assays, 2:495-496. |
| [23] | Balamurgan K., Akalanka D., Sivakumar G.(2007). Some neuropharamacological effects of the crude extract of Conus Parvatus in mice. Pak. J. Biol. Sci., 10: 4136-4139. |
| [24] | Möhler H., (2002). A new benzodiazepine pharmacology. J Pharmacol Exp Ther., 300:2–8 |
| [25] | Fujimori H. (1965). Potentiation of barbital hypnosis as an evaluation method for central nervous system depressants. Psychopharmacologia. 7:374–378. |
| [26] | Nelson L. (2002). The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nat Neurosci., 5:979–984. |
| [27] | Upendra B., Akash Y., Navneet A., Durga J., Indranil K., Yari P., Dinesh C., Jain A., (2009). Hypnotic effect of essential oil and methanolic extract of fruits of zanthoxylum budrunga w. IJPRIF (1) 4:1494-1498. |
| [28] | Emamghoreishi M., Heidari-Hamedani G. (2006). Sedative-Hypnotic Activity of Extracts and, Essential Oil of Coriander Seeds. Iran J Med Sci., (1)31: 22-27. |
| [29] | Alexander A., Torbjiirn k., Odile B., Florian H., Ian O. (1991). Hypnotics and Sleep Physiology: A Consensus Report. Eur. Arch Psychiatry Clin. Neurosci., 241: 13-21. |
| [30] | Hartmut U. (1979). Oral toxicity of an essential oil from myrtle and adaptive liver stimulation. Toxicology 12(3): 335-342. |
| [31] | Dennis S., Charney S., John M., Adron H. (2006). Hypnotics and sedatives. In Goodmans and Gilmans, the pharmacological basis of therapeutics. 11(16): 401-429. |
| [32] | Ramanathan S., Shanmuga R., Sivakumar P., Nethaji R., Senthil V., Venkateswara N., Kanagasabi R. (2008). CNS activity of the methanol extracts of Careya arborea in experimental animal model. Bangladesh J Pharmacol., 3: 36-43. |
| [33] | Srikanth J., Muralidharan P. (2009). CNS Activity of the Methanol Extracts of Sapindus emarginatus Vahl in Experimental Animal Models. J. Sci. Res., 1 (3): 583-593. |
| [34] | Hall. (1988). The anesthetic efficacy of midazolam in enfluraneanesthetized dog. Anesthesiology 68:862–866. |
| [35] | Wilfred R., (2010). Diagnosis, prevalence, pathways, consequences & treatment of insomnia. Indian J Med Res 131: 321-332 |
APA Style
Muluken Walle, Bizuayehu Walle, Legesse Zerihun, Eyasu Makonnen. (2014). Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice. American Journal of Biomedical and Life Sciences, 2(4), 70-77. https://doi.org/10.11648/j.ajbls.20140204.12
ACS Style
Muluken Walle; Bizuayehu Walle; Legesse Zerihun; Eyasu Makonnen. Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice. Am. J. Biomed. Life Sci. 2014, 2(4), 70-77. doi: 10.11648/j.ajbls.20140204.12
AMA Style
Muluken Walle, Bizuayehu Walle, Legesse Zerihun, Eyasu Makonnen. Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice. Am J Biomed Life Sci. 2014;2(4):70-77. doi: 10.11648/j.ajbls.20140204.12
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Download@article{10.11648/j.ajbls.20140204.12,
author = {Muluken Walle and Bizuayehu Walle and Legesse Zerihun and Eyasu Makonnen},
title = {Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice},
journal = {American Journal of Biomedical and Life Sciences},
volume = {2},
number = {4},
pages = {70-77},
doi = {10.11648/j.ajbls.20140204.12},
url = {https://doi.org/10.11648/j.ajbls.20140204.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20140204.12},
abstract = {Myrtus communis has been recommended for relief of insomnia in Ethiopian traditional medicine and aromatherapy. However, no pharmacological studies have yet evaluated its sedative-hypnotic like effect. The aim of this study was to determine if the essential oil of Myrtus communis has sedative-hypnotic like activity. The essential oil of Myrtus communis (500,600, 800, and 1000 mg/kg) were administered orally to Swiss albino mice of both sex, 60 minutes before pentobarbital injection (50 mg/kg). Latency to sleep and sleep duration were recorded. More over the effect of the EO on motor-coordination and muscle relaxation were evaluated using Chimney and Traction test 60 and 90 min after administration of the respective doses of the EO respectively. The essential oil prolonged pentobarbital-induced sleeping time at 600, 800 (comparable to diazepam 3mg/kg), and at 1000 mg/kg compared to vehicle-treated group. The 50% negative response was observed on the Chimney and Traction test at 800 and 1000mg/kg respectively. The essential oil of Myrtus communis possesses dose dependent sedative-hypnotic like activity and CNS depressant activity.},
year = {2014}
}
TY - JOUR T1 - Sedative-Hypnotic Like Effect of the Essential Oil from the Leaves of Myrtus Communis on Mice AU - Muluken Walle AU - Bizuayehu Walle AU - Legesse Zerihun AU - Eyasu Makonnen Y1 - 2014/08/10 PY - 2014 N1 - https://doi.org/10.11648/j.ajbls.20140204.12 DO - 10.11648/j.ajbls.20140204.12 T2 - American Journal of Biomedical and Life Sciences JF - American Journal of Biomedical and Life Sciences JO - American Journal of Biomedical and Life Sciences SP - 70 EP - 77 PB - Science Publishing Group SN - 2330-880X UR - https://doi.org/10.11648/j.ajbls.20140204.12 AB - Myrtus communis has been recommended for relief of insomnia in Ethiopian traditional medicine and aromatherapy. However, no pharmacological studies have yet evaluated its sedative-hypnotic like effect. The aim of this study was to determine if the essential oil of Myrtus communis has sedative-hypnotic like activity. The essential oil of Myrtus communis (500,600, 800, and 1000 mg/kg) were administered orally to Swiss albino mice of both sex, 60 minutes before pentobarbital injection (50 mg/kg). Latency to sleep and sleep duration were recorded. More over the effect of the EO on motor-coordination and muscle relaxation were evaluated using Chimney and Traction test 60 and 90 min after administration of the respective doses of the EO respectively. The essential oil prolonged pentobarbital-induced sleeping time at 600, 800 (comparable to diazepam 3mg/kg), and at 1000 mg/kg compared to vehicle-treated group. The 50% negative response was observed on the Chimney and Traction test at 800 and 1000mg/kg respectively. The essential oil of Myrtus communis possesses dose dependent sedative-hypnotic like activity and CNS depressant activity. VL - 2 IS - 4 ER -
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