Evaluation of the Impact of the Trivedi Effect® -Energy of Consciousness on the Structure and Isotopic Abundance Ratio of Magnesium Gluconate Using LC-MS and NMR Spectroscopy
American Journal of Biomedical and Life Sciences
Volume 5, Issue 1, February 2017, Pages: 6-15
Received: Feb. 7, 2017; Accepted: Feb. 18, 2017; Published: Mar. 9, 2017
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Authors
Mahendra Kumar Trivedi, Trivedi Global, Inc., Henderson, Nevada, USA
Alice Branton, Trivedi Global, Inc., Henderson, Nevada, USA
Dahryn Trivedi, Trivedi Global, Inc., Henderson, Nevada, USA
Gopal Nayak, Trivedi Global, Inc., Henderson, Nevada, USA
Michael Peter Ellis, Trivedi Global, Inc., Henderson, Nevada, USA
James Jeffery Peoples, Trivedi Global, Inc., Henderson, Nevada, USA
James Joseph Meuer, Trivedi Global, Inc., Henderson, Nevada, USA
Johanne Dodon, Trivedi Global, Inc., Henderson, Nevada, USA
John Lawrence Griffin, Trivedi Global, Inc., Henderson, Nevada, USA
John Suzuki, Trivedi Global, Inc., Henderson, Nevada, USA
Joseph Michael Foty, Trivedi Global, Inc., Henderson, Nevada, USA
Judy Weber, Trivedi Global, Inc., Henderson, Nevada, USA
Julia Grace McCammon, Trivedi Global, Inc., Henderson, Nevada, USA
Karen Brynes Allen, Trivedi Global, Inc., Henderson, Nevada, USA
Kathryn Regina Sweas, Trivedi Global, Inc., Henderson, Nevada, USA
Lezley Jo-Anne Wright, Trivedi Global, Inc., Henderson, Nevada, USA
Lisa A. Knoll, Trivedi Global, Inc., Henderson, Nevada, USA
Madeline E. Michaels, Trivedi Global, Inc., Henderson, Nevada, USA
Margaret Kweya Wahl, Trivedi Global, Inc., Henderson, Nevada, USA
Mark E. Stutheit, Trivedi Global, Inc., Henderson, Nevada, USA
Michelle Barnard, Trivedi Global, Inc., Henderson, Nevada, USA
Muriel Mae Ranger, Trivedi Global, Inc., Henderson, Nevada, USA
Paromvong Sinbandhit, Trivedi Global, Inc., Henderson, Nevada, USA
V. J. Kris Elig, Trivedi Global, Inc., Henderson, Nevada, USA
Kalyan Kumar Sethi, Trivedi Science Research Laboratory Pvt. Ltd., Bhopal, Madhya Pradesh, India
Parthasarathi Panda, Trivedi Science Research Laboratory Pvt. Ltd., Bhopal, Madhya Pradesh, India
Snehasis Jana, Trivedi Science Research Laboratory Pvt. Ltd., Bhopal, Madhya Pradesh, India
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Abstract
Magnesium gluconate is a classical pharmaceutical/nutraceutical compound used as a magnesium ion source for the prevention and treatment of hypomagnesemia. The present study was aimed to investigate the effect of The Trivedi Effect® - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on magnesium gluconate for the change in the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect® - Biofield Energy Healing Treatment remotely by twenty renowned Biofield Energy Healers and defined as The Trivedi Effect® Treated sample. The LC-MS analysis of both the control and treated samples indicated the presence of mass of the protonated magnesium gluconate at m/z 415 at the retention time of 1.52 min and fragmentation pattern of the both sample were almost similar. The relative peak intensities of the fragment ions were significantly changed in the treated sample compared with the control sample. The proton and carbon signals for CH, CH2 and CO groups in the proton and carbon NMR spectra were observed almost similar for the control and the treated samples. The percentage change in the isotopic abundance ratio of PM+1/PM (2H/1H or 13C/12C or 17O/16O or 25Mg/24Mg) was significantly decreased in the treated sample by 17.51% compared with the control sample. Consequently, the isotopic abundance ratio of PM+2/PM (18O/16O or 26Mg/24Mg) in the treated sample was significantly increased by 79.44% compared to the control sample. Briefly, 13C, 2H, 17O, and 25Mg contributions from (C12H23MgO14)+ to m/z 416; 18O and 26Mg contributions from (C12H23MgO14)+ to m/z 417 in treated sample were significantly altered compared with the control sample. Thus, The Trivedi Effect® Treated magnesium gluconate might be supportive to design the novel potent enzyme inhibitors using its kinetic isotope effects. Consequently, The Trivedi Effect® Treated magnesium gluconate would be valuable for designing better pharmaceutical and/or nutraceutical formulations through its changed physicochemical and thermal properties, which might be providing better therapeutic response against various diseases such as diabetes mellitus, allergy, aging, inflammatory diseases, immunological disorders, and other chronic infections.
Keywords
Magnesium Gluconate, Biofield Energy Healing Treatment, Consciousness Energy Healing Treatment, Biofield Energy Healers, The Trivedi Effect®, LC-MS, NMR, Isotopic Abundance Ratio, Isotope Effect
To cite this article
Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Michael Peter Ellis, James Jeffery Peoples, James Joseph Meuer, Johanne Dodon, John Lawrence Griffin, John Suzuki, Joseph Michael Foty, Judy Weber, Julia Grace McCammon, Karen Brynes Allen, Kathryn Regina Sweas, Lezley Jo-Anne Wright, Lisa A. Knoll, Madeline E. Michaels, Margaret Kweya Wahl, Mark E. Stutheit, Michelle Barnard, Muriel Mae Ranger, Paromvong Sinbandhit, V. J. Kris Elig, Kalyan Kumar Sethi, Parthasarathi Panda, Snehasis Jana, Evaluation of the Impact of the Trivedi Effect® -Energy of Consciousness on the Structure and Isotopic Abundance Ratio of Magnesium Gluconate Using LC-MS and NMR Spectroscopy, American Journal of Biomedical and Life Sciences. Vol. 5, No. 1, 2017, pp. 6-15. doi: 10.11648/j.ajbls.20170501.12
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Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Ramachandran S, Fontanille P, Pandey A, Larroche C (2006) Gluconic acid: Properties, applications and microbial production. Food Technol Biotechnol 44. 185-195.
[2]
Heaton FW (1990) Role of magnesium in enzyme systems in metal ions in biological systems, In: Sigel H, Sigel A (Eds.), Volume 26. Compendium on magnesium and its role in biology, nutrition and physiology, Marcel Dekker Inc., New York.
[3]
Garfinkel L, Garfinkel D (1985) Magnesium regulation of the glycolytic pathway and the enzymes involved. Magnesium 4: 60-72.
[4]
Swaminathan R (2003) Magnesium metabolism and its disorders. Clin Biochem Rev 24: 47-66.
[5]
Gröber U, Schmidt J, Kisters K (2015) Magnesium in prevention and therapy. Nutrients 7: 8199-8226.
[6]
William JH, Danziger J (2016) Magnesium deficiency and proton-pump inhibitor use: A clinical review. J Clin Pharmacol 56. 660-668.
[7]
Guerrera MP, Volpe SL, Mao JJ (2009) Therapeutic uses of magnesium. Am Fam Physician 80: 157-162.
[8]
Coudray C, Rambeau M, Feillet-Coudray C, Gueux E, Tressol JC, Mazur A, Rayssiguier Y (2005) Study of magnesium bioavailability from ten organic and inorganic Mg salts in Mg-depleted rats using a stable isotope approach. Magnes Res 18: 215-223.
[9]
Fleming TE, Mansmann Jr HC (1999) Methods and compositions for the prevention and treatment of diabetes mellitus. United States Patent 5871769, 1-10.
[10]
Fleming TE, Mansmann Jr HC (1999) Methods and compositions for the prevention and treatment of immunological disorders, inflammatory diseases and infections. United States Patent 5939394, 1-11.
[11]
Weglicki WB (2000) Intravenous magnesium gluconate for treatment of conditions caused by excessive oxidative stress due to free radical distribution. United States Patent 6100297, 1-6.
[12]
Turner RJ, Dasilva KW, O'Connor C, van den Heuvel C, Vink R (2004) Magnesium gluconate offers no more protection than magnesium sulphate following diffuse trau-matic braininjury in rats. J Am Coll Nutr 23: 541S-544S.
[13]
Martin RW, Martin JN Jr, Pryor JA, Gaddy DK, Wiser WL, Morrison JC (1988) Comparison of oral ritodrine and magnesium gluconate for ambulatory tocolysis. Am J Obstet Gynecol 158: 1440-1445.
[14]
Lee KH, Chung SH, Song JH, Yoon JS, Lee J, Jung MJ, Kim JH (2013) Cosmetic compositions for skin-tightening and method of skin-tightening using the same. United States Patent 8580741 B2.
[15]
Stenger VJ (1999) Bioenergetic fields. Sci Rev Alternative Med 3.
[16]
Sances F, Flora E, Patil S, Spence A, Shinde V (2013) Impact of biofield treatment on ginseng and organic blueberry yield. Agrivita 35. 22-29.
[17]
Hammerschlag R, Jain S, Baldwin AL, Gronowicz G, Lutgendor SK, Oschman JL, Yount GL (2012) Biofield research: A roundtable discussion of scientific and methodological issues. J Altern Complement Med 18: 1081-1086.
[18]
Rubik B (2002) The biofield hypothesis: Its biophysical basis and role in medicine. J Altern Complement Med 8: 703-717.
[19]
Koithan M (2009) Introducing complementary and alternative therapies. J Nurse Pract 5: 18-20.
[20]
Trivedi MK, Branton A, Trivedi D, Nayak G, Mondal SC, Jana S (2015) Antibiogram, biochemical reactions and biotyping of biofield treated Providencia rettgeri. American Journal of Health Research 3: 344-351.
[21]
Trivedi MK, Patil S, Shettigar H, Bairwa K, Jana S (2015) Phenotypic and biotypic characterization of Klebsiella oxytoca: An impact of biofield treatment. J Microb Biochem Technol 7. 202-205.
[22]
Trivedi MK, Patil S, Shettigar H, Gangwar M, Jana S (2015) In vitro evaluation of biofield treatment on cancer biomarkers involved in endometrial and prostate cancer cell lines. J Cancer Sci Ther 7. 253-257.
[23]
Trivedi MK, Branton A, Trivedi D, Nayak G, Gangwar M, Jana S (2015) Analysis of genetic diversity using simple sequence repeat (SSR) markers and growth regulator response in biofield treated cotton (Gossypium hirsutum L.). American Journal of Agriculture and Forestry 3: 216-221.
[24]
Trivedi MK, Branton A, Trivedi D, Nayak G, Mondal SC, Jana S (2015) Evaluation of biochemical marker - glutathione and DNA fingerprinting of biofield energy treated Oryza sativa. American Journal of BioScience 3. 243-248.
[25]
Trivedi MK, Branton A, Trivedi D, Nayak G, Mondal SC, Jana S (2015) Effect of biofield treated energized water on the growth and health status in chicken (Gallus gallus domesticus). Poult Fish Wildl Sci 3. 140.
[26]
Trivedi MK, Branton A, Trivedi D, Nayak G, Singh R, Jana S (2015) Physicochemical and spectroscopic characterization of biofield energy treated gerbera multiplication medium. Plant 3: 57-63.
[27]
Trivedi MK, Nayak G, Patil S, Tallapragada RM, Jana S, Mishra R (2015) Evaluation of the impact of biofield treatment on physical and thermal properties of casein enzyme hydrolysate and casein yeast peptone. Clin Pharmacol Biopharm 4: 138.
[28]
Trivedi MK, Nayak G, Patil S, Tallapragada RM, Latiyal O (2015) Evaluation of biofield treatment on physical, atomic and structural characteristics of manganese (II, III) oxide. J Material Sci Eng 4. 177.
[29]
Trivedi MK, Tallapragada RM, Branton A, Trivedi D, Nayak G, Latiyal O, Jana S (2015) Physicochemical and atomic characterization of silver powder after biofield treatment. J Bioengineer & Biomedical Sci 5. 165.
[30]
Trivedi MK, Patil S, Shettigar H, Singh R, Jana S (2015) An impact of biofield treatment on spectroscopic characterization of pharmaceutical compounds. Mod Chem Appl 3. 159.
[31]
Trivedi MK, Branton A, Trivedi D, Nayak G, Singh R, Jana S (2015) Characterisation of physical, spectral and thermal properties of biofield treated resorcinol. Organic Chem Curr Res 4: 146.
[32]
Trivedi MK, Tallapragada RM, Branton A, Trivedi D, Nayak G, Latiyal O, Jana S (2015) Evaluation of biofield energy treatment on physical and thermal characteristics of selenium powder. Journal of Food and Nutrition Sciences.3: 223-228.
[33]
Trivedi MK, Nayak G, Patil S, Tallapragada RM, Jana S, Mishra RK (2015) Bio-field treatment: An effective strategy to improve the quality of beef extract and meat infusion powder. J Nutr Food Sci 5. 389.
[34]
Trivedi MK, Tallapragada RM, Branton A, Trivedi D, Nayak G, Mishra RK, Jana S (2015) Biofield energy treatment: A potential strategy for modulating physical, thermal and spectral properties of 3-chloro-4-fluoroaniline. J Thermodyn Catal 6. 151.
[35]
Trivedi MK, Tallapragada RM, Branton A, Trivedi D, Nayak G, Mishra RK, Jana S (2015) Physical, thermal and spectral properties of biofield treated 3-nitroacetophenone, Science Journal of Analytical Chemistry 3: 71-79.
[36]
Trivedi MK, Branton A, Trivedi D, Nayak G, Saikia G, Jana S (2016) Determination of isotopic abundance of 2H, 13C, 18O, and 37Cl in biofield energy treated dichlorophenol isomers. Science Journal of Analytical Chemistry 4: 1-6.
[37]
Trivedi MK, Branton A, Trivedi D, Nayak G, Sethi KK, Jana S (2016) Determination of isotopic abundance ratio of biofield energy treated 1, 4-dichlorobenzene using gas chromatography-mass spectrometry (GC-MS). Modern Chemistry 4: 30-37.
[38]
Trivedi MK, Branton A, Trivedi D, Nayak G, Panda P, Jana S (2016) Isotopic abundance ratio analysis of 1, 2, 3-trimethoxybenzene (TMB) after biofield energy treatment (The Trivedi Effect®) using gas chromatography-mass spectrometry, American Journal of Applied Chemistry 4: 132-140.
[39]
Trivedi MK, Branton A, Trivedi D, Nayak G, Sethi KK, Jana S (2016) Evaluation of isotopic abundance ratio in biofield energy treated nitrophenol derivatives using gas chromatography-mass spectrometry. American Journal of Chemical Engineering 4. 68-77.
[40]
Schellekens RC, Stellaard F, Woerdenbag HJ, Frijlink HW, Kosterink JG (2011) Applications of stable isotopes in clinical pharmacology. Br J Clin Pharmacol 72. 879-897.
[41]
Muccio Z, Jackson GP (2009) Isotope ratio mass spectrometry. Analyst 134: 213-222.
[42]
Vanhaecke F, Kyser K (2012) Isotopic composition of the elements In Isotopic Analysis: Fundamentals and applications using ICP-MS (1stedn), Edited by Vanhaecke F, Degryse P. Wiley-VCH GmbH & Co. KGaA, Weinheim.
[43]
Smith RM (2004) Understanding Mass Spectra: A Basic Approach, Second Edition, John Wiley & Sons, Inc, ISBN 0-471-42949-X.
[44]
Meija J, Coplen TB, Berglund M, Brand WA, De Bievre P, Groning M, Holden NE, Irrgeher J, Loss RD, Walczyk T, Prohaska T (2016) Isotopic compositions of the elements 2013 (IUPAC technical Report). Pure Appl Chem 88: 293-306.
[45]
Asperger S (2003) Chemical Kinetics and Inorganic Reaction Mechanisms Springer science + Business media, New York.
[46]
Trivedi MK, Mohan TRR (2016) Biofield energy signals, energy transmission and neutrinos. American Journal of Modern Physics 5: 172-176.
[47]
Cleland WW (2003) The use of isotope effects to determine enzyme mechanisms. J Biol Chem 278: 51975-51984.
[48]
Nikolic VD, Illic DP, Nikolic LB, Stanojevic LP, Cakic MD, Tacic AD, Ilic-Stojanovic SS (2014) The synthesis and characterization of iron (II) gluconate. Advanced technologies 3: 16-24.
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