Eucalyptus globulus Oil Versus Bleach Use as Antiseptic Agents in Podoconiosis Treatment: An Interventional Study in Wolaita Zone, Southern Ethiopia
American Journal of Biomedical and Life Sciences
Volume 5, Issue 6, December 2017, Pages: 113-118
Received: Jun. 5, 2017; Accepted: Jun. 19, 2017; Published: Nov. 8, 2017
Views 643      Downloads 62
Bereket Alemayehu, Biomedical Science Division, Biology Department, College of Natural and Computational Sciences, Wolaita Sodo University, Wolaita Sodo, Ethiopia
Terefe Gelibo, Health System Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia
Zewde Zema Kanche, Department of Pharmacy, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia
Article Tools
Follow on us
Eucalyptus globulus essential oil is widely used for medicinal purpose because of its pharmacological constituents. The present study aimed to use water emulsified E. globulus oil as an antiseptic agent in the treatment protocol of podoconiosis (non-filarial elephantiasis) and compare disease improvement upon E. globulus oil versus bleach (usual antiseptic chemical) use in the treatment protocol. An interventional study was conducted from January to March, 2012 to compare disease improvement on podoconiosis upon using water emulsified E. globulus oil versus bleach-water solution as antiseptic agents in podoconiosis treatment. Forty podoconiosis patients purposely selected and randomly allocated into intervention (E. globulus oil) group and comparison (bleach) group with matched clinical stage of podoconiosis. After the baseline data recording, home based treatment was started and follow-up had been undertaken every week for 3-month period. The data were analyzed using SPSS version 16 statistical package. The mean clinical stages of the disease among the study participants were 2.72 for the right and 2.80 for the left legs before the treatment start. Seventeen (32.5%) of patients suffered from the disease for more than 25 years. For all the outcomes measured at the end of study period, the individual treatment effects of eucalyptus oil and bleach antiseptic agents were compared and the result showed no significant difference. Hence, eucalyptus oil emulsified in water can be used as alternative antiseptic agent in podoconiosis treatment protocol.
Eucalyptus Oil, Podoconiosis, Bleach, Wolaita, Ethiopia
To cite this article
Bereket Alemayehu, Terefe Gelibo, Zewde Zema Kanche, Eucalyptus globulus Oil Versus Bleach Use as Antiseptic Agents in Podoconiosis Treatment: An Interventional Study in Wolaita Zone, Southern Ethiopia, American Journal of Biomedical and Life Sciences. Vol. 5, No. 6, 2017, pp. 113-118. doi: 10.11648/j.ajbls.20170506.11
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Ayepola OO, Adeniyi BA (2008) The Antibacterial Activity of Leaf Extracts of Eucalyptus camaldulensis (Myrtaceae). J App Sci Res 4: 1410-1413.
Cimanga K, Kambu K, Tona L, et al. (2002) Correlation between chemical composition and antibacterial activity of essential oils of some aromatic medicinal plants growing in the Democratic Republic of Congo. J Ethnopharmacol 2: 213-220.
Braca A, Siciliano T, D’Arrigo M, Germanò MP (2008) Chemical composition and antimicrobial activity of Momordica charantia seed essential oil. Fitoterapia 79:123-125.
Nair R, Vaghasiya Y, Chanda S (2008) Antibacterial activity of Eucalpytus citriodora Hk. oil on few clinically important bacteria. Afr J Biotechnol 7: 25-26.
Adeniyi BA, Lawal TO, Olaleye SB (2006) Antimicrobial and gastro-protective activities of Eucalyptus camaldulensis (Myrtaceae) crude extracts. J Bio Sci 6: 1141-1145.
Ranjit RR, Ajit RS, Bhagyashree BJ (2014) Antimicrobial activity of Azadirachta indica (Neem) against Pathogenic Microorganisms. JAIR 3:327-329.
Brantner A, Grein E (1994) Antibacterial activity of plant extracts used externally in traditional medicine. J Ethnopharmacol 44:35-40.
El-Keltawi NEM (1980) Antimicrobial activity of some Egyptian aromatic plants. Herba Polonica 26:245-250.
Janssen AM (1986) Screening for antibacterial activity of some essential oils by the agar overlay technique. Pharmaceutisch Weekblad 8:289-292.
Wagner H (1986) In vitro inhibition of prostaglandin biosynthesis by essential oils and phenolic compounds. Planta Medica 3:184-187.
Göbel H (1995) Essential plant oils and headache mechanisms. Phytomedicine 2:93-102.
Mark L, Meskele A, Gail D (2010) Podoconiosis control guideline. Page 26.
Molla YB, Davey G (2012) Podoconiosis control in rural Ethiopia: the roles of expert patients, appropriate treatment and community mobilization. Community Dermatology Page 3.
Price EW (1976) The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks. Trans R Soc Trop Med Hyg 70: 288- 295.
Davey G, Tekola F, Newport MJ (2007) Podoconiosis: non-infectious geochemical elephantiasis. trans R Soc Trop Med Hyg 101(12):1175-1180.
Davey G, Burridge E (2009) Community based control of a neglected tropical disease: the Mossy Foot Treatment and Prevention Association. PLoS Negl Trop Dis 3(5): e424.
Dreyer G, Addiss D, Dreyer P, Noroes J (2002) Basic Lymphedema Management, first Ed. New Hampshire, US: Hollis Publishing Company Page 25.
Tekola F, Ayele Z, Haile Mariam D, Fuller LC, Davey G (2008) Development and testing of a de novo clinical staging system for podoconiosis (endemic nonfilarial elephantiasis). Trop Med Int Health 13: 1277-1283.
Incident Management and Toxicology (IMT) (2016) Sodium hypochlorite: health effects. Accessed at: access date: 21/1/2016.
Central Statistical Authority of Ethiopia (CSA) (2012) Population and housing census. Available from
Abrahams PW (2002) Soils: their implications to human health. Sci Tota Environ 291: 1-32.
Desta K, Ashine M, Davey G (2003) "Prevalence of podoconiosis (endemic non-filarial elephantiasis) in Wolaita, Southern Ethiopia". Trop Doct 32: 217- 220.
Kokate K, Purohit AP (1999) Textbook of Pharmacognosy. Page 267-268.
Cooksley VG (1996) In: Aromatherapy-A lifetime guide healing with essential oils, Prentice Hall New Jersey Page 159-195.
Gediya SK, Mistry RB, Patel UK, Blessy M, Jain HN (2011) Herbal Plants: Used as a cosmetics. J Nat Prod Plant Resour 1(1): 24-32.
Silva J, Abebe W, Sousa SM, Duarte VG, Machado MI, Matos FJ (2003) Analgesic and anti-inflammatory effects of essential oils of Eucalyptus. J Ethnopharmacol 89(2-3): 277-283.
Nagpal G, Shah M, Arora N, Shri R, Arya Y (2010) Phytochemical and Pharmacological Aspects of Eucalyptus Genus. Int J Pharmaceutic Sci Res 1:28-36.
Science Publishing Group
NEW YORK, NY 10018
Tel: (001)347-688-8931