A Study to Assess the Significance of Urinary Collagen IV Excretion to Predict Preeclampsia in Early Pregnancy
American Journal of Biomedical and Life Sciences
Volume 7, Issue 4, August 2019, Pages: 93-98
Received: Nov. 7, 2018;
Accepted: Aug. 22, 2019;
Published: Sep. 10, 2019
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Kaneez Fatema, Deptment of Obstetrics and Gynecology, Faridpur Medical College, Faridpur, Bangladesh
Fatema Jebunnesa, Deptment of Biochemistry and Cell Biology, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh
Salima Akter, Deptment of Medical Biotechnology, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh
Towhidul Alam Chowdhury, Deptment of Obstetrics and Gynecology Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh
Liaquat Ali, Deptment of Medical Biotechnology, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh
It was a prospective study with a case control design. The purpose of the study was to measure the urinary collagens IV (U-coll IV) and microalbumin (MA) level in early pregnancy and to explore the role of excretion U-coll IV in prediction of preeclampsia (PE). A total number of 119 pregnant women at 10-14 weeks of pregnancy were selected on the basis of availability. MA by immunoturbidimetry assay and U-coll IV by enzyme immunoassay method were measured in these subjects and they were followed up to the term for the possible development of PE. MA was defined by albumin-creatinine ratio (ACR) above 32mg/g and high U-coll IV was defined by values above the cut-off point 2.74 ng/ml determined by the median value of the (controls). The data were analyzed by grouping the subjects who developed PE in later stages of pregnancy (the PE group) and those who did not develop PE in later stages (Control group). From the total subjects, 10 developed PE which shows a prevalence of about 8.4%. The PE group had higher value of ACR as compared to Control [ACR, mg/g, median (range), 42.3]. The sensitivity of ACR in predicting PE was 80%, specificity 49.54%, PPV 12.69% and NPV 96.42% respectively. The sensitivity of high U-coll IV in predicting PE was 70%, specificity 50.5%, PPV 11.5% and NPV 94.8%. It may be concluded that early pregnancy levels of MA and U-coll IV can be used as predictors of PE with high negative predictive value; and U-coll IV has no added advantage over MA in this respect.
Towhidul Alam Chowdhury,
A Study to Assess the Significance of Urinary Collagen IV Excretion to Predict Preeclampsia in Early Pregnancy, American Journal of Biomedical and Life Sciences.
Vol. 7, No. 4,
2019, pp. 93-98.
Medicine for Africa - Medical Information Service (2008). Preeclampsia/ eclampsia. http://www.medicinemd.com/
World Health Organization (2002) Global Program to Conquer preeclampsia/Eclampsia.
C Dolea, C AbouZahr,“Global burden of hypertensive disorders of pregnancy in the year 2000” In: Global Burden of Diseases; 2000; World Health Organization.
A Shah, B Fawole, JM M’Imunya et al. “Cesarean delivery outcomes from the WHO global survey on maternal and perinatal health in Africa”, International Journal of Gynecology and Obstetrics, vol. 107 (3), pp. 191–197, 2009. [PubMed]
EM McClure, S Saleem, O Pasha, RL Goldenberg, “Stillbirth in developing countries: a review of causes, risk factors and prevention strategies”, Journal of Maternal-Fetal and Neonatal Medicine, vol. 22 (3), pp. 183–190, 2009. [PMC free article] [PubMed]
WHO. Make every mother and child count, in The world health report 2005. Geneva, Switzerland: World Health Organization; 2005.
M Warden, B Euerle, “Preeclampsia (Toxaemia of Pregnancy)”, Medicine [serial online] Retrieved: 2005 May 07 Available from: URL: http://www.emedicine.com/med/topic/1905.htm [acessed on 12-11-10]
C Reynold, WC Mabie, BM Sibai, AH DeCherny, L Nathan, “Hypertensive States of Pregnancy”, In DeCherney AH, Nathan L (eds) Current Obstetric & Gynecologic Diagnosis & Treatment 9th ed. New York: Mc Graw-Hill; 2003: 338-353.
A Conde-Agudelo, J Villar, M Lindheimer, “World Health Organization systematic review of screening tests for preeclampsia”, Obstet Gynecol, vol. 104, pp. 1367–1391, 2004. [PubMed]
A Conde-Agudelo, R Romero, M Lindheimer, ‘Tests to predict preeclampsia”, In: Lindheimer MD, Roberts JM, Cunningham FG (eds), Chesley's Hypertensive Disorders of Pregnancy, 3d ed. Elsevier; San Diego Ca: 2009. in press (May 09).
RJ Levine, C Lam, C Qian, KF Yu, SE Maynard, BP Sachs, et al. “Soluble endoglin and other circulating antiangiogenic factors in preeclampsia”, N Engl J Med, vol. 355, pp. 992–1005, 2006.
BC Young, RJ Levine, SA Karumanchi, “Pathogenesis of preeclampsia”, Annu Rev Pathol, vol. 5 pp. 173–92, 2010.
F Khan, JJ Belch, M MacLeod, G Mires, “Changes in endothelial function precedes the clinical disease in women in whom preeclampsia develops”, Hypertension, vol. 46, pp. 1123–8, 2005.
P Verdecchia, GP Reboldi, “Hypertension and microalbuminuria: the new detrimental duo”. Blood Press, vol. 13, pp. 198-211, 2004.
RM Van de Wal, AA Voors, RT Gansevoort, “Urinary albumin excretion and the renin-angiotensin system in cardiovascular risk management”. Expert OpinPharmacother, vol. 7, pp. 2505-20, 2006.
S Chua, CW Redman, “Prognosis for preeclampsia complicated by 5 g or more of proteinuria in 24 hours”, Eur J ObstetGynecolReprodBiol, vol. 43, pp. 9-12, 1992.
RA North, RS Taylor, JC Schellenberg, “Evaluation of a definition of pre-eclampsia”. Br J ObstetGynaecol, vol. 106, pp. 767-73, 1999.
T Lijima, S Sujuki, K Sekijuka, T Hishika, M Yagme, K Jinde et al, “Follow-up study on urinary type IV collagen in patients with early stage diabetic nephropathy”, J Clin Lab Anal, vol. 12, pp. 378-382, 1998.
J. Clin. Lab. Anal. Vol. 11, pp. 110–116. © 1997 Wiley‐Liss, Inc.
MH Rodriguez, DI Masaki, J Mestman, D Kumar, R Rude, “Calcium/creatinine ratio and microalbuminuria in the prediction of pre-eclampsia”. Am J Obstet Gynecol. vol. 159, pp. 1452-5, 1988.
BA Fielding, DA Price, CA Houton, “Enzyme immunoassay for urinary albumin”, ClinChem vol. 29 (2), pp. 355-357, 1983.
M Yagme, “Significance of urinary type IV collagen in patients with nephropathy using a highly sensitive one-step sandwich enzyme immunoassay”, J Clin Lab Anal, vol. 11, pp. 110-116, 1997.
CP McCormick, JC Konen, ZK Shihabi, “Microtransferrinuria and microalbuminuria in the diabetic human”, ClinPhysiolBiochem, vol. 8, pp. 538, 1990.
G Igberase, P Ebeigbe, “Eclampsia: ten-years of experience in a rural tertiary hospital in the Niger delta, Nigeria”, Journal of Obstetrics and Gynaecology, vol. 26 (5), 414–417, 2006. [PubMed]
YM Adamu, HM Salihu, N Sathiakumar, GR Alexander, “Maternal mortality in Northern Nigeria: a population-based study”, European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 109 (2) pp. 153–159, 2003. [PubMed]
FG Cunningham, KJ Leveno, SL Bloom, J Hauth, LC Gilstrap, KD Wenstrom, eds. “Hypertensive Disorders in Pregnancy”, Williams Obstetrics. 22 nd ed. New York: McGraw-Hill; 2005. p. 761-808.
V Das, T Bhargava, SK Das, S Pandey, “Microalbuminuria: a predictor of pregnancy-induced hypertension”, Br J ObstetGynaecol, vol. 103, pp. 928-30, 1996.
M Shaarawy, ME Salem, The Clinical value of microtransferrinuria and microalbuminuria in the prediction of pre-eclampsia”, ClinChem Lab Med, vol. 39 (1), pp. 29-34, 2001.