Large Granular Lymphocytes Leukemia: A Case Report with a Review of the Literature
American Journal of Biomedical and Life Sciences
Volume 8, Issue 1, February 2020, Pages: 1-4
Received: Dec. 6, 2019;
Accepted: Dec. 26, 2019;
Published: Jan. 9, 2020
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Maryam Mouamin, Hematology Laboratory of Avicene Military Hospital, Faculty of Medicine and Pharmacy, Qadi Iyyad University, Marrakech, Morrocco
Ghita Badou, Hematology Laboratory of Avicene Military Hospital, Faculty of Medicine and Pharmacy, Qadi Iyyad University, Marrakech, Morrocco
Hicham Yahyaoui, Hematology Laboratory of Avicene Military Hospital, Faculty of Medicine and Pharmacy, Qadi Iyyad University, Marrakech, Morrocco
Imane Benjelloun, Hematology Laboratory of Avicene Military Hospital, Faculty of Medicine and Pharmacy, Qadi Iyyad University, Marrakech, Morrocco
Mohamed Raissi, Hematology Department of Avicene Military Hospital, Faculty of Medicine and Pharmacy, Qadi Iyyad University, Marrakech, Morrocco
Mustapha Ait Ameur, Hematology Laboratory of Avicene Military Hospital, Faculty of Medicine and Pharmacy, Qadi Iyyad University, Marrakech, Morrocco
Mohamed Chakour, Hematology Laboratory of Avicene Military Hospital, Faculty of Medicine and Pharmacy, Qadi Iyyad University, Marrakech, Morrocco
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Larges granulars lymphocytes (LGL) leukemias correspond to rare haemopathies secondary to clonal proliferation of larges lymphocytes rich in azurophilic granules with phenotype T of CD3+ or CD3- (NK cell) profile. We report the case of a patient, 75 years old, who was admitted for pancytopenia associated with lymphocytosis at 8G / L all evolving in a febrile context. The clinical examination did not find tumoral syndrome. The blood smear founded very numerous granulars lymphocytes representing 46% of all lymphocytes. The myelogram shows an aspect in favor of peripheral thrombocytopenia without other notable abnormalities. There is a cellular expansion of CD8+ NK T cells compatible with LGL-type proliferation. The bone marrow is infiltrated by these lymphocytes with a percentage of 28%. It is a pathology with an heterogeneous spectrum classified by the World Health Organization into three entities: LGL T leukemia and chronic NK cell expansions with chronic and indolent evolution and aggressive cell leukemia NK with usually a reserved prognosis. Recent advances in the knowledge of the pathophysiology of these haemopathies have made it possible to specify the mechanisms underlying the perpetuation of the LGL clone and to identify new therapeutic targets.
Large Granular Lymphocytes Leukemias, Case Report, Three Entities, Literature Review
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Mustapha Ait Ameur,
Large Granular Lymphocytes Leukemia: A Case Report with a Review of the Literature, American Journal of Biomedical and Life Sciences.
Vol. 8, No. 1,
2020, pp. 1-4.
Copyright © 2020 Authors retain the copyright of this article.
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