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Assessment of the Risk of Hemochromatosis in Polytransfused Sickle Cell Patients at the Abidjan Transfusion Therapy Unit
American Journal of Biomedical and Life Sciences
Volume 8, Issue 1, February 2020, Pages: 20-24
Received: Jan. 15, 2020; Accepted: Jan. 27, 2020; Published: Feb. 7, 2020
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Yassongui Mamadou Sekongo, Department of Training and Research, National Blood Transfusion Center, Abidjan, Côte D’Ivoire
Kabore Saydou, Laboratory of quality control, National Blood Transfusion Center, Abidjan, Côte D’Ivoire
Kouakou Boidy, Hematology Department, Training and Research Unit of Medical Sciences, Abidjan, Côte D’Ivoire
Kouamenan Sidonie, Hemovigilance Service, National Blood Transfusion Center, Abidjan, Côte D’Ivoire
Kassogue Kadidja, Transfusion Therapy Unit, National Blood Transfusion Center, Abidjan, Côte D’Ivoire
N’Guessan Parfait, Transfusion Therapy Unit, National Blood Transfusion Center, Abidjan, Côte D’Ivoire
Oue Nabo Bertin, Transfusion Therapy Unit, National Blood Transfusion Center, Abidjan, Côte D’Ivoire
Konate Seidou, General Direction, National Blood Transfusion Center, Abidjan, Côte D’Ivoire
Sanogo Ibrahima, Hematology Service, Teaching Hospital Center of Yopogon, Abidjan, Côte D’Ivoire
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In Côte d'Ivoire, sickle cell disease affects 14% of the population. It is responsible for significant morbidity and mortality. Transfusion is a significant element in the management of major sickle cell anemia, which exposes them to post-transfusion hemochromatosis. The biological diagnosis is based on the determination of serum iron and the transferrin saturation coefficient (CST). As the determination of the CST was not available in our exercise context in Côte d'Ivoire, we determined only the ferritinemia. The interest of this work lies in the therapeutic implication linked to the identification of patients at risk of hemochromatosis because chelators are difficult to access for most patients. This was a prospective, descriptive and analytical study, on polytransfused sickle cell patients, followed at the transfusion therapy unit (UTT) of the CNTS of Abidjan, from 2010 to 2018. We included 78 sickle cell patients, all ages and genders who have received at least ten transfusions. The ferritinemia assay was carried out by ELISA. Transfusion exchange, with 59% of cases, was the most used mode of transfusion. The mean ferritinemia was 1719.19 ng / ml. Hyperferritinemia was found in 63% of patients. Most of the patients were on a long-term transfusion program with an average of 27.5 bags of red blood cell concentrates. Thirty-two patients had received at least 20 bags of red blood cell concentrates. We noted 21 patients treated, including 3 with deferoxamine and 18 treated with oral deferasirox. We have identified 33 sickle cell anemia patients at risk for hemochromatosis. The determinants of the risk of hemochromatosis were the high number of blood bags and the method of transfusion.
Hemochromatosis, Sickle Cell Disease, Tranfusion
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Yassongui Mamadou Sekongo, Kabore Saydou, Kouakou Boidy, Kouamenan Sidonie, Kassogue Kadidja, N’Guessan Parfait, Oue Nabo Bertin, Konate Seidou, Sanogo Ibrahima, Assessment of the Risk of Hemochromatosis in Polytransfused Sickle Cell Patients at the Abidjan Transfusion Therapy Unit, American Journal of Biomedical and Life Sciences. Vol. 8, No. 1, 2020, pp. 20-24. doi: 10.11648/j.ajbls.20200801.15
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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