Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics
American Journal of Biomedical and Life Sciences
Volume 8, Issue 4, August 2020, Pages: 119-125
Received: Aug. 20, 2020; Published: Aug. 25, 2020
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Authors
Jianzhang Hou, Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, China; Department of Hepatobiliary and Pancreatic (Minimally Invasive) Surgery, Cangzhou People's Hospital, Cangzhou, China
Yong Li, Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, China
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Abstract
Objective: To explore the value of integrin-linked kinase (ILK) in the diagnosis of gastric cancer, its mechanism of action in the pathogenesis and its influence on tumor metastasis. Methods: Collect 100 cases of gastric cancer diagnosed pathologically, detect the positive expression of ILK, and analyze its biological characteristics. Results: The positive rate of ILK in gastric cancer tissue (57.0%) is significantly higher than that in the control group (12%), and the positive rate of ILK gradually increased with the progress of superficial gastritis, chronic atrophic gastritis with atypical hyperplasia and gastric cancer. The differences between the four groups are statistically significant. There is a significant difference in the positive rate of ILK among well-differentiated, moderately-differentiated, poorly-differentiated and undifferentiated adenocarcinomas (P<0.001). The positive rate (25%) of ILK in the uninvaded serosal layer (T1+T2) is significantly lower than the positive rate (75.0%) in the invaded serosal layer (T3+T4). There is a significant difference in the positive rate of ILK in stage I, II, III and IV (P<0.001). In the localized type (I+II), the positive rate of ILK (24.39%) is significantly lower than that of the invasive type (III+IV) (79.66%). The positive rate of ILK in patients without lymph node metastasis (30.23%) is significantly lower than that of patients with lymph node metastasis (77.19%). Conclusion: The positive rate of ILK in gastric cancer tissue is significantly higher than that in adjacent tissues. The higher the positive rate, the worse the prognosis. ILK is an independent risk factor affecting the prognosis of patients.
Keywords
Gastric Cancer, Degree of Differentiation, Borrmann Classification, TNM Staging, Lymph Node Metastasis, Integrin-Linked Kinase
To cite this article
Jianzhang Hou, Yong Li, Expression of Integrin-linked Kinase in Gastric Cancer and Its Relationship with Clinicopathological Characteristics, American Journal of Biomedical and Life Sciences. Vol. 8, No. 4, 2020, pp. 119-125. doi: 10.11648/j.ajbls.20200804.18
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