Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats

Vadim Vyacheslavovich Davydov; Anatoliy Ivanovich Bozhkov; Evgeniya Romanovna Grabovetskaya

doi:doi:10.11648/j.ajbls.s.2014020601.11

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Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats

Vadim Vyacheslavovich Davydov, Anatoliy Ivanovich Bozhkov, Evgeniya Romanovna Grabovetskaya

Published in American Journal of Biomedical and Life Sciences (Volume 2, Issue 6-1)

Received: 3 August 2014 Accepted: 6 August 2014 Published: 13 August 2014

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Abstract

Resistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products of free radical oxidation in cells, we have suggested that the one of the reasons for this phenomenon is age-related changes in the efficiency of the scavenging of endogenous aldehydes in the organism. In view of this fact, spectrum of aldo-keto reductases in blood serum of rats at different stages of ontogenesis was investigated by means of electrophoresis. Identical changes in the composition of aldo-keto reductases spectrum of blood in early immature age and in aging have been shown. Change in aldo-keto reductases spectrum modulates the role of reductive pathway of endogenous aldehydes scavenging in the organism. Thus, in child age and aging efficiency of scavenging of carbonyl products of free radical oxidation in cells is limited and especially when they are intensively produced. This results in increase of the susceptibility of the organism to oxidative stress.

Published in	American Journal of Biomedical and Life Sciences (Volume 2, Issue 6-1) This article belongs to the Special Issue Mechanisms of Protection Against Oxidative Stress
DOI	10.11648/j.ajbls.s.2014020601.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Aldo-Keto Reductases, Blood, Ontogenesis, Oxidative Stress, Stress

References

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Vadim Vyacheslavovich Davydov, Anatoliy Ivanovich Bozhkov, Evgeniya Romanovna Grabovetskaya. (2014). Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats. American Journal of Biomedical and Life Sciences, 2(6-1), 1-4. https://doi.org/10.11648/j.ajbls.s.2014020601.11

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ACS Style

Vadim Vyacheslavovich Davydov; Anatoliy Ivanovich Bozhkov; Evgeniya Romanovna Grabovetskaya. Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats. Am. J. Biomed. Life Sci. 2014, 2(6-1), 1-4. doi: 10.11648/j.ajbls.s.2014020601.11

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AMA Style

Vadim Vyacheslavovich Davydov, Anatoliy Ivanovich Bozhkov, Evgeniya Romanovna Grabovetskaya. Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats. Am J Biomed Life Sci. 2014;2(6-1):1-4. doi: 10.11648/j.ajbls.s.2014020601.11

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@article{10.11648/j.ajbls.s.2014020601.11,
  author = {Vadim Vyacheslavovich Davydov and Anatoliy Ivanovich Bozhkov and Evgeniya Romanovna Grabovetskaya},
  title = {Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {2},
  number = {6-1},
  pages = {1-4},
  doi = {10.11648/j.ajbls.s.2014020601.11},
  url = {https://doi.org/10.11648/j.ajbls.s.2014020601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.s.2014020601.11},
  abstract = {Resistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products of free radical oxidation in cells, we have suggested that the one of the reasons for this phenomenon is age-related changes in the efficiency of the scavenging of endogenous aldehydes in the organism. In view of this fact, spectrum of aldo-keto reductases in blood serum of rats at different stages of ontogenesis was investigated by means of electrophoresis. Identical changes in the composition of aldo-keto reductases spectrum of blood in early immature age and in aging have been shown. Change in aldo-keto reductases spectrum modulates the role of reductive pathway of endogenous aldehydes scavenging in the organism. Thus, in child age and aging efficiency of scavenging of carbonyl products of free radical oxidation in cells is limited and especially when they are intensively produced. This results in increase of the susceptibility of the organism to oxidative stress.},
 year = {2014}
}

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TY  - JOUR
T1  - Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats
AU  - Vadim Vyacheslavovich Davydov
AU  - Anatoliy Ivanovich Bozhkov
AU  - Evgeniya Romanovna Grabovetskaya
Y1  - 2014/08/13
PY  - 2014
N1  - https://doi.org/10.11648/j.ajbls.s.2014020601.11
DO  - 10.11648/j.ajbls.s.2014020601.11
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.s.2014020601.11
AB  - Resistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products of free radical oxidation in cells, we have suggested that the one of the reasons for this phenomenon is age-related changes in the efficiency of the scavenging of endogenous aldehydes in the organism. In view of this fact, spectrum of aldo-keto reductases in blood serum of rats at different stages of ontogenesis was investigated by means of electrophoresis. Identical changes in the composition of aldo-keto reductases spectrum of blood in early immature age and in aging have been shown. Change in aldo-keto reductases spectrum modulates the role of reductive pathway of endogenous aldehydes scavenging in the organism. Thus, in child age and aging efficiency of scavenging of carbonyl products of free radical oxidation in cells is limited and especially when they are intensively produced. This results in increase of the susceptibility of the organism to oxidative stress.
VL  - 2
IS  - 6-1
ER  -

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Author Information

Vadim Vyacheslavovich Davydov

State Institution "Institute of Children and Adolescent Health NAMS of Ukraine", Kharkov, Ukraine
Anatoliy Ivanovich Bozhkov

V. N. Karazin Kharkov National University, Kharkov, Ukraine
Evgeniya Romanovna Grabovetskaya

Kharkov National Medical University, Kharkov, Ukraine

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APA Style

Vadim Vyacheslavovich Davydov, Anatoliy Ivanovich Bozhkov, Evgeniya Romanovna Grabovetskaya. (2014). Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats. American Journal of Biomedical and Life Sciences, 2(6-1), 1-4. https://doi.org/10.11648/j.ajbls.s.2014020601.11

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ACS Style

Vadim Vyacheslavovich Davydov; Anatoliy Ivanovich Bozhkov; Evgeniya Romanovna Grabovetskaya. Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats. Am. J. Biomed. Life Sci. 2014, 2(6-1), 1-4. doi: 10.11648/j.ajbls.s.2014020601.11

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AMA Style

Vadim Vyacheslavovich Davydov, Anatoliy Ivanovich Bozhkov, Evgeniya Romanovna Grabovetskaya. Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats. Am J Biomed Life Sci. 2014;2(6-1):1-4. doi: 10.11648/j.ajbls.s.2014020601.11

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@article{10.11648/j.ajbls.s.2014020601.11,
  author = {Vadim Vyacheslavovich Davydov and Anatoliy Ivanovich Bozhkov and Evgeniya Romanovna Grabovetskaya},
  title = {Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {2},
  number = {6-1},
  pages = {1-4},
  doi = {10.11648/j.ajbls.s.2014020601.11},
  url = {https://doi.org/10.11648/j.ajbls.s.2014020601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.s.2014020601.11},
  abstract = {Resistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products of free radical oxidation in cells, we have suggested that the one of the reasons for this phenomenon is age-related changes in the efficiency of the scavenging of endogenous aldehydes in the organism. In view of this fact, spectrum of aldo-keto reductases in blood serum of rats at different stages of ontogenesis was investigated by means of electrophoresis. Identical changes in the composition of aldo-keto reductases spectrum of blood in early immature age and in aging have been shown. Change in aldo-keto reductases spectrum modulates the role of reductive pathway of endogenous aldehydes scavenging in the organism. Thus, in child age and aging efficiency of scavenging of carbonyl products of free radical oxidation in cells is limited and especially when they are intensively produced. This results in increase of the susceptibility of the organism to oxidative stress.},
 year = {2014}
}

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TY  - JOUR
T1  - Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats
AU  - Vadim Vyacheslavovich Davydov
AU  - Anatoliy Ivanovich Bozhkov
AU  - Evgeniya Romanovna Grabovetskaya
Y1  - 2014/08/13
PY  - 2014
N1  - https://doi.org/10.11648/j.ajbls.s.2014020601.11
DO  - 10.11648/j.ajbls.s.2014020601.11
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.s.2014020601.11
AB  - Resistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products of free radical oxidation in cells, we have suggested that the one of the reasons for this phenomenon is age-related changes in the efficiency of the scavenging of endogenous aldehydes in the organism. In view of this fact, spectrum of aldo-keto reductases in blood serum of rats at different stages of ontogenesis was investigated by means of electrophoresis. Identical changes in the composition of aldo-keto reductases spectrum of blood in early immature age and in aging have been shown. Change in aldo-keto reductases spectrum modulates the role of reductive pathway of endogenous aldehydes scavenging in the organism. Thus, in child age and aging efficiency of scavenging of carbonyl products of free radical oxidation in cells is limited and especially when they are intensively produced. This results in increase of the susceptibility of the organism to oxidative stress.
VL  - 2
IS  - 6-1
ER  -

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