Cytotoxic, Acute Toxicity and Phytotoxic Activity of Callicarpa macrophylla in Various Models
American Journal of Biomedical and Life Sciences
Volume 3, Issue 2-1, March 2015, Pages: 1-4
Received: Oct. 21, 2014; Accepted: Oct. 30, 2014; Published: Nov. 5, 2014
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Authors
Barkatullah , Department of Botany, University of Peshawar, Peshawar-25120, Pakistan
Muhammad Ibrar, Department of Botany, University of Peshawar, Peshawar-25120, Pakistan
Muhammad Nafees, Department of Botany, University of Peshawar, Peshawar-25120, Pakistan
Abdur Rauf, Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, KPK, Pakistan
Haroon Khan, Department of Pharmacy, Abdul Wali Khan University Mardan-23200, Pakistan
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Abstract
The present study describes the cytotoxic, acute toxicity and phytotoxic activities of Callicarpa macrophylla belonging to family Verbanaceae. Brine shrimps cytotoxic bioassay of crude extract of bark of C. macrophylla (CBE) showed 975.22 LD50 value and crude extract of leaves of C. macrophylla (CLE) showed no significant results. However, all the test animals were found absolutely safe in acute toxicity test. In phytotoxic assay against Lemna minor, CLE showed FI50 value of 464.55 and CBE showed no significant results. In conclusion, the CLE showed significant phytotoxic activity and therefore, could be a useful natural herbicidal.
Keywords
Callicarpa Macrophylla, Cytotoxicity, Acute Toxicity, Phytotoxicity
To cite this article
Barkatullah , Muhammad Ibrar, Muhammad Nafees, Abdur Rauf, Haroon Khan, Cytotoxic, Acute Toxicity and Phytotoxic Activity of Callicarpa macrophylla in Various Models, American Journal of Biomedical and Life Sciences. Special Issue: Phytochemical and Pharmacological Study of Medicinal Plants. Vol. 3, No. 2-1, 2015, pp. 1-4. doi: 10.11648/j.ajbls.s.2015030201.11
References
[1]
V. Yadav, S. Jayalakshmi, R. K. Singla, and A. Patra, “Preliminary assessment of Anti-Inflammatory activity of Callicarpa macrophylla Vahl. leaves extracts,” Indo-Global J. Pharma. Sci. 1(3), 219- 222, 2011.
[2]
A. A. Munir, “A taxonomic revision of the genus Callicarpa l. (verbenaceae) in Australia,”.J. Adelaide Bot. Gard. 6(1), 5-39, 1982.
[3]
D. Bensky, A. Gamble, and T. Kaptchuk, Chinese Herbal Medicine: Material Medica. Seattle: Eastland Press; 1986.
[4]
Khare CP, editor. Indian Herbal Remedies: Rational Western Therapy, Ayurvedic and Other Traditional Usage, Botany. New York: Springer-Verlag; 2004.
[5]
R. K. Verma, A. K. Singh, P. Srivastava, K. Shanker, A. Kalra and M. M. Gupta, “Determination of Novel Plant Growth Promoting Diterpenes in Callicarpa macrophylla by HPLC and HPTLC,” J. Liq. Chromato. Related Technol. 32(16), 2437-2450, 2009.
[6]
H. Khan, M. A. Khan, and Abdullah, “Antibacterial, antioxidant and cytotoxic studies of total saponin, alkaloid and sterols contents of decoction of Joshanda: Identification of components identification through thin layer chromatography,” Toxic. Indus. Health, 2012. DOI: 10.1177/0748233712468023.
[7]
S. M. Shah, S. Hussain, A. Khan, H. Khan, F. Ullah, and B. Tullah, “Cytotoxic and phytotoxic actions of Heliotropium strigosum,” Toxic. Indus. Health, 2013. DOI: 10.1177/0748233712471706.
[8]
Barkatullah, M. Ibrar, and N. Muhammad, “Evaluation of Zanthoxylum armatum DC for in-vitro and in-vivo pharmacological screening,” Afr. J. Pharm. Pharmacol. 5(14): 1718-1723, 2011.
[9]
A. Rauf, G. Uddin, B. S. Siddiqui, A. Khan, H. Khan, M. Arfan, and A. Wadood, “In-vivo antinociceptive, anti-inflammatory and antipyretic activity of pistagremic acid isolated from Pistacia integerrima,” Phytomedicine, 21(12), 1509-1515, 2014.
[10]
I. Khan, H. Ahmad, N. Ali, B. Ahmad, and H. Tanoli, “Screening of Bunium bulbocastanum for antibacterial, antifungal, phytotoxic and haemagglutination activities,” Pak. J. Pharm. Sci., 26(4), 787-791, 2013.
[11]
G. Uddin, A. Rauf, B. S. Siddiqui, and H. Khan, “Cytotoxic Activity of Extracts/Fractions of Various Parts of Pistacia Integerrima Stewart,” Transl. Med. 3(118), 2161-1025 2013.
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