American Journal of Biomedical and Life Sciences

| Peer-Reviewed |

Normo Hyper and Extreme Hypercomplementemia in Human Chronic Periodontitis

Received: 11 February 2015    Accepted: 13 February 2015    Published: 02 March 2015
Views:       Downloads:

Share This Article

Abstract

Fourty-Nine chronic periodontitis patients were diagnosed by the dentist of the team. Of which 27 were generalized chronic and the other 22 were localized chronic periodontitis. Ten subjects with normal mouth hygienewere considered as controls. Blood,and saliva samples were collected from both of the test patients and controls. Sera, saliva and salivary proteins were subjected to C3 and C4 determinations using ready made plates ofradial immunodiffusion in gel containing anti-C3 and anti-C4 antibodies. Generalized chronic periodontitis patients were showing higher C3 levels than localized chronic periodontitis patients. Both of thedisease forms were of higher C3 and C4 levels than controls. Females have lower C3 levels than male chronic periodontitis patients. C4 levels were slightly increased than normal control levels. Male C4 levels approximate female levels. Four cases ofC3 and C4 hypercomplementemia in each of the disease forms.One extremecombinedC3 and C4 hypercomplementemia in the generalized form and one extreme C4 hypercomplementemiawas noted in the localized form. Thus, normo, hyper and extreme hypercomplementemia C3 and C4 were noted among chronic periodontitis patients. These hypercomplementemia cases are secondary non-genetic, infection and /or inflammation induced.

DOI 10.11648/j.ajbls.s.2015030401.12
Published in American Journal of Biomedical and Life Sciences (Volume 3, Issue 4-1, July 2015)

This article belongs to the Special Issue Advances in Oral Immunity

Page(s) 4-6
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Chronic, Complement C3 and C4, Localized, Generalized, Periodontitis

References
[1] Paul W 2000, Fundamental Immunology, 5th ed. , Lippincott, Williams and Wilkins, Philadelphia
[2] Katisikis PD, PulendranB, Schoenberger SP, 2007. Cross-roads between innate and adaptive immunity, Adv. Exp. Med. Biol., 590, Springer.
[3] Ahmid AEE, Peter JB, 1995, Clinical utility of complement assessment. Clin. Diag. Lab. Immunol. 2 (5):509-517.
[4] Whaley K, 1985, MethodsIn Complement for Clinical Immunologist, Churchil-Livingstone, UK.
[5] HajshengallisG 2010. Complement and periodontitis, Biochem. Pharmocol. , 80 (2):1992-2001.
[6] Abe T, Hosur KB, Hajishengallis E, Ries ES, Ricklin D, Lambris AD, Hajishengallis G, 2012, Local complement targeted intervention in periodontitis, J. Immunol. , 189 (11):5442-5448.
[7] Aurer A, Jorgic-Srdjak ,Palancak D, Starljenio-RukavinaA. and Aurer-Kozelj J 2005, Proinflammatory factors in saliva as possible marker for periodontal diseases, Coll. Anthropol. , 29 (2):435-439.
[8] Samakanayake LP, Jones BM, 2002, Essentials Of Dental Microbiology, Churchill-Livingstone, London.
[9] Arimitage GC 1999, Development of classification system for periodontal diseases. Annals of Periodontol. , 4:1-6.
[10] Salimeterics, 2013, Saliva collection and handling advice 3rded. saliva B Co. A, Salimeterics ,LLC, Co.
[11] Shnawa IMS, ALSadi MAK, 2001. Gut mucosal immunoglobulin ; separation, Partial Characterization and utility as infection Probe. , Irq. J. Microbiol. 13 (3):
[12] Stevens DC, 2012, Clinical Immunology:A Laboratory Perspective, 3rd ed. Davis Company FA, USA.
[13] Steel RGD, TOrrie JH, Dickey DA, 1997, PriciplesAnd Procedures Of Statistics:A biometricalApproach, 3rd, McGraw-Hill INC, N. Y.
[14] Shnawa IMS 2014, Individual Variation andHuman Herd Immunity, J. Nat. Sci. Res. 4 (8):31-38.
[15] Haffajee AD, Socransky SS, 1994, Microbial aetiological of the distructive periodontal disease, Periodotol. , 5-78-111.
[16] Marche skeyAM, Wick MR, 2014, PathologyOf Mediastinum, CambridgeUniversity Press.
[17] Boackle RJ 1991, Interaction of salivary secretion with human complement system, A model for the study of host defense system on the inflamed surfaces, Crit. Oral. Biol. Med. ,2 (2):355-367.
[18] Thomas SG, Boackle RJ, Long K, Lass J, Medof ME, 1990, Identification and isolation of two forms of decayacclyrating factors DAF from parotide saliva FASEB J, 4:2852.
[19] Cruse JM, Lewis Jr, 1993, Complement Today, Karger, New York.
[20] Veetil BMA, Osborn TG, Mayer DF, 2011, Extreme hypercomplementemia in setting of mixed cryoglobulinemia, Clin. Rheumatol. , 30 (3):415-418.
[21] Shnawa IMS, ALAmiedi, BHH, ALFatlawy, ZMH, 2014, Hypercomplementemia among periodontal disease patients:Gengivitis, Global. J. Med. Res. ,F, Disease, 14 (4):15-19.
Author Information
  • College of Biotechnology, University of Kasim , Kasim , Babylon / IRAQ

  • Department of Basic Sciences, College of Dentistry, University of Babylon , Babylon / IRAQ

  • Department of Oral Medicine, College of Dentistry, University of Babylon , Babylon / IRAQ

Cite This Article
  • APA Style

    Ibrahim M. S. Shnawa, Baha H. H. Alamiedi, Zainab M. H. Al Fatlawy. (2015). Normo Hyper and Extreme Hypercomplementemia in Human Chronic Periodontitis. American Journal of Biomedical and Life Sciences, 3(4-1), 4-6. https://doi.org/10.11648/j.ajbls.s.2015030401.12

    Copy | Download

    ACS Style

    Ibrahim M. S. Shnawa; Baha H. H. Alamiedi; Zainab M. H. Al Fatlawy. Normo Hyper and Extreme Hypercomplementemia in Human Chronic Periodontitis. Am. J. Biomed. Life Sci. 2015, 3(4-1), 4-6. doi: 10.11648/j.ajbls.s.2015030401.12

    Copy | Download

    AMA Style

    Ibrahim M. S. Shnawa, Baha H. H. Alamiedi, Zainab M. H. Al Fatlawy. Normo Hyper and Extreme Hypercomplementemia in Human Chronic Periodontitis. Am J Biomed Life Sci. 2015;3(4-1):4-6. doi: 10.11648/j.ajbls.s.2015030401.12

    Copy | Download

  • @article{10.11648/j.ajbls.s.2015030401.12,
      author = {Ibrahim M. S. Shnawa and Baha H. H. Alamiedi and Zainab M. H. Al Fatlawy},
      title = {Normo Hyper and Extreme Hypercomplementemia in Human Chronic Periodontitis},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {3},
      number = {4-1},
      pages = {4-6},
      doi = {10.11648/j.ajbls.s.2015030401.12},
      url = {https://doi.org/10.11648/j.ajbls.s.2015030401.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajbls.s.2015030401.12},
      abstract = {Fourty-Nine chronic periodontitis patients were diagnosed by the dentist of the team. Of which 27 were generalized chronic and the other 22 were localized chronic periodontitis. Ten subjects with normal mouth hygienewere considered as controls. Blood,and saliva samples were collected from both of the test patients and controls. Sera, saliva and salivary proteins were subjected to C3 and C4 determinations using ready made plates ofradial immunodiffusion in gel containing anti-C3 and anti-C4 antibodies. Generalized chronic periodontitis patients were showing higher C3 levels than localized chronic periodontitis patients. Both of thedisease forms were of higher C3 and C4 levels than controls. Females have lower C3 levels than male chronic periodontitis patients. C4 levels were slightly increased than normal control levels. Male C4 levels approximate female levels. Four cases ofC3 and C4 hypercomplementemia in each of the disease forms.One extremecombinedC3 and C4 hypercomplementemia in the generalized form and one extreme C4 hypercomplementemiawas noted in the localized form. Thus, normo, hyper and extreme hypercomplementemia C3 and C4 were noted among chronic periodontitis patients. These hypercomplementemia cases are secondary non-genetic, infection and /or inflammation induced.},
     year = {2015}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Normo Hyper and Extreme Hypercomplementemia in Human Chronic Periodontitis
    AU  - Ibrahim M. S. Shnawa
    AU  - Baha H. H. Alamiedi
    AU  - Zainab M. H. Al Fatlawy
    Y1  - 2015/03/02
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajbls.s.2015030401.12
    DO  - 10.11648/j.ajbls.s.2015030401.12
    T2  - American Journal of Biomedical and Life Sciences
    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
    SP  - 4
    EP  - 6
    PB  - Science Publishing Group
    SN  - 2330-880X
    UR  - https://doi.org/10.11648/j.ajbls.s.2015030401.12
    AB  - Fourty-Nine chronic periodontitis patients were diagnosed by the dentist of the team. Of which 27 were generalized chronic and the other 22 were localized chronic periodontitis. Ten subjects with normal mouth hygienewere considered as controls. Blood,and saliva samples were collected from both of the test patients and controls. Sera, saliva and salivary proteins were subjected to C3 and C4 determinations using ready made plates ofradial immunodiffusion in gel containing anti-C3 and anti-C4 antibodies. Generalized chronic periodontitis patients were showing higher C3 levels than localized chronic periodontitis patients. Both of thedisease forms were of higher C3 and C4 levels than controls. Females have lower C3 levels than male chronic periodontitis patients. C4 levels were slightly increased than normal control levels. Male C4 levels approximate female levels. Four cases ofC3 and C4 hypercomplementemia in each of the disease forms.One extremecombinedC3 and C4 hypercomplementemia in the generalized form and one extreme C4 hypercomplementemiawas noted in the localized form. Thus, normo, hyper and extreme hypercomplementemia C3 and C4 were noted among chronic periodontitis patients. These hypercomplementemia cases are secondary non-genetic, infection and /or inflammation induced.
    VL  - 3
    IS  - 4-1
    ER  - 

    Copy | Download

  • Sections