Normo Hyper and Extreme Hypercomplementemia in Human Chronic Periodontitis
American Journal of Biomedical and Life Sciences
Volume 3, Issue 4-1, July 2015, Pages: 4-6
Received: Feb. 11, 2015; Accepted: Feb. 13, 2015; Published: Mar. 2, 2015
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Ibrahim M. S. Shnawa, College of Biotechnology, University of Kasim , Kasim , Babylon / IRAQ
Baha H. H. Alamiedi, Department of Basic Sciences, College of Dentistry, University of Babylon , Babylon / IRAQ
Zainab M. H. Al Fatlawy, Department of Oral Medicine, College of Dentistry, University of Babylon , Babylon / IRAQ
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Fourty-Nine chronic periodontitis patients were diagnosed by the dentist of the team. Of which 27 were generalized chronic and the other 22 were localized chronic periodontitis. Ten subjects with normal mouth hygienewere considered as controls. Blood,and saliva samples were collected from both of the test patients and controls. Sera, saliva and salivary proteins were subjected to C3 and C4 determinations using ready made plates ofradial immunodiffusion in gel containing anti-C3 and anti-C4 antibodies. Generalized chronic periodontitis patients were showing higher C3 levels than localized chronic periodontitis patients. Both of thedisease forms were of higher C3 and C4 levels than controls. Females have lower C3 levels than male chronic periodontitis patients. C4 levels were slightly increased than normal control levels. Male C4 levels approximate female levels. Four cases ofC3 and C4 hypercomplementemia in each of the disease forms.One extremecombinedC3 and C4 hypercomplementemia in the generalized form and one extreme C4 hypercomplementemiawas noted in the localized form. Thus, normo, hyper and extreme hypercomplementemia C3 and C4 were noted among chronic periodontitis patients. These hypercomplementemia cases are secondary non-genetic, infection and /or inflammation induced.
Chronic, Complement C3 and C4, Localized, Generalized, Periodontitis
To cite this article
Ibrahim M. S. Shnawa, Baha H. H. Alamiedi, Zainab M. H. Al Fatlawy, Normo Hyper and Extreme Hypercomplementemia in Human Chronic Periodontitis, American Journal of Biomedical and Life Sciences. Special Issue:Advances in Oral Immunity. Vol. 3, No. 4-1, 2015, pp. 4-6. doi: 10.11648/j.ajbls.s.2015030401.12
Paul W 2000, Fundamental Immunology, 5th ed. , Lippincott, Williams and Wilkins, Philadelphia
Katisikis PD, PulendranB, Schoenberger SP, 2007. Cross-roads between innate and adaptive immunity, Adv. Exp. Med. Biol., 590, Springer.
Ahmid AEE, Peter JB, 1995, Clinical utility of complement assessment. Clin. Diag. Lab. Immunol. 2 (5):509-517.
Whaley K, 1985, MethodsIn Complement for Clinical Immunologist, Churchil-Livingstone, UK.
HajshengallisG 2010. Complement and periodontitis, Biochem. Pharmocol. , 80 (2):1992-2001.
Abe T, Hosur KB, Hajishengallis E, Ries ES, Ricklin D, Lambris AD, Hajishengallis G, 2012, Local complement targeted intervention in periodontitis, J. Immunol. , 189 (11):5442-5448.
Aurer A, Jorgic-Srdjak ,Palancak D, Starljenio-RukavinaA. and Aurer-Kozelj J 2005, Proinflammatory factors in saliva as possible marker for periodontal diseases, Coll. Anthropol. , 29 (2):435-439.
Samakanayake LP, Jones BM, 2002, Essentials Of Dental Microbiology, Churchill-Livingstone, London.
Arimitage GC 1999, Development of classification system for periodontal diseases. Annals of Periodontol. , 4:1-6.
Salimeterics, 2013, Saliva collection and handling advice 3rded. saliva B Co. A, Salimeterics ,LLC, Co.
Shnawa IMS, ALSadi MAK, 2001. Gut mucosal immunoglobulin ; separation, Partial Characterization and utility as infection Probe. , Irq. J. Microbiol. 13 (3):
Stevens DC, 2012, Clinical Immunology:A Laboratory Perspective, 3rd ed. Davis Company FA, USA.
Steel RGD, TOrrie JH, Dickey DA, 1997, PriciplesAnd Procedures Of Statistics:A biometricalApproach, 3rd, McGraw-Hill INC, N. Y.
Shnawa IMS 2014, Individual Variation andHuman Herd Immunity, J. Nat. Sci. Res. 4 (8):31-38.
Haffajee AD, Socransky SS, 1994, Microbial aetiological of the distructive periodontal disease, Periodotol. , 5-78-111.
Marche skeyAM, Wick MR, 2014, PathologyOf Mediastinum, CambridgeUniversity Press.
Boackle RJ 1991, Interaction of salivary secretion with human complement system, A model for the study of host defense system on the inflamed surfaces, Crit. Oral. Biol. Med. ,2 (2):355-367.
Thomas SG, Boackle RJ, Long K, Lass J, Medof ME, 1990, Identification and isolation of two forms of decayacclyrating factors DAF from parotide saliva FASEB J, 4:2852.
Cruse JM, Lewis Jr, 1993, Complement Today, Karger, New York.
Veetil BMA, Osborn TG, Mayer DF, 2011, Extreme hypercomplementemia in setting of mixed cryoglobulinemia, Clin. Rheumatol. , 30 (3):415-418.
Shnawa IMS, ALAmiedi, BHH, ALFatlawy, ZMH, 2014, Hypercomplementemia among periodontal disease patients:Gengivitis, Global. J. Med. Res. ,F, Disease, 14 (4):15-19.
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