Oral Mucosal Tolerance Versus Systemic Immune Response to Salmonella typhi Antigen
American Journal of Biomedical and Life Sciences
Volume 3, Issue 4-1, July 2015, Pages: 13-16
Received: Mar. 17, 2015; Accepted: Mar. 28, 2015; Published: Apr. 23, 2015
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Authors
Ibrahim Mohamed Saeed Shnawa, College of Biotechnology, Al-Kasim University, Babylon Province, Iraq
Zainab Khudhur Ahmed Al-Mahdi, Medical Science Department, College of Nursing, Babylon University, Babylon Province, Iraq
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Abstract
It was demonstrated that the oral vaccine application of Salmonella typhi antigen can activate low antibody agglutinin titer (mean:40±0) comparing with high agglutination titer induced by Intramuscular administration of Salmonella typhi antigen (mean 560.0 ± 51.64) as well as anti-Salmonella typhi IgG ELIZA shows high mean index value(mean = 0.6957±0.10) comparing with the low index value induced by oral rout were (mean= 0.028±0.014) while anti Salmonella typhi IgM ELIZA test show mean index value = 0.6339±0.0385 comparing with low IgM index value (mean= 0.1560±0.070) induced by oral rout (Rsquared 0.7457, t test 3.3. The pro –inflammatory cytokines IL-1α was high in intramuscular rout 217.089±39.78 than its concentration with in oral administrated group (100.4±12.09), IL-12 was about the same concentration both in oral rout and intramuscular rout subsequently (23.607 and 23.17) p value 0.01, R squared (0.3958).However the immune responses were not absolutely absent in the oral administrated group, this reflect the fact that there is a selectivity in taking oral antigens from digestive mucosal surfaces but this immune feature and selectivity theme may vary from antigen to another. In conclusion the recent and ongoing expansion of a new information about the mucosal and systemic immune responses lend a promise to provide the tools needed to exploit the full potential and development of both mucosal and intramuscular vaccines.
Keywords
Oral Tolerance, Systemic Immune Response, Intramuscular Rout
To cite this article
Ibrahim Mohamed Saeed Shnawa, Zainab Khudhur Ahmed Al-Mahdi, Oral Mucosal Tolerance Versus Systemic Immune Response to Salmonella typhi Antigen, American Journal of Biomedical and Life Sciences. Special Issue: Advances in Oral Immunity. Vol. 3, No. 4-1, 2015, pp. 13-16. doi: 10.11648/j.ajbls.s.2015030401.15
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