American Journal of Biomedical and Life Sciences

| Peer-Reviewed |

Cytotoxic, Acute Toxicity and Phytotoxic Activity of Callicarpa macrophylla in Various Models

Received: 21 October 2014    Accepted: 30 October 2014    Published: 05 November 2014
Views:       Downloads:

Share This Article

Abstract

The present study describes the cytotoxic, acute toxicity and phytotoxic activities of Callicarpa macrophylla belonging to family Verbanaceae. Brine shrimps cytotoxic bioassay of crude extract of bark of C. macrophylla (CBE) showed 975.22 LD50 value and crude extract of leaves of C. macrophylla (CLE) showed no significant results. However, all the test animals were found absolutely safe in acute toxicity test. In phytotoxic assay against Lemna minor, CLE showed FI50 value of 464.55 and CBE showed no significant results. In conclusion, the CLE showed significant phytotoxic activity and therefore, could be a useful natural herbicidal.

DOI 10.11648/j.ajbls.s.2015030201.11
Published in American Journal of Biomedical and Life Sciences (Volume 3, Issue 2-1, March 2015)

This article belongs to the Special Issue Phytochemical and Pharmacological Study of Medicinal Plants

Page(s) 1-4
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Callicarpa Macrophylla, Cytotoxicity, Acute Toxicity, Phytotoxicity

References
[1] V. Yadav, S. Jayalakshmi, R. K. Singla, and A. Patra, “Preliminary assessment of Anti-Inflammatory activity of Callicarpa macrophylla Vahl. leaves extracts,” Indo-Global J. Pharma. Sci. 1(3), 219- 222, 2011.
[2] A. A. Munir, “A taxonomic revision of the genus Callicarpa l. (verbenaceae) in Australia,”.J. Adelaide Bot. Gard. 6(1), 5-39, 1982.
[3] D. Bensky, A. Gamble, and T. Kaptchuk, Chinese Herbal Medicine: Material Medica. Seattle: Eastland Press; 1986.
[4] Khare CP, editor. Indian Herbal Remedies: Rational Western Therapy, Ayurvedic and Other Traditional Usage, Botany. New York: Springer-Verlag; 2004.
[5] R. K. Verma, A. K. Singh, P. Srivastava, K. Shanker, A. Kalra and M. M. Gupta, “Determination of Novel Plant Growth Promoting Diterpenes in Callicarpa macrophylla by HPLC and HPTLC,” J. Liq. Chromato. Related Technol. 32(16), 2437-2450, 2009.
[6] H. Khan, M. A. Khan, and Abdullah, “Antibacterial, antioxidant and cytotoxic studies of total saponin, alkaloid and sterols contents of decoction of Joshanda: Identification of components identification through thin layer chromatography,” Toxic. Indus. Health, 2012. DOI: 10.1177/0748233712468023.
[7] S. M. Shah, S. Hussain, A. Khan, H. Khan, F. Ullah, and B. Tullah, “Cytotoxic and phytotoxic actions of Heliotropium strigosum,” Toxic. Indus. Health, 2013. DOI: 10.1177/0748233712471706.
[8] Barkatullah, M. Ibrar, and N. Muhammad, “Evaluation of Zanthoxylum armatum DC for in-vitro and in-vivo pharmacological screening,” Afr. J. Pharm. Pharmacol. 5(14): 1718-1723, 2011.
[9] A. Rauf, G. Uddin, B. S. Siddiqui, A. Khan, H. Khan, M. Arfan, and A. Wadood, “In-vivo antinociceptive, anti-inflammatory and antipyretic activity of pistagremic acid isolated from Pistacia integerrima,” Phytomedicine, 21(12), 1509-1515, 2014.
[10] I. Khan, H. Ahmad, N. Ali, B. Ahmad, and H. Tanoli, “Screening of Bunium bulbocastanum for antibacterial, antifungal, phytotoxic and haemagglutination activities,” Pak. J. Pharm. Sci., 26(4), 787-791, 2013.
[11] G. Uddin, A. Rauf, B. S. Siddiqui, and H. Khan, “Cytotoxic Activity of Extracts/Fractions of Various Parts of Pistacia Integerrima Stewart,” Transl. Med. 3(118), 2161-1025 2013.
Author Information
  • Department of Botany, University of Peshawar, Peshawar-25120, Pakistan

  • Department of Botany, University of Peshawar, Peshawar-25120, Pakistan

  • Department of Botany, University of Peshawar, Peshawar-25120, Pakistan

  • Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, KPK, Pakistan

  • Department of Pharmacy, Abdul Wali Khan University Mardan-23200, Pakistan

Cite This Article
  • APA Style

    Barkatullah, Muhammad Ibrar, Muhammad Nafees, Abdur Rauf, Haroon Khan. (2014). Cytotoxic, Acute Toxicity and Phytotoxic Activity of Callicarpa macrophylla in Various Models. American Journal of Biomedical and Life Sciences, 3(2-1), 1-4. https://doi.org/10.11648/j.ajbls.s.2015030201.11

    Copy | Download

    ACS Style

    Barkatullah; Muhammad Ibrar; Muhammad Nafees; Abdur Rauf; Haroon Khan. Cytotoxic, Acute Toxicity and Phytotoxic Activity of Callicarpa macrophylla in Various Models. Am. J. Biomed. Life Sci. 2014, 3(2-1), 1-4. doi: 10.11648/j.ajbls.s.2015030201.11

    Copy | Download

    AMA Style

    Barkatullah, Muhammad Ibrar, Muhammad Nafees, Abdur Rauf, Haroon Khan. Cytotoxic, Acute Toxicity and Phytotoxic Activity of Callicarpa macrophylla in Various Models. Am J Biomed Life Sci. 2014;3(2-1):1-4. doi: 10.11648/j.ajbls.s.2015030201.11

    Copy | Download

  • @article{10.11648/j.ajbls.s.2015030201.11,
      author = {Barkatullah and Muhammad Ibrar and Muhammad Nafees and Abdur Rauf and Haroon Khan},
      title = {Cytotoxic, Acute Toxicity and Phytotoxic Activity of Callicarpa macrophylla in Various Models},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {3},
      number = {2-1},
      pages = {1-4},
      doi = {10.11648/j.ajbls.s.2015030201.11},
      url = {https://doi.org/10.11648/j.ajbls.s.2015030201.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajbls.s.2015030201.11},
      abstract = {The present study describes the cytotoxic, acute toxicity and phytotoxic activities of Callicarpa macrophylla belonging to family Verbanaceae. Brine shrimps cytotoxic bioassay of crude extract of bark of C. macrophylla (CBE) showed 975.22 LD50 value and crude extract of leaves of C. macrophylla (CLE) showed no significant results. However, all the test animals were found absolutely safe in acute toxicity test. In phytotoxic assay against Lemna minor, CLE showed FI50 value of 464.55 and CBE showed no significant results. In conclusion, the CLE showed significant phytotoxic activity and therefore, could be a useful natural herbicidal.},
     year = {2014}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Cytotoxic, Acute Toxicity and Phytotoxic Activity of Callicarpa macrophylla in Various Models
    AU  - Barkatullah
    AU  - Muhammad Ibrar
    AU  - Muhammad Nafees
    AU  - Abdur Rauf
    AU  - Haroon Khan
    Y1  - 2014/11/05
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajbls.s.2015030201.11
    DO  - 10.11648/j.ajbls.s.2015030201.11
    T2  - American Journal of Biomedical and Life Sciences
    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
    SP  - 1
    EP  - 4
    PB  - Science Publishing Group
    SN  - 2330-880X
    UR  - https://doi.org/10.11648/j.ajbls.s.2015030201.11
    AB  - The present study describes the cytotoxic, acute toxicity and phytotoxic activities of Callicarpa macrophylla belonging to family Verbanaceae. Brine shrimps cytotoxic bioassay of crude extract of bark of C. macrophylla (CBE) showed 975.22 LD50 value and crude extract of leaves of C. macrophylla (CLE) showed no significant results. However, all the test animals were found absolutely safe in acute toxicity test. In phytotoxic assay against Lemna minor, CLE showed FI50 value of 464.55 and CBE showed no significant results. In conclusion, the CLE showed significant phytotoxic activity and therefore, could be a useful natural herbicidal.
    VL  - 3
    IS  - 2-1
    ER  - 

    Copy | Download

  • Sections