Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG)

Nasma Nasser; Yusuf Suleiman; Habib Yousef

doi:doi:10.11648/j.ajbls.20200806.13

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Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG)

Nasma Nasser, Yusuf Suleiman, Habib Yousef

Published in American Journal of Biomedical and Life Sciences (Volume 8, Issue 6)

Received: 30 September 2020 Accepted: 16 October 2020 Published: 23 November 2020

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Abstract

Objective: Assessment of the macular ganglion cells function in myopic subjects using pattern electroretinogram (PERG) in comparison with healthy controls to help in diagnosing of retinal diseases, and studying the relationship of the changes seen in PERG with the axial length (AL) of the eye. Methods: The study was cross sectional, included 62 subjects (121 eyes). Three groups were examined: group 1: controls or emmetropics; group 2: mild myopics; group 3: moderate myopics. For all participants, a detailed pathological story was taken, a comprehensive eye examination was performed, AL was measured, and PERG was recorded, then the variables of the recorded waves (peak time and amplitude) were analyzed. Results: A statistically significant decrease in mean amplitudes of (P50, N95) waves was observed in group 2 (36 eyes) and 3 (25 eyes) compared to group 1 (60 eyes) (P-value <0.01), and a statistically significant elongation of mean N95 peak time was observed in (group 2 and 3) compared to group 1 (P-value <0.01) without being associated with elongation of mean P50 peak time. By studying the relationship between AL and each of peak time and amplitude of (P50, N95) waves, we have found that when AL increased, amplitudes decreased and peak times prolonged in a statistically significant way (P-value <0.01). Conclusion: The decreased amplitude of P50 wave may indicate a functional impairment of the macula in myopic subjects, and the decreased amplitude of N95 wave may be due to a functional impairment of their ganglion cells. The elongation of P50 peak time with increasing of AL may be due to a delay of the synaptic transmission between photoreceptors, bipolar cells, and ganglion cells.

Published in	American Journal of Biomedical and Life Sciences (Volume 8, Issue 6)
DOI	10.11648/j.ajbls.20200806.13
Page(s)	206-211
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Myopia, Pattern Electroretinogram, Axial Length, Macula, Ganglion Cell

References

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APA Style

Nasma Nasser, Yusuf Suleiman, Habib Yousef. (2020). Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG). American Journal of Biomedical and Life Sciences, 8(6), 206-211. https://doi.org/10.11648/j.ajbls.20200806.13

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ACS Style

Nasma Nasser; Yusuf Suleiman; Habib Yousef. Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG). Am. J. Biomed. Life Sci. 2020, 8(6), 206-211. doi: 10.11648/j.ajbls.20200806.13

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AMA Style

Nasma Nasser, Yusuf Suleiman, Habib Yousef. Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG). Am J Biomed Life Sci. 2020;8(6):206-211. doi: 10.11648/j.ajbls.20200806.13

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@article{10.11648/j.ajbls.20200806.13,
  author = {Nasma Nasser and Yusuf Suleiman and Habib Yousef},
  title = {Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG)},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {8},
  number = {6},
  pages = {206-211},
  doi = {10.11648/j.ajbls.20200806.13},
  url = {https://doi.org/10.11648/j.ajbls.20200806.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20200806.13},
  abstract = {Objective: Assessment of the macular ganglion cells function in myopic subjects using pattern electroretinogram (PERG) in comparison with healthy controls to help in diagnosing of retinal diseases, and studying the relationship of the changes seen in PERG with the axial length (AL) of the eye. Methods: The study was cross sectional, included 62 subjects (121 eyes). Three groups were examined: group 1: controls or emmetropics; group 2: mild myopics; group 3: moderate myopics. For all participants, a detailed pathological story was taken, a comprehensive eye examination was performed, AL was measured, and PERG was recorded, then the variables of the recorded waves (peak time and amplitude) were analyzed. Results: A statistically significant decrease in mean amplitudes of (P50, N95) waves was observed in group 2 (36 eyes) and 3 (25 eyes) compared to group 1 (60 eyes) (P-value Conclusion: The decreased amplitude of P50 wave may indicate a functional impairment of the macula in myopic subjects, and the decreased amplitude of N95 wave may be due to a functional impairment of their ganglion cells. The elongation of P50 peak time with increasing of AL may be due to a delay of the synaptic transmission between photoreceptors, bipolar cells, and ganglion cells.},
 year = {2020}
}

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TY  - JOUR
T1  - Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG)
AU  - Nasma Nasser
AU  - Yusuf Suleiman
AU  - Habib Yousef
Y1  - 2020/11/23
PY  - 2020
N1  - https://doi.org/10.11648/j.ajbls.20200806.13
DO  - 10.11648/j.ajbls.20200806.13
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 206
EP  - 211
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20200806.13
AB  - Objective: Assessment of the macular ganglion cells function in myopic subjects using pattern electroretinogram (PERG) in comparison with healthy controls to help in diagnosing of retinal diseases, and studying the relationship of the changes seen in PERG with the axial length (AL) of the eye. Methods: The study was cross sectional, included 62 subjects (121 eyes). Three groups were examined: group 1: controls or emmetropics; group 2: mild myopics; group 3: moderate myopics. For all participants, a detailed pathological story was taken, a comprehensive eye examination was performed, AL was measured, and PERG was recorded, then the variables of the recorded waves (peak time and amplitude) were analyzed. Results: A statistically significant decrease in mean amplitudes of (P50, N95) waves was observed in group 2 (36 eyes) and 3 (25 eyes) compared to group 1 (60 eyes) (P-value Conclusion: The decreased amplitude of P50 wave may indicate a functional impairment of the macula in myopic subjects, and the decreased amplitude of N95 wave may be due to a functional impairment of their ganglion cells. The elongation of P50 peak time with increasing of AL may be due to a delay of the synaptic transmission between photoreceptors, bipolar cells, and ganglion cells.
VL  - 8
IS  - 6
ER  -

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Author Information

Nasma Nasser

Ophthalmology Department, Faculty of Medicine, Tishreen University, Lattakia, Syria
Yusuf Suleiman

Ophthalmology Department, Faculty of Medicine, Tishreen University, Lattakia, Syria
Habib Yousef

Ophthalmology Department, Faculty of Medicine, Tishreen University, Lattakia, Syria

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APA Style

Nasma Nasser, Yusuf Suleiman, Habib Yousef. (2020). Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG). American Journal of Biomedical and Life Sciences, 8(6), 206-211. https://doi.org/10.11648/j.ajbls.20200806.13

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ACS Style

Nasma Nasser; Yusuf Suleiman; Habib Yousef. Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG). Am. J. Biomed. Life Sci. 2020, 8(6), 206-211. doi: 10.11648/j.ajbls.20200806.13

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AMA Style

Nasma Nasser, Yusuf Suleiman, Habib Yousef. Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG). Am J Biomed Life Sci. 2020;8(6):206-211. doi: 10.11648/j.ajbls.20200806.13

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@article{10.11648/j.ajbls.20200806.13,
  author = {Nasma Nasser and Yusuf Suleiman and Habib Yousef},
  title = {Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG)},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {8},
  number = {6},
  pages = {206-211},
  doi = {10.11648/j.ajbls.20200806.13},
  url = {https://doi.org/10.11648/j.ajbls.20200806.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20200806.13},
  abstract = {Objective: Assessment of the macular ganglion cells function in myopic subjects using pattern electroretinogram (PERG) in comparison with healthy controls to help in diagnosing of retinal diseases, and studying the relationship of the changes seen in PERG with the axial length (AL) of the eye. Methods: The study was cross sectional, included 62 subjects (121 eyes). Three groups were examined: group 1: controls or emmetropics; group 2: mild myopics; group 3: moderate myopics. For all participants, a detailed pathological story was taken, a comprehensive eye examination was performed, AL was measured, and PERG was recorded, then the variables of the recorded waves (peak time and amplitude) were analyzed. Results: A statistically significant decrease in mean amplitudes of (P50, N95) waves was observed in group 2 (36 eyes) and 3 (25 eyes) compared to group 1 (60 eyes) (P-value Conclusion: The decreased amplitude of P50 wave may indicate a functional impairment of the macula in myopic subjects, and the decreased amplitude of N95 wave may be due to a functional impairment of their ganglion cells. The elongation of P50 peak time with increasing of AL may be due to a delay of the synaptic transmission between photoreceptors, bipolar cells, and ganglion cells.},
 year = {2020}
}

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TY  - JOUR
T1  - Evaluation of the Function of Ganglion Cells in Myopic Patients Using Pattern Electroretinogram (PERG)
AU  - Nasma Nasser
AU  - Yusuf Suleiman
AU  - Habib Yousef
Y1  - 2020/11/23
PY  - 2020
N1  - https://doi.org/10.11648/j.ajbls.20200806.13
DO  - 10.11648/j.ajbls.20200806.13
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 206
EP  - 211
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20200806.13
AB  - Objective: Assessment of the macular ganglion cells function in myopic subjects using pattern electroretinogram (PERG) in comparison with healthy controls to help in diagnosing of retinal diseases, and studying the relationship of the changes seen in PERG with the axial length (AL) of the eye. Methods: The study was cross sectional, included 62 subjects (121 eyes). Three groups were examined: group 1: controls or emmetropics; group 2: mild myopics; group 3: moderate myopics. For all participants, a detailed pathological story was taken, a comprehensive eye examination was performed, AL was measured, and PERG was recorded, then the variables of the recorded waves (peak time and amplitude) were analyzed. Results: A statistically significant decrease in mean amplitudes of (P50, N95) waves was observed in group 2 (36 eyes) and 3 (25 eyes) compared to group 1 (60 eyes) (P-value Conclusion: The decreased amplitude of P50 wave may indicate a functional impairment of the macula in myopic subjects, and the decreased amplitude of N95 wave may be due to a functional impairment of their ganglion cells. The elongation of P50 peak time with increasing of AL may be due to a delay of the synaptic transmission between photoreceptors, bipolar cells, and ganglion cells.
VL  - 8
IS  - 6
ER  -

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