American Journal of Health Research

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The Rate of Anti-Chlamydia Pneumoniae IgG and IgA Antibodies Among Patients With Coronary Heart Diseases in Diyala Province, Iraq

Received: 25 March 2015    Accepted: 07 April 2015    Published: 17 April 2015
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Abstract

Background: Chlamydia pneumoniae is found worldwide, it causes acute respiratory infection, especially atypical pneumonia. High prevalence of past infection with Ch. pneumoniae have been found in developing countries that may has a role in pathogenesis of coronary heart disease. Objective: The present study was sought todetermined the rate of anti- Ch. pneumoniae IgG and IgA antibodies among patients with coronary heart diseases in Diyala province, Iraq. Material and Methods: This study was conducted during the period from November/ 2013 to December/ 2014. 91 Participants were included; 45 patients with coronary heart disease (myocardial infarction, angina, and atherosclerosis) who were chosen according to clinical criteria and 46 apparently healthy individuals as control group. The mean age of the patients was (59.20 ± 11.45) years with an age rang (40-90) years, and for the controls, and the mean age was (35.43 ± 8.67) years with an age rang (32-86) years. Detection of anti- Ch. pneumoniae IgG and IgA antibodies was done by Enzyme – Linked Immunosorbant Assay (Nova Tec immundiagnostica GmbH, Germany). Results: The present results study show that the positivity rate of anti-Ch. pneumoniae IgG antibodies was significantly higher among patients compared to controls (66.67%vs54.35%, P ≤ 0.05). While, the seroprevalence of anti- Ch. pneumoniae IgA antibodies among patients and controls was 24.44%and 13.04% respectively, this results showed that there is a statistically significant association between Chlamydia pneumoniae and CHD, P ≤ 0.05. Conclusion: The presence of anti-Ch. pneumoniae IgG and IgA are significantly associated with CHD patients in Diyala province.

DOI 10.11648/j.ajhr.20150303.11
Published in American Journal of Health Research (Volume 3, Issue 3, May 2015)
Page(s) 121-124
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Coronary Heart Diseases, Anti-Ch. Pneumoniae IgG and IgA, Diyala

References
[1] Ward, M.E. Chlamydia. In: Greenwood, D.; Slack, R.; Peutherer, J. and Barer, M. Medical Microbiology. 17th. Ed 2007. Churchill Livingstone. PP 375-84.
[2] Saikku, P. ; Leinonen, M. ; Tenkanen, L. ; Linnanmaki, E. ; Ekman, M. R. ; et al. Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study. Ann Intern Med. 1992;116: 273–278.
[3] Patel, P. ; Kendall, M. A. Carrington, D. et al. Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease. BMJ. 1995;311:711–14.
[4] World Health Organization. Global status report on non-communicable diseases 2014. Geneva-Switzerland.
[5] Malinverni, R. Infective Chlamydia pneumoniae and coronary disease: where is the truth?. Rev. Med. Suisse Romande. 2000;120(1):43-6.
[6] Ieven, M. M. and Hoymans, V. Y. Involvement of Chlamydia pneumoniae in Atherosclerosis: More Evidence for Lack of Evidence.J. Clin. Microbiol. 2005;43(1): 19–24.
[7] Agarwal, L. A.; Chander, C. Y. and Nagendra, B. A. Serological evidence of chronic Chlamydia pneumoniae infection in coronary heart disease. MJAFI. 2007; 63: 229-32.
[8] Altannavch, T.S. ; Roubalova, K .; Broz, J. ; Hruba, D. and Andel, M. Serological markers of Chlamydia pneumoniae, cytomegalovirus and Helicobacter pylori infection in diabetic and non-diabetic patients with unstable angina pectoris. Cent. Eur. J. Publ. Health. 2003;11(2):102-6.
[9] Jha, H.C .; Prasad, J. and Mittal, A. High immunoglobulin A seropositivity for combined Chlamydia pneumoniae, Helicobacter pylori infection, and high-sensitivity C-reactive protein in coronary artery disease patients in India can serve as atherosclerotic marker. Heart Vessels. 2008;23(6):390-6.
[10] Al-Ghamdi, A. ; Jiman-Fatani, A.A. and El-Banna, H. Role of Chlamydia pneumoniae,helicobacter pylori and cytomegalovirus in coronary artery disease. Pak. J. Pharm. Sci. 2011;24(2):95-101.
[11] Grdanoska, T. ; Zafirovska, P. ; Jaglikovski, B. ; Pavlovska, I. ; Zafirova, B. ; Tosheska-Trajkovska, K. ; Trajkovska-Dokic, E. ; Petrovska, M. ; Cekovska, Z. ; Kondova-Topuzovska, I. ; Georgievska-Ismail, L. and Panovsk,i N. Chlamydia pneumoniae and helicobacter pylori serology - importance in patients with coronary heart disease. Mater Sociomed. 2012;24(3):151-6.
[12] Kazar, J.; Kovacova, E.; Koncova, K.; Cvachova, S.; Mongiellova, V.; Lietava, J. and Simko, F. Chlamydia pneumoniae antibodies and markers of inflammation in patients with cardiovascular diseases. Bratisl Lek Lisly. 2005;106(11):341-4.
[13] Romano Carratelli, C.; Nuzzo, I. ; Cozzolino, D. ; Bentivoglio, C.; Paolillo, R. and Rizzo, A. Relationship between Chlamydia pneumoniae infection, inflammatory markers, and coronary heart diseases. Int. Immunopharmacol. 2006;6(5):848-53.
[14] Pesonen, E. ; Andsberg, E. ; Ohlin, H. ; Puolakkainen, M. ; Rautelin, H. ; Sarna, S. and Persson, K. Dual role of infections as risk factors for coronary heart disease. Atherosclerosis. 2007;192(2):370-5.
[15] Piechowski-Jozwiak, B. ; Mickielewicz, A. ; Gaciong, Z. ; Berent, H. and Kwiecinski, H. Elevated levels of anti-Chlamydia pneumoniae IgA and IgG antibodies in young adults with ischemic stroke. Acta Neurol Scand. 2007;116(3):144-9.
[16] Latsios, G. ; Saetta, A. ; Michalopoulos, N.V. ; Agapitos, E. and Patsouris, E. Detection of cytomegalovirus, Helicobacter pylori and Chlamydia pneumoniae DNA in carotid atherosclerotic plaques by the polymerase chain reaction. Acta Cardiol. 2004;59(6):652-7.
[17] Jha, H.C. and Mitta, I. A. Sequencing of Chlamydia pneumoniae in coronary artery disease patients attending tertiary hospital in India. Am. J. Infect. Control. 2010;38(6):497-8.
[18] Gurfinked, E. and Bozovich, G. Chlamydia pneumoniae : Inflammation and instability of atherosclerotic plaque. Atherosclerotic. 1998;140 [Suppl 1]: S31-35.
[19] Guech-Ongey, M. ; Brenner, H.; Twardella, D. and Rothenbacher, D. Chlamydia pneumoniae, heat shock proteins 60 and risk of secondary cardiovascular events in patients with coronary heart disease under special consideration of diabetes: a prospective study. BMC Cardiovasc. Disord. 2006;6:17.
[20] Schumacher, A. ; Seljeflot, I. ; Lerkerod, A.B.; Sommervoll, L. ; Otterstad, J.E. and Arnesen, H. Chlamydia LPS and MOMP seropositivity are associated with different cytokine profiles in patients with coronary heart disease. Eur. J. Clin. Invest. 2005;35(7):431-7.
[21] Haider, M. ; Rizvi, M. ; Malik, A. ; et al. Acute and chronic Chlamydia pneumoniae infection and inflammatory markers in coronary heart disease patients. J. Infect. Dev. Ctries. 2011;5(8): 580-6.
[22] Tanne, D. ; Haim, M. ; Boyko, V. ; Goldbourt, U.; Reshef. T. ; Adler, Y.; Brunner, D.; Mekori, Y.A. andBehar, S. Prospective study of Chlamydia pneumoniae IgG and IgA seropositivity and risk of incident ischemic stroke. Cerebrovasc. Dis. 2003;16(2):166-70.
[23] Chaudhury, A.; Rajasekhar, D. ; Latheef, S.A. and Subramanyam, G. Seroprevalence of IgG antibodies to Chlamydia pneumoniae and Helicobacter pylori among coronary heart disease patients and normal individuals in South Indian population. Indian J. Pathol. Microbiol. 2004;47(3):433-4.
[24] Vainas, T. ; Sayed, S. ; Bruggeman, C.A. and Stassen, F.R. Exploring the role of Chlamydia pneumoniae in cardiovascular disease: a narrative review. Drug Today (Brac) 2009;45 Suppl B:165-72.
[25] Chen, J. ; Zhu, M. ; Ma, G. ; Zhao, Z. and Sun, Z. Chlamydia pneumoniae infection and cerebrovascular disease: a systematic review and meta-analysis. BMC Neurol. 2013;13:183.
[26] Kurano, M. and Tsukamoto, K. Etiology of atherosclerosis-- special reference to bacterial infection and viral infection. Nihon Rinsho. 2011;69(1):25-9
[27] Zodpey, S. P. ; Shrikhande, S. N. ; Negandhi, H. N. ; Ughade, S. N. ; Joshi, P. P. Risk factors for acute myocardial infarction in central India. Indian J Community Med. 2015;40(1):19-26.
[28] Ali, H. A. ; Al-Humrani, A. H. and Al-Hadithi, H. T. Chlamydia pneumoniae infection in coronary heart disease in Basrah. The Medical Journal of Basrah University. 2010;25(1) : 23-6.
[29] Azarkar, Z. ;Jafarnejad, M. ; Zardast, M. ; et al. Chlamydia pneumoniae infection and cardiac risk factors in patients with myocardial infection. ARYA Atherosclerosis Journal. 2011;6(4): 127-30.
[30] Ashkenazi, H. ; Rudensky, B. ; Paz, E. ; Raveh. D. ; Balkin, J. A.; et al. Incidence of Immunoglobulin G antibodies to Chlamydia pneumoniae in acute myocardial infarction patients. IMAJ. 2001;3: 818-21.
[31] Momenah, A.M. and Tayeb, M.T. Chlamydia pneumoniae seropositivity and risk of developing coronary heart disease in Western Saudi Arabia. Saudi Med. J. 2005;26(12):1926-9.
[32] Monno, R. ;Fumarola, L. ; Trerotoli, P. ; Giannelli, G. ; Correale, M. ; et al. Seroprevalence of Chlamydophila pneumoniae in ischaemic heart disease. New Microbiologia. 2010;33: 381-385.
[33] Sakurai-Komada, N. ; Iso, H. ; Kaike, K. A. ; Ikeda, A. ; Umesawa, M. ; et al. Association between Chlamydophila pneumoniae infection and risk of coronary heart disease for Japanese : the JPHCN study. Atherosclerosis. 2014;233(2) : 338-42.
[34] Arcari, C. ; Gaydos, C. ; Nieto, F. ; et al. Association between Chlamydia pneumoniae and acute myocardial infarction in young men in the united states military: the importance of timing of exposure measurement. Clin Infect Dis. 2005;40:1123–1132.
Author Information
  • Department of Biology, College of Education for Pure Science, Diyala University, Diyala Province, Iraq

  • Department of Biology, College of Education for Pure Science, Diyala University, Diyala Province, Iraq

  • Department of Biology, College of Education for Pure Science, Diyala University, Diyala Province, Iraq

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  • APA Style

    Abbas Abood Al-Duliami, Asmaa Haseeb Hwaid, Fatin Ali Al-Chalabi. (2015). The Rate of Anti-Chlamydia Pneumoniae IgG and IgA Antibodies Among Patients With Coronary Heart Diseases in Diyala Province, Iraq. American Journal of Health Research, 3(3), 121-124. https://doi.org/10.11648/j.ajhr.20150303.11

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    ACS Style

    Abbas Abood Al-Duliami; Asmaa Haseeb Hwaid; Fatin Ali Al-Chalabi. The Rate of Anti-Chlamydia Pneumoniae IgG and IgA Antibodies Among Patients With Coronary Heart Diseases in Diyala Province, Iraq. Am. J. Health Res. 2015, 3(3), 121-124. doi: 10.11648/j.ajhr.20150303.11

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    AMA Style

    Abbas Abood Al-Duliami, Asmaa Haseeb Hwaid, Fatin Ali Al-Chalabi. The Rate of Anti-Chlamydia Pneumoniae IgG and IgA Antibodies Among Patients With Coronary Heart Diseases in Diyala Province, Iraq. Am J Health Res. 2015;3(3):121-124. doi: 10.11648/j.ajhr.20150303.11

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  • @article{10.11648/j.ajhr.20150303.11,
      author = {Abbas Abood Al-Duliami and Asmaa Haseeb Hwaid and Fatin Ali Al-Chalabi},
      title = {The Rate of Anti-Chlamydia Pneumoniae IgG and IgA Antibodies Among Patients With Coronary Heart Diseases in Diyala Province, Iraq},
      journal = {American Journal of Health Research},
      volume = {3},
      number = {3},
      pages = {121-124},
      doi = {10.11648/j.ajhr.20150303.11},
      url = {https://doi.org/10.11648/j.ajhr.20150303.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajhr.20150303.11},
      abstract = {Background: Chlamydia pneumoniae is found worldwide, it causes acute respiratory infection, especially atypical pneumonia. High prevalence of past infection with Ch. pneumoniae have been found in developing countries that may has a role in pathogenesis of coronary heart disease. Objective: The present study was sought todetermined the rate of anti- Ch. pneumoniae IgG and IgA antibodies among patients with coronary heart diseases in Diyala province, Iraq. Material and Methods: This study was conducted during the period from November/ 2013 to December/ 2014. 91 Participants were included; 45 patients with coronary heart disease (myocardial infarction, angina, and atherosclerosis) who were chosen according to clinical criteria and 46 apparently healthy individuals as control group. The mean age of the patients was (59.20 ± 11.45) years with an age rang (40-90) years, and for the controls, and the mean age was (35.43 ± 8.67) years with an age rang (32-86) years. Detection of anti- Ch. pneumoniae IgG and IgA antibodies was done by Enzyme – Linked Immunosorbant Assay (Nova Tec immundiagnostica GmbH, Germany). Results: The present results study show that the positivity rate of anti-Ch. pneumoniae IgG antibodies was significantly higher among patients compared to controls (66.67%vs54.35%, P ≤ 0.05). While, the seroprevalence of anti- Ch. pneumoniae IgA antibodies among patients and controls was 24.44%and 13.04% respectively, this results showed that there is a statistically significant association between Chlamydia pneumoniae and CHD, P ≤ 0.05. Conclusion: The presence of anti-Ch. pneumoniae IgG and IgA are significantly associated with CHD patients in Diyala province.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - The Rate of Anti-Chlamydia Pneumoniae IgG and IgA Antibodies Among Patients With Coronary Heart Diseases in Diyala Province, Iraq
    AU  - Abbas Abood Al-Duliami
    AU  - Asmaa Haseeb Hwaid
    AU  - Fatin Ali Al-Chalabi
    Y1  - 2015/04/17
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajhr.20150303.11
    DO  - 10.11648/j.ajhr.20150303.11
    T2  - American Journal of Health Research
    JF  - American Journal of Health Research
    JO  - American Journal of Health Research
    SP  - 121
    EP  - 124
    PB  - Science Publishing Group
    SN  - 2330-8796
    UR  - https://doi.org/10.11648/j.ajhr.20150303.11
    AB  - Background: Chlamydia pneumoniae is found worldwide, it causes acute respiratory infection, especially atypical pneumonia. High prevalence of past infection with Ch. pneumoniae have been found in developing countries that may has a role in pathogenesis of coronary heart disease. Objective: The present study was sought todetermined the rate of anti- Ch. pneumoniae IgG and IgA antibodies among patients with coronary heart diseases in Diyala province, Iraq. Material and Methods: This study was conducted during the period from November/ 2013 to December/ 2014. 91 Participants were included; 45 patients with coronary heart disease (myocardial infarction, angina, and atherosclerosis) who were chosen according to clinical criteria and 46 apparently healthy individuals as control group. The mean age of the patients was (59.20 ± 11.45) years with an age rang (40-90) years, and for the controls, and the mean age was (35.43 ± 8.67) years with an age rang (32-86) years. Detection of anti- Ch. pneumoniae IgG and IgA antibodies was done by Enzyme – Linked Immunosorbant Assay (Nova Tec immundiagnostica GmbH, Germany). Results: The present results study show that the positivity rate of anti-Ch. pneumoniae IgG antibodies was significantly higher among patients compared to controls (66.67%vs54.35%, P ≤ 0.05). While, the seroprevalence of anti- Ch. pneumoniae IgA antibodies among patients and controls was 24.44%and 13.04% respectively, this results showed that there is a statistically significant association between Chlamydia pneumoniae and CHD, P ≤ 0.05. Conclusion: The presence of anti-Ch. pneumoniae IgG and IgA are significantly associated with CHD patients in Diyala province.
    VL  - 3
    IS  - 3
    ER  - 

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